| MeSH term | MeSH ID | Detail |
|---|---|---|
| Osteosarcoma | D012516 | 50 associated lipids |
| Brain Neoplasms | D001932 | 15 associated lipids |
| Leukemia, Erythroblastic, Acute | D004915 | 41 associated lipids |
| Melanoma | D008545 | 69 associated lipids |
| Muscular Dystrophies | D009136 | 10 associated lipids |
| Asthma | D001249 | 52 associated lipids |
| Abnormalities, Multiple | D000015 | 13 associated lipids |
| Intellectual Disability | D008607 | 13 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
trichostatin A
Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with trichostatin A?
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with trichostatin A
PubChem Associated disorders and diseases
What pathways are associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with trichostatin A?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with trichostatin A?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with trichostatin A?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with trichostatin A?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with trichostatin A?
Mouse Model
Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with trichostatin A
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Yu F et al. | Histone deacetylase-independent transcriptional repression by methyl-CpG-binding protein 2. | 2000 | Nucleic Acids Res. | pmid:10773092 |
| Huang X et al. | Nitric oxide (NO), methylation and TIMP-1 expression in BL6 melanoma cells transfected with MHC class I genes. | 2000 | Clin. Exp. Metastasis | pmid:11448064 |
| Kitamura K et al. | Histone deacetylase inhibitor but not arsenic trioxide differentiates acute promyelocytic leukaemia cells with t(11;17) in combination with all-trans retinoic acid. | 2000 | Br. J. Haematol. | pmid:10792271 |
| Saleh M et al. | Cell signaling switches HOX-PBX complexes from repressors to activators of transcription mediated by histone deacetylases and histone acetyltransferases. | 2000 | Mol. Cell. Biol. | pmid:11046157 |
| Chang LK and Liu ST | Activation of the BRLF1 promoter and lytic cycle of Epstein-Barr virus by histone acetylation. | 2000 | Nucleic Acids Res. | pmid:11024171 |
| Suzuki T et al. | Effect of trichostatin A on cell growth and expression of cell cycle- and apoptosis-related molecules in human gastric and oral carcinoma cell lines. | 2000 | Int. J. Cancer | pmid:11093826 |
| Sutcliffe JE et al. | Retinoblastoma protein disrupts interactions required for RNA polymerase III transcription. | 2000 | Mol. Cell. Biol. | pmid:11094071 |
| Mao C and Shapiro DJ | A histone deacetylase inhibitor potentiates estrogen receptor activation of a stably integrated vitellogenin promoter in HepG2 cells. | 2000 | Endocrinology | pmid:10875235 |
| Clayton AL et al. | Phosphoacetylation of histone H3 on c-fos- and c-jun-associated nucleosomes upon gene activation. | 2000 | EMBO J. | pmid:10899125 |
| Kang J et al. | Heat shock protein 90 mediates protein-protein interactions between human aminoacyl-tRNA synthetases. | 2000 | J. Biol. Chem. | pmid:10913161 |
| Yu J et al. | Transcriptional repression by blimp-1 (PRDI-BF1) involves recruitment of histone deacetylase. | 2000 | Mol. Cell. Biol. | pmid:10713181 |
| Adachi N et al. | Cell-cycle regulation of the DNA topoisomerase IIalpha promoter is mediated by proximal CCAAT boxes: possible involvement of acetylation. | 2000 | Gene | pmid:10713444 |
| Shin JY et al. | Mechanism for inactivation of the KIP family cyclin-dependent kinase inhibitor genes in gastric cancer cells. | 2000 | Cancer Res. | pmid:10667572 |
| Stöckel B et al. | Characterization of the 5'-flanking region of the human multidrug resistance protein 2 (MRP2) gene and its regulation in comparison withthe multidrug resistance protein 3 (MRP3) gene. | 2000 | Eur. J. Biochem. | pmid:10691972 |
| Imai S et al. | Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase. | 2000 | Nature | pmid:10693811 |
| Sirchia SM et al. | Evidence of epigenetic changes affecting the chromatin state of the retinoic acid receptor beta2 promoter in breast cancer cells. | 2000 | Oncogene | pmid:10734315 |
| Hodny Z et al. | Sp1 and chromatin environment are important contributors to the formation of repressive chromatin structures on the transfected human adenine nucleotide translocase-2 promoter. | 2000 | Biochem. J. | pmid:10657244 |
| Garrison PM et al. | Effects of histone deacetylase inhibitors on the Ah receptor gene promoter. | 2000 | Arch. Biochem. Biophys. | pmid:10666294 |
| Smith RD et al. | Quantitative PCR analysis of HbF inducers in primary human adult erythroid cells. | 2000 | Blood | pmid:10648397 |
| Nakayama T et al. | Epigenetic regulation of androgen receptor gene expression in human prostate cancers. | 2000 | Lab. Invest. | pmid:11140692 |
| Fukuda K | Apoptosis-associated cleavage of beta-catenin in human colon cancer and rat hepatoma cells. | 1999 Mar-Apr | Int. J. Biochem. Cell Biol. | pmid:10224675 |
| Schmidt K et al. | Inhibitors of histone deacetylase suppress the growth of MCF-7 breast cancer cells. | 1999 | Arch. Pharm. (Weinheim) | pmid:10575368 |
| Jung M et al. | Amide analogues of trichostatin A as inhibitors of histone deacetylase and inducers of terminal cell differentiation. | 1999 | J. Med. Chem. | pmid:10579829 |
| Chien PY et al. | A fusion protein of the estrogen receptor (ER) and nuclear receptor corepressor (NCoR) strongly inhibits estrogen-dependent responses in breast cancer cells. | 1999 | Mol. Endocrinol. | pmid:10598586 |
| Taddei A et al. | Duplication and maintenance of heterochromatin domains. | 1999 | J. Cell Biol. | pmid:10601331 |
| Nielsen AL et al. | Interaction with members of the heterochromatin protein 1 (HP1) family and histone deacetylation are differentially involved in transcriptional silencing by members of the TIF1 family. | 1999 | EMBO J. | pmid:10562550 |
| Habeck M | Gelsolin: a new marker for breast cancer? | 1999 | Mol Med Today | pmid:10562712 |
| Gray SG et al. | IGF-II enhances trichostatin A-induced TGFbeta1 and p21(Waf1,Cip1, sdi1) expression in Hep3B cells. | 1999 | Exp. Cell Res. | pmid:10585285 |
| Saunders N et al. | Histone deacetylase inhibitors as potential anti-skin cancer agents. | 1999 | Cancer Res. | pmid:9927053 |
| O'Neill LP et al. | A developmental switch in H4 acetylation upstream of Xist plays a role in X chromosome inactivation. | 1999 | EMBO J. | pmid:10329635 |
| Strouboulis J et al. | Transcriptional repression by XPc1, a new Polycomb homolog in Xenopus laevis embryos, is independent of histone deacetylase. | 1999 | Mol. Cell. Biol. | pmid:10330136 |
| Condreay JP et al. | Transient and stable gene expression in mammalian cells transduced with a recombinant baculovirus vector. | 1999 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9874783 |
| Cameron EE et al. | Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer. | 1999 | Nat. Genet. | pmid:9916800 |
| Bakin AV and Curran T | Role of DNA 5-methylcytosine transferase in cell transformation by fos. | 1999 | Science | pmid:9888853 |
| Verdel A and Khochbin S | Identification of a new family of higher eukaryotic histone deacetylases. Coordinate expression of differentiation-dependent chromatin modifiers. | 1999 | J. Biol. Chem. | pmid:9891014 |
| Niki T et al. | A histone deacetylase inhibitor, trichostatin A, suppresses myofibroblastic differentiation of rat hepatic stellate cells in primary culture. | 1999 | Hepatology | pmid:10051490 |
| Hasegawa T et al. | Cloning of a GADD34-like gene that interacts with the zinc-finger transcription factor which binds to the p21(WAF) promoter. | 1999 | Biochem. Biophys. Res. Commun. | pmid:10066455 |
| Inokoshi J et al. | Neuronal differentiation of neuro 2a cells by inhibitors of cell cycle progression, trichostatin A and butyrolactone I. | 1999 | Biochem. Biophys. Res. Commun. | pmid:10079191 |
| Olsson TG et al. | Transient inhibition of histone deacetylase activity overcomes silencing in the mating-type region in fission yeast. | 1999 | Curr. Genet. | pmid:10079326 |
| Collas P et al. | Active transgenes in zebrafish are enriched in acetylated histone H4 and dynamically associate with RNA Pol II and splicing complexes. | 1999 | J. Cell. Sci. | pmid:10198286 |
| Saito A et al. | A synthetic inhibitor of histone deacetylase, MS-27-275, with marked in vivo antitumor activity against human tumors. | 1999 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10200307 |
| Dang VD et al. | A new member of the Sin3 family of corepressors is essential for cell viability and required for retroelement propagation in fission yeast. | 1999 | Mol. Cell. Biol. | pmid:10022921 |
| Murphy M et al. | Transcriptional repression by wild-type p53 utilizes histone deacetylases, mediated by interaction with mSin3a. | 1999 | Genes Dev. | pmid:10521394 |
| Gobl AE et al. | Menin represses JunD-activated transcription by a histone deacetylase-dependent mechanism. | 1999 | Biochim. Biophys. Acta | pmid:10500243 |
| Kosugi H et al. | Histone deacetylase inhibitors are the potent inducer/enhancer of differentiation in acute myeloid leukemia: a new approach to anti-leukemia therapy. | 1999 | Leukemia | pmid:10482980 |
| Carmen AA et al. | Yeast HOS3 forms a novel trichostatin A-insensitive homodimer with intrinsic histone deacetylase activity. | 1999 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10535926 |
| Rüller S et al. | Sensitization of tumor cells to ribotoxic stress-induced apoptotic cell death: a new therapeutic strategy. | 1999 | Clin. Cancer Res. | pmid:10537334 |
| Vanden Berghe W et al. | The nuclear factor-kappaB engages CBP/p300 and histone acetyltransferase activity for transcriptional activation of the interleukin-6 gene promoter. | 1999 | J. Biol. Chem. | pmid:10542243 |
| Ng HH et al. | MBD2 is a transcriptional repressor belonging to the MeCP1 histone deacetylase complex. | 1999 | Nat. Genet. | pmid:10471499 |
| Sowa Y et al. | Sp3, but not Sp1, mediates the transcriptional activation of the p21/WAF1/Cip1 gene promoter by histone deacetylase inhibitor. | 1999 | Cancer Res. | pmid:10485470 |