trichostatin A

Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.

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Introduction

To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with trichostatin A?

trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with trichostatin A

MeSH term MeSH ID Detail
Osteosarcoma D012516 50 associated lipids
Brain Neoplasms D001932 15 associated lipids
Leukemia, Erythroblastic, Acute D004915 41 associated lipids
Melanoma D008545 69 associated lipids
Muscular Dystrophies D009136 10 associated lipids
Asthma D001249 52 associated lipids
Abnormalities, Multiple D000015 13 associated lipids
Intellectual Disability D008607 13 associated lipids
Glioma D005910 112 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Per page 10 20 50 100 | Total 139

PubChem Associated disorders and diseases

What pathways are associated with trichostatin A

Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.

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Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with trichostatin A?

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Location Cross reference Weighted score Related literatures
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What functions are associated with trichostatin A?


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Function Cross reference Weighted score Related literatures

What lipids are associated with trichostatin A?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with trichostatin A?

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Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with trichostatin A?

Mouse Model

Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).

Xenograft Model

Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).

Cancer Model

Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with trichostatin A

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Per page 10 20 50 100 | Total 3126
Authors Title Published Journal PubMed Link
Schmidt K et al. Inhibitors of histone deacetylase suppress the growth of MCF-7 breast cancer cells. 1999 Arch. Pharm. (Weinheim) pmid:10575368
Jung M et al. Amide analogues of trichostatin A as inhibitors of histone deacetylase and inducers of terminal cell differentiation. 1999 J. Med. Chem. pmid:10579829
Chien PY et al. A fusion protein of the estrogen receptor (ER) and nuclear receptor corepressor (NCoR) strongly inhibits estrogen-dependent responses in breast cancer cells. 1999 Mol. Endocrinol. pmid:10598586
Taddei A et al. Duplication and maintenance of heterochromatin domains. 1999 J. Cell Biol. pmid:10601331
Yoshida M and Horinouchi S Trichostatin and leptomycin. Inhibition of histone deacetylation and signal-dependent nuclear export. 1999 Ann. N. Y. Acad. Sci. pmid:10667200
Sowa Y et al. Histone deacetylase inhibitor activates the p21/WAF1/Cip1 gene promoter through the Sp1 sites. 1999 Ann. N. Y. Acad. Sci. pmid:10667218
Kim YB et al. Selective induction of cyclin-dependent kinase inhibitors and their roles in cell cycle arrest caused by trichostatin A, an inhibitor of histone deacetylase. 1999 Ann. N. Y. Acad. Sci. pmid:10667219
Marenzi S et al. Efficiency of expression of transfected genes depends on the cell cycle. 1999 Mol. Biol. Rep. pmid:10634509
Gray SG et al. IGF-II enhances trichostatin A-induced TGFbeta1 and p21(Waf1,Cip1, sdi1) expression in Hep3B cells. 1999 Exp. Cell Res. pmid:10585285
Saunders N et al. Histone deacetylase inhibitors as potential anti-skin cancer agents. 1999 Cancer Res. pmid:9927053
O'Neill LP et al. A developmental switch in H4 acetylation upstream of Xist plays a role in X chromosome inactivation. 1999 EMBO J. pmid:10329635
Strouboulis J et al. Transcriptional repression by XPc1, a new Polycomb homolog in Xenopus laevis embryos, is independent of histone deacetylase. 1999 Mol. Cell. Biol. pmid:10330136
Condreay JP et al. Transient and stable gene expression in mammalian cells transduced with a recombinant baculovirus vector. 1999 Proc. Natl. Acad. Sci. U.S.A. pmid:9874783
Cameron EE et al. Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer. 1999 Nat. Genet. pmid:9916800
Bakin AV and Curran T Role of DNA 5-methylcytosine transferase in cell transformation by fos. 1999 Science pmid:9888853
Verdel A and Khochbin S Identification of a new family of higher eukaryotic histone deacetylases. Coordinate expression of differentiation-dependent chromatin modifiers. 1999 J. Biol. Chem. pmid:9891014
Coffee B et al. Acetylated histones are associated with FMR1 in normal but not fragile X-syndrome cells. 1999 Nat. Genet. pmid:10319871
Inokoshi J et al. Neuronal differentiation of neuro 2a cells by inhibitors of cell cycle progression, trichostatin A and butyrolactone I. 1999 Biochem. Biophys. Res. Commun. pmid:10079191
Olsson TG et al. Transient inhibition of histone deacetylase activity overcomes silencing in the mating-type region in fission yeast. 1999 Curr. Genet. pmid:10079326
Collas P et al. Active transgenes in zebrafish are enriched in acetylated histone H4 and dynamically associate with RNA Pol II and splicing complexes. 1999 J. Cell. Sci. pmid:10198286
Saito A et al. A synthetic inhibitor of histone deacetylase, MS-27-275, with marked in vivo antitumor activity against human tumors. 1999 Proc. Natl. Acad. Sci. U.S.A. pmid:10200307
Dang VD et al. A new member of the Sin3 family of corepressors is essential for cell viability and required for retroelement propagation in fission yeast. 1999 Mol. Cell. Biol. pmid:10022921
Murphy M et al. Transcriptional repression by wild-type p53 utilizes histone deacetylases, mediated by interaction with mSin3a. 1999 Genes Dev. pmid:10521394
Gobl AE et al. Menin represses JunD-activated transcription by a histone deacetylase-dependent mechanism. 1999 Biochim. Biophys. Acta pmid:10500243
Kosugi H et al. Histone deacetylase inhibitors are the potent inducer/enhancer of differentiation in acute myeloid leukemia: a new approach to anti-leukemia therapy. 1999 Leukemia pmid:10482980
Carmen AA et al. Yeast HOS3 forms a novel trichostatin A-insensitive homodimer with intrinsic histone deacetylase activity. 1999 Proc. Natl. Acad. Sci. U.S.A. pmid:10535926
Rüller S et al. Sensitization of tumor cells to ribotoxic stress-induced apoptotic cell death: a new therapeutic strategy. 1999 Clin. Cancer Res. pmid:10537334
Vanden Berghe W et al. The nuclear factor-kappaB engages CBP/p300 and histone acetyltransferase activity for transcriptional activation of the interleukin-6 gene promoter. 1999 J. Biol. Chem. pmid:10542243
Ng HH et al. MBD2 is a transcriptional repressor belonging to the MeCP1 histone deacetylase complex. 1999 Nat. Genet. pmid:10471499
Sowa Y et al. Sp3, but not Sp1, mediates the transcriptional activation of the p21/WAF1/Cip1 gene promoter by histone deacetylase inhibitor. 1999 Cancer Res. pmid:10485470
Finnin MS et al. Structures of a histone deacetylase homologue bound to the TSA and SAHA inhibitors. 1999 Nature pmid:10490031
Dangond F and Gullans SR Differential expression of human histone deacetylase mRNAs in response to immune cell apoptosis induction by trichostatin A and butyrate. 1998 Biochem. Biophys. Res. Commun. pmid:9647779
Komatsu Y and Hayashi H Histone deacetylase inhibitors up-regulate the expression of cell surface MHC class-I molecules in B16/BL6 cells. 1998 J. Antibiot. pmid:9531994
Svensson K et al. The paternal allele of the H19 gene is progressively silenced during early mouse development: the acetylation status of histones may be involved in the generation of variegated expression patterns. 1998 Development pmid:9389664
Emiliani S et al. Characterization of a human RPD3 ortholog, HDAC3. 1998 Proc. Natl. Acad. Sci. U.S.A. pmid:9501169
El Kharroubi A et al. Transcriptional activation of the integrated chromatin-associated human immunodeficiency virus type 1 promoter. 1998 Mol. Cell. Biol. pmid:9566873
Gray SG and Ekström TJ Effects of cell density and trichostatin A on the expression of HDAC1 and p57Kip2 in Hep 3B cells. 1998 Biochem. Biophys. Res. Commun. pmid:9571167
Belyaev ND et al. The acetylation patterns of histones H3 and H4 along Vicia faba chromosomes are different. 1998 Chromosome Res. pmid:9510512
Richon VM et al. A class of hybrid polar inducers of transformed cell differentiation inhibits histone deacetylases. 1998 Proc. Natl. Acad. Sci. U.S.A. pmid:9501205
Grewal SI et al. Histone deacetylase homologs regulate epigenetic inheritance of transcriptional silencing and chromosome segregation in fission yeast. 1998 Genetics pmid:9755190
Llorente A et al. Expression of mutant dynamin inhibits toxicity and transport of endocytosed ricin to the Golgi apparatus. 1998 J. Cell Biol. pmid:9456316
De Luca P et al. Retinoblastoma protein tethered to promoter DNA represses TBP-mediated transcription. 1998 J. Cell. Biochem. pmid:9671233
Selker EU Trichostatin A causes selective loss of DNA methylation in Neurospora. 1998 Proc. Natl. Acad. Sci. U.S.A. pmid:9689097
Jin S and Scotto KW Transcriptional regulation of the MDR1 gene by histone acetyltransferase and deacetylase is mediated by NF-Y. 1998 Mol. Cell. Biol. pmid:9632821
Nakajima H et al. FR901228, a potent antitumor antibiotic, is a novel histone deacetylase inhibitor. 1998 Exp. Cell Res. pmid:9633520
Thompson EM and Renard JP Preferential nuclear location of a transgene does not depend on its transcriptional activity during early mouse development. 1998 Chromosoma pmid:9880765
Durum SK et al. Interleukin 7 receptor control of T cell receptor gamma gene rearrangement: role of receptor-associated chains and locus accessibility. 1998 J. Exp. Med. pmid:9858510
Nemer M Histone deacetylase mRNA temporally and spatially regulated in its expression in sea urchin embryos. 1998 Dev. Growth Differ. pmid:9865968
Ishiguro K and Sartorelli AC Coinduction of embryonic and adult-type globin mRNAs by sodium butyrate and trichostatin A in two murine interleukin-3-dependent bone marrow-derived cell lines. 1998 Blood pmid:9834245
Walia H et al. Histone acetylation is required to maintain the unfolded nucleosome structure associated with transcribing DNA. 1998 J. Biol. Chem. pmid:9603965