trichostatin A

Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.

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Introduction

To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with trichostatin A?

trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with trichostatin A

MeSH term MeSH ID Detail
Adenocarcinoma, Follicular D018263 3 associated lipids
Hypereosinophilic Syndrome D017681 3 associated lipids
Lymphoma, Follicular D008224 3 associated lipids
Lymphoma, Large-Cell, Anaplastic D017728 3 associated lipids
Retinal Neoplasms D019572 3 associated lipids
Progeria D011371 3 associated lipids
Mastocytoma D034801 3 associated lipids
Uveal Neoplasms D014604 3 associated lipids
Leukemia, Promyelocytic, Acute D015473 3 associated lipids
Conjunctival Neoplasms D003230 3 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with trichostatin A

Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.

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Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with trichostatin A?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with trichostatin A?


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Function Cross reference Weighted score Related literatures

What lipids are associated with trichostatin A?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with trichostatin A?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with trichostatin A?

Mouse Model

Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).

Xenograft Model

Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).

Cancer Model

Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with trichostatin A

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Per page 10 20 50 100 | Total 3126
Authors Title Published Journal PubMed Link
Dagnas M et al. HDAC inhibition facilitates the switch between memory systems in young but not aged mice. 2013 J. Neurosci. pmid:23365234
Seuter S et al. Chromatin acetylation at transcription start sites and vitamin D receptor binding regions relates to effects of 1α,25-dihydroxyvitamin D3 and histone deacetylase inhibitors on gene expression. 2013 Nucleic Acids Res. pmid:23093607
Jin H et al. HDAC inhibitor trichostatin A promotes proliferation and odontoblast differentiation of human dental pulp stem cells. 2013 Tissue Eng Part A pmid:23013422
Wang YG et al. Mechanisms of trichostatin A inhibiting AGS proliferation and identification of lysine-acetylated proteins. 2013 World J. Gastroenterol. pmid:23745024
Liesz A et al. Boosting regulatory T cells limits neuroinflammation in permanent cortical stroke. 2013 J. Neurosci. pmid:24174668
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Zych J et al. The epigenetic modifiers 5-aza-2'-deoxycytidine and trichostatin A influence adipocyte differentiation in human mesenchymal stem cells. 2013 Braz. J. Med. Biol. Res. pmid:23797495
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Tang X et al. Protocadherin 10 is frequently downregulated by promoter methylation and functions as a tumor suppressor gene in non-small cell lung cancer. 2012-2013 Cancer Biomark pmid:23321465
Hou W et al. Hypoxia-induced deacetylation is required for tetraploid differentiation in response to testicular ischemia-reperfusion (IR) injury. 2012 Nov-Dec J. Androl. pmid:22556385
Darlyuk-Saadon I et al. The bZIP repressor proteins, c-Jun dimerization protein 2 and activating transcription factor 3, recruit multiple HDAC members to the ATF3 promoter. 2012 Nov-Dec Biochim. Biophys. Acta pmid:22989952
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Mehdi O et al. HDAC gene expression in pancreatic tumor cell lines following treatment with the HDAC inhibitors panobinostat (LBH589) and trichostatine (TSA). 2012 Mar-Apr Pancreatology pmid:22487525
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Kang FW et al. Effects of trichostatin A on HIF-1α and VEGF expression in human tongue squamous cell carcinoma cells in vitro. 2012 Oncol. Rep. pmid:22552321
Meng J et al. The histone deacetylase inhibitor trichostatin A induces cell cycle arrest and apoptosis in colorectal cancer cells via p53-dependent and -independent pathways. 2012 Oncol. Rep. pmid:22552631
Balsas P et al. Bortezomib resistance in a myeloma cell line is associated to PSMβ5 overexpression and polyploidy. 2012 Leuk. Res. pmid:21978467
Deckmann K et al. Dimethylcelecoxib induces an inhibitory complex consisting of HDAC1/NF-κB(p65)RelA leading to transcriptional downregulation of mPGES-1 and EGR1. 2012 Cell. Signal. pmid:21983014
Hoque MA et al. Cyclic tetrapeptides with thioacetate tails or intramolecular disulfide bridge as potent inhibitors of histone deacetylases. 2012 Bioorg. Med. Chem. Lett. pmid:23021104
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Merschbaecher K et al. Acetylation-mediated suppression of transcription-independent memory: bidirectional modulation of memory by acetylation. 2012 PLoS ONE pmid:23028801
Zhao ZN et al. TSA suppresses miR-106b-93-25 cluster expression through downregulation of MYC and inhibits proliferation and induces apoptosis in human EMC. 2012 PLoS ONE pmid:23028803
Banik D et al. Interferon regulatory factor-8 is important for histone deacetylase inhibitor-mediated antitumor activity. 2012 PLoS ONE pmid:23028998
Bergman JA et al. Selective histone deacetylase 6 inhibitors bearing substituted urea linkers inhibit melanoma cell growth. 2012 J. Med. Chem. pmid:23009203
Shi YL et al. Histone deacetylases inhibitor Trichostatin A ameliorates DNFB-induced allergic contact dermatitis and reduces epidermal Langerhans cells in mice. 2012 J. Dermatol. Sci. pmid:22999682
Tomosugi M et al. Retinoblastoma gene-independent G1 phase arrest by flavone, phosphatidylinositol 3-kinase inhibitor, and histone deacetylase inhibitor. 2012 Cancer Sci. pmid:22957647
Miyagawa K et al. Possible involvement of histone acetylation in the development of emotional resistance to stress stimuli in mice. 2012 Behav. Brain Res. pmid:22963996
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Sancho-Pelluz J and Paquet-Durand F HDAC inhibition prevents Rd1 mouse photoreceptor degeneration. 2012 Adv. Exp. Med. Biol. pmid:22183322
Chen H et al. LTBP-2 confers pleiotropic suppression and promotes dormancy in a growth factor permissive microenvironment in nasopharyngeal carcinoma. 2012 Cancer Lett. pmid:22743615
Vadnal J et al. Transcriptional signatures mediated by acetylation overlap with early-stage Alzheimer's disease. 2012 Exp Brain Res pmid:22811216
Lin KT et al. HDAC inhibitors augmented cell migration and metastasis through induction of PKCs leading to identification of low toxicity modalities for combination cancer therapy. 2012 Clin. Cancer Res. pmid:22811583
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Zhang HN et al. Endogenous glucocorticoids inhibit myocardial inflammation induced by lipopolysaccharide: involvement of regulation of histone deacetylation. 2012 J. Cardiovasc. Pharmacol. pmid:22472906
Qin ZX et al. [Effect of TSA and VPA treatment on long-tailed macaque (Macaca fascicularis)-pig interspecies somatic cell nuclear transfer]. 2012 Yi Chuan pmid:22425953
Zhou X et al. Preclinical evaluation of combined antineoplastic effect of DLC1 tumor suppressor protein and suberoylanilide hydroxamic acid on prostate cancer cells. 2012 Biochem. Biophys. Res. Commun. pmid:22425986
Fleiss B et al. Neuroprotection by the histone deacetylase inhibitor trichostatin A in a model of lipopolysaccharide-sensitised neonatal hypoxic-ischaemic brain injury. 2012 J Neuroinflammation pmid:22512781
Eun CH et al. Activation and epigenetic regulation of DNA transposon nDart1 in rice. 2012 Plant Cell Physiol. pmid:22514089
Bence M et al. Transcriptional modulation of monoaminergic neurotransmission genes by the histone deacetylase inhibitor trichostatin A in neuroblastoma cells. 2012 J Neural Transm pmid:21785940
Zhu S et al. TSA-induced JMJD2B downregulation is associated with cyclin B1-dependent survivin degradation and apoptosis in LNCap cells. 2012 J. Cell. Biochem. pmid:22388778
Usui T et al. HDAC4 mediates development of hypertension via vascular inflammation in spontaneous hypertensive rats. 2012 Am. J. Physiol. Heart Circ. Physiol. pmid:22389387
Wang H et al. Different effects of histone deacetylase inhibitors nicotinamide and trichostatin A (TSA) in C17.2 neural stem cells. 2012 J Neural Transm pmid:22407380
Yang PM et al. CD1d induction in solid tumor cells by histone deacetylase inhibitors through inhibition of HDAC1/2 and activation of Sp1. 2012 Epigenetics pmid:22419072
Colussi C et al. P300/CBP associated factor regulates nitroglycerin-dependent arterial relaxation by N(ε)-lysine acetylation of contractile proteins. 2012 Arterioscler. Thromb. Vasc. Biol. pmid:22859492
Wang C et al. Genotoxic stress and activation of novel DNA repair enzymes in human endothelial cells and in the retinas and kidneys of streptozotocin diabetic rats. 2012 Diabetes Metab. Res. Rev. pmid:22228707