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Loss of NECL1, a novel tumor suppressor, can be restored in glioma by HDAC inhibitor-Trichostatin A through Sp1 binding site. |
2009 |
Glia |
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Structural studies of human histone deacetylase 8 and its site-specific variants complexed with substrate and inhibitors. |
2008 |
Biochemistry |
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Characterizing heterogeneous cellular responses to perturbations. |
2008 |
Proc. Natl. Acad. Sci. U.S.A. |
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The developmental potential of parthenogenetic and somatic cell nuclear-transferred rat oocytes in vitro. |
2008 |
Cloning Stem Cells |
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Epigenetic enhancement of antigen processing and presentation promotes immune recognition of tumors. |
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Cancer Res. |
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HDAC2 deacetylates class II transactivator and suppresses its activity in macrophages and smooth muscle cells. |
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J. Mol. Cell. Cardiol. |
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An HDAC inhibitor, trichostatin A, induces a delay at G2/M transition, slippage of spindle checkpoint, and cell death in a transcription-dependent manner. |
2009 |
Biochem. Biophys. Res. Commun. |
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Psammaplin A as a general activator of cell-based signaling assays via HDAC inhibition and studies on some bromotyrosine derivatives. |
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Bioorg. Med. Chem. |
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Suppression of caspase-11 expression by histone deacetylase inhibitors. |
2009 |
Biochem. Biophys. Res. Commun. |
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Timing is everything: order of administration of 5-aza 2' deoxycytidine, trichostatin A and tamoxifen changes estrogen receptor mRNA expression and cell sensitivity. |
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Cancer Lett. |
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HDAC inhibition upregulates the expression of angiostatic ADAMTS1. |
2008 |
FEBS Lett. |
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AZGP1 autoantibody predicts survival and histone deacetylase inhibitors increase expression in lung adenocarcinoma. |
2008 |
J Thorac Oncol |
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The class I histone deacetylases of the platyhelminth parasite Schistosoma mansoni. |
2008 |
Biochem. Biophys. Res. Commun. |
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Histone deacetylase inhibitors: a new mode for inhibition of cholesterol metabolism. |
2008 |
BMC Genomics |
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Histone deacetylase activity in conjunction with E2F-1 and p53 regulates Apaf-1 expression in 661W cells and the retina. |
2009 |
J. Neurosci. Res. |
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Effects of trichostatin A on neuronal mu-opioid receptor gene expression. |
2008 |
Brain Res. |
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Effects of trichostatin A, a histone deacetylase inhibitor, on the regulation of apoptosis in H-ras-transformed breast epithelial cells. |
2008 |
Int. J. Mol. Med. |
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The effects of trichostatin A on the oncolytic ability of herpes simplex virus for oral squamous cell carcinoma cells. |
2009 |
Cancer Gene Ther. |
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Ridolfi E et al. |
Inhibitory effect of HGF on invasiveness of aggressive MDA-MB231 breast carcinoma cells, and role of HDACs. |
2008 |
Br. J. Cancer |
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Hayashi K et al. |
Dynamic equilibrium and heterogeneity of mouse pluripotent stem cells with distinct functional and epigenetic states. |
2008 |
Cell Stem Cell |
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Aberrant methylation of human L- and M-fructose 1,6-bisphosphatase genes in cancer. |
2008 |
Biochem. Biophys. Res. Commun. |
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Gu Z et al. |
Promoter hypermethylation is not the major mechanism for inactivation of the FBXW7 beta-form in human gliomas. |
2008 |
Genes Genet. Syst. |
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Bao Y et al. |
Identification of trichostatin A as a novel transcriptional up-regulator of scavenger receptor BI both in HepG2 and RAW 264.7 cells. |
2009 |
Atherosclerosis |
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Histone-deacetylase inhibition reverses atrial arrhythmia inducibility and fibrosis in cardiac hypertrophy independent of angiotensin. |
2008 |
J. Mol. Cell. Cardiol. |
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Tshuikina M et al. |
Epigenetic silencing of the interferon regulatory factor ICSBP/IRF8 in human multiple myeloma. |
2008 |
Exp. Hematol. |
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Trichostatin A improved epigenetic modifications of transfected cells but did not improve subsequent cloned embryo development. |
2008 |
Anim. Biotechnol. |
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Hypoxic silencing of tumor suppressor RUNX3 by histone modification in gastric cancer cells. |
2009 |
Oncogene |
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Epigenetic silencing of SOD2 by histone modifications in human breast cancer cells. |
2008 |
Free Radic. Biol. Med. |
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To the nucleolar density and size in apoptotic human leukemic myeloblasts produced in vitro by Trichostatin A. |
2008 Jul-Sep |
Eur J Histochem |
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Demircan B et al. |
Comparative epigenomics of human and mouse mammary tumors. |
2009 |
Genes Chromosomes Cancer |
pmid:18836996
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Pellicciotta I et al. |
Presentation of telomerase reverse transcriptase, a self-tumor antigen, is down-regulated by histone deacetylase inhibition. |
2008 |
Cancer Res. |
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Screening of amide analogues of Trichostatin A in cultures of primary rat hepatocytes: search for potent and safe HDAC inhibitors. |
2009 |
Invest New Drugs |
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[Effects of trichostatin A on the interaction between HBx and histone deacetylase protein 1]. |
2008 |
Zhonghua Gan Zang Bing Za Zhi |
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Aberrant methylation of candidate tumor suppressor genes in neuroblastoma. |
2009 |
Cancer Lett. |
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Insights into mechanisms linking cardiac hypertrophy and atrial fibrosis: evidence for a role of histone deacetylase in atrial fibrillation pathophysiology and therapy. |
2008 |
J. Mol. Cell. Cardiol. |
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Histone deacetylase inhibitor scriptaid induces cell cycle arrest and epigenetic change in colon cancer cells. |
2008 |
Int. J. Oncol. |
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Identification of candidate tumor suppressor genes inactivated by promoter methylation in melanoma. |
2009 |
Genes Chromosomes Cancer |
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Nonsteroidal anti-inflammatory drug-activated gene (NAG-1/GDF15) expression is increased by the histone deacetylase inhibitor trichostatin A. |
2008 |
J. Biol. Chem. |
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Histone deacetylase inhibitors decrease cocaine but not sucrose self-administration in rats. |
2008 |
J. Neurosci. |
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Defining the molecular action of HDAC inhibitors and synergism with androgen deprivation in ERG-positive prostate cancer. |
2008 |
Int. J. Cancer |
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Upregulation of human with-no-lysine kinase-4 gene expression by GATA-1 acetylation. |
2009 |
Int. J. Biochem. Cell Biol. |
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Blocking TH17-polarizing cytokines by histone deacetylase inhibitors in vitro and in vivo. |
2008 |
J. Leukoc. Biol. |
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Inhibition of protein deacetylation by trichostatin A impairs microtubule-kinetochore attachment. |
2008 |
Cell. Mol. Life Sci. |
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LRRC3B, encoding a leucine-rich repeat-containing protein, is a putative tumor suppressor gene in gastric cancer. |
2008 |
Cancer Res. |
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Zn(II)-dependent histone deacetylase inhibitors: suberoylanilide hydroxamic acid and trichostatin A. |
2009 |
Int. J. Biochem. Cell Biol. |
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Short-chain fatty acids and trichostatin A alter tight junction permeability in human umbilical vein endothelial cells. |
2008 Nov-Dec |
Nutrition |
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Gastric cancer cell lines induced by trichostatin A. |
2008 |
World J. Gastroenterol. |
pmid:18720545
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[Effect of decitabine combined with Trichostatin A on MDS cell line SKM-1 in vitro]. |
2008 |
Zhongguo Shi Yan Xue Ye Xue Za Zhi |
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Histone deacetylase inhibitors modify pancreatic cell fate determination and amplify endocrine progenitors. |
2008 |
Mol. Cell. Biol. |
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The histone acetyltransferase PCAF associates with actin and hnRNP U for RNA polymerase II transcription. |
2008 |
Mol. Cell. Biol. |
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[Effects of trichostatin A and paclitaxel on apoptosis and mitochondrial membrane potential of human endometrial carcinoma Ark2 cells]. |
2008 |
Ai Zheng |
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Active extracts of wild fruiting bodies of Antrodia camphorata (EEAC) induce leukemia HL 60 cells apoptosis partially through histone hypoacetylation and synergistically promote anticancer effect of trichostatin A. |
2009 |
Arch. Toxicol. |
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Aurora A, Aurora B and survivin are novel targets of transcriptional regulation by histone deacetylase inhibitors in non-small cell lung cancer. |
2008 |
Cancer Biol. Ther. |
pmid:18708766
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Falk M et al. |
Chromatin structure influences the sensitivity of DNA to gamma-radiation. |
2008 |
Biochim. Biophys. Acta |
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Epigenetic mechanisms and Sp1 regulate mitochondrial citrate carrier gene expression. |
2008 |
Biochem. Biophys. Res. Commun. |
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Duan H et al. |
Functional long-range interactions of the IgH 3' enhancers with the bcl-2 promoter region in t(14;18) lymphoma cells. |
2008 |
Oncogene |
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Selenite reactivates silenced genes by modifying DNA methylation and histones in prostate cancer cells. |
2008 |
Carcinogenesis |
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Lee TB et al. |
Epigenetic mechanisms involved in differential MDR1 mRNA expression between gastric and colon cancer cell lines and rationales for clinical chemotherapy. |
2008 |
BMC Gastroenterol |
pmid:18673531
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Yu J et al. |
Epigenetic identification of ubiquitin carboxyl-terminal hydrolase L1 as a functional tumor suppressor and biomarker for hepatocellular carcinoma and other digestive tumors. |
2008 |
Hepatology |
pmid:18666234
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Peng DF et al. |
DNA hypermethylation regulates the expression of members of the Mu-class glutathione S-transferases and glutathione peroxidases in Barrett's adenocarcinoma. |
2009 |
Gut |
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Sustained improvement of spinal muscular atrophy mice treated with trichostatin A plus nutrition. |
2008 |
Ann. Neurol. |
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Prevention of murine experimental corneal trauma by epigenetic events regulating claudin 6 and claudin 9. |
2008 May-Jun |
Jpn. J. Ophthalmol. |
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Histone deacetylase inhibitor-induced cellular apoptosis involves stanniocalcin-1 activation. |
2008 |
Exp. Cell Res. |
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The histone deacetylase inhibitor trichostatin A upregulates regulatory T cells and modulates autoimmunity in NZB/W F1 mice. |
2008 |
J. Autoimmun. |
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Array-based analysis of the effects of trichostatin A and CG-1521 on cell cycle and cell death in LNCaP prostate cancer cells. |
2008 |
Mol. Cancer Ther. |
pmid:18645003
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Modulation of the cyclin-dependent kinase inhibitor p21(WAF1/Cip1) gene by Zac1 through the antagonistic regulators p53 and histone deacetylase 1 in HeLa Cells. |
2008 |
Mol. Cancer Res. |
pmid:18644983
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Dow GS et al. |
Antimalarial activity of phenylthiazolyl-bearing hydroxamate-based histone deacetylase inhibitors. |
2008 |
Antimicrob. Agents Chemother. |
pmid:18644969
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Kozikowski AP et al. |
Use of the nitrile oxide cycloaddition (NOC) reaction for molecular probe generation: a new class of enzyme selective histone deacetylase inhibitors (HDACIs) showing picomolar activity at HDAC6. |
2008 |
J. Med. Chem. |
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A novel effect of DNA methyltransferase and histone deacetylase inhibitors: NFkappaB inhibition in malignant myeloblasts. |
2008 |
Cell Cycle |
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Histone deacetylase inhibitors improve learning consolidation in young and in KA-induced-neurodegeneration and SAMP-8-mutant mice. |
2008 |
Mol. Cell. Neurosci. |
pmid:18638560
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Kawamura T et al. |
Inhibitory effects of short-chain fatty acids on matrix metalloproteinase secretion from human colonic subepithelial myofibroblasts. |
2009 |
Dig. Dis. Sci. |
pmid:18629644
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Shakèd M et al. |
Histone deacetylases control neurogenesis in embryonic brain by inhibition of BMP2/4 signaling. |
2008 |
PLoS ONE |
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Wu JY et al. |
Enhancement of glutamate uptake in 1-methyl-4-phenylpyridinium-treated astrocytes by trichostatin A. |
2008 |
Neuroreport |
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Hayakawa F et al. |
Acetylation of PML is involved in histone deacetylase inhibitor-mediated apoptosis. |
2008 |
J. Biol. Chem. |
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Expression of coxsackie-adenovirus receptor is related to estrogen sensitivity in breast cancer. |
2009 |
Breast Cancer Res. Treat. |
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Tischler JL et al. |
Simple inhibitors of histone deacetylase activity that combine features of short-chain fatty acid and hydroxamic acid inhibitors. |
2008 |
J Enzyme Inhib Med Chem |
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Antitumor activity of histone deacetylase inhibitors in non-small cell lung cancer cells: development of a molecular predictive model. |
2008 |
Mol. Cancer Ther. |
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Histone acetylation and flagellin are essential for Legionella pneumophila-induced cytokine expression. |
2008 |
J. Immunol. |
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Cutting edge: chromatin remodeling as a molecular basis for the enhanced functionality of memory CD8 T cells. |
2008 |
J. Immunol. |
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Åuczak MW and JagodziÅ„ski PP |
Trichostatin A down-regulates CYP19 transcript and protein levels in MCF-7 breast cancer cells. |
2009 |
Biomed. Pharmacother. |
pmid:18602794
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Zhang Y et al. |
Unlocking repression of the human luteinizing hormone receptor gene by trichostatin A-induced cell-specific phosphatase release. |
2008 |
J. Biol. Chem. |
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Attenuation of c-Jun and Sp1 expression and p300 recruitment to gene promoter confers the trichostatin A-induced inhibition of 12(S)-lipoxygenase expression in EGF-treated A431 cells. |
2008 |
Eur. J. Pharmacol. |
pmid:18590721
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Kato A et al. |
Induction of truncated form of tenascin-X (XB-S) through dissociation of HDAC1 from SP-1/HDAC1 complex in response to hypoxic conditions. |
2008 |
Exp. Cell Res. |
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Liu Y et al. |
Histone H3 (lys-9) deacetylation is associated with transcriptional silencing of E-cadherin in colorectal cancer cell lines. |
2008 |
Cancer Invest. |
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HDAC2 deficiency and histone acetylation. |
2008 |
Nat. Genet. |
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Modulation of transcription parameters in glucocorticoid receptor-mediated repression. |
2008 |
Mol. Cell. Endocrinol. |
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Plouffe D et al. |
In silico activity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen. |
2008 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:18579783
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Liu Z et al. |
Incubation with somatostatin, 5-aza decitabine and trichostatin up-regulates somatostatin receptor expression in prostate cancer cells. |
2008 |
Oncol. Rep. |
pmid:18575731
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Li J et al. |
High in vitro development after somatic cell nuclear transfer and trichostatin A treatment of reconstructed porcine embryos. |
2008 |
Theriogenology |
pmid:18573521
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Bieliauskas AV and Pflum MK |
Isoform-selective histone deacetylase inhibitors. |
2008 |
Chem Soc Rev |
pmid:18568166
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Muscolini M et al. |
Trichostatin A up-regulates p73 and induces Bax-dependent apoptosis in cisplatin-resistant ovarian cancer cells. |
2008 |
Mol. Cancer Ther. |
pmid:18566213
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Jia J and Chen J |
Histone hyperacetylation is involved in the quercetin-induced human leukemia cell death. |
2008 |
Pharmazie |
pmid:18557424
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Ding X et al. |
Increased pre-implantation development of cloned bovine embryos treated with 5-aza-2'-deoxycytidine and trichostatin A. |
2008 |
Theriogenology |
pmid:18556056
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Chan DW et al. |
Genetic and epigenetic inactivation of T-cadherin in human hepatocellular carcinoma cells. |
2008 |
Int. J. Cancer |
pmid:18553387
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Tavera-Mendoza LE et al. |
Incorporation of histone deacetylase inhibition into the structure of a nuclear receptor agonist. |
2008 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:18550844
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Kim B et al. |
Clinically relevant concentrations of valproic acid modulate melatonin MT(1) receptor, HDAC and MeCP2 mRNA expression in C6 glioma cells. |
2008 |
Eur. J. Pharmacol. |
pmid:18550052
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Mühlethaler-Mottet A et al. |
Complex molecular mechanisms cooperate to mediate histone deacetylase inhibitors anti-tumour activity in neuroblastoma cells. |
2008 |
Mol. Cancer |
pmid:18549473
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Gaviraghi M et al. |
Identification of a candidate alternative promoter region of the human Bcl2L11 (Bim) gene. |
2008 |
BMC Mol. Biol. |
pmid:18549468
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Zhu X et al. |
Deoxyribonucleic acid methyltransferase 3B promotes epigenetic silencing through histone 3 chromatin modifications in pituitary cells. |
2008 |
J. Clin. Endocrinol. Metab. |
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