| MeSH term | MeSH ID | Detail |
|---|---|---|
| Adenocarcinoma, Follicular | D018263 | 3 associated lipids |
| Hypereosinophilic Syndrome | D017681 | 3 associated lipids |
| Lymphoma, Follicular | D008224 | 3 associated lipids |
| Lymphoma, Large-Cell, Anaplastic | D017728 | 3 associated lipids |
| Retinal Neoplasms | D019572 | 3 associated lipids |
| Progeria | D011371 | 3 associated lipids |
| Mastocytoma | D034801 | 3 associated lipids |
| Uveal Neoplasms | D014604 | 3 associated lipids |
| Leukemia, Promyelocytic, Acute | D015473 | 3 associated lipids |
| Conjunctival Neoplasms | D003230 | 3 associated lipids |
trichostatin A
Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with trichostatin A?
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with trichostatin A
PubChem Associated disorders and diseases
What pathways are associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with trichostatin A?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with trichostatin A?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with trichostatin A?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with trichostatin A?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with trichostatin A?
Mouse Model
Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with trichostatin A
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Tomioka T et al. | The histone deacetylase inhibitor trichostatin A induces neurite outgrowth in PC12 cells via the epigenetically regulated expression of the nur77 gene. | 2014 | Neurosci. Res. | pmid:25128386 |
| Zhang Q et al. | Interferon regulatory factor 8 functions as a tumor suppressor in renal cell carcinoma and its promoter methylation is associated with patient poor prognosis. | 2014 | Cancer Lett. | pmid:25109451 |
| Helm D et al. | Ion mobility tandem mass spectrometry enhances performance of bottom-up proteomics. | 2014 | Mol. Cell Proteomics | pmid:25106551 |
| Yoshida T et al. | Kruppel-like factor 4 protein regulates isoproterenol-induced cardiac hypertrophy by modulating myocardin expression and activity. | 2014 | J. Biol. Chem. | pmid:25100730 |
| Scholpa NE et al. | Epigenetic changes in p21 expression in renal cells after exposure to bromate. | 2014 | Toxicol. Sci. | pmid:25015661 |
| Busbee PB et al. | Natural indoles, indole-3-carbinol and 3,3'-diindolymethane, inhibit T cell activation by staphylococcal enterotoxin B through epigenetic regulation involving HDAC expression. | 2014 | Toxicol. Appl. Pharmacol. | pmid:24200994 |
| Shin HJ et al. | Histone deacetylase classes I and II regulate Kaposi's sarcoma-associated herpesvirus reactivation. | 2014 | J. Virol. | pmid:24227836 |
| Skoge RH et al. | Regulation of SIRT2-dependent α-tubulin deacetylation by cellular NAD levels. | 2014 | DNA Repair (Amst.) | pmid:24814981 |
| Meier BC and Wagner BK | Inhibition of HDAC3 as a strategy for developing novel diabetes therapeutics. | 2014 | Epigenomics | pmid:24811789 |
| Motevalli A et al. | The effect of chemotherapeutic agents on telomere length maintenance in breast cancer cell lines. | 2014 | Breast Cancer Res. Treat. | pmid:24807106 |
| Guo W et al. | Aberrant methylation and decreased expression of the TGF-β/Smad target gene FBXO32 in esophageal squamous cell carcinoma. | 2014 | Cancer | pmid:24798237 |
| Michalak P | Evidence for maternal imprinting of 45S ribosomal RNA genes in Xenopus hybrids. | 2014 | Dev. Genes Evol. | pmid:24477594 |
| Uhlenbrock F et al. | The NKG2D ligand ULBP2 is specifically regulated through an invariant chain-dependent endosomal pathway. | 2014 | J. Immunol. | pmid:25024379 |
| Xiao W et al. | Trichostatin A, a histone deacetylase inhibitor, suppresses proliferation and epithelial-mesenchymal transition in retinal pigment epithelium cells. | 2014 | J. Cell. Mol. Med. | pmid:24456602 |
| Oride A et al. | Trichostatin A specifically stimulates gonadotropin FSHβ gene expression in gonadotroph LβT2 cells. | 2014 | Endocr. J. | pmid:24430728 |
| Sugimoto K et al. | Improving allogeneic islet transplantation by suppressing Th17 and enhancing Treg with histone deacetylase inhibitors. | 2014 | Transpl. Int. | pmid:24410777 |
| Zhu M et al. | Histone decacetylase inhibitors prevent mitochondrial fragmentation and elicit early neuroprotection against MPP+. | 2014 | CNS Neurosci Ther | pmid:24351065 |
| Brglez V et al. | Secreted phospholipases Aâ‚‚are differentially expressed and epigenetically silenced in human breast cancer cells. | 2014 | Biochem. Biophys. Res. Commun. | pmid:24508801 |
| Smith S et al. | Histone deacetylase inhibitors selectively target homology dependent DNA repair defective cells and elevate non-homologous endjoining activity. | 2014 | PLoS ONE | pmid:24466340 |
| Chen HY et al. | Histone deacetylase inhibitors trichostatin A and suberoylanilide hydroxamic acid attenuate ventilator-induced lung injury. | 2014 | Pharmazie | pmid:24601225 |
| Kilinc V et al. | Do iron chelators increase the antiproliferative effect of trichostatin A through a glucose-regulated protein 78 mediated mechanism? | 2014 | Tumour Biol. | pmid:24622883 |
| Kizuka Y et al. | Epigenetic regulation of a brain-specific glycosyltransferase N-acetylglucosaminyltransferase-IX (GnT-IX) by specific chromatin modifiers. | 2014 | J. Biol. Chem. | pmid:24619417 |
| Kondo Y et al. | Histone deacetylase inhibitor valproic acid promotes the differentiation of human induced pluripotent stem cells into hepatocyte-like cells. | 2014 | PLoS ONE | pmid:25084468 |
| Kanski R et al. | Histone acetylation in astrocytes suppresses GFAP and stimulates a reorganization of the intermediate filament network. | 2014 | J. Cell. Sci. | pmid:25128567 |
| Hennig D et al. | Novel insights into appropriate encapsulation methods for bioactive compounds into polymers: a study with peptides and HDAC inhibitors. | 2014 | Macromol Biosci | pmid:23966296 |
| Mahmud N et al. | Differential effects of epigenetic modifiers on the expansion and maintenance of human cord blood stem/progenitor cells. | 2014 | Biol. Blood Marrow Transplant. | pmid:24374212 |
| Chen MH et al. | A new trichostatin analog from Streptomyces sp. CPCC 203909. | 2015 | J Asian Nat Prod Res | pmid:25977996 |
| Inoue K et al. | Trichostatin A specifically improves the aberrant expression of transcription factor genes in embryos produced by somatic cell nuclear transfer. | 2015 | Sci Rep | pmid:25974394 |
| El-Awady RA et al. | Epigenetics and miRNA as predictive markers and targets for lung cancer chemotherapy. | 2015 | Cancer Biol. Ther. | pmid:25962089 |
| Huan Y et al. | Trichostatin A rescues the disrupted imprinting induced by somatic cell nuclear transfer in pigs. | 2015 | PLoS ONE | pmid:25962071 |
| Koumbadinga GA et al. | Increased stability of heterogeneous ribonucleoproteins by a deacetylase inhibitor. | 2015 | Biochim. Biophys. Acta | pmid:25959059 |
| Meschini R et al. | Role of chromatin structure modulation by the histone deacetylase inhibitor trichostatin A on the radio-sensitivity of ataxia telangiectasia. | 2015 | Mutat. Res. | pmid:25942615 |
| Ooi JY et al. | HDAC inhibition attenuates cardiac hypertrophy by acetylation and deacetylation of target genes. | 2015 | Epigenetics | pmid:25941940 |
| Zelko IN and Folz RJ | Regulation of Oxidative Stress in Pulmonary Artery Endothelium. Modulation of Extracellular Superoxide Dismutase and NOX4 Expression Using Histone Deacetylase Class I Inhibitors. | 2015 | Am. J. Respir. Cell Mol. Biol. | pmid:25749103 |
| Cao K et al. | Histone deacetylase inhibitors prevent activation-induced cell death and promote anti-tumor immunity. | 2015 | Oncogene | pmid:25745993 |
| Mostafavi-Pour Z et al. | Methylation of Integrin α4 and E-Cadherin Genes in Human Prostate Cancer. | 2015 | Pathol. Oncol. Res. | pmid:25743258 |
| Hsu HH et al. | Protection against reperfusion lung injury via aborgating multiple signaling cascades by trichostatin A. | 2015 | Int. Immunopharmacol. | pmid:25698558 |
| Meng J et al. | Ku70 is essential for histone deacetylase inhibitor trichostatin A-induced apoptosis. | 2015 | Mol Med Rep | pmid:25695595 |
| Wang P et al. | Epigenetic Changes are Associated with Programmed Cell Death Induced by Heat Stress in Seedling Leaves of Zea mays. | 2015 | Plant Cell Physiol. | pmid:25670712 |
| Sharma S et al. | Histone deacetylase inhibitor, trichostatin A, improves learning and memory in high-fat diet-induced cognitive deficits in mice. | 2015 | J. Mol. Neurosci. | pmid:25391764 |
| Ma XH et al. | Neuroprotective capabilities of TSA against cerebral ischemia/reperfusion injury via PI3K/Akt signaling pathway in rats. | 2015 | Int. J. Neurosci. | pmid:24730998 |
| Mackmull MT et al. | Histone Deacetylase Inhibitors (HDACi) Cause the Selective Depletion of Bromodomain Containing Proteins (BCPs). | 2015 | Mol. Cell Proteomics | pmid:25755299 |
| Cavalieri V and Spinelli G | Ectopic hbox12 Expression Evoked by Histone Deacetylase Inhibition Disrupts Axial Specification of the Sea Urchin Embryo. | 2015 | PLoS ONE | pmid:26618749 |
| Zhang Y et al. | The Induction Effect of Am80 and TSA on ESC Differentiation via Regulation of Stra8 in Chicken. | 2015 | PLoS ONE | pmid:26606052 |
| Nakada Y et al. | Inhibitory effects of trichostatin A on adrenocorticotropic hormone production and proliferation of corticotroph tumor AtT-20 cells. | 2015 | Endocr. J. | pmid:26497760 |
| Kotze AC et al. | Histone deacetylase enzymes as drug targets for the control of the sheep blowfly, Lucilia cuprina. | 2015 | Int J Parasitol Drugs Drug Resist | pmid:27120067 |
| Mehta A et al. | HDAC inhibitor prevents LPS mediated inhibition of CYP19A1 expression and 17β-estradiol production in granulosa cells. | 2015 | Mol. Cell. Endocrinol. | pmid:26213324 |
| Sancak D and Ozden S | Global histone modifications in Fumonisin B1 exposure in rat kidney epithelial cells. | 2015 | Toxicol In Vitro | pmid:26208285 |
| Cabanel M et al. | Epigenetic Control of Macrophage Shape Transition towards an Atypical Elongated Phenotype by Histone Deacetylase Activity. | 2015 | PLoS ONE | pmid:26196676 |
| Suo H et al. | NRSF is an essential mediator for the neuroprotection of trichostatin A in the MPTP mouse model of Parkinson's disease. | 2015 | Neuropharmacology | pmid:26188143 |