trichostatin A

Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.

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Introduction

To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with trichostatin A?

trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with trichostatin A

MeSH term MeSH ID Detail
Thyroid Neoplasms D013964 33 associated lipids
Neurodegenerative Diseases D019636 32 associated lipids
Hypertension, Pulmonary D006976 32 associated lipids
Stroke D020521 32 associated lipids
Cardiomegaly D006332 31 associated lipids
Endometrial Neoplasms D016889 30 associated lipids
Endometriosis D004715 29 associated lipids
Adrenoleukodystrophy D000326 29 associated lipids
Ventricular Remodeling D020257 28 associated lipids
Autoimmune Diseases D001327 27 associated lipids
Per page 10 20 50 100 | Total 139

PubChem Associated disorders and diseases

What pathways are associated with trichostatin A

Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.

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Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with trichostatin A?

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What functions are associated with trichostatin A?


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Function Cross reference Weighted score Related literatures

What lipids are associated with trichostatin A?

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Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with trichostatin A?

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Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with trichostatin A?

Mouse Model

Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).

Xenograft Model

Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).

Cancer Model

Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with trichostatin A

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Per page 10 20 50 100 | Total 3126
Authors Title Published Journal PubMed Link
Viñuelas J et al. Towards experimental manipulation of stochasticity in gene expression. 2012 Prog. Biophys. Mol. Biol. pmid:22609563
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Stepanek I et al. Effects of 5-azacytidine and trichostatin A on dendritic cell maturation. 2011 Oct-Dec J. Biol. Regul. Homeost. Agents pmid:22217985
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Meng CF et al. DNA demethylation is superior to histone acetylation for reactivating cancer-associated genes in ovarian cancer cells. 2011 Nov-Dec Mol Med Rep pmid:21850374
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Cosner CC and Helquist P Concise, convergent syntheses of (±)-trichostatin A utilizing a Pd-catalyzed ketone enolate α-alkenylation reaction. 2011 Org. Lett. pmid:21688856
Kojima S et al. Asymmetric leaves2 and Elongator, a histone acetyltransferase complex, mediate the establishment of polarity in leaves of Arabidopsis thaliana. 2011 Plant Cell Physiol. pmid:21700721
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Lin S et al. HIV-1 reactivation induced by apicidin involves histone modification in latently infected cells. 2011 Curr. HIV Res. pmid:21631428
Jugová A et al. Effects of epigenetic-based anti-cancer drugs in leukaemia and multiple myeloma cells. 2011 Cell Biol. Int. pmid:21635225
Wong CY et al. Epigenetic regulation of phosphatidylinositol 3,4,5-triphosphate-dependent Rac exchanger 1 gene expression in prostate cancer cells. 2011 J. Biol. Chem. pmid:21636851
Hayashi-Takanaka Y et al. Tracking epigenetic histone modifications in single cells using Fab-based live endogenous modification labeling. 2011 Nucleic Acids Res. pmid:21576221
Qian Y et al. DeltaNp63, a target of DEC1 and histone deacetylase 2, modulates the efficacy of histone deacetylase inhibitors in growth suppression and keratinocyte differentiation. 2011 J. Biol. Chem. pmid:21317427
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Zhou X et al. Trichostatin differentially regulates Th1 and Th2 responses and alleviates rheumatoid arthritis in mice. 2011 J. Clin. Immunol. pmid:21305388
Meli M et al. Histone deacetylase inhibition modulates deoxyribonucleotide pools and enhances the antitumor effects of the ribonucleotide reductase inhibitor 3'-C-methyladenosine in leukaemia cells. 2011 Int. J. Oncol. pmid:21318222
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Patel T et al. Chromatin remodeling resets the immune system to protect against autoimmune diabetes in mice. 2011 Immunol. Cell Biol. pmid:21321581
Chaurasia P et al. Chromatin-modifying agents promote the ex vivo production of functional human erythroid progenitor cells. 2011 Blood pmid:21355088
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Fan Y et al. Derivation of cloned human blastocysts by histone deacetylase inhibitor treatment after somatic cell nuclear transfer with β-thalassemia fibroblasts. 2011 Stem Cells Dev. pmid:21322785
Kim YJ et al. Comparison of potency between histone deacetylase inhibitors trichostatin A and valproic acid on enhancing in vitro development of porcine somatic cell nuclear transfer embryos. 2011 In Vitro Cell. Dev. Biol. Anim. pmid:21359816
Jang ER et al. Different effect of protein kinase B/Akt and extracellular signal-regulated kinase inhibition on trichostatin A-induced apoptosis in epithelial ovarian carcinoma cell lines. 2011 Mol. Cell. Biochem. pmid:21380726
Fan T et al. EZH2-dependent suppression of a cellular senescence phenotype in melanoma cells by inhibition of p21/CDKN1A expression. 2011 Mol. Cancer Res. pmid:21383005
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