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2006 |
Ann. Thorac. Surg. |
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The major histocompatibility complex class II transactivator is differentially regulated by interferon-gamma and transforming growth factor-beta in microglial cells. |
2006 |
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NF-kappaB and activator protein 1 response elements and the role of histone modifications in IL-1beta-induced TGF-beta1 gene transcription. |
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Evolutionary-conserved telomere-linked helicase genes of fission yeast are repressed by silencing factors, RNAi components and the telomere-binding protein Taz1. |
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Histone deacetylase inhibitors and paclitaxel cause synergistic effects on apoptosis and microtubule stabilization in papillary serous endometrial cancer cells. |
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Histone acetylation dependent allelic expression imbalance of BAPX1 in patients with the oculo-auriculo-vertebral spectrum. |
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Ornithine decarboxylase activity in tumor cell lines correlates with sensitivity to cell death induced by histone deacetylase inhibitors. |
2006 |
Mol. Cancer Ther. |
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Novel three-pronged strategy to enhance cancer cell killing in glioblastoma cell lines: histone deacetylase inhibitor, chemotherapy, and oncolytic adenovirus dl520. |
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Hum. Gene Ther. |
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NF-kappaB p50 promotes HIV latency through HDAC recruitment and repression of transcriptional initiation. |
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Correlation between the single-site CpG methylation and expression silencing of the XAF1 gene in human gastric and colon cancers. |
2006 |
Gastroenterology |
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Deacetylase inhibitors aid recovery in muscular dystrophy. |
2006 |
Lancet Neurol |
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Mixtures of SCFA, composed according to physiologically available concentrations in the gut lumen, modulate histone acetylation in human HT29 colon cancer cells. |
2006 |
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Histone deacetylation is required for orderly meiosis. |
2006 |
Cell Cycle |
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Histone deacetylase activity is necessary for chromosome condensation during meiotic maturation in Xenopus laevis. |
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Phosphorylation of SATB1, a global gene regulator, acts as a molecular switch regulating its transcriptional activity in vivo. |
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Mol. Cell |
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Trichostatin a enhances gap junctional intercellular communication in primary cultures of adult rat hepatocytes. |
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Carcinogenesis |
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Histone deacetylase activity regulates apaf-1 and caspase 3 expression in the developing mouse retina. |
2006 |
Invest. Ophthalmol. Vis. Sci. |
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Multiple mechanisms underlie the aberrant expression of the human kallikrein 6 gene in breast cancer. |
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Biol. Chem. |
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Association between enhanced type I collagen expression and epigenetic repression of the FLI1 gene in scleroderma fibroblasts. |
2006 |
Arthritis Rheum. |
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Thyroid hormone-mediated negative transcriptional regulation of Necdin expression. |
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NF-kappaB activation upregulates fibroblast growth factor 8 expression in prostate cancer cells. |
2006 |
Prostate |
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MUC2 expression is regulated by histone H3 modification and DNA methylation in pancreatic cancer. |
2006 |
Int. J. Cancer |
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2006 |
J. Steroid Biochem. Mol. Biol. |
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Tubulin must be acetylated in order to form a complex with membrane Na(+),K (+)-ATPase and to inhibit its enzyme activity. |
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Mol. Cell. Biochem. |
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Suppression of class I and II histone deacetylases blunts pressure-overload cardiac hypertrophy. |
2006 |
Circulation |
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Differential regulation of the alcohol dehydrogenase 1B (ADH1B) and ADH1C genes by DNA methylation and histone deacetylation. |
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Alcohol. Clin. Exp. Res. |
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Mol. Biol. Cell |
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HDAC inhibition is associated to valproic acid induction of early megakaryocytic markers. |
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Phosphatidylinositol 3-kinase/protein kinase Czeta-induced phosphorylation of Sp1 and p107 repressor release have a critical role in histone deacetylase inhibitor-mediated derepression [corrected] of transcription of the luteinizing hormone receptor gene. |
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Mol. Cell. Biol. |
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2006 |
Mol. Cell. Biol. |
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Epigenetic repression of RASSF1A but not CASP8 in supratentorial PNET (sPNET) and atypical teratoid/rhabdoid tumors (AT/RT) of childhood. |
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Oncogene |
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Src family kinase members have a common response to histone deacetylase inhibitors in human colon cancer cells. |
2006 |
Int. J. Cancer |
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5-Aza-2'-deoxycytidine (decitabine) can relieve p21WAF1 repression in human acute myeloid leukemia by a mechanism involving release of histone deacetylase 1 (HDAC1) without requiring p21WAF1 promoter demethylation. |
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Leuk. Res. |
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Epigenetic regulation of lentiviral transgene vectors in a large animal model. |
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Mol. Ther. |
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Association of the mSin3A-histone deacetylase 1/2 corepressor complex with the mouse steroidogenic acute regulatory protein gene. |
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Mol. Endocrinol. |
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NF-kappaB signaling pathway is involved in growth inhibition, G2/M arrest and apoptosis induced by Trichostatin A in human tongue carcinoma cells. |
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Arterioscler. Thromb. Vasc. Biol. |
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Inhibitors of histone deacetylases and DNA methyltransferases alter imprinted gene regulation in embryonic stem cells. |
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Cloning Stem Cells |
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[Mechanism of apoptosis induced by trichostatin A in leukemia Molt-4 cells analyzed by microarray]. |
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Effects of the histone deacetylases inhibitors sodium butyrate and trichostatin A on the inhibition of gap junctional intercellular communication by H2O2- and 12-O-tetradecanoylphorbol-13-acetate in rat liver epithelial cells. |
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Cancer Lett. |
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Trichostatin A, an inhibitor of histone deacetylase, inhibits smooth muscle cell proliferation via induction of p21(WAF1). |
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Enhancement of sodium/iodide symporter expression in thyroid and breast cancer. |
2006 |
Endocr. Relat. Cancer |
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Characterization of cellular retinoid-binding proteins in human myometrium during pregnancy. |
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Mol. Hum. Reprod. |
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Trichostatin A improves the anticancer activity of low concentrations of curcumin in human leukemia cells. |
2006 |
Pharmazie |
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A repressor complex, AP4 transcription factor and geminin, negatively regulates expression of target genes in nonneuronal cells. |
2006 |
Proc. Natl. Acad. Sci. U.S.A. |
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Histone deacetylase inhibitors strongly sensitise neuroblastoma cells to TRAIL-induced apoptosis by a caspases-dependent increase of the pro- to anti-apoptotic proteins ratio. |
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BMC Cancer |
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Epigenomic profiling reveals novel and frequent targets of aberrant DNA methylation-mediated silencing in malignant glioma. |
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Cancer Res. |
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Alteration of developmental program in Paramecium by treatment with trichostatin a: a possible involvement of histone modification. |
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Protist |
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An ex vivo method for rapid generation of monoclonal antibodies (ADLib system). |
2006 |
Nat Protoc |
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Role of histone acetylation in reprogramming of somatic nuclei following nuclear transfer. |
2006 |
Biol. Reprod. |
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J. Biol. Chem. |
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Maternal care effects on the hippocampal transcriptome and anxiety-mediated behaviors in the offspring that are reversible in adulthood. |
2006 |
Proc. Natl. Acad. Sci. U.S.A. |
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Trichostatin A sensitizes TRAIL-resistant myeloma cells by downregulation of the antiapoptotic Bcl-2 proteins. |
2006 |
Cancer Chemother. Pharmacol. |
pmid:16435155
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Regional hypermethylation and global hypomethylation are associated with altered chromatin conformation and histone acetylation in colorectal cancer. |
2006 |
Int. J. Cancer |
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Activation of ATP-sensitive K channels protects hippocampal CA1 neurons from hypoxia by suppressing p53 expression. |
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Histone deacetylase inhibitor-mediated radiosensitization of human cancer cells: class differences and the potential influence of p53. |
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Clin. Cancer Res. |
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Aberrant methylation of the eyes absent 4 gene in ulcerative colitis-associated dysplasia. |
2006 |
Clin. Gastroenterol. Hepatol. |
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Tumor suppressor p53 regulates heparanase gene expression. |
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Oncogene |
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Coordinated changes of histone modifications and HDAC mobilization regulate the induction of MHC class II genes by Trichostatin A. |
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Nucleic Acids Res. |
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Retinoic acids and trichostatin A (TSA), a histone deacetylase inhibitor, induce human pyruvate dehydrogenase kinase 4 (PDK4) gene expression. |
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Biochim. Biophys. Acta |
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Successful mouse cloning of an outbred strain by trichostatin A treatment after somatic nuclear transfer. |
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Histone deacetylase inhibitor Trichostatin A induces global and gene-specific DNA demethylation in human cancer cell lines. |
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Proteomic analysis of waldenstrom macroglobulinemia. |
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Cancer Res. |
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Proteomic analysis of pancreatic endocrine tumor cell lines treated with the histone deacetylase inhibitor trichostatin A. |
2007 |
Proteomics |
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Histone H2A mobility is regulated by its tails and acetylation of core histone tails. |
2007 |
Biochem. Biophys. Res. Commun. |
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Igf-2r expression regulated by epigenetic modification and the locus of gene imprinting disrupted in cloned cattle. |
2007 |
Gene |
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[The relationship of mTOR signaling pathway and histone acetylation in human gastric cancer cell lines]. |
2007 |
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The histone deacetylase inhibitor sodium butyrate inhibits baculovirus-mediated transgene expression in Sf9 cells. |
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[Impact of trichostatin A on gastric carcinoma cell line SGC-7901]. |
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Activating gene expression in mammalian cells with promoter-targeted duplex RNAs. |
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Nat. Chem. Biol. |
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Cardiac side population cells have a potential to migrate and differentiate into cardiomyocytes in vitro and in vivo. |
2007 |
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Chromatin-modifying agents permit human hematopoietic stem cells to undergo multiple cell divisions while retaining their repopulating potential. |
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Blood |
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Impaired activity of volume-sensitive Cl- channel is involved in cisplatin resistance of cancer cells. |
2007 |
J. Cell. Physiol. |
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Trichostatin A and 5-aza-2'-deoxycytidine switch S1P from an inhibitor to a stimulator of motility through epigenetic regulation of S1P receptors. |
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Cancer Lett. |
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Attenuated DNA damage repair by trichostatin A through BRCA1 suppression. |
2007 |
Radiat. Res. |
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The interferon-alpha responsive gene TMEM7 suppresses cell proliferation and is downregulated in human hepatocellular carcinoma. |
2007 |
Cancer Genet. Cytogenet. |
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High-frequency epigenetic repression and silencing of retroviruses can be antagonized by histone deacetylase inhibitors and transcriptional activators, but uniform reactivation in cell clones is restricted by additional mechanisms. |
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J. Virol. |
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Antiproliferative activities of a library of hybrids between indanones and HDAC inhibitor SAHA and MS-275 analogues. |
2007 |
Bioorg. Med. Chem. Lett. |
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A novel role of transforming growth factor beta1 in transcriptional repression of human cholesterol 7alpha-hydroxylase gene. |
2007 |
Gastroenterology |
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Deacetylase inhibition promotes the generation and function of regulatory T cells. |
2007 |
Nat. Med. |
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HIV-1 protease inhibitors do not interfere with provirus transcription and host cell apoptosis induced by combined treatment TNF-alpha + TSA. |
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Biochem. Pharmacol. |
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Differentiation-promoting drugs up-regulate NKG2D ligand expression and enhance the susceptibility of acute myeloid leukemia cells to natural killer cell-mediated lysis. |
2007 |
Leuk. Res. |
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Histone deacetylase 6 inhibition compensates for the transport deficit in Huntington's disease by increasing tubulin acetylation. |
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J. Neurosci. |
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Up-regulation of ras-GAP genes is reversed by a MEK inhibitor and doxorubicin in v-Ki-ras-transformed NIH/3T3 fibroblasts. |
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Biochem. Biophys. Res. Commun. |
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