Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Dar RD et al. | Transcriptional burst frequency and burst size are equally modulated across the human genome. | 2012 | Proc. Natl. Acad. Sci. U.S.A. | pmid:23064634 |
Grisolano JL et al. | An activated receptor tyrosine kinase, TEL/PDGFbetaR, cooperates with AML1/ETO to induce acute myeloid leukemia in mice. | 2003 | Proc. Natl. Acad. Sci. U.S.A. | pmid:12881486 |
Xu D et al. | Switch from Myc/Max to Mad1/Max binding and decrease in histone acetylation at the telomerase reverse transcriptase promoter during differentiation of HL60 cells. | 2001 | Proc. Natl. Acad. Sci. U.S.A. | pmid:11274400 |
Chen WY and Townes TM | Molecular mechanism for silencing virally transduced genes involves histone deacetylation and chromatin condensation. | 2000 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10618426 |
Zhang L et al. | Small molecule regulators of autophagy identified by an image-based high-throughput screen. | 2007 | Proc. Natl. Acad. Sci. U.S.A. | pmid:18024584 |
Thompson EM et al. | Real time imaging of transcriptional activity in live mouse preimplantation embryos using a secreted luciferase. | 1995 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7877974 |
Duffy S et al. | Overexpression screens identify conserved dosage chromosome instability genes in yeast and human cancer. | 2016 | Proc. Natl. Acad. Sci. U.S.A. | pmid:27551064 |
Jenster G et al. | Steroid receptor induction of gene transcription: a two-step model. | 1997 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9223281 |
Bartsch J et al. | Moderate increase in histone acetylation activates the mouse mammary tumor virus promoter and remodels its nucleosome structure. | 1996 | Proc. Natl. Acad. Sci. U.S.A. | pmid:8855250 |
Richon VM et al. | A class of hybrid polar inducers of transformed cell differentiation inhibits histone deacetylases. | 1998 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9501205 |
Matoba S et al. | RNAi-mediated knockdown of Xist can rescue the impaired postimplantation development of cloned mouse embryos. | 2011 | Proc. Natl. Acad. Sci. U.S.A. | pmid:22065773 |
Crump NT et al. | Dynamic acetylation of all lysine-4 trimethylated histone H3 is evolutionarily conserved and mediated by p300/CBP. | 2011 | Proc. Natl. Acad. Sci. U.S.A. | pmid:21518915 |
Selker EU | Trichostatin A causes selective loss of DNA methylation in Neurospora. | 1998 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9689097 |
Yeo M et al. | Bisphenol A delays the perinatal chloride shift in cortical neurons by epigenetic effects on the Kcc2 promoter. | 2013 | Proc. Natl. Acad. Sci. U.S.A. | pmid:23440186 |
Tavera-Mendoza LE et al. | Incorporation of histone deacetylase inhibition into the structure of a nuclear receptor agonist. | 2008 | Proc. Natl. Acad. Sci. U.S.A. | pmid:18550844 |
Ji Y et al. | A multistep mechanism for the activation of rearrangement in the immune system. | 2003 | Proc. Natl. Acad. Sci. U.S.A. | pmid:12802019 |
Liu Z et al. | Steroid receptor coactivator-1 (SRC-1) enhances ligand-dependent and receptor-dependent cell-free transcription of chromatin. | 1999 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10449719 |
Monte M et al. | MAGE-A tumor antigens target p53 transactivation function through histone deacetylase recruitment and confer resistance to chemotherapeutic agents. | 2006 | Proc. Natl. Acad. Sci. U.S.A. | pmid:16847267 |
Subramanian C et al. | Ku70 acetylation mediates neuroblastoma cell death induced by histone deacetylase inhibitors. | 2005 | Proc. Natl. Acad. Sci. U.S.A. | pmid:15778293 |
Li B et al. | FOXP3 interactions with histone acetyltransferase and class II histone deacetylases are required for repression. | 2007 | Proc. Natl. Acad. Sci. U.S.A. | pmid:17360565 |