trichostatin A
Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with trichostatin A?
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with trichostatin A
PubChem Associated disorders and diseases
What pathways are associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with trichostatin A?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with trichostatin A?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with trichostatin A?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with trichostatin A?
Related references are published most in these journals:
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What common seen animal models are associated with trichostatin A?
Mouse Model
Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with trichostatin A
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Plant KE et al. | Intergenic transcription in the human beta-globin gene cluster. | 2001 | Mol. Cell. Biol. | pmid:11533239 |
| Chen Lf W et al. | Duration of nuclear NF-kappaB action regulated by reversible acetylation. | 2001 | Science | pmid:11533489 |
| Vinatzer U et al. | The leukaemia-associated transcription factors EVI-1 and MDS1/EVI1 repress transcription and interact with histone deacetylase. | 2001 | Br. J. Haematol. | pmid:11552981 |
| Sawa H et al. | Histone deacetylase inhibitors such as sodium butyrate and trichostatin A induce apoptosis through an increase of the bcl-2-related protein Bad. | 2001 | Brain Tumor Pathol | pmid:11908866 |
| Seth KA and Majzoub JA | Repressor element silencing transcription factor/neuron-restrictive silencing factor (REST/NRSF) can act as an enhancer as well as a repressor of corticotropin-releasing hormone gene transcription. | 2001 | J. Biol. Chem. | pmid:11278361 |
| Matsuda E et al. | Targeting of Krüppel-associated box-containing zinc finger proteins to centromeric heterochromatin. Implication for the gene silencing mechanisms. | 2001 | J. Biol. Chem. | pmid:11278721 |
| Kim MS et al. | Histone deacetylases induce angiogenesis by negative regulation of tumor suppressor genes. | 2001 | Nat. Med. | pmid:11283670 |
| Vigushin DM et al. | Trichostatin A is a histone deacetylase inhibitor with potent antitumor activity against breast cancer in vivo. | 2001 | Clin. Cancer Res. | pmid:11309348 |
| Magdinier F and Wolffe AP | Selective association of the methyl-CpG binding protein MBD2 with the silent p14/p16 locus in human neoplasia. | 2001 | Proc. Natl. Acad. Sci. U.S.A. | pmid:11309512 |
| Grande A et al. | A functionally active RARalpha nuclear receptor is expressed in retinoic acid non responsive early myeloblastic cell lines. | 2001 | Cell Death Differ. | pmid:11313705 |
| Wu Y et al. | Negative regulation of bcl-2 expression by p53 in hematopoietic cells. | 2001 | Oncogene | pmid:11313951 |
| Greenberg VL et al. | Histone deacetylase inhibitors promote apoptosis and differential cell cycle arrest in anaplastic thyroid cancer cells. | 2001 | Thyroid | pmid:11349829 |
| Chen C et al. | Evidence that silencing of the HPRT promoter by DNA methylation is mediated by critical CpG sites. | 2001 | J. Biol. Chem. | pmid:11013250 |
| Arthur JL et al. | Herpes simplex virus type 1 promoter activity during latency establishment, maintenance, and reactivation in primary dorsal root neurons in vitro. | 2001 | J. Virol. | pmid:11264377 |
| Nervi C et al. | Inhibition of histone deacetylase activity by trichostatin A modulates gene expression during mouse embryogenesis without apparent toxicity. | 2001 | Cancer Res. | pmid:11245412 |
| Zhu WG et al. | DNA methyltransferase inhibition enhances apoptosis induced by histone deacetylase inhibitors. | 2001 | Cancer Res. | pmid:11245429 |
| Muth V et al. | Acetylation of TAF(I)68, a subunit of TIF-IB/SL1, activates RNA polymerase I transcription. | 2001 | EMBO J. | pmid:11250901 |
| Laribee RN and Klemsz MJ | Loss of PU.1 expression following inhibition of histone deacetylases. | 2001 | J. Immunol. | pmid:11673528 |
| Biade S et al. | Chemical agents that promote chromatin compaction radiosensitize tumour cells. | 2001 | Int. J. Radiat. Biol. | pmid:11682008 |
| Mishra SK et al. | Dynamic chromatin remodeling on the HER2 promoter in human breast cancer cells. | 2001 | FEBS Lett. | pmid:11682064 |