Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Rabineau M et al. | Cell guidance into quiescent state through chromatin remodeling induced by elastic modulus of substrate. | 2015 | Biomaterials | pmid:25453945 |
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Du J et al. | HDAC4 degradation mediates HDAC inhibition-induced protective effects against hypoxia/reoxygenation injury. | 2015 | J. Cell. Physiol. | pmid:25475100 |
Jiang H et al. | Changes of spontaneous parthenogenetic activation and development potential of golden hamster oocytes during the aging process. | 2015 | Acta Histochem. | pmid:25480399 |
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Hartman H et al. | Histone deacetylase regulates trypsin activation, inflammation, and tissue damage in acute pancreatitis in mice. | 2015 | Dig. Dis. Sci. | pmid:25492506 |
Rodrigues MF et al. | Reciprocal modulation of histone deacetylase inhibitors sodium butyrate and trichostatin A on the energy metabolism of breast cancer cells. | 2015 | J. Cell. Biochem. | pmid:25510910 |
Jeong SG and Cho GW | Trichostatin A modulates intracellular reactive oxygen species through SOD2 and FOXO1 in human bone marrow-mesenchymal stem cells. | 2015 | Cell Biochem. Funct. | pmid:25515622 |
Mataki H et al. | Downregulation of the microRNA-1/133a cluster enhances cancer cell migration and invasion in lung-squamous cell carcinoma via regulation of Coronin1C. | 2015 | J. Hum. Genet. | pmid:25518741 |
Qiao Y et al. | Dual roles of histone H3 lysine 9 acetylation in human embryonic stem cell pluripotency and neural differentiation. | 2015 | J. Biol. Chem. | pmid:25519907 |
Lim SY et al. | Enhancing Human Cardiomyocyte Differentiation from Induced Pluripotent Stem Cells with Trichostatin A. | 2016 | Methods Mol. Biol. | pmid:25520285 |
Qiang M et al. | Epigenetic mechanisms are involved in the regulation of ethanol consumption in mice. | 2014 | Int. J. Neuropsychopharmacol. | pmid:25522411 |
Dagnas M et al. | Post-training, intrahippocampal HDAC inhibition differentially impacts neural circuits underlying spatial memory in adult and aged mice. | 2015 | Hippocampus | pmid:25530477 |
Kitchen MO et al. | Epidrug mediated re-expression of miRNA targeting the HMGA transcripts in pituitary cells. | 2015 | Pituitary | pmid:25557289 |
Guo W et al. | RASSF5A, a candidate tumor suppressor, is epigenetically inactivated in esophageal squamous cell carcinoma. | 2015 | Clin. Exp. Metastasis | pmid:25579665 |
Adi Harel S et al. | Reactivation of epigenetically silenced miR-512 and miR-373 sensitizes lung cancer cells to cisplatin and restricts tumor growth. | 2015 | Cell Death Differ. | pmid:25591738 |
Zhang F et al. | Assessment of the effect of trichostatin A on HeLa cells through FT-IR spectroscopy. | 2015 | Anal. Chem. | pmid:25602746 |
Zhang Q et al. | Trichostatin A Protects Against Experimental Acute-on-Chronic Liver Failure in Rats Through Regulating the Acetylation of Nuclear Factor-κB. | 2015 | Inflammation | pmid:25604312 |
Shah S et al. | Impact of viral activators and epigenetic regulators on HIV-1 LTRs containing naturally occurring single nucleotide polymorphisms. | 2015 | Biomed Res Int | pmid:25629043 |
Ma J et al. | Trichostatin A, a histone deacetylase inhibitor, suppresses proliferation and promotes apoptosis of esophageal squamous cell lines. | 2015 | Mol Med Rep | pmid:25634603 |
Mizutani E et al. | Generation of cloned mice from adult neurons by direct nuclear transfer. | 2015 | Biol. Reprod. | pmid:25653280 |
Wang P et al. | Epigenetic Changes are Associated with Programmed Cell Death Induced by Heat Stress in Seedling Leaves of Zea mays. | 2015 | Plant Cell Physiol. | pmid:25670712 |
Huang H et al. | Regulation of TWIK-related potassium channel-1 (Trek1) restitutes intestinal epithelial barrier function. | 2016 | Cell. Mol. Immunol. | pmid:25683610 |
Meng J et al. | Ku70 is essential for histone deacetylase inhibitor trichostatin A-induced apoptosis. | 2015 | Mol Med Rep | pmid:25695595 |
Hsu HH et al. | Protection against reperfusion lung injury via aborgating multiple signaling cascades by trichostatin A. | 2015 | Int. Immunopharmacol. | pmid:25698558 |
Wang Y et al. | Identification of histone deacetylase inhibitors with benzoylhydrazide scaffold that selectively inhibit class I histone deacetylases. | 2015 | Chem. Biol. | pmid:25699604 |
Mostafavi-Pour Z et al. | Methylation of Integrin α4 and E-Cadherin Genes in Human Prostate Cancer. | 2015 | Pathol. Oncol. Res. | pmid:25743258 |
Cao K et al. | Histone deacetylase inhibitors prevent activation-induced cell death and promote anti-tumor immunity. | 2015 | Oncogene | pmid:25745993 |
Zelko IN and Folz RJ | Regulation of Oxidative Stress in Pulmonary Artery Endothelium. Modulation of Extracellular Superoxide Dismutase and NOX4 Expression Using Histone Deacetylase Class I Inhibitors. | 2015 | Am. J. Respir. Cell Mol. Biol. | pmid:25749103 |
Mackmull MT et al. | Histone Deacetylase Inhibitors (HDACi) Cause the Selective Depletion of Bromodomain Containing Proteins (BCPs). | 2015 | Mol. Cell Proteomics | pmid:25755299 |
Fukui T et al. | Histone deacetylase inhibitor attenuates neurotoxicity of clioquinol in PC12 cells. | 2015 | Toxicology | pmid:25758465 |
Cao QF et al. | TRPM2 mediates histone deacetylase inhibition-induced apoptosis in bladder cancer cells. | 2015 | Cancer Biother. Radiopharm. | pmid:25760728 |
Pinz S et al. | Deacetylase inhibitors repress STAT5-mediated transcription by interfering with bromodomain and extra-terminal (BET) protein function. | 2015 | Nucleic Acids Res. | pmid:25769527 |
Yamanegi K et al. | Sodium valproate, a histone deacetylase inhibitor, modulates the vascular endothelial growth inhibitor-mediated cell death in human osteosarcoma and vascular endothelial cells. | 2015 | Int. J. Oncol. | pmid:25778932 |
Butler PL et al. | Acetylation stimulates the epithelial sodium channel by reducing its ubiquitination and degradation. | 2015 | J. Biol. Chem. | pmid:25787079 |
Tao Y et al. | HDAC1 regulates the proliferation of radial glial cells in the developing Xenopus tectum. | 2015 | PLoS ONE | pmid:25789466 |
Asaoka N et al. | Inhibition of histone deacetylases enhances the function of serotoninergic neurons in organotypic raphe slice cultures. | 2015 | Neurosci. Lett. | pmid:25796177 |
Chan N et al. | Attenuation of choroidal neovascularization by histone deacetylase inhibitor. | 2015 | PLoS ONE | pmid:25807249 |
Ji M et al. | HDAC inhibitors induce epithelial-mesenchymal transition in colon carcinoma cells. | 2015 | Oncol. Rep. | pmid:25813246 |
Pandey SC et al. | Potential role of adolescent alcohol exposure-induced amygdaloid histone modifications in anxiety and alcohol intake during adulthood. | 2015 | Neurobiol. Dis. | pmid:25814047 |
Fujii K et al. | Lactogenic hormone stimulation and epigenetic control of L-amino acid oxidase expression in lactating mammary glands. | 2015 | J. Cell. Physiol. | pmid:25820447 |
Huisman C et al. | Prolonged re-expression of the hypermethylated gene EPB41L3 using artificial transcription factors and epigenetic drugs. | 2015 | Epigenetics | pmid:25830725 |
Acun T et al. | PTPRD is homozygously deleted and epigenetically downregulated in human hepatocellular carcinomas. | 2015 | OMICS | pmid:25831062 |
Rumbaugh G et al. | Pharmacological Selectivity Within Class I Histone Deacetylases Predicts Effects on Synaptic Function and Memory Rescue. | 2015 | Neuropsychopharmacology | pmid:25837283 |
Bieluszewski T et al. | AtEAF1 is a potential platform protein for Arabidopsis NuA4 acetyltransferase complex. | 2015 | BMC Plant Biol. | pmid:25849764 |
Tao W et al. | Brainstem brain-derived neurotrophic factor signaling is required for histone deacetylase inhibitor-induced pain relief. | 2015 | Mol. Pharmacol. | pmid:25852071 |
Ganatra DA et al. | Association of histone acetylation at the ACTA2 promoter region with epithelial mesenchymal transition of lens epithelial cells. | 2015 | Eye (Lond) | pmid:25853442 |
Devaney JM et al. | Genome-wide differentially methylated genes in prostate cancer tissues from African-American and Caucasian men. | 2015 | Epigenetics | pmid:25864488 |
Hou H et al. | Influence of intra-articular administration of trichostatin a on autologous osteochondral transplantation in a rabbit model. | 2015 | Biomed Res Int | pmid:25866784 |
Samiec M et al. | Trichostatin A-mediated epigenetic transformation of adult bone marrow-derived mesenchymal stem cells biases the in vitro developmental capability, quality, and pluripotency extent of porcine cloned embryos. | 2015 | Biomed Res Int | pmid:25866813 |
Nordström L et al. | DNA methylation and histone modifications regulate SOX11 expression in lymphoid and solid cancer cells. | 2015 | BMC Cancer | pmid:25880212 |
Di Zanni E et al. | Identification of novel pathways and molecules able to down-regulate PHOX2B gene expression by in vitro drug screening approaches in neuroblastoma cells. | 2015 | Exp. Cell Res. | pmid:25882494 |
Lin S et al. | IL-4 Modulates Macrophage Polarization in Ankylosing Spondylitis. | 2015 | Cell. Physiol. Biochem. | pmid:25896783 |
Zhao W et al. | A traditional Chinese medicine, Lujiao prescription, as a potential therapy for hypertrophic cardiomyocytes by acting on histone acetylation. | 2015 | J Chin Med Assoc | pmid:25913212 |
Mishra DR et al. | Identification of Critical Elements for Regulation of Inorganic Pyrophosphatase (PPA1) in MCF7 Breast Cancer Cells. | 2015 | PLoS ONE | pmid:25923237 |
Han Y et al. | Murine hematopoietic stem cell dormancy controlled by induction of a novel short form of PSF1 by histone deacetylase inhibitors. | 2015 | Exp. Cell Res. | pmid:25933513 |
Marquardt JU et al. | Curcumin effectively inhibits oncogenic NF-κB signaling and restrains stemness features in liver cancer. | 2015 | J. Hepatol. | pmid:25937435 |
Ooi JY et al. | HDAC inhibition attenuates cardiac hypertrophy by acetylation and deacetylation of target genes. | 2015 | Epigenetics | pmid:25941940 |
Meschini R et al. | Role of chromatin structure modulation by the histone deacetylase inhibitor trichostatin A on the radio-sensitivity of ataxia telangiectasia. | 2015 | Mutat. Res. | pmid:25942615 |
Koumbadinga GA et al. | Increased stability of heterogeneous ribonucleoproteins by a deacetylase inhibitor. | 2015 | Biochim. Biophys. Acta | pmid:25959059 |
Huan Y et al. | Trichostatin A rescues the disrupted imprinting induced by somatic cell nuclear transfer in pigs. | 2015 | PLoS ONE | pmid:25962071 |
El-Awady RA et al. | Epigenetics and miRNA as predictive markers and targets for lung cancer chemotherapy. | 2015 | Cancer Biol. Ther. | pmid:25962089 |
Inoue K et al. | Trichostatin A specifically improves the aberrant expression of transcription factor genes in embryos produced by somatic cell nuclear transfer. | 2015 | Sci Rep | pmid:25974394 |
Chen MH et al. | A new trichostatin analog from Streptomyces sp. CPCC 203909. | 2015 | J Asian Nat Prod Res | pmid:25977996 |
Nayak S et al. | Superior Versus Inferior Vestibular Neuritis: Are There Intrinsic Differences in Infection, Reactivation, or Production of Infectious Particles Between the Vestibular Ganglia? | 2015 | Otol. Neurotol. | pmid:25978655 |
Chen Z et al. | Promotion of Metastasis-associated Gene Expression in Survived PANC-1 Cells Following Trichostatin A Treatment. | 2015 | Anticancer Agents Med Chem | pmid:25991546 |
Ukaegbu UE et al. | A Unique Virulence Gene Occupies a Principal Position in Immune Evasion by the Malaria Parasite Plasmodium falciparum. | 2015 | PLoS Genet. | pmid:25993442 |
Koppaka V et al. | Effect of HDAC Inhibitors on Corneal Keratocyte Mechanical Phenotypes in 3-D Collagen Matrices. | 2015 | Mol. Vis. | pmid:25999677 |
Singh RD et al. | Arsenic exposure causes epigenetic dysregulation of IL-8 expression leading to proneoplastic changes in kidney cells. | 2015 | Toxicol. Lett. | pmid:26008221 |
Jost JO et al. | A miniaturized readout strategy for endogenous histone deacetylase activity. | 2015 | Mol Biosyst | pmid:26009008 |
Liu Y and Li S | A Cell Culture Model of Latent and Lytic Herpes Simplex Virus Type 1 Infection in Spiral Ganglion. | 2015 | ORL J. Otorhinolaryngol. Relat. Spec. | pmid:26022499 |
Kaldre D et al. | Optimization of histone deacetylase inhibitor activity in non-secosteroidal vitamin D-receptor agonist hybrids. | 2015 | Bioorg. Med. Chem. | pmid:26048026 |
Iancu-Rubin C and Hoffman R | Role of epigenetic reprogramming in hematopoietic stem cell function. | 2015 | Curr. Opin. Hematol. | pmid:26049747 |
Huan Y et al. | Epigenetic Modification of Cloned Embryos Improves Nanog Reprogramming in Pigs. | 2015 | Cell Reprogram | pmid:26053519 |
Huan Y et al. | Epigenetic Modification Agents Improve Gene-Specific Methylation Reprogramming in Porcine Cloned Embryos. | 2015 | PLoS ONE | pmid:26068219 |
Huang J et al. | Trichostatin A reduces cisplatin-induced ototoxicity through the STAT6 signaling pathway. | 2015 | Int. J. Mol. Med. | pmid:26080623 |
Liu J et al. | Trichostatin A suppresses lung adenocarcinoma development in Grg1 overexpressing transgenic mice. | 2015 | Biochem. Biophys. Res. Commun. | pmid:26086099 |
Brandão FA et al. | Histone deacetylases inhibitors effects on Cryptococcus neoformans major virulence phenotypes. | 2015 | Virulence | pmid:26103530 |
Dupré-Aucouturier S et al. | Trichostatin A, a histone deacetylase inhibitor, modulates unloaded-induced skeletal muscle atrophy. | 2015 | J. Appl. Physiol. | pmid:26112243 |
Kanasaki H et al. | Trichostatin A reduces GnRH mRNA expression with a concomitant increase in retinaldehyde dehydrogenase in GnRH-producing neurons. | 2015 | Mol. Cell. Endocrinol. | pmid:26116234 |
Thangavel J et al. | Epigenetic modifiers reduce inflammation and modulate macrophage phenotype during endotoxemia-induced acute lung injury. | 2015 | J. Cell. Sci. | pmid:26116574 |
Lee YR et al. | Extracellularly secreted APE1/Ref-1 triggers apoptosis in triple-negative breast cancer cells via RAGE binding, which is mediated through acetylation. | 2015 | Oncotarget | pmid:26125438 |
Singh AK et al. | Evaluation of Epigenetic Drug Targeting of Heterogenous Tumor Cell Fractions Using Potential Biomarkers of Response in Ovarian Cancer. | 2015 | Clin. Cancer Res. | pmid:26130461 |
Ota C et al. | Histone deacetylase inhibitor restores surfactant protein-C expression in alveolar-epithelial type II cells and attenuates bleomycin-induced pulmonary fibrosis in vivo. | 2015 | Exp. Lung Res. | pmid:26151196 |
Vadie N et al. | MYCNOS functions as an antisense RNA regulating MYCN. | 2015 | RNA Biol | pmid:26156430 |
Liao HF et al. | Dnmt3l-knockout donor cells improve somatic cell nuclear transfer reprogramming efficiency. | 2015 | Reproduction | pmid:26159833 |
Tan CS et al. | Epigenetic Regulation of Cytosolic Phospholipase A2 in SH-SY5Y Human Neuroblastoma Cells. | 2016 | Mol. Neurobiol. | pmid:26162318 |
Ji S et al. | [Association of irradiation-induced hippocampal neurogenesis impairment with histone H3 acetylation]. | 2015 | Zhonghua Yi Xue Za Zhi | pmid:26168675 |
Hedberg Oldfors C et al. | Analysis of an independent tumor suppressor locus telomeric to Tp53 suggested Inpp5k and Myo1c as novel tumor suppressor gene candidates in this region. | 2015 | BMC Genet. | pmid:26170120 |
Wu Y et al. | Acetylation-dependent function of human single-stranded DNA binding protein 1. | 2015 | Nucleic Acids Res. | pmid:26170237 |
Gutiérrez J et al. | Human papillomavirus type 16 E7 oncoprotein upregulates the retinoic acid receptor-beta expression in cervical cancer cell lines and K14E7 transgenic mice. | 2015 | Mol. Cell. Biochem. | pmid:26173416 |
Suo H et al. | NRSF is an essential mediator for the neuroprotection of trichostatin A in the MPTP mouse model of Parkinson's disease. | 2015 | Neuropharmacology | pmid:26188143 |
Cabanel M et al. | Epigenetic Control of Macrophage Shape Transition towards an Atypical Elongated Phenotype by Histone Deacetylase Activity. | 2015 | PLoS ONE | pmid:26196676 |
Sancak D and Ozden S | Global histone modifications in Fumonisin B1 exposure in rat kidney epithelial cells. | 2015 | Toxicol In Vitro | pmid:26208285 |
Mehta A et al. | HDAC inhibitor prevents LPS mediated inhibition of CYP19A1 expression and 17β-estradiol production in granulosa cells. | 2015 | Mol. Cell. Endocrinol. | pmid:26213324 |
Kim SH et al. | The heat shock protein 90 inhibitor SNX5422 has a synergistic activity with histone deacetylase inhibitors in induction of death of anaplastic thyroid carcinoma cells. | 2016 | Endocrine | pmid:26219406 |
Dreser N et al. | Grouping of histone deacetylase inhibitors and other toxicants disturbing neural crest migration by transcriptional profiling. | 2015 | Neurotoxicology | pmid:26238599 |
Zheng J et al. | Gain-of-function STAT1 mutations impair STAT3 activity in patients with chronic mucocutaneous candidiasis (CMC). | 2015 | Eur. J. Immunol. | pmid:26255980 |
Passeri E et al. | Enhanced conversion of induced neuronal cells (iN cells) from human fibroblasts: Utility in uncovering cellular deficits in mental illness-associated chromosomal abnormalities. | 2015 | Neurosci. Res. | pmid:26260244 |
Pang X et al. | Knockdown of Rad9A enhanced DNA damage induced by trichostatin A in esophageal cancer cells. | 2016 | Tumour Biol. | pmid:26264615 |