Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Lu SC et al. | The essential role of Oct-2 in LPS-induced expression of iNOS in RAW 264.7 macrophages and its regulation by trichostatin A. | 2009 | Am. J. Physiol., Cell Physiol. | pmid:19279235 |
Zampetaki A et al. | Lacking cytokine production in ES cells and ES-cell-derived vascular cells stimulated by TNF-alpha is rescued by HDAC inhibitor trichostatin A. | 2007 | Am. J. Physiol., Cell Physiol. | pmid:17626239 |
Zhang W and Kone BC | NF-kappaB inhibits transcription of the H(+)-K(+)-ATPase alpha(2)-subunit gene: role of histone deacetylases. | 2002 | Am. J. Physiol. Renal Physiol. | pmid:12372765 |
Kroening S et al. | Characterization of connective tissue growth factor expression in primary cultures of human tubular epithelial cells: modulation by hypoxia. | 2010 | Am. J. Physiol. Renal Physiol. | pmid:20032117 |
Yu Z and Kone BC | Targeted histone H4 acetylation via phosphoinositide 3-kinase- and p70s6-kinase-dependent pathways inhibits iNOS induction in mesangial cells. | 2006 | Am. J. Physiol. Renal Physiol. | pmid:16174862 |
Arany I et al. | Restoration of CREB function ameliorates cisplatin cytotoxicity in renal tubular cells. | 2008 | Am. J. Physiol. Renal Physiol. | pmid:18094030 |
Noh H et al. | Histone deacetylase-2 is a key regulator of diabetes- and transforming growth factor-beta1-induced renal injury. | 2009 | Am. J. Physiol. Renal Physiol. | pmid:19553350 |
Pang M et al. | Inhibition of histone deacetylase activity attenuates renal fibroblast activation and interstitial fibrosis in obstructive nephropathy. | 2009 | Am. J. Physiol. Renal Physiol. | pmid:19640900 |
Li L et al. | Use of mouse hematopoietic stem and progenitor cells to treat acute kidney injury. | 2012 | Am. J. Physiol. Renal Physiol. | pmid:21937606 |
Marumo T et al. | Histone deacetylase modulates the proinflammatory and -fibrotic changes in tubulointerstitial injury. | 2010 | Am. J. Physiol. Renal Physiol. | pmid:19906951 |
Freidkin I et al. | Effects of histone deacetylase inhibitors on rat mesangial cells. | 2010 | Am. J. Physiol. Renal Physiol. | pmid:19923417 |
Dong G et al. | Inhibitors of histone deacetylases suppress cisplatin-induced p53 activation and apoptosis in renal tubular cells. | 2010 | Am. J. Physiol. Renal Physiol. | pmid:19889954 |
Alamdari N et al. | Sepsis and glucocorticoids upregulate p300 and downregulate HDAC6 expression and activity in skeletal muscle. | 2010 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:20538901 |
Yang H et al. | Dexamethasone-induced protein degradation in cultured myotubes is p300/HAT dependent. | 2007 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:16973938 |
Yang Q et al. | Pulmonary artery smooth muscle cell proliferation and migration in fetal lambs acclimatized to high-altitude long-term hypoxia: role of histone acetylation. | 2012 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:23043075 |
Guo W et al. | Abrogation of TGF-beta1-induced fibroblast-myofibroblast differentiation by histone deacetylase inhibition. | 2009 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:19700647 |
Popova AP et al. | Autocrine production of TGF-beta1 promotes myofibroblastic differentiation of neonatal lung mesenchymal stem cells. | 2010 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:20190033 |
Zhang Y et al. | Autophagy in pulmonary macrophages mediates lung inflammatory injury via NLRP3 inflammasome activation during mechanical ventilation. | 2014 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:24838752 |
Kuang PP et al. | Activation of elastin transcription by transforming growth factor-beta in human lung fibroblasts. | 2007 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:17209135 |
Mizuno S et al. | Inhibition of histone deacetylase causes emphysema. | 2011 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:21224215 |
Gang H et al. | Epigenetic regulation of canonical TNFα pathway by HDAC1 determines survival of cardiac myocytes. | 2013 | Am. J. Physiol. Heart Circ. Physiol. | pmid:23585133 |
Davis FJ et al. | Concurrent opposite effects of trichostatin A, an inhibitor of histone deacetylases, on expression of alpha-MHC and cardiac tubulins: implication for gain in cardiac muscle contractility. | 2005 | Am. J. Physiol. Heart Circ. Physiol. | pmid:15388503 |
Xu Q et al. | Changes in cardiac Nav1.5 expression, function, and acetylation by pan-histone deacetylase inhibitors. | 2016 | Am. J. Physiol. Heart Circ. Physiol. | pmid:27638876 |
Usui T et al. | HDAC4 mediates development of hypertension via vascular inflammation in spontaneous hypertensive rats. | 2012 | Am. J. Physiol. Heart Circ. Physiol. | pmid:22389387 |
Zhang LX et al. | Targeted deletion of NF-kappaB p50 diminishes the cardioprotection of histone deacetylase inhibition. | 2010 | Am. J. Physiol. Heart Circ. Physiol. | pmid:20382965 |
Kiela PR et al. | Regulation of the rat NHE3 gene promoter by sodium butyrate. | 2001 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:11557515 |
Yang H et al. | Role of promoter methylation in increased methionine adenosyltransferase 2A expression in human liver cancer. | 2001 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:11208539 |
Gaudier E et al. | Butyrate specifically modulates MUC gene expression in intestinal epithelial goblet cells deprived of glucose. | 2004 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:15308471 |
Wu JT et al. | Transient vs. prolonged histone hyperacetylation: effects on colon cancer cell growth, differentiation, and apoptosis. | 2001 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:11171632 |
Pender SL et al. | Butyrate upregulates stromelysin-1 production by intestinal mesenchymal cells. | 2000 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:11052988 |
Sonoyama K et al. | Upregulation of activin A gene by butyrate in human colon cancer cell lines. | 2003 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:12540370 |
Sato TA and Mitchell MD | Molecular inhibition of histone deacetylation results in major enhancement of the production of IL-1beta in response to LPS. | 2006 | Am. J. Physiol. Endocrinol. Metab. | pmid:16234266 |
Wang XH et al. | S100A6 overexpression is associated with poor prognosis and is epigenetically up-regulated in gastric cancer. | 2010 | Am. J. Pathol. | pmid:20581057 |
Thangavel J et al. | Combinatorial therapy with acetylation and methylation modifiers attenuates lung vascular hyperpermeability in endotoxemia-induced mouse inflammatory lung injury. | 2014 | Am. J. Pathol. | pmid:24929240 |
Miyatake Y et al. | Protective roles of epithelial cells in the survival of adult T-cell leukemia/lymphoma cells. | 2013 | Am. J. Pathol. | pmid:23474084 |
Nakamura J et al. | Expression of hypoxic marker CA IX is regulated by site-specific DNA methylation and is associated with the histology of gastric cancer. | 2011 | Am. J. Pathol. | pmid:21281785 |
Moynihan AT et al. | Histone deacetylase inhibitors and a functional potent inhibitory effect on human uterine contractility. | 2008 | Am. J. Obstet. Gynecol. | pmid:18455134 |
Zhou H et al. | Epigenetic allele silencing unveils recessive RYR1 mutations in core myopathies. | 2006 | Am. J. Hum. Genet. | pmid:17033962 |
Lavelle D et al. | Histone deacetylase inhibitors increase p21(WAF1) and induce apoptosis of human myeloma cell lines independent of decreased IL-6 receptor expression. | 2001 | Am. J. Hematol. | pmid:11754398 |
Halldórsdóttir AM et al. | Mantle cell lymphoma displays a homogenous methylation profile: a comparative analysis with chronic lymphocytic leukemia. | 2012 | Am. J. Hematol. | pmid:22374828 |
Atanackovic D et al. | Cancer-testis antigen expression and its epigenetic modulation in acute myeloid leukemia. | 2011 | Am. J. Hematol. | pmid:21898529 |
Cho JS et al. | Effects of histone deacetylase inhibitor on extracellular matrix production in human nasal polyp organ cultures. | 2013 | Am J Rhinol Allergy | pmid:23406592 |
Elaut G et al. | Rat hepatocyte suspensions as a suitable in vitro model for studying the biotransformation of histone deacetylase inhibitors. | 2004 | Altern Lab Anim | pmid:23577441 |
Dannenberg LO et al. | Differential regulation of the alcohol dehydrogenase 1B (ADH1B) and ADH1C genes by DNA methylation and histone deacetylation. | 2006 | Alcohol. Clin. Exp. Res. | pmid:16737450 |
Agudelo M et al. | Effects of alcohol on histone deacetylase 2 (HDAC2) and the neuroprotective role of trichostatin A (TSA). | 2011 | Alcohol. Clin. Exp. Res. | pmid:21447001 |
Agudelo M et al. | Alcohol-induced serotonergic modulation: the role of histone deacetylases. | 2012 | Alcohol | pmid:22796363 |
Chen G et al. | [Enhancive effect of histone deacetylase inhibitor trichostatin a on transfection efficiency of adenovirus in ovarian carcinoma cell line A2780]. | 2005 | Ai Zheng | pmid:16219132 |
Hong ZY et al. | [Mechanism of apoptosis induced by trichostatin A in leukemia Molt-4 cells analyzed by microarray]. | 2006 | Ai Zheng | pmid:16965673 |
Huang H et al. | [HDAC1 expression and effect of TSA on proliferation and apoptosis of A549 cells]. | 2003 | Ai Zheng | pmid:12969522 |
Yang YN et al. | [Effects of trichostatin A and paclitaxel on apoptosis and mitochondrial membrane potential of human endometrial carcinoma Ark2 cells]. | 2008 | Ai Zheng | pmid:18710614 |