Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Zhang J et al. | Inhibition of glyceroneogenesis by histone deacetylase 3 contributes to lipodystrophy in mice with adipose tissue inflammation. | 2011 | Endocrinology | pmid:21406501 |
Kawasaki H et al. | Mouse embryonic stem cells inhibit murine cytomegalovirus infection through a multi-step process. | 2011 | PLoS ONE | pmid:21407806 |
Zhang Y et al. | ERK1/2 activation plays important roles in the opposite effects of Trichostatin A in non-cancer and cancer cells. | 2011 | Toxicon | pmid:21419152 |
WEI Q et al. | [Trichostatin A inhibits the activation of CD(4)(+) T cells by suppressing CD(28) expression in mice]. | 2011 | Nan Fang Yi Ke Da Xue Xue Bao | pmid:21421475 |
Jergil M et al. | Short-time gene expression response to valproic acid and valproic acid analogs in mouse embryonic stem cells. | 2011 | Toxicol. Sci. | pmid:21427059 |
Kadowaki M et al. | DNA methylation-mediated silencing of nonsteroidal anti-inflammatory drug-activated gene (NAG-1/GDF15) in glioma cell lines. | 2012 | Int. J. Cancer | pmid:21437897 |
Briggs B et al. | Photosensitization by iodinated DNA minor groove binding ligands: Evaluation of DNA double-strand break induction and repair. | 2011 | J. Photochem. Photobiol. B, Biol. | pmid:21440453 |
Agudelo M et al. | Effects of alcohol on histone deacetylase 2 (HDAC2) and the neuroprotective role of trichostatin A (TSA). | 2011 | Alcohol. Clin. Exp. Res. | pmid:21447001 |
Sun JY et al. | Histone deacetylase inhibitors demonstrate significant preclinical activity as single agents, and in combination with bortezomib in Waldenström's macroglobulinemia. | 2011 | Clin Lymphoma Myeloma Leuk | pmid:21454220 |
Min XJ et al. | Dysfunction of volume-sensitive chloride channels contributes to cisplatin resistance in human lung adenocarcinoma cells. | 2011 | Exp. Biol. Med. (Maywood) | pmid:21454376 |
Belakavadi M et al. | Thyroid hormone suppression of β-amyloid precursor protein gene expression in the brain involves multiple epigenetic regulatory events. | 2011 | Mol. Cell. Endocrinol. | pmid:21458529 |
Miller L et al. | Histone deacetylase 1 (HDAC1) participates in the down-regulation of corticotropin releasing hormone gene (crh) expression. | 2011 | Physiol. Behav. | pmid:21463644 |
Law AY et al. | Sp1 is a transcription repressor to stanniocalcin-1 expression in TSA-treated human colon cancer cells, HT29. | 2011 | J. Cell. Biochem. | pmid:21465530 |
Pang M et al. | Histone deacetylase 1/2 mediates proliferation of renal interstitial fibroblasts and expression of cell cycle proteins. | 2011 | J. Cell. Biochem. | pmid:21465537 |
Kimura T et al. | Chromium (VI) inhibits mouse metallothionein-I gene transcription by modifying the transcription potential of the co-activator p300. | 2011 | J Toxicol Sci | pmid:21467744 |
Zhang CZ et al. | Trichostatin A sensitizes HBx-expressing liver cancer cells to etoposide treatment. | 2011 | Apoptosis | pmid:21468663 |
Nagamine MK et al. | In vitro inhibitory effect of trichostatin A on canine grade 3 mast cell tumor. | 2011 | Vet. Res. Commun. | pmid:21472452 |
Yang J et al. | [Study of RASSF1A expression and promoter demethylation in Hep-2 cell line]. | 2011 | Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi | pmid:21473137 |
Cui XS et al. | Trichostatin A modulates apoptotic-related gene expression and improves embryo viability in cloned bovine embryos. | 2011 | Cell Reprogram | pmid:21473694 |
Wang Y et al. | The effects of 5-aza-2'- deoxycytidine and trichostatin A on gene expression and DNA methylation status in cloned bovine blastocysts. | 2011 | Cell Reprogram | pmid:21486115 |
Hattori N et al. | Methylation silencing of angiopoietin-like 4 in rat and human mammary carcinomas. | 2011 | Cancer Sci. | pmid:21489049 |
Chen MY et al. | Decitabine and suberoylanilide hydroxamic acid (SAHA) inhibit growth of ovarian cancer cell lines and xenografts while inducing expression of imprinted tumor suppressor genes, apoptosis, G2/M arrest, and autophagy. | 2011 | Cancer | pmid:21491416 |
Zelko IN et al. | Histone acetylation regulates the cell-specific and interferon-γ-inducible expression of extracellular superoxide dismutase in human pulmonary arteries. | 2011 | Am. J. Respir. Cell Mol. Biol. | pmid:21493784 |
Kretzner L et al. | Combining histone deacetylase inhibitor vorinostat with aurora kinase inhibitors enhances lymphoma cell killing with repression of c-Myc, hTERT, and microRNA levels. | 2011 | Cancer Res. | pmid:21502403 |
Eskeland R et al. | Histone acetylation and the maintenance of chromatin compaction by Polycomb repressive complexes. | 2010 | Cold Spring Harb. Symp. Quant. Biol. | pmid:21502416 |
Park JW et al. | Microbial transformation of trichostatin A to 2,3-dihydrotrichostatin A. | 2011 | J. Nat. Prod. | pmid:21504214 |
Bolleyn J et al. | Effect of Trichostatin A on miRNA expression in cultures of primary rat hepatocytes. | 2011 | Toxicol In Vitro | pmid:21513791 |
Nishikata I et al. | Sumoylation of MEL1S at lysine 568 and its interaction with CtBP facilitates its repressor activity and the blockade of G-CSF-induced myeloid differentiation. | 2011 | Oncogene | pmid:21516122 |
Crump NT et al. | Dynamic acetylation of all lysine-4 trimethylated histone H3 is evolutionarily conserved and mediated by p300/CBP. | 2011 | Proc. Natl. Acad. Sci. U.S.A. | pmid:21518915 |
Fortson WS et al. | Histone deacetylase inhibitors, valproic acid and trichostatin-A induce apoptosis and affect acetylation status of p53 in ERG-positive prostate cancer cells. | 2011 | Int. J. Oncol. | pmid:21519790 |
Xiong H et al. | Trichostatin A, a histone deacetylase inhibitor, suppresses JAK2/STAT3 signaling via inducing the promoter-associated histone acetylation of SOCS1 and SOCS3 in human colorectal cancer cells. | 2012 | Mol. Carcinog. | pmid:21520296 |
Ramsey MR et al. | Physical association of HDAC1 and HDAC2 with p63 mediates transcriptional repression and tumor maintenance in squamous cell carcinoma. | 2011 | Cancer Res. | pmid:21527555 |
Qiu GH et al. | Recognition and suppression of transfected plasmids by protein ZNF511-PRAP1, a potential molecular barrier to transgene expression. | 2011 | Mol. Ther. | pmid:21540836 |
Kong Q et al. | Effect of trichostatin A and 5-Aza-2'-deoxycytidine on transgene reactivation and epigenetic modification in transgenic pig fibroblast cells. | 2011 | Mol. Cell. Biochem. | pmid:21541675 |
Shu G et al. | Zac1 is a histone acetylation-regulated NF-κB suppressor that mediates histone deacetylase inhibitor-induced apoptosis. | 2011 | Cell Death Differ. | pmid:21546906 |
Vojdani Z et al. | Cardiomyocyte marker expression in a human lymphocyte cell line using mouse cardiomyocyte extract. | 2011 | Hum. Cell | pmid:21547694 |
Neelarapu R et al. | Design, synthesis, docking, and biological evaluation of novel diazide-containing isoxazole- and pyrazole-based histone deacetylase probes. | 2011 | J. Med. Chem. | pmid:21548582 |
Vassiliev I et al. | Isolation and in vitro characterization of putative porcine embryonic stem cells from cloned embryos treated with trichostatin A. | 2011 | Cell Reprogram | pmid:21548828 |
Meng Y et al. | Epigenetic inactivation of the SFRP1 gene in esophageal squamous cell carcinoma. | 2011 | Dig. Dis. Sci. | pmid:21567192 |
Hayashi-Takanaka Y et al. | Tracking epigenetic histone modifications in single cells using Fab-based live endogenous modification labeling. | 2011 | Nucleic Acids Res. | pmid:21576221 |
Bouquet F et al. | A DNA-dependent stress response involving DNA-PK occurs in hypoxic cells and contributes to cellular adaptation to hypoxia. | 2011 | J. Cell. Sci. | pmid:21576354 |
Hawk JD et al. | Post-training intrahippocampal inhibition of class I histone deacetylases enhances long-term object-location memory. | 2011 | Learn. Mem. | pmid:21576516 |
Ververis K et al. | Histone deacetylase inhibitors augment doxorubicin-induced DNA damage in cardiomyocytes. | 2011 | Cell. Mol. Life Sci. | pmid:21584806 |
Misaki K et al. | Histone deacetylase inhibition alters dendritic cells to assume a tolerogenic phenotype and ameliorates arthritis in SKG mice. | 2011 | Arthritis Res. Ther. | pmid:21592365 |
Selinger CI et al. | Loss of special AT-rich binding protein 1 expression is a marker of poor survival in lung cancer. | 2011 | J Thorac Oncol | pmid:21597389 |
Puppin C et al. | Histone deacetylase inhibitors induce thymidine phosphorylase expression in cultured breast cancer cell lines. | 2011 | Oncol. Rep. | pmid:21617864 |
Hou J et al. | Structure-based optimization of click-based histone deacetylase inhibitors. | 2011 | Eur J Med Chem | pmid:21621883 |
Lin S et al. | HIV-1 reactivation induced by apicidin involves histone modification in latently infected cells. | 2011 | Curr. HIV Res. | pmid:21631428 |
Jugová A et al. | Effects of epigenetic-based anti-cancer drugs in leukaemia and multiple myeloma cells. | 2011 | Cell Biol. Int. | pmid:21635225 |
Wong CY et al. | Epigenetic regulation of phosphatidylinositol 3,4,5-triphosphate-dependent Rac exchanger 1 gene expression in prostate cancer cells. | 2011 | J. Biol. Chem. | pmid:21636851 |
Xia B et al. | Chromium(VI) causes down regulation of biotinidase in human bronchial epithelial cells by modifications of histone acetylation. | 2011 | Toxicol. Lett. | pmid:21641978 |
Seo SK et al. | Histone deacetylase inhibitors sensitize human non-small cell lung cancer cells to ionizing radiation through acetyl p53-mediated c-myc down-regulation. | 2011 | J Thorac Oncol | pmid:21642861 |
Acun T et al. | SIP1 is downregulated in hepatocellular carcinoma by promoter hypermethylation. | 2011 | BMC Cancer | pmid:21645397 |
Cowell IG et al. | Histone deacetylase inhibition redistributes topoisomerase IIβ from heterochromatin to euchromatin. | 2011 Jan-Feb | Nucleus | pmid:21647300 |
Dávalos-Salas M et al. | Gain of DNA methylation is enhanced in the absence of CTCF at the human retinoblastoma gene promoter. | 2011 | BMC Cancer | pmid:21663659 |
Zhang L et al. | ABA treatment of germinating maize seeds induces VP1 gene expression and selective promoter-associated histone acetylation. | 2011 | Physiol Plant | pmid:21679193 |
Sar P et al. | 3, 3'5 Triiodo L thyronine induces apoptosis in human breast cancer MCF-7 cells, repressing SMP30 expression through negative thyroid response elements. | 2011 | PLoS ONE | pmid:21687737 |
Cosner CC and Helquist P | Concise, convergent syntheses of (±)-trichostatin A utilizing a Pd-catalyzed ketone enolate α-alkenylation reaction. | 2011 | Org. Lett. | pmid:21688856 |
Kojima S et al. | Asymmetric leaves2 and Elongator, a histone acetyltransferase complex, mediate the establishment of polarity in leaves of Arabidopsis thaliana. | 2011 | Plant Cell Physiol. | pmid:21700721 |
Chik CL et al. | Histone modifications on the adrenergic induction of type II deiodinase in rat pinealocytes. | 2011 | Mol. Cell. Endocrinol. | pmid:21704117 |
Gaub P et al. | The histone acetyltransferase p300 promotes intrinsic axonal regeneration. | 2011 | Brain | pmid:21705428 |
Song K et al. | Heparan sulfate D-glucosaminyl 3-O-sulfotransferase-3B1, a novel epithelial-mesenchymal transition inducer in pancreatic cancer. | 2011 | Cancer Biol. Ther. | pmid:21709440 |
Hauff KD et al. | Mifepristone treatment results in differential regulation of glycerolipid biosynthesis in baby hamster kidney cells expressing a mifepristone-inducible ABCA1. | 2011 | Lipids | pmid:21710238 |
Yoo YE and Ko CP | Treatment with trichostatin A initiated after disease onset delays disease progression and increases survival in a mouse model of amyotrophic lateral sclerosis. | 2011 | Exp. Neurol. | pmid:21712032 |
Gómez MC et al. | Trichostatin A modified histone covalent pattern and enhanced expression of pluripotent genes in interspecies black-footed cat cloned embryos but did not improve in vitro and in vivo viability. | 2011 | Cell Reprogram | pmid:21718106 |
Whitehead L et al. | Human HDAC isoform selectivity achieved via exploitation of the acetate release channel with structurally unique small molecule inhibitors. | 2011 | Bioorg. Med. Chem. | pmid:21723733 |
SustáÄková G et al. | Acetylation-dependent nuclear arrangement and recruitment of BMI1 protein to UV-damaged chromatin. | 2012 | J. Cell. Physiol. | pmid:21732356 |
Bui HT et al. | Histone deacetylase inhibition improves activation of ribosomal RNA genes and embryonic nucleolar reprogramming in cloned mouse embryos. | 2011 | Biol. Reprod. | pmid:21753193 |
Huang KT et al. | Aberrant DNA methylation but not mutation of CITED4 is associated with alteration of HIF-regulated genes in breast cancer. | 2011 | Breast Cancer Res. Treat. | pmid:21755341 |
Inoue H et al. | Analysis of expression and structure of the rat GH-secretagogue/ghrelin receptor (Ghsr) gene: roles of epigenetic modifications in transcriptional regulation. | 2011 | Mol. Cell. Endocrinol. | pmid:21756973 |
Blanquart C et al. | Pharmacological characterization of histone deacetylase inhibitor and tumor cell-growth inhibition properties of new benzofuranone compounds. | 2011 | Curr Cancer Drug Targets | pmid:21762083 |
Wan Y et al. | Transcriptome profiling reveals a novel role for trichostatin A in antagonizing histone chaperone Chz1 mediated telomere anti-silencing. | 2011 | FEBS Lett. | pmid:21763693 |
Kee HJ et al. | Trichostatin A prevents neointimal hyperplasia via activation of Krüppel like factor 4. | 2011 Nov-Dec | Vascul. Pharmacol. | pmid:21763782 |
Watanabe Y and Tanaka M | p62/SQSTM1 in autophagic clearance of a non-ubiquitylated substrate. | 2011 | J. Cell. Sci. | pmid:21771882 |
Zhu K et al. | Expression characterization and the promoter activity analysis of zebrafish hdac4. | 2012 | Fish Physiol. Biochem. | pmid:21773810 |
Tost J et al. | Methylation of specific CpG sites in the P2 promoter of parathyroid hormone-related protein determines the invasive potential of breast cancer cell lines. | 2011 | Epigenetics | pmid:21775817 |
Zhou S et al. | Repression of P66Shc expression by SIRT1 contributes to the prevention of hyperglycemia-induced endothelial dysfunction. | 2011 | Circ. Res. | pmid:21778425 |
Bence M et al. | Transcriptional modulation of monoaminergic neurotransmission genes by the histone deacetylase inhibitor trichostatin A in neuroblastoma cells. | 2012 | J Neural Transm | pmid:21785940 |
Amoêdo ND et al. | Energy metabolism in H460 lung cancer cells: effects of histone deacetylase inhibitors. | 2011 | PLoS ONE | pmid:21789245 |
Arzenani MK et al. | Genomic DNA hypomethylation by histone deacetylase inhibition implicates DNMT1 nuclear dynamics. | 2011 | Mol. Cell. Biol. | pmid:21791605 |
Rajasingh J et al. | Improvement of cardiac function in mouse myocardial infarction after transplantation of epigenetically-modified bone marrow progenitor cells. | 2011 | PLoS ONE | pmid:21799893 |
Klawitter M et al. | Human MMP28 expression is unresponsive to inflammatory stimuli and does not correlate to the grade of intervertebral disc degeneration. | 2011 | J Negat Results Biomed | pmid:21801383 |
Hu Y et al. | Trichostatin A selectively suppresses the cold-induced transcription of the ZmDREB1 gene in maize. | 2011 | PLoS ONE | pmid:21811564 |
Kumar A et al. | γ-radiation induces cellular sensitivity and aberrant methylation in human tumor cell lines. | 2011 | Int. J. Radiat. Biol. | pmid:21815748 |
Xiao J et al. | Discovery, synthesis, and biological evaluation of novel SMN protein modulators. | 2011 | J. Med. Chem. | pmid:21819082 |
Sahu GK and Cloyd MW | Latent HIV in primary T lymphocytes is unresponsive to histone deacetylase inhibitors. | 2011 | Virol. J. | pmid:21838863 |
Yu D et al. | Clonal Rett Syndrome cell lines to test compounds for activation of wild-type MeCP2 expression. | 2011 | Bioorg. Med. Chem. Lett. | pmid:21840716 |
Costa VL et al. | TCF21 and PCDH17 methylation: An innovative panel of biomarkers for a simultaneous detection of urological cancers. | 2011 | Epigenetics | pmid:21847011 |
Meng CF et al. | DNA demethylation is superior to histone acetylation for reactivating cancer-associated genes in ovarian cancer cells. | 2011 Nov-Dec | Mol Med Rep | pmid:21850374 |
Mayor R et al. | Dynamics of bivalent chromatin domains upon drug induced reactivation and resilencing in cancer cells. | 2011 | Epigenetics | pmid:21852760 |
Tong Y et al. | PTTG1 attenuates drug-induced cellular senescence. | 2011 | PLoS ONE | pmid:21858218 |
Oliveira CS et al. | Supplementation with the histone deacetylase inhibitor trichostatin A during in vitro culture of bovine embryos. | 2013 | Zygote | pmid:21867598 |
Rajak H et al. | 2,5-Disubstituted-1,3,4-oxadiazoles/thiadiazole as surface recognition moiety: design and synthesis of novel hydroxamic acid based histone deacetylase inhibitors. | 2011 | Bioorg. Med. Chem. Lett. | pmid:21875796 |
Pufahl L et al. | Trichostatin A induces 5-lipoxygenase promoter activity and mRNA expression via inhibition of histone deacetylase 2 and 3. | 2012 | J. Cell. Mol. Med. | pmid:21883892 |
Crandall JE et al. | Retinoic acid influences neuronal migration from the ganglionic eminence to the cerebral cortex. | 2011 | J. Neurochem. | pmid:21895658 |
Atanackovic D et al. | Cancer-testis antigen expression and its epigenetic modulation in acute myeloid leukemia. | 2011 | Am. J. Hematol. | pmid:21898529 |
Fan LX et al. | Inhibition of histone deacetylases targets the transcription regulator Id2 to attenuate cystic epithelial cell proliferation. | 2012 | Kidney Int. | pmid:21900881 |
Wang JP et al. | Recapitulation of fibromatosis nodule by multipotential stem cells in immunodeficient mice. | 2011 | PLoS ONE | pmid:21901157 |
Zhu L et al. | Hyperoxia arrests alveolar development through suppression of histone deacetylases in neonatal rats. | 2012 | Pediatr. Pulmonol. | pmid:21905265 |
Maruoka H et al. | Low-molecular-weight compounds having neurotrophic activity in cultured PC12 cells and neurons. | 2011 | J. Biochem. | pmid:21908547 |