Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Amor DJ et al. | Human centromere repositioning "in progress". | 2004 | Proc. Natl. Acad. Sci. U.S.A. | pmid:15084747 |
Akiyama T et al. | Inadequate histone deacetylation during oocyte meiosis causes aneuploidy and embryo death in mice. | 2006 | Proc. Natl. Acad. Sci. U.S.A. | pmid:16651529 |
Ohno Y et al. | Macrophage inflammatory protein-2: chromosomal regulation in rat small intestinal epithelial cells. | 1997 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9294201 |
Condon JC et al. | A decline in the levels of progesterone receptor coactivators in the pregnant uterus at term may antagonize progesterone receptor function and contribute to the initiation of parturition. | 2003 | Proc. Natl. Acad. Sci. U.S.A. | pmid:12886011 |
Slack MD et al. | Characterizing heterogeneous cellular responses to perturbations. | 2008 | Proc. Natl. Acad. Sci. U.S.A. | pmid:19052231 |
Magdinier F and Wolffe AP | Selective association of the methyl-CpG binding protein MBD2 with the silent p14/p16 locus in human neoplasia. | 2001 | Proc. Natl. Acad. Sci. U.S.A. | pmid:11309512 |
Ma P et al. | Compensatory functions of histone deacetylase 1 (HDAC1) and HDAC2 regulate transcription and apoptosis during mouse oocyte development. | 2012 | Proc. Natl. Acad. Sci. U.S.A. | pmid:22223663 |
Mishra N et al. | Trichostatin A reverses skewed expression of CD154, interleukin-10, and interferon-gamma gene and protein expression in lupus T cells. | 2001 | Proc. Natl. Acad. Sci. U.S.A. | pmid:11226290 |
Cao Y et al. | Chemical modifier screen identifies HDAC inhibitors as suppressors of PKD models. | 2009 | Proc. Natl. Acad. Sci. U.S.A. | pmid:19966229 |
Porter NJ et al. | Unusual zinc-binding mode of HDAC6-selective hydroxamate inhibitors. | 2017 | Proc. Natl. Acad. Sci. U.S.A. | pmid:29203661 |
Xu CR et al. | Histone acetylation affects expression of cellular patterning genes in the Arabidopsis root epidermis. | 2005 | Proc. Natl. Acad. Sci. U.S.A. | pmid:16176989 |
Minucci S et al. | A histone deacetylase inhibitor potentiates retinoid receptor action in embryonal carcinoma cells. | 1997 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9326603 |
Jin S et al. | Ecteinascidin 743, a transcription-targeted chemotherapeutic that inhibits MDR1 activation. | 2000 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10841572 |
Claassen GF and Hann SR | A role for transcriptional repression of p21CIP1 by c-Myc in overcoming transforming growth factor beta -induced cell-cycle arrest. | 2000 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10920185 |
Emiliani S et al. | Characterization of a human RPD3 ortholog, HDAC3. | 1998 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9501169 |
Kenneth NS et al. | TRRAP and GCN5 are used by c-Myc to activate RNA polymerase III transcription. | 2007 | Proc. Natl. Acad. Sci. U.S.A. | pmid:17848523 |
Iezzi S et al. | Stage-specific modulation of skeletal myogenesis by inhibitors of nuclear deacetylases. | 2002 | Proc. Natl. Acad. Sci. U.S.A. | pmid:12032356 |
Richon VM et al. | A class of hybrid polar inducers of transformed cell differentiation inhibits histone deacetylases. | 1998 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9501205 |
Ito K et al. | A molecular mechanism of action of theophylline: Induction of histone deacetylase activity to decrease inflammatory gene expression. | 2002 | Proc. Natl. Acad. Sci. U.S.A. | pmid:12070353 |
Condreay JP et al. | Transient and stable gene expression in mammalian cells transduced with a recombinant baculovirus vector. | 1999 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9874783 |
Selker EU | Trichostatin A causes selective loss of DNA methylation in Neurospora. | 1998 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9689097 |
Saito A et al. | A synthetic inhibitor of histone deacetylase, MS-27-275, with marked in vivo antitumor activity against human tumors. | 1999 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10200307 |
Carmen AA et al. | Yeast HOS3 forms a novel trichostatin A-insensitive homodimer with intrinsic histone deacetylase activity. | 1999 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10535926 |
Jansen MS et al. | Short-chain fatty acids enhance nuclear receptor activity through mitogen-activated protein kinase activation and histone deacetylase inhibition. | 2004 | Proc. Natl. Acad. Sci. U.S.A. | pmid:15103026 |
Furumai R et al. | Potent histone deacetylase inhibitors built from trichostatin A and cyclic tetrapeptide antibiotics including trapoxin. | 2001 | Proc. Natl. Acad. Sci. U.S.A. | pmid:11134513 |
Liberatore RA et al. | NF-kappaB activity is constitutively elevated in c-Abl null fibroblasts. | 2009 | Proc. Natl. Acad. Sci. U.S.A. | pmid:19805123 |
Sasaki K et al. | Real-time imaging of histone H4 hyperacetylation in living cells. | 2009 | Proc. Natl. Acad. Sci. U.S.A. | pmid:19805290 |
Gibbs A et al. | Sulforaphane destabilizes the androgen receptor in prostate cancer cells by inactivating histone deacetylase 6. | 2009 | Proc. Natl. Acad. Sci. U.S.A. | pmid:19805354 |
McCullough SD et al. | Reelin is a target of polyglutamine expanded ataxin-7 in human spinocerebellar ataxia type 7 (SCA7) astrocytes. | 2012 | Proc. Natl. Acad. Sci. U.S.A. | pmid:23236151 |
Weaver IC et al. | Maternal care effects on the hippocampal transcriptome and anxiety-mediated behaviors in the offspring that are reversible in adulthood. | 2006 | Proc. Natl. Acad. Sci. U.S.A. | pmid:16484373 |
Viñuelas J et al. | Towards experimental manipulation of stochasticity in gene expression. | 2012 | Prog. Biophys. Mol. Biol. | pmid:22609563 |
Soleymani Fard S et al. | Prostaglandin E2 induces growth inhibition, apoptosis and differentiation in T and B cell-derived acute lymphoblastic leukemia cell lines (CCRF-CEM and Nalm-6). | 2012 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22749740 |
Hernandez M et al. | A histone deacetylation-dependent mechanism for transcriptional repression of the gap junction gene cx43 in prostate cancer cells. | 2006 | Prostate | pmid:16652385 |
Armstrong K et al. | NF-kappaB activation upregulates fibroblast growth factor 8 expression in prostate cancer cells. | 2006 | Prostate | pmid:16683270 |
Mavis CK et al. | Expression level and DNA methylation status of glutathione-S-transferase genes in normal murine prostate and TRAMP tumors. | 2009 | Prostate | pmid:19444856 |
Frønsdal K and Saatcioglu F | Histone deacetylase inhibitors differentially mediate apoptosis in prostate cancer cells. | 2005 | Prostate | pmid:15389787 |
Walton TJ et al. | DNA demethylation and histone deacetylation inhibition co-operate to re-express estrogen receptor beta and induce apoptosis in prostate cancer cell-lines. | 2008 | Prostate | pmid:18092350 |
Spenger A et al. | Influence of promoter choice and trichostatin A treatment on expression of baculovirus delivered genes in mammalian cells. | 2004 | Protein Expr. Purif. | pmid:15477077 |
Yan C et al. | Comparative molecular dynamics simulations of histone deacetylase-like protein: binding modes and free energy analysis to hydroxamic acid inhibitors. | 2008 | Proteins | pmid:18398905 |
Cecconi D et al. | Synergistic effect of trichostatin A and 5-aza-2'-deoxycytidine on growth inhibition of pancreatic endocrine tumour cell lines: a proteomic study. | 2009 | Proteomics | pmid:19294695 |
Cecconi D et al. | Proteomic analysis of pancreatic endocrine tumor cell lines treated with the histone deacetylase inhibitor trichostatin A. | 2007 | Proteomics | pmid:17443844 |
Kimura N et al. | Alteration of developmental program in Paramecium by treatment with trichostatin a: a possible involvement of histone modification. | 2006 | Protist | pmid:16839811 |
Tran L et al. | Importance of epigenetic mechanisms in visceral pain induced by chronic water avoidance stress. | 2013 | Psychoneuroendocrinology | pmid:23084728 |
Dombrowsky H et al. | Conserved responses to trichostatin A in rodent lungs exposed to endotoxin or stretch. | 2009 | Pulm Pharmacol Ther | pmid:19744573 |
Hämäläinen M et al. | Inhibition of iNOS expression and NO production by anti-inflammatory steroids. Reversal by histone deacetylase inhibitors. | 2008 | Pulm Pharmacol Ther | pmid:17913526 |
Zhang Y et al. | Attenuated DNA damage repair by trichostatin A through BRCA1 suppression. | 2007 | Radiat. Res. | pmid:17722998 |
Zhang Y et al. | Enhancement of radiation sensitivity of human squamous carcinoma cells by histone deacetylase inhibitors. | 2004 | Radiat. Res. | pmid:15161353 |
Brown SL et al. | Histone deacetylase inhibitors protect against and mitigate the lethality of total-body irradiation in mice. | 2008 | Radiat. Res. | pmid:18363436 |
Banwell CM et al. | Antiproliferative signalling by 1,25(OH)2D3 in prostate and breast cancer is suppressed by a mechanism involving histone deacetylation. | 2003 | Recent Results Cancer Res. | pmid:12899515 |
Wang G et al. | The effects of DNA methyltransferase inhibitors and histone deacetylase inhibitors on digit regeneration in mice. | 2010 | Regen Med | pmid:20210581 |