trichostatin A

Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.

Cross Reference

Introduction

To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with trichostatin A?

trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with trichostatin A

MeSH term MeSH ID Detail
Hypertension, Pulmonary D006976 32 associated lipids
Endometriosis D004715 29 associated lipids
Uterine Neoplasms D014594 18 associated lipids
Adrenoleukodystrophy D000326 29 associated lipids
Prostatic Hyperplasia D011470 20 associated lipids
Alzheimer Disease D000544 76 associated lipids
Thyroid Neoplasms D013964 33 associated lipids
Leukemia D007938 74 associated lipids
Neuroblastoma D009447 66 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Per page 10 20 50 100 | Total 139

PubChem Associated disorders and diseases

What pathways are associated with trichostatin A

Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
Loading... please refresh the page if content is not showing up.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with trichostatin A?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with trichostatin A?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with trichostatin A?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with trichostatin A?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with trichostatin A?

Mouse Model

Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).

Xenograft Model

Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).

Cancer Model

Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

NCBI Entrez Crosslinks

All references with trichostatin A

Download all related citations
Per page 10 20 50 100 | Total 3126
Authors Title Published Journal PubMed Link
Ikeda S et al. Enhancement of histone acetylation by trichostatin A during in vitro fertilization of bovine oocytes affects cell number of the inner cell mass of the resulting blastocysts. 2009 Zygote pmid:19356267
Bo F et al. Effect of trichostatin A on transfected donor cells and subsequent development of porcine cloned embryos. 2011 Zygote pmid:20569515
Mousai M et al. Effect of epigenetic modification with trichostatin A and S-adenosylhomocysteine on developmental competence and POU5F1-EGFP expression of interspecies cloned embryos in dog. 2015 Zygote pmid:25314965
Burlibaşa L and Gavrilă L Molecular and ultrastructural studies of the sperm chromatin from Triturus cristatus. 2005 Zygote pmid:16261764
Segev H et al. Expression patterns of histone deacetylases in bovine oocytes and early embryos, and the effect of their inhibition on embryo development. 2001 Zygote pmid:11358320
Petr J et al. Histone deacetylase inhibition improves meiotic competence but not developmental competence in growing pig oocytes. 2009 Zygote pmid:19460191
Sugimoto H et al. Production of somatic cell nuclear transfer embryos using in vitro-grown and in vitro-matured oocytes in rabbits. 2015 Zygote pmid:24666637
Ning SF et al. Methylation characteristics and developmental potential of Guangxi Bama minipig (Sus scrofa domestica) cloned embryos from donor cells treated with trichostatin A and 5-aza-2'-deoxycytidine. 2013 Zygote pmid:22355002
Oliveira CS et al. Supplementation with the histone deacetylase inhibitor trichostatin A during in vitro culture of bovine embryos. 2013 Zygote pmid:21867598
Jee BC et al. Effect of trichostatin A on fertilization and embryo development during extended culture of mouse oocyte. 2012 Zygote pmid:21269543
Jeseta M et al. In vitro ageing of pig oocytes: effects of the histone deacetylase inhibitor trichostatin A. 2008 Zygote pmid:18405435
Selokar NL et al. Buffalo (Bubalus bubalis) SCNT embryos produced from somatic cells isolated from frozen-thawed semen: effect of trichostatin A on the in vitro and in vivo developmental potential, quality and epigenetic status. 2016 Zygote pmid:26503476
Tsuji Y et al. The developmental potential of mouse somatic cell nuclear-transferred oocytes treated with trichostatin A and 5-aza-2'-deoxycytidine. 2009 Zygote pmid:19175955
Fan J et al. [Expression of ER alpha in chemically induced MDA-MB-435 cells and its responsiveness to endocrine]. 2006 Zhonghua Zhong Liu Za Zhi pmid:17533736
Zhang S et al. [Effect of trichostatin A and paclitaxel on the growth and apoptosis of lung adenocarcinoma cell lines]. 2012 Zhonghua Zhong Liu Za Zhi pmid:22967465
Qi J et al. [Hypermethylation and regulation of expression of secreted frizzled-related protein genes in colorectal tumor]. 2007 Zhonghua Zhong Liu Za Zhi pmid:18396643
Wu P et al. [Role of human telomerase reverse transcriptase in apoptosis of human umbilical vein endothelial cells induced by trichostatin A]. 2007 Zhonghua Zhong Liu Za Zhi pmid:17892126
Chen YX et al. [Regulation of histone acetylation on the expression of cell cycle-associated genes in human colon cancer cell lines]. 2004 Zhonghua Yi Xue Za Zhi pmid:15059516
Wang CT and Meng M [Experimental study on the effect of trichostatin A on differentiation of human lung carcinoma cell]. 2007 Zhonghua Yi Xue Za Zhi pmid:17650409
Jiang SJ et al. [Effects of trichostatin A and paclitaxel on apoptosis and microtubule stabilization in endometrial carcinoma cells: an in vitro research]. 2008 Zhonghua Yi Xue Za Zhi pmid:19087722
Ma XL et al. [Construction of anti-sense cDNA library of human breast cancer cells during apoptosis induced by trichostatin A and preliminary screening of essential genes]. 2009 Zhonghua Yi Xue Za Zhi pmid:19567099
Qi J et al. [The role of secreted Wnt-antagonist genes hypermethylation in early detection of colorectal tumor]. 2007 Zhonghua Yi Xue Za Zhi pmid:17923031
Ji S et al. [Association of irradiation-induced hippocampal neurogenesis impairment with histone H3 acetylation]. 2015 Zhonghua Yi Xue Za Zhi pmid:26168675
Sun DF et al. [The relationship of mTOR signaling pathway and histone acetylation in human gastric cancer cell lines]. 2007 Zhonghua Yi Xue Yi Chuan Xue Za Zhi pmid:17680526
Zheng L et al. [Detecting acetylated proteins by affinity chromatography column]. 2012 Zhonghua Xue Ye Xue Za Zhi pmid:22781610
Meng CF et al. [Effects of 5-Aza-2'-deoxycytidine and trichostatin A on P16, hMLH1 and MGMT genes and DNA methylation in human gastric cancer cells]. 2009 Zhonghua Wei Chang Wai Ke Za Zhi pmid:19742343
Li YL et al. [Impact of trichostatin A on gastric carcinoma cell line SGC-7901]. 2007 Zhonghua Wei Chang Wai Ke Za Zhi pmid:17659468
Ju ZH et al. [Effects of 5-Aza-2'-deoxycitydine and trichostatin A on expression and apoptosis of ALDH1a2 gene in human bladder cancer cell lines]. 2010 Zhonghua Wai Ke Za Zhi pmid:20450613
Wang H et al. [Effect of trichostatin A on the osteogenic differentiation potential of periodontal ligament stem cells in inflammatory microenvironment induced by tumor necrosis factor-α stimulation]. 2016 Zhonghua Kou Qiang Yi Xue Za Zhi pmid:27117217
Han JQ et al. [Effects of trichostatin A on the interaction between HBx and histone deacetylase protein 1]. 2008 Zhonghua Gan Zang Bing Za Zhi pmid:18822204
Wang XX and Fu L [Recent advances in DNA demethylation in tumor therapy]. 2009 Zhonghua Bing Li Xue Za Zhi pmid:19575888
Zhang D et al. [Effects of trichostatin A on human lung cancer cell strains A549]. 2010 Zhongguo Yi Xue Ke Xue Yuan Xue Bao pmid:20450546
He HM et al. [The effects of a histone deacetylase (HDAC) inhibitor on endotoxin-induced endothelial cell injury]. 2011 Zhongguo Wei Zhong Bing Ji Jiu Yi Xue pmid:22005560
Chen LJ et al. [hCG-PLZF-RARalpha/hCG-RARalpha-PLZF transgenic mice developing into leukemia]. 2005 Zhongguo Shi Yan Xue Ye Xue Za Zhi pmid:16403252
Liu H et al. [Antineoplastic effect of valproic acid and trichostatin on HL-60 and K562 cells]. 2005 Zhongguo Shi Yan Xue Ye Xue Za Zhi pmid:16403260
Lu XC et al. [Effect of inhibitors for demethylation and histone deacetylase on proliferation of cell line K562 and expression of tumor related genes]. 2004 Zhongguo Shi Yan Xue Ye Xue Za Zhi pmid:14989767
Wang QS et al. [Silence mechanism of WT1 gene in leukemic cell line U937]. 2011 Zhongguo Shi Yan Xue Ye Xue Za Zhi pmid:22040952
Song Y et al. [The mechanisms of p21WAF1/Cip-1 expression in MOLT-4 cell line induced by TSA]. 2005 Zhongguo Shi Yan Xue Ye Xue Za Zhi pmid:15854272
Xu ZM et al. [Analysis of the methylation in the promoter of LRP15 gene and its expression]. 2005 Zhongguo Shi Yan Xue Ye Xue Za Zhi pmid:15854274
Guo J et al. Effect of 5-aza-2'-deoxycytidine combined with trichostatin A on RPMI-8226 cell proliferation, apoptosis and DLC-1 gene expression. 2014 Zhongguo Shi Yan Xue Ye Xue Za Zhi pmid:24763005
Yang L et al. [Effect of decitabine combined with Trichostatin A on MDS cell line SKM-1 in vitro]. 2008 Zhongguo Shi Yan Xue Ye Xue Za Zhi pmid:18718068
Chen WK et al. [Effect of trichostatin A on histone acetylation level and apoptosis in HL-60 cells]. 2004 Zhongguo Shi Yan Xue Ye Xue Za Zhi pmid:15228659
Chen S et al. [Effect of trichostatin alone and combination with imatinb on the proliferation and apoptosis of the K562R cells]. 2011 Zhong Nan Da Xue Xue Bao Yi Xue Ban pmid:21937807
He M and Guo Q [Cerebral protection of Trichostatin A preconditioning in rats with middle cerebral artery occlusion and the relationship between Trichostatin A and IL-1β]. 2012 Zhong Nan Da Xue Xue Bao Yi Xue Ban pmid:22561570
Qin ZX et al. [Effect of TSA and VPA treatment on long-tailed macaque (Macaca fascicularis)-pig interspecies somatic cell nuclear transfer]. 2012 Yi Chuan pmid:22425953
Wei G et al. [Functional analysis of Oct4 promoter in Xuhuai goat]. 2014 Yi Chuan pmid:25143277
Kong QR et al. [TSA improve transgenic porcine cloned embryo development and transgene expression]. 2011 Yi Chuan pmid:22049689
Xie BT et al. [Telomere lengthening by trichostatin A treatment in cloned pigs]. 2012 Yi Chuan pmid:23262106
Liu AL et al. [A new target of cancer therapy: advances in the study of histone deacetylase]. 2005 Yao Xue Xue Bao pmid:16196262
Ishihara K [Role of eosinophils in allergic inflammation]. 2005 Yakugaku Zasshi pmid:16141691