trichostatin A

Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.

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Introduction

To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with trichostatin A?

trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with trichostatin A

MeSH term MeSH ID Detail
Hypertension, Pulmonary D006976 32 associated lipids
Endometriosis D004715 29 associated lipids
Uterine Neoplasms D014594 18 associated lipids
Adrenoleukodystrophy D000326 29 associated lipids
Prostatic Hyperplasia D011470 20 associated lipids
Alzheimer Disease D000544 76 associated lipids
Thyroid Neoplasms D013964 33 associated lipids
Leukemia D007938 74 associated lipids
Neuroblastoma D009447 66 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Per page 10 20 50 100 | Total 139

PubChem Associated disorders and diseases

What pathways are associated with trichostatin A

Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.

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Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with trichostatin A?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with trichostatin A?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with trichostatin A?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with trichostatin A?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with trichostatin A?

Mouse Model

Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).

Xenograft Model

Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).

Cancer Model

Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with trichostatin A

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Per page 10 20 50 100 | Total 3126
Authors Title Published Journal PubMed Link
Ji Z et al. Integrating genomics and proteomics data to predict drug effects using binary linear programming. 2014 PLoS ONE pmid:25036040
Yang W et al. Effect of trichostatin A on gelsolin levels, proteolysis of amyloid precursor protein, and amyloid beta-protein load in the brain of transgenic mouse model of Alzheimer's disease. 2014 Curr Alzheimer Res pmid:25387339
Ying H et al. Pressure overload-induced cardiac hypertrophy response requires janus kinase 2-histone deacetylase 2 signaling. 2014 Int J Mol Sci pmid:25380525
Nishida N et al. Identification of epigenetically inactivated genes in human hepatocellular carcinoma by integrative analyses of methylation profiling and pharmacological unmasking. 2014 Dig Dis pmid:25376292
Xie M et al. Effects of 5-aza-2'-deoxycytidine and trichostatin A on high glucose- and interleukin-1β-induced secretory mediators from human retinal endothelial cells and retinal pigment epithelial cells. 2014 Mol. Vis. pmid:25352747
Xiong J et al. USP22 transcriptional activity is negatively regulated by the histone deacetylase inhibitor trichostatin A. 2014 Mol Med Rep pmid:25323692
Li G et al. Short-chain fatty acids enhance adipocyte differentiation in the stromal vascular fraction of porcine adipose tissue. 2014 J. Nutr. pmid:25320182
Quan H et al. Hepatitis C virus core protein epigenetically silences SFRP1 and enhances HCC aggressiveness by inducing epithelial-mesenchymal transition. 2014 Oncogene pmid:23770846
Shi Q et al. [Inhibitory effect of trichostatin A on HepG2 cell proliferation and the mechanisms]. 2014 Nan Fang Yi Ke Da Xue Xue Bao pmid:25057056
Tsuji M et al. Epigenetic regulation of resistance to emotional stress: possible involvement of 5-HT1A receptor-mediated histone acetylation. 2014 J. Pharmacol. Sci. pmid:25048113
Huan YJ et al. Epigenetic modification agents improve genomic methylation reprogramming in porcine cloned embryos. 2014 J. Reprod. Dev. pmid:25047549
Sun G et al. Insights into the lysine acetylproteome of human sperm. 2014 J Proteomics pmid:25038526
Ishihara K Eosinophil cell lines. 2014 Methods Mol. Biol. pmid:24986606
Liu H et al. The Smn-independent beneficial effects of trichostatin A on an intermediate mouse model of spinal muscular atrophy. 2014 PLoS ONE pmid:24984019
Maldonado L et al. An epigenetic marker panel for recurrence risk prediction of low grade papillary urothelial cell carcinoma (LGPUCC) and its potential use for surveillance after transurethral resection using urine. 2014 Oncotarget pmid:24980822
Wilson-Edell KA et al. RPL24: a potential therapeutic target whose depletion or acetylation inhibits polysome assembly and cancer cell growth. 2014 Oncotarget pmid:24970821
Yang XL et al. Effect of trichostatin A on CNE2 nasopharyngeal carcinoma cells--genome-wide DNA methylation alteration. 2014 Asian Pac. J. Cancer Prev. pmid:24969901
Poljak M et al. Class I to III histone deacetylases differentially regulate inflammation-induced matrix metalloproteinase 9 expression in primary amnion cells. 2014 Reprod Sci pmid:24429678
Unland R et al. Epigenetic repression of the dopamine receptor D4 in pediatric tumors of the central nervous system. 2014 J. Neurooncol. pmid:24264533
Sun DF et al. Inhibition of mTOR signalling potentiates the effects of trichostatin A in human gastric cancer cell lines by promoting histone acetylation. 2014 Cell Biol. Int. pmid:24030871
Lee J et al. Therapeutic targeting of epigenetic components in amyotrophic lateral sclerosis (ALS). 2014 Curr. Med. Chem. pmid:25005187
He G et al. Inhibition of autophagy induced by TSA sensitizes colon cancer cell to radiation. 2014 Tumour Biol. pmid:24122231
Poplutz MK et al. Regulation of the Interleukin-6 gene expression during monocytic differentiation of HL-60 cells by chromatin remodeling and methylation. 2014 Immunobiology pmid:24746556
Rafehi H et al. Vascular histone deacetylation by pharmacological HDAC inhibition. 2014 Genome Res. pmid:24732587
Hassan MK et al. Histone deacetylase inhibitors sensitize lung cancer cells to hyperthermia: involvement of Ku70/SirT-1 in thermo-protection. 2014 PLoS ONE pmid:24728004
Drela K et al. Low oxygen atmosphere facilitates proliferation and maintains undifferentiated state of umbilical cord mesenchymal stem cells in an hypoxia inducible factor-dependent manner. 2014 Cytotherapy pmid:24726658
Zhu XJ et al. Novel tumor-suppressor gene epidermal growth factor-containing fibulin-like extracellular matrix protein 1 is epigenetically silenced and associated with invasion and metastasis in human gastric cancer. 2014 Mol Med Rep pmid:24718752
Tu CY et al. Trichostatin A suppresses EGFR expression through induction of microRNA-7 in an HDAC-independent manner in lapatinib-treated cells. 2014 Biomed Res Int pmid:24707474
Zhang YW et al. Integrated analysis of DNA methylation and mRNA expression profiling reveals candidate genes associated with cisplatin resistance in non-small cell lung cancer. 2014 Epigenetics pmid:24699858
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Deneberg S et al. microRNA-34b/c on chromosome 11q23 is aberrantly methylated in chronic lymphocytic leukemia. 2014 Epigenetics pmid:24686393
Song BS et al. Valproic acid enhances early development of bovine somatic cell nuclear transfer embryos by alleviating endoplasmic reticulum stress. 2014 Reprod. Fertil. Dev. pmid:23506644
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Xu S et al. Cytostatic and apoptotic effects of DNMT and HDAC inhibitors in endometrial cancer cells. 2014 Curr. Pharm. Des. pmid:23888960
Zou JY and Crews FT Release of neuronal HMGB1 by ethanol through decreased HDAC activity activates brain neuroimmune signaling. 2014 PLoS ONE pmid:24551070
Jin YX et al. Histone deacetylase inhibitor trichostatin A affects porcine oocyte maturation in vitro. 2014 Reprod. Fertil. Dev. pmid:23759302
Guilluy C et al. Isolated nuclei adapt to force and reveal a mechanotransduction pathway in the nucleus. 2014 Nat. Cell Biol. pmid:24609268
Varol N et al. The epigenetically regulated effects of Wnt antagonists on the expression of genes in the apoptosis pathway in human bladder cancer cell line (T24). 2014 DNA Cell Biol. pmid:24665856
Wisnieski F et al. Differential expression of histone deacetylase and acetyltransferase genes in gastric cancer and their modulation by trichostatin A. 2014 Tumour Biol. pmid:24668547
Yan YE et al. Prenatal nicotinic exposure suppresses fetal adrenal steroidogenesis via steroidogenic factor 1 (SF-1) deacetylation. 2014 Toxicol. Appl. Pharmacol. pmid:24709674
Cherry KE et al. Identification of Tf1 integration events in S. pombe under nonselective conditions. 2014 Gene pmid:24680781
Yang J et al. PTEN methylation involved in benzene-induced hematotoxicity. 2014 Exp. Mol. Pathol. pmid:24680972
Karki P et al. Yin Yang 1 is a repressor of glutamate transporter EAAT2, and it mediates manganese-induced decrease of EAAT2 expression in astrocytes. 2014 Mol. Cell. Biol. pmid:24469401
Serrat N et al. The response of secondary genes to lipopolysaccharides in macrophages depends on histone deacetylase and phosphorylation of C/EBPβ. 2014 J. Immunol. pmid:24307736
Hou SY et al. Expressions of MAGE-A9 and MAGE-A11 in breast cancer and their expression mechanism. 2014 Arch. Med. Res. pmid:24316396
Johnson JL et al. The desmosomal protein desmoglein 1 aids recovery of epidermal differentiation after acute UV light exposure. 2014 J. Invest. Dermatol. pmid:24594668
Chu Y et al. Chromatin composition alterations and the critical role of MeCP2 for epigenetic silencing of progesterone receptor-B gene in endometrial cancers. 2014 Cell. Mol. Life Sci. pmid:24531693
Reeves ME et al. Evidence that RASSF1C stimulation of lung cancer cell proliferation depends on IGFBP-5 and PIWIL1 expression levels. 2014 PLoS ONE pmid:25007054
Green BB and Kerr DE Epigenetic contribution to individual variation in response to lipopolysaccharide in bovine dermal fibroblasts. 2014 Vet. Immunol. Immunopathol. pmid:24268632