trichostatin A

Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.

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Introduction

To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with trichostatin A?

trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with trichostatin A

MeSH term MeSH ID Detail
Spinocerebellar Ataxias D020754 4 associated lipids
Nasopharyngeal Neoplasms D009303 4 associated lipids
Neuroendocrine Tumors D018358 4 associated lipids
Porcine Reproductive and Respiratory Syndrome D019318 4 associated lipids
Cicatrix, Hypertrophic D017439 4 associated lipids
Opioid-Related Disorders D009293 5 associated lipids
Osteomalacia D010018 5 associated lipids
Fragile X Syndrome D005600 5 associated lipids
Myeloproliferative Disorders D009196 5 associated lipids
Leukemia, Myelomonocytic, Acute D015479 6 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with trichostatin A

Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.

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Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with trichostatin A?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with trichostatin A?


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Function Cross reference Weighted score Related literatures

What lipids are associated with trichostatin A?

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Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with trichostatin A?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with trichostatin A?

Mouse Model

Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).

Xenograft Model

Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).

Cancer Model

Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with trichostatin A

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Per page 10 20 50 100 | Total 3126
Authors Title Published Journal PubMed Link
He LZ et al. Histone deacetylase inhibitors induce remission in transgenic models of therapy-resistant acute promyelocytic leukemia. 2001 J. Clin. Invest. pmid:11696577
Amin HM et al. Histone deacetylase inhibitors induce caspase-dependent apoptosis and downregulation of daxx in acute promyelocytic leukaemia with t(15;17). 2001 Br. J. Haematol. pmid:11703323
Sanyal S et al. Differential regulation of the orphan nuclear receptor small heterodimer partner (SHP) gene promoter by orphan nuclear receptor ERR isoforms. 2002 J. Biol. Chem. pmid:11705994
Pile LA et al. The histone deacetylase inhibitor trichostatin A influences the development of Drosophila melanogaster. 2001 Cell. Mol. Life Sci. pmid:11706997
Galasinski SC et al. Global regulation of post-translational modifications on core histones. 2002 J. Biol. Chem. pmid:11709551
Sachs LM et al. An essential role of histone deacetylases in postembryonic organ transformations in Xenopus laevis. 2001 Int. J. Mol. Med. pmid:11712071
Lefevre P et al. Identification of factors mediating the developmental regulation of the early acting -3.9 kb chicken lysozyme enhancer element. 2001 Nucleic Acids Res. pmid:11713304
Hatama S et al. Isolation and sequencing of infectious clones of feline foamy virus and a human/feline foamy virus Env chimera. 2001 J. Gen. Virol. pmid:11714976
Yoshioka H et al. A novel in vitro system for analyzing parental allele-specific histone acetylation in genomic imprinting. 2001 J. Hum. Genet. pmid:11721881
Stimson KM and Vertino PM Methylation-mediated silencing of TMS1/ASC is accompanied by histone hypoacetylation and CpG island-localized changes in chromatin architecture. 2002 J. Biol. Chem. pmid:11733524
Cabral AL et al. Regulation of the cellular prion protein gene expression depends on chromatin conformation. 2002 J. Biol. Chem. pmid:11739375
Park SH et al. Transcriptional regulation of the transforming growth factor beta type II receptor gene by histone acetyltransferase and deacetylase is mediated by NF-Y in human breast cancer cells. 2002 J. Biol. Chem. pmid:11744689
Pujuguet P et al. Trichostatin A inhibits beta-casein expression in mammary epithelial cells. 2001 J. Cell. Biochem. pmid:11746508
Matsusue K et al. Characterization of mouse metastasis-associated gene 2: genomic structure, nuclear localization signal, and alternative potentials as transcriptional activator and repressor. 2001 DNA Cell Biol. pmid:11749719
Lavelle D et al. Histone deacetylase inhibitors increase p21(WAF1) and induce apoptosis of human myeloma cell lines independent of decreased IL-6 receptor expression. 2001 Am. J. Hematol. pmid:11754398
Sourlingas TG et al. The effect of the histone deacetylase inhibitor, trichostatin A, on total histone synthesis, H1(0) synthesis and histone H4 acetylation in peripheral blood lymphocytes increases as a function of increasing age: a model study. 2002 Jan-Mar Exp. Gerontol. pmid:11772521
Bordonaro M et al. Cell type- and promoter-dependent modulation of the Wnt signaling pathway by sodium butyrate. 2002 Int. J. Cancer pmid:11774242
Kikuchi T et al. Aberrant methylation and histone deacetylation of cyclooxygenase 2 in gastric cancer. 2002 Int. J. Cancer pmid:11774276
Ginjala V et al. Multiple cis elements within the Igf2/H19 insulator domain organize a distance-dependent silencer. A cautionary note. 2002 J. Biol. Chem. pmid:11777900
Williams RJ Trichostatin A, an inhibitor of histone deacetylase, inhibits hypoxia-induced angiogenesis. 2001 Expert Opin Investig Drugs pmid:11785457