trichostatin A

Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.

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Introduction

To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with trichostatin A?

trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with trichostatin A

MeSH term MeSH ID Detail
Spinocerebellar Ataxias D020754 4 associated lipids
Nasopharyngeal Neoplasms D009303 4 associated lipids
Neuroendocrine Tumors D018358 4 associated lipids
Porcine Reproductive and Respiratory Syndrome D019318 4 associated lipids
Cicatrix, Hypertrophic D017439 4 associated lipids
Opioid-Related Disorders D009293 5 associated lipids
Osteomalacia D010018 5 associated lipids
Fragile X Syndrome D005600 5 associated lipids
Myeloproliferative Disorders D009196 5 associated lipids
Primary Myelofibrosis D055728 6 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with trichostatin A

Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with trichostatin A?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with trichostatin A?


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Function Cross reference Weighted score Related literatures

What lipids are associated with trichostatin A?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with trichostatin A?

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Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with trichostatin A?

Mouse Model

Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).

Xenograft Model

Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).

Cancer Model

Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with trichostatin A

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Per page 10 20 50 100 | Total 3126
Authors Title Published Journal PubMed Link
Chen MH et al. A new trichostatin analog from Streptomyces sp. CPCC 203909. 2015 J Asian Nat Prod Res pmid:25977996
Inoue K et al. Trichostatin A specifically improves the aberrant expression of transcription factor genes in embryos produced by somatic cell nuclear transfer. 2015 Sci Rep pmid:25974394
El-Awady RA et al. Epigenetics and miRNA as predictive markers and targets for lung cancer chemotherapy. 2015 Cancer Biol. Ther. pmid:25962089
Huan Y et al. Trichostatin A rescues the disrupted imprinting induced by somatic cell nuclear transfer in pigs. 2015 PLoS ONE pmid:25962071
Koumbadinga GA et al. Increased stability of heterogeneous ribonucleoproteins by a deacetylase inhibitor. 2015 Biochim. Biophys. Acta pmid:25959059
Meschini R et al. Role of chromatin structure modulation by the histone deacetylase inhibitor trichostatin A on the radio-sensitivity of ataxia telangiectasia. 2015 Mutat. Res. pmid:25942615
Ooi JY et al. HDAC inhibition attenuates cardiac hypertrophy by acetylation and deacetylation of target genes. 2015 Epigenetics pmid:25941940
Marquardt JU et al. Curcumin effectively inhibits oncogenic NF-κB signaling and restrains stemness features in liver cancer. 2015 J. Hepatol. pmid:25937435
Han Y et al. Murine hematopoietic stem cell dormancy controlled by induction of a novel short form of PSF1 by histone deacetylase inhibitors. 2015 Exp. Cell Res. pmid:25933513
Mishra DR et al. Identification of Critical Elements for Regulation of Inorganic Pyrophosphatase (PPA1) in MCF7 Breast Cancer Cells. 2015 PLoS ONE pmid:25923237
Zhao W et al. A traditional Chinese medicine, Lujiao prescription, as a potential therapy for hypertrophic cardiomyocytes by acting on histone acetylation. 2015 J Chin Med Assoc pmid:25913212
Lin S et al. IL-4 Modulates Macrophage Polarization in Ankylosing Spondylitis. 2015 Cell. Physiol. Biochem. pmid:25896783
Di Zanni E et al. Identification of novel pathways and molecules able to down-regulate PHOX2B gene expression by in vitro drug screening approaches in neuroblastoma cells. 2015 Exp. Cell Res. pmid:25882494
Nordström L et al. DNA methylation and histone modifications regulate SOX11 expression in lymphoid and solid cancer cells. 2015 BMC Cancer pmid:25880212
Martini M et al. Postmitotic Expression of SOD1(G93A) Gene Affects the Identity of Myogenic Cells and Inhibits Myoblasts Differentiation. 2015 Mediators Inflamm. pmid:26491230
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Hsu HH et al. Protection against reperfusion lung injury via aborgating multiple signaling cascades by trichostatin A. 2015 Int. Immunopharmacol. pmid:25698558
Meng J et al. Ku70 is essential for histone deacetylase inhibitor trichostatin A-induced apoptosis. 2015 Mol Med Rep pmid:25695595
Wang P et al. Epigenetic Changes are Associated with Programmed Cell Death Induced by Heat Stress in Seedling Leaves of Zea mays. 2015 Plant Cell Physiol. pmid:25670712
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Ma J et al. Trichostatin A, a histone deacetylase inhibitor, suppresses proliferation and promotes apoptosis of esophageal squamous cell lines. 2015 Mol Med Rep pmid:25634603
Shah S et al. Impact of viral activators and epigenetic regulators on HIV-1 LTRs containing naturally occurring single nucleotide polymorphisms. 2015 Biomed Res Int pmid:25629043
Zhang Q et al. Trichostatin A Protects Against Experimental Acute-on-Chronic Liver Failure in Rats Through Regulating the Acetylation of Nuclear Factor-κB. 2015 Inflammation pmid:25604312
Zhang F et al. Assessment of the effect of trichostatin A on HeLa cells through FT-IR spectroscopy. 2015 Anal. Chem. pmid:25602746
Adi Harel S et al. Reactivation of epigenetically silenced miR-512 and miR-373 sensitizes lung cancer cells to cisplatin and restricts tumor growth. 2015 Cell Death Differ. pmid:25591738
Li PT et al. Increased Histone Deacetylase Activity Involved in the Suppressed Invasion of Cancer Cells Survived from ALA-Mediated Photodynamic Treatment. 2015 Int J Mol Sci pmid:26473836
Sharma S et al. Histone deacetylase inhibitor, trichostatin A, improves learning and memory in high-fat diet-induced cognitive deficits in mice. 2015 J. Mol. Neurosci. pmid:25391764
Hao ZF et al. Activating transcription factor 3 interferes with p21 activation in histone deacetylase inhibitor-induced growth inhibition of epidermoid carcinoma cells. 2015 Tumour Biol. pmid:25371069
Saraf S et al. Ex vivo expansion of human mobilized peripheral blood stem cells using epigenetic modifiers. 2015 Transfusion pmid:25363624
Mousai M et al. Effect of epigenetic modification with trichostatin A and S-adenosylhomocysteine on developmental competence and POU5F1-EGFP expression of interspecies cloned embryos in dog. 2015 Zygote pmid:25314965
Ma XH et al. Neuroprotective capabilities of TSA against cerebral ischemia/reperfusion injury via PI3K/Akt signaling pathway in rats. 2015 Int. J. Neurosci. pmid:24730998
Zhang Y et al. The Induction Effect of Am80 and TSA on ESC Differentiation via Regulation of Stra8 in Chicken. 2015 PLoS ONE pmid:26606052
Nakada Y et al. Inhibitory effects of trichostatin A on adrenocorticotropic hormone production and proliferation of corticotroph tumor AtT-20 cells. 2015 Endocr. J. pmid:26497760
Uchida H and Ito S Differential regulation of expression of RNA-editing enzymes, ADAR1 and ADAR2, by 5-aza-2'-deoxycytidine and trichostatin A in human neuronal SH-SY5Y cells. 2015 Neuroreport pmid:26485095
Barr MP et al. VEGF-mediated cell survival in non-small-cell lung cancer: implications for epigenetic targeting of VEGF receptors as a therapeutic approach. 2015 Epigenomics pmid:26479311
Liu J and Li Y Trichostatin A and Tamoxifen inhibit breast cancer cell growth by miR-204 and ERα reducing AKT/mTOR pathway. 2015 Biochem. Biophys. Res. Commun. pmid:26436206
Cai D et al. Histone deacetylase inhibition activates Nrf2 and protects against osteoarthritis. 2015 Arthritis Res. Ther. pmid:26408027
Kotze AC et al. Histone deacetylase enzymes as drug targets for the control of the sheep blowfly, Lucilia cuprina. 2015 Int J Parasitol Drugs Drug Resist pmid:27120067
Mehta A et al. HDAC inhibitor prevents LPS mediated inhibition of CYP19A1 expression and 17β-estradiol production in granulosa cells. 2015 Mol. Cell. Endocrinol. pmid:26213324
Sancak D and Ozden S Global histone modifications in Fumonisin B1 exposure in rat kidney epithelial cells. 2015 Toxicol In Vitro pmid:26208285
Cabanel M et al. Epigenetic Control of Macrophage Shape Transition towards an Atypical Elongated Phenotype by Histone Deacetylase Activity. 2015 PLoS ONE pmid:26196676
Suo H et al. NRSF is an essential mediator for the neuroprotection of trichostatin A in the MPTP mouse model of Parkinson's disease. 2015 Neuropharmacology pmid:26188143
Gutiérrez J et al. Human papillomavirus type 16 E7 oncoprotein upregulates the retinoic acid receptor-beta expression in cervical cancer cell lines and K14E7 transgenic mice. 2015 Mol. Cell. Biochem. pmid:26173416
Hedberg Oldfors C et al. Analysis of an independent tumor suppressor locus telomeric to Tp53 suggested Inpp5k and Myo1c as novel tumor suppressor gene candidates in this region. 2015 BMC Genet. pmid:26170120
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Liao HF et al. Dnmt3l-knockout donor cells improve somatic cell nuclear transfer reprogramming efficiency. 2015 Reproduction pmid:26159833
Vadie N et al. MYCNOS functions as an antisense RNA regulating MYCN. 2015 RNA Biol pmid:26156430
Ota C et al. Histone deacetylase inhibitor restores surfactant protein-C expression in alveolar-epithelial type II cells and attenuates bleomycin-induced pulmonary fibrosis in vivo. 2015 Exp. Lung Res. pmid:26151196
Sharifulina SA et al. Epigenetic regulation of death of crayfish glial cells but not neurons induced by photodynamic impact. 2014 Brain Res. Bull. pmid:24502940
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Nieto-Pelegrin E et al. Nck adaptors, besides promoting N-WASP mediated actin-nucleation activity at pedestals, influence the cellular levels of enteropathogenic Escherichia coli Tir effector. 2014 Cell Adh Migr pmid:25482634
Wong CH et al. CTSL2 is a pro-apoptotic target of E2F1 and a modulator of histone deacetylase inhibitor and DNA damage-induced apoptosis. 2014 Oncogene pmid:23542171
Shi QQ et al. Effect of trichostatin A on anti HepG2 liver carcinoma cells: inhibition of HDAC activity and activation of Wnt/β-Catenin signaling. 2014 Asian Pac. J. Cancer Prev. pmid:25292076
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Han RF et al. Trichostatin A induces mesenchymal-like morphological change and gene expression but inhibits migration and colony formation in human cancer cells. 2014 Mol Med Rep pmid:25269990
Boucher J et al. Insulin and insulin-like growth factor 1 receptors are required for normal expression of imprinted genes. 2014 Proc. Natl. Acad. Sci. U.S.A. pmid:25246545
Wang BY et al. Epigenetic suppression of hippocampal BDNF mediates the memory deficiency induced by amyloid fibrils. 2014 Pharmacol. Biochem. Behav. pmid:25242807
Wang B et al. Reversion of trichostatin A resistance via inhibition of the Wnt signaling pathway in human pancreatic cancer cells. 2014 Oncol. Rep. pmid:25224651
Svegliati S et al. Oxidative DNA damage induces the ATM-mediated transcriptional suppression of the Wnt inhibitor WIF-1 in systemic sclerosis and fibrosis. 2014 Sci Signal pmid:25185156
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Charni Chaabane S et al. PDGF-D expression is down-regulated by TGFβ in fibroblasts. 2014 PLoS ONE pmid:25280005
Hu Z and Wang J Histone deacetylase inhibitor induces the expression of select epithelial genes in mouse utricle sensory epithelia-derived progenitor cells. 2014 Cell Reprogram pmid:24945595
Ma H et al. HSPC117 is regulated by epigenetic modification and is involved in the migration of JEG-3 cells. 2014 Int J Mol Sci pmid:24941254
Thangavel J et al. Combinatorial therapy with acetylation and methylation modifiers attenuates lung vascular hyperpermeability in endotoxemia-induced mouse inflammatory lung injury. 2014 Am. J. Pathol. pmid:24929240
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Chan ST et al. Oral and intraperitoneal administration of quercetin decreased lymphocyte DNA damage and plasma lipid peroxidation induced by TSA in vivo. 2014 Biomed Res Int pmid:24868531
Kiliccioglu I et al. Apoptotic effects of proteasome and histone deacetylase inhibitors in prostate cancer cell lines. 2014 Genet. Mol. Res. pmid:24854658
Yang DH et al. Dynamic rearrangement of F-actin is required to maintain the antitumor effect of trichostatin A. 2014 PLoS ONE pmid:24846135
Kumafuji M et al. Mediator MED18 subunit plays a negative role in transcription via the CDK/cyclin module. 2014 Genes Cells pmid:24840924
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Koriyama Y et al. Neuritogenic activity of trichostatin A in adult rat retinal ganglion cells through acetylation of histone H3 lysine 9 and RARβ induction. 2014 J. Pharmacol. Sci. pmid:24389816
Liu J et al. DNA promoter and histone H3 methylation downregulate NGX6 in gastric cancer cells. 2014 Med. Oncol. pmid:24338274
Chu Y et al. Chromatin composition alterations and the critical role of MeCP2 for epigenetic silencing of progesterone receptor-B gene in endometrial cancers. 2014 Cell. Mol. Life Sci. pmid:24531693
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Cheng X et al. Generation and characterization of gsuα:EGFP transgenic zebrafish for evaluating endocrine-disrupting effects. 2014 Toxicol. Appl. Pharmacol. pmid:24747804
Guo J et al. Effect of 5-aza-2'-deoxycytidine combined with trichostatin A on RPMI-8226 cell proliferation, apoptosis and DLC-1 gene expression. 2014 Zhongguo Shi Yan Xue Ye Xue Za Zhi pmid:24763005
Alsarraf O et al. Acetylation: a lysine modification with neuroprotective effects in ischemic retinal degeneration. 2014 Exp. Eye Res. pmid:25064603
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