trichostatin A

Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.

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Introduction

To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with trichostatin A?

trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with trichostatin A

MeSH term MeSH ID Detail
Hypertension D006973 115 associated lipids
Hypertension, Pulmonary D006976 32 associated lipids
Hypesthesia D006987 1 associated lipids
Immunologic Deficiency Syndromes D007153 8 associated lipids
Inflammation D007249 119 associated lipids
Chromosome Inversion D007446 1 associated lipids
Keloid D007627 12 associated lipids
Leishmaniasis D007896 19 associated lipids
Leukemia D007938 74 associated lipids
Leukemia, Myeloid D007951 52 associated lipids
Per page 10 20 50 100 | Total 139

PubChem Associated disorders and diseases

What pathways are associated with trichostatin A

Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.

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Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with trichostatin A?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with trichostatin A?


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Function Cross reference Weighted score Related literatures

What lipids are associated with trichostatin A?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with trichostatin A?

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Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with trichostatin A?

Mouse Model

Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).

Xenograft Model

Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).

Cancer Model

Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with trichostatin A

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Per page 10 20 50 100 | Total 3126
Authors Title Published Journal PubMed Link
Dhawan D et al. DNMT1: an emerging target in the treatment of invasive urinary bladder cancer. 2013 Urol. Oncol. pmid:22609058
Dagnas M et al. HDAC inhibition facilitates the switch between memory systems in young but not aged mice. 2013 J. Neurosci. pmid:23365234
Fernandez G et al. Targeting IκB proteins for HIV latency activation: the role of individual IκB and NF-κB proteins. 2013 J. Virol. pmid:23365428
Meng F et al. Anticancer efficacy of cisplatin and trichostatin A or 5-aza-2'-deoxycytidine on ovarian cancer. 2013 Br. J. Cancer pmid:23370212
Wang Z et al. Arabidopsis paired amphipathic helix proteins SNL1 and SNL2 redundantly regulate primary seed dormancy via abscisic acid-ethylene antagonism mediated by histone deacetylation. 2013 Plant Cell pmid:23371947
Horvat T et al. Reversibility of membrane N-glycome of HeLa cells upon treatment with epigenetic inhibitors. 2013 PLoS ONE pmid:23336012
Li H et al. Epigenetic regulation of CXCR4 expression by the ocular microenvironment. 2013 Invest. Ophthalmol. Vis. Sci. pmid:23188729
Gill RK et al. Regulation of intestinal serotonin transporter expression via epigenetic mechanisms: role of HDAC2. 2013 Am. J. Physiol., Cell Physiol. pmid:23195070
Kuno A et al. Resveratrol improves cardiomyopathy in dystrophin-deficient mice through SIRT1 protein-mediated modulation of p300 protein. 2013 J. Biol. Chem. pmid:23297412
Jin H et al. HDAC inhibitor trichostatin A promotes proliferation and odontoblast differentiation of human dental pulp stem cells. 2013 Tissue Eng Part A pmid:23013422
Wang YG et al. Mechanisms of trichostatin A inhibiting AGS proliferation and identification of lysine-acetylated proteins. 2013 World J. Gastroenterol. pmid:23745024
Guo SW et al. Dysmenorrhea and its severity are associated with increased uterine contractility and overexpression of oxytocin receptor (OTR) in women with symptomatic adenomyosis. 2013 Fertil. Steril. pmid:22999795
Pitta CA et al. Reversal of ER-β silencing by chromatin modifying agents overrides acquired tamoxifen resistance. 2013 Cancer Lett. pmid:23752064
Zhang C et al. Decreased PADI4 mRNA association with global hypomethylation in hepatocellular carcinoma during HBV exposure. 2013 Cell Biochem. Biophys. pmid:22907585
Van Beneden K et al. Comparison of trichostatin A and valproic acid treatment regimens in a mouse model of kidney fibrosis. 2013 Toxicol. Appl. Pharmacol. pmid:23707763
Meng F et al. Inhibition of DNA methyltransferases, histone deacetylases and lysine-specific demethylase-1 suppresses the tumorigenicity of the ovarian cancer ascites cell line SKOV3. 2013 Int. J. Oncol. pmid:23709006
Liu Y et al. MCM-2 is a therapeutic target of Trichostatin A in colon cancer cells. 2013 Toxicol. Lett. pmid:23770000
Welch MD et al. Hypomethylation of the CTGF gene locus is a common feature of paediatric pre-B acute lymphoblastic leukaemia. 2013 Br. J. Haematol. pmid:23772794
Spallotta F et al. A nitric oxide-dependent cross-talk between class I and III histone deacetylases accelerates skin repair. 2013 J. Biol. Chem. pmid:23463510
Liesz A et al. Boosting regulatory T cells limits neuroinflammation in permanent cortical stroke. 2013 J. Neurosci. pmid:24174668
Wu DS et al. Epigallocatechin-3-gallate and trichostatin A synergistically inhibit human lymphoma cell proliferation through epigenetic modification of p16INK4a. 2013 Oncol. Rep. pmid:24064951
Al-Nakhle H et al. Regulation of estrogen receptor β1 expression in breast cancer by epigenetic modification of the 5' regulatory region. 2013 Int. J. Oncol. pmid:24068253
Yu CW et al. Quinazolin-4-one derivatives as selective histone deacetylase-6 inhibitors for the treatment of Alzheimer's disease. 2013 J. Med. Chem. pmid:23905680
Chikamatsu K et al. Alteration of cancer stem cell-like phenotype by histone deacetylase inhibitors in squamous cell carcinoma of the head and neck. 2013 Cancer Sci. pmid:23992541
Fujiki R et al. A proapoptotic effect of valproic acid on progenitors of embryonic stem cell-derived glutamatergic neurons. 2013 Cell Death Dis pmid:23788034
Chang X et al. DNA methylation of NDRG2 in gastric cancer and its clinical significance. 2013 Dig. Dis. Sci. pmid:23010743
Li KK et al. MiR-383 is downregulated in medulloblastoma and targets peroxiredoxin 3 (PRDX3). 2013 Brain Pathol. pmid:23227829
Matsubara K et al. Dynamics and regulation of lysine-acetylation during one-cell stage mouse embryos. 2013 Biochem. Biophys. Res. Commun. pmid:23567968
Contreras AU et al. Deacetylation of p53 induces autophagy by suppressing Bmf expression. 2013 J. Cell Biol. pmid:23629966
Duo J et al. Metformin synergistically enhances antitumor activity of histone deacetylase inhibitor trichostatin a against osteosarcoma cell line. 2013 DNA Cell Biol. pmid:23451817
Chen CQ et al. Pure curcumin increases the expression of SOCS1 and SOCS3 in myeloproliferative neoplasms through suppressing class I histone deacetylases. 2013 Carcinogenesis pmid:23430957
Choi S et al. Histone deacetylases inhibitor trichostatin A modulates the extracellular release of APE1/Ref-1. 2013 Biochem. Biophys. Res. Commun. pmid:23665318
Katsuno M et al. [Dysfunction of dynactin 1 in motor neuron degeneration]. 2013 Rinsho Shinkeigaku pmid:24291886
Wang P et al. Trichostatin A protects against cisplatin-induced ototoxicity by regulating expression of genes related to apoptosis and synaptic function. 2013 Neurotoxicology pmid:23558232
Krause M et al. Probing the compressibility of tumor cell nuclei by combined atomic force-confocal microscopy. 2013 Phys Biol pmid:24304807
Zych J et al. The epigenetic modifiers 5-aza-2'-deoxycytidine and trichostatin A influence adipocyte differentiation in human mesenchymal stem cells. 2013 Braz. J. Med. Biol. Res. pmid:23797495
Guo LH et al. The Tumor Suppressor Roles of miR-433 and miR-127 in Gastric Cancer. 2013 Int J Mol Sci pmid:23880861
Jo SJ et al. Valproic acid promotes human hair growth in in vitro culture model. 2013 J. Dermatol. Sci. pmid:23810771
Keuser B et al. Influences of histone deacetylase inhibitors and resveratrol on DNA repair and chromatin compaction. 2013 Mutagenesis pmid:23814181
Lim SY et al. Trichostatin A enhances differentiation of human induced pluripotent stem cells to cardiogenic cells for cardiac tissue engineering. 2013 Stem Cells Transl Med pmid:23884641
Shim SH et al. Histone deacetylase inhibitors suppress coxsackievirus B3 growth in vitro and myocarditis induced in mice. 2013 Acta Virol. pmid:24294962
Asthana J et al. Inhibition of HDAC6 deacetylase activity increases its binding with microtubules and suppresses microtubule dynamic instability in MCF-7 cells. 2013 J. Biol. Chem. pmid:23798680
Gundersen B Pair-bonding through epigenetics. 2013 Nat. Neurosci. pmid:23799469
Zhang S et al. Effect of trichostatin A and paclitaxel on the proliferation and apoptosis of lung adenocarcinoma cells. 2013 Chin. Med. J. pmid:23286491
Gao C et al. Targeting transcription factor SALL4 in acute myeloid leukemia by interrupting its interaction with an epigenetic complex. 2013 Blood pmid:23287862
Marek L et al. Histone deacetylase (HDAC) inhibitors with a novel connecting unit linker region reveal a selectivity profile for HDAC4 and HDAC5 with improved activity against chemoresistant cancer cells. 2013 J. Med. Chem. pmid:23252603
Li KK et al. MIR-137 suppresses growth and invasion, is downregulated in oligodendroglial tumors and targets CSE1L. 2013 Brain Pathol. pmid:23252729
Seuter S et al. The gene for the transcription factor BHLHE40/DEC1/stra13 is a dynamically regulated primary target of the vitamin D receptor. 2013 J. Steroid Biochem. Mol. Biol. pmid:23220548
Singh T et al. Inhibition of class I histone deacetylases in non-small cell lung cancer by honokiol leads to suppression of cancer cell growth and induction of cell death in vitro and in vivo. 2013 Epigenetics pmid:23221619
Chen CQ et al. Histone deacetylases inhibitor trichostatin A increases the expression of Dleu2/miR-15a/16-1 via HDAC3 in non-small cell lung cancer. 2013 Mol. Cell. Biochem. pmid:23867991