| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hypertension | D006973 | 115 associated lipids |
| Hypertension, Pulmonary | D006976 | 32 associated lipids |
| Hypesthesia | D006987 | 1 associated lipids |
| Immunologic Deficiency Syndromes | D007153 | 8 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Chromosome Inversion | D007446 | 1 associated lipids |
| Keloid | D007627 | 12 associated lipids |
| Leishmaniasis | D007896 | 19 associated lipids |
| Leukemia | D007938 | 74 associated lipids |
| Leukemia, Myeloid | D007951 | 52 associated lipids |
trichostatin A
Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with trichostatin A?
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with trichostatin A
PubChem Associated disorders and diseases
What pathways are associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with trichostatin A?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with trichostatin A?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with trichostatin A?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with trichostatin A?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with trichostatin A?
Mouse Model
Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with trichostatin A
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Wong CH et al. | CTSL2 is a pro-apoptotic target of E2F1 and a modulator of histone deacetylase inhibitor and DNA damage-induced apoptosis. | 2014 | Oncogene | pmid:23542171 |
| Gurova KV et al. | Expression of prostate specific antigen (PSA) is negatively regulated by p53. | 2002 | Oncogene | pmid:11791186 |
| Zhong S et al. | Phosphorylation at serine 28 and acetylation at lysine 9 of histone H3 induced by trichostatin A. | 2003 | Oncogene | pmid:12917630 |
| Futamura M et al. | Trichostatin A inhibits both ras-induced neurite outgrowth of PC12 cells and morphological transformation of NIH3T3 cells. | 1995 | Oncogene | pmid:7700637 |
| Hajji N et al. | Combinatorial action of the HDAC inhibitor trichostatin A and etoposide induces caspase-mediated AIF-dependent apoptotic cell death in non-small cell lung carcinoma cells. | 2008 | Oncogene | pmid:18071312 |
| Mühlisch J et al. | Epigenetic repression of RASSF1A but not CASP8 in supratentorial PNET (sPNET) and atypical teratoid/rhabdoid tumors (AT/RT) of childhood. | 2006 | Oncogene | pmid:16186793 |
| Cismasiu VB et al. | BCL11B functionally associates with the NuRD complex in T lymphocytes to repress targeted promoter. | 2005 | Oncogene | pmid:16091750 |
| Jiemjit A et al. | p21(WAF1/CIP1) induction by 5-azacytosine nucleosides requires DNA damage. | 2008 | Oncogene | pmid:18223691 |
| Sirchia SM et al. | Evidence of epigenetic changes affecting the chromatin state of the retinoic acid receptor beta2 promoter in breast cancer cells. | 2000 | Oncogene | pmid:10734315 |
| Kostyniuk CL et al. | The ubiquitous and tissue specific promoters of the human SRC gene are repressed by inhibitors of histone deacetylases. | 2002 | Oncogene | pmid:12214274 |
| Shim JS et al. | Plakoglobin is a new target gene of histone deacetylase in human fibrosarcoma HT1080 cells. | 2004 | Oncogene | pmid:14661058 |
| Fleury L et al. | Eliminating epigenetic barriers induces transient hormone-regulated gene expression in estrogen receptor negative breast cancer cells. | 2008 | Oncogene | pmid:18317449 |
| Shin HJ et al. | Inhibition of histone deacetylase activity increases chromosomal instability by the aberrant regulation of mitotic checkpoint activation. | 2003 | Oncogene | pmid:12813458 |
| Kim TY et al. | Transcriptional silencing of the DLC-1 tumor suppressor gene by epigenetic mechanism in gastric cancer cells. | 2003 | Oncogene | pmid:12813468 |
| Vaghefi H and Neet KE | Deacetylation of p53 after nerve growth factor treatment in PC12 cells as a post-translational modification mechanism of neurotrophin-induced tumor suppressor activation. | 2004 | Oncogene | pmid:15361854 |
| Sato N et al. | Epigenetic inactivation of TFPI-2 as a common mechanism associated with growth and invasion of pancreatic ductal adenocarcinoma. | 2005 | Oncogene | pmid:15592528 |
| Acun T et al. | PTPRD is homozygously deleted and epigenetically downregulated in human hepatocellular carcinomas. | 2015 | OMICS | pmid:25831062 |
| Acun T et al. | HLJ1 (DNAJB4) Gene Is a Novel Biomarker Candidate in Breast Cancer. | 2017 | OMICS | pmid:28481734 |
| Aoyama M et al. | Butyrate and propionate induced activated or non-activated neutrophil apoptosis via HDAC inhibitor activity but without activating GPR-41/GPR-43 pathways. | 2010 | Nutrition | pmid:20004081 |
| Miyoshi M et al. | Short-chain fatty acids and trichostatin A alter tight junction permeability in human umbilical vein endothelial cells. | 2008 Nov-Dec | Nutrition | pmid:18723323 |
| Usami M et al. | Butyrate and trichostatin A attenuate nuclear factor kappaB activation and tumor necrosis factor alpha secretion and increase prostaglandin E2 secretion in human peripheral blood mononuclear cells. | 2008 | Nutr Res | pmid:19083427 |
| Cowell IG et al. | Histone deacetylase inhibition redistributes topoisomerase IIβ from heterochromatin to euchromatin. | 2011 Jan-Feb | Nucleus | pmid:21647300 |
| Pérez-Garrastachu M et al. | Nucleoporins redistribute inside the nucleus after cell cycle arrest induced by histone deacetylases inhibition. | 2017 | Nucleus | pmid:28696859 |
| Kishikawa S et al. | Roles of histone acetylation in the Dnmt1 gene expression. | 2002 | Nucleic Acids Res. Suppl. | pmid:12903179 |
| Kishikawa S et al. | Control elements of Dnmt1 gene are regulated in cell-cycle dependent manner. | 2003 | Nucleic Acids Res. Suppl. | pmid:14510503 |
| Lefevre P et al. | Identification of factors mediating the developmental regulation of the early acting -3.9 kb chicken lysozyme enhancer element. | 2001 | Nucleic Acids Res. | pmid:11713304 |
| Hsu DW et al. | Dynamic acetylation of lysine-4-trimethylated histone H3 and H3 variant biology in a simple multicellular eukaryote. | 2012 | Nucleic Acids Res. | pmid:22600736 |
| Wang W et al. | The acetylation of transcription factor HBP1 by p300/CBP enhances p16INK4A expression. | 2012 | Nucleic Acids Res. | pmid:21967847 |
| Ziesché E et al. | The coactivator role of histone deacetylase 3 in IL-1-signaling involves deacetylation of p65 NF-κB. | 2013 | Nucleic Acids Res. | pmid:23087373 |
| Drewell RA et al. | Methylation-dependent silencing at the H19 imprinting control region by MeCP2. | 2002 | Nucleic Acids Res. | pmid:11861904 |
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| Yáñez RJ and Porter AC | A chromosomal position effect on gene targeting in human cells. | 2002 | Nucleic Acids Res. | pmid:12433992 |
| Vikhanskaya F et al. | Cancer-derived p53 mutants suppress p53-target gene expression--potential mechanism for gain of function of mutant p53. | 2007 | Nucleic Acids Res. | pmid:17344317 |
| Chuang HC et al. | Histone deacetylase 3 binds to and regulates the GCMa transcription factor. | 2006 | Nucleic Acids Res. | pmid:16528103 |
| Benjamin D and Jost JP | Reversal of methylation-mediated repression with short-chain fatty acids: evidence for an additional mechanism to histone deacetylation. | 2001 | Nucleic Acids Res. | pmid:11522830 |
| Hirschler-Laszkiewicz I et al. | The role of acetylation in rDNA transcription. | 2001 | Nucleic Acids Res. | pmid:11600700 |
| Yu F et al. | Histone deacetylase-independent transcriptional repression by methyl-CpG-binding protein 2. | 2000 | Nucleic Acids Res. | pmid:10773092 |
| Malinen M et al. | Distinct HDACs regulate the transcriptional response of human cyclin-dependent kinase inhibitor genes to Trichostatin A and 1alpha,25-dihydroxyvitamin D3. | 2008 | Nucleic Acids Res. | pmid:17999998 |
| Fang D et al. | Selective down-regulation of tyrosinase family gene TYRP1 by inhibition of the activity of melanocyte transcription factor, MITF. | 2002 | Nucleic Acids Res. | pmid:12136092 |
| Aapola U et al. | Imprinting regulator DNMT3L is a transcriptional repressor associated with histone deacetylase activity. | 2002 | Nucleic Acids Res. | pmid:12177302 |
| Kemp MG et al. | The histone deacetylase inhibitor trichostatin A alters the pattern of DNA replication origin activity in human cells. | 2005 | Nucleic Acids Res. | pmid:15653633 |
| Chen Y et al. | On the epigenetic regulation of the human reelin promoter. | 2002 | Nucleic Acids Res. | pmid:12087179 |
| Makki MS et al. | TSA downregulates Wilms tumor gene 1 (Wt1) expression at multiple levels. | 2008 | Nucleic Acids Res. | pmid:18535006 |
| Allgayer J et al. | Widespread transcriptional gene inactivation initiated by a repair intermediate of 8-oxoguanine. | 2016 | Nucleic Acids Res. | pmid:27220469 |
| Khobta A et al. | Gene silencing induced by oxidative DNA base damage: association with local decrease of histone H4 acetylation in the promoter region. | 2010 | Nucleic Acids Res. | pmid:20338881 |
| Ferguson M et al. | Histone deacetylase inhibition is associated with transcriptional repression of the Hmga2 gene. | 2003 | Nucleic Acids Res. | pmid:12799440 |
| Lopez-Atalaya JP et al. | Genomic targets, and histone acetylation and gene expression profiling of neural HDAC inhibition. | 2013 | Nucleic Acids Res. | pmid:23821663 |
| Mao DY et al. | Promoter-binding and repression of PDGFRB by c-Myc are separable activities. | 2004 | Nucleic Acids Res. | pmid:15226411 |
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| Gialitakis M et al. | Coordinated changes of histone modifications and HDAC mobilization regulate the induction of MHC class II genes by Trichostatin A. | 2006 | Nucleic Acids Res. | pmid:16452299 |