trichostatin A

Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.

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Introduction

To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with trichostatin A?

trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with trichostatin A

MeSH term MeSH ID Detail
Hypertension D006973 115 associated lipids
Hypertension, Pulmonary D006976 32 associated lipids
Hypesthesia D006987 1 associated lipids
Immunologic Deficiency Syndromes D007153 8 associated lipids
Inflammation D007249 119 associated lipids
Chromosome Inversion D007446 1 associated lipids
Keloid D007627 12 associated lipids
Leishmaniasis D007896 19 associated lipids
Leukemia D007938 74 associated lipids
Leukemia, Myeloid D007951 52 associated lipids
Per page 10 20 50 100 | Total 139

PubChem Associated disorders and diseases

What pathways are associated with trichostatin A

Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.

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Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with trichostatin A?

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What functions are associated with trichostatin A?


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Function Cross reference Weighted score Related literatures

What lipids are associated with trichostatin A?

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Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with trichostatin A?

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Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with trichostatin A?

Mouse Model

Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).

Xenograft Model

Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).

Cancer Model

Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with trichostatin A

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Per page 10 20 50 100 | Total 3126
Authors Title Published Journal PubMed Link
Moreaux J et al. Gene expression-based prediction of myeloma cell sensitivity to histone deacetylase inhibitors. 2013 Br. J. Cancer pmid:23868005
Sharma A et al. Trichostatin-A modulates claudin-1 mRNA stability through the modulation of Hu antigen R and tristetraprolin in colon cancer cells. 2013 Carcinogenesis pmid:23880304
Guo LH et al. The Tumor Suppressor Roles of miR-433 and miR-127 in Gastric Cancer. 2013 Int J Mol Sci pmid:23880861
Lim SY et al. Trichostatin A enhances differentiation of human induced pluripotent stem cells to cardiogenic cells for cardiac tissue engineering. 2013 Stem Cells Transl Med pmid:23884641
Xu S et al. Cytostatic and apoptotic effects of DNMT and HDAC inhibitors in endometrial cancer cells. 2014 Curr. Pharm. Des. pmid:23888960
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Jang SM et al. Transcription factor Sox4 is required for PUMA-mediated apoptosis induced by histone deacetylase inhibitor, TSA. 2013 Biochem. Biophys. Res. Commun. pmid:23916609
Fang J et al. Epigenetic modulation of neuronal apoptosis and cognitive functions in sepsis-associated encephalopathy. 2014 Neurol. Sci. pmid:23925573
Kadiyala V et al. Class I lysine deacetylases facilitate glucocorticoid-induced transcription. 2013 J. Biol. Chem. pmid:23946490
Lu JC et al. Trichostatin A modulates thiazolidinedione-mediated suppression of tumor necrosis factor α-induced lipolysis in 3T3-L1 adipocytes. 2013 PLoS ONE pmid:23951179
Biernacka KM et al. Hyperglycaemia-induced chemoresistance of prostate cancer cells due to IGFBP2. 2013 Endocr. Relat. Cancer pmid:23959956
Hennig D et al. Novel insights into appropriate encapsulation methods for bioactive compounds into polymers: a study with peptides and HDAC inhibitors. 2014 Macromol Biosci pmid:23966296
Knobloch J et al. Resveratrol attenuates the release of inflammatory cytokines from human bronchial smooth muscle cells exposed to lipoteichoic acid in chronic obstructive pulmonary disease. 2014 Basic Clin. Pharmacol. Toxicol. pmid:23981542
Chikamatsu K et al. Alteration of cancer stem cell-like phenotype by histone deacetylase inhibitors in squamous cell carcinoma of the head and neck. 2013 Cancer Sci. pmid:23992541
Luo C et al. Treatment of donor cells with trichostatin A improves in vitro development and reprogramming of buffalo (Bubalus bubalis) nucleus transfer embryos. 2013 Theriogenology pmid:24007823
Sun DF et al. Inhibition of mTOR signalling potentiates the effects of trichostatin A in human gastric cancer cell lines by promoting histone acetylation. 2014 Cell Biol. Int. pmid:24030871
Matsushita Y et al. HDAC inhibitors restore C-fibre sensitivity in experimental neuropathic pain model. 2013 Br. J. Pharmacol. pmid:24032674
Wu DS et al. Epigallocatechin-3-gallate and trichostatin A synergistically inhibit human lymphoma cell proliferation through epigenetic modification of p16INK4a. 2013 Oncol. Rep. pmid:24064951
Al-Nakhle H et al. Regulation of estrogen receptor β1 expression in breast cancer by epigenetic modification of the 5' regulatory region. 2013 Int. J. Oncol. pmid:24068253
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Singh RK et al. Kinetic and thermodynamic rationale for suberoylanilide hydroxamic acid being a preferential human histone deacetylase 8 inhibitor as compared to the structurally similar ligand, trichostatin a. 2013 Biochemistry pmid:24079912
Liu YQ et al. Identification of a novel human testicular interstitial gene, RNF148, and its expression regulated by histone deacetylases. 2013 Genet. Mol. Res. pmid:24089095
Florea AM DNA methylation pyrosequencing assay is applicable for the assessment of epigenetic active environmental or clinical relevant chemicals. 2013 Biomed Res Int pmid:24093099
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Peng L et al. [Tricostantin A inhibits self-renewal of breast cancer stem cells in vitro]. 2013 Nan Fang Yi Ke Da Xue Xue Bao pmid:24144739
Chen X et al. The epigenetic modifier trichostatin A, a histone deacetylase inhibitor, suppresses proliferation and epithelial-mesenchymal transition of lens epithelial cells. 2013 Cell Death Dis pmid:24157878
Kim TW et al. Nuclear-encoded mitochondrial MTO1 and MRPL41 are regulated in an opposite epigenetic mode based on estrogen receptor status in breast cancer. 2013 BMC Cancer pmid:24160266
Liesz A et al. Boosting regulatory T cells limits neuroinflammation in permanent cortical stroke. 2013 J. Neurosci. pmid:24174668
Seo J et al. Trichostatin A epigenetically increases calpastatin expression and inhibits calpain activity and calcium-induced SH-SY5Y neuronal cell toxicity. 2013 FEBS J. pmid:24200051
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Chandwani S et al. Induction of DARPP-32 by brain-derived neurotrophic factor in striatal neurons in vitro is modified by histone deacetylase inhibitors and Nab2. 2013 PLoS ONE pmid:24204683
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Jagirdar K et al. The NR4A2 nuclear receptor is recruited to novel nuclear foci in response to UV irradiation and participates in nucleotide excision repair. 2013 PLoS ONE pmid:24223135
Liu Y et al. Expression loss and revivification of RhoB gene in ovary carcinoma carcinogenesis and development. 2013 PLoS ONE pmid:24223801
Shin HJ et al. Histone deacetylase classes I and II regulate Kaposi's sarcoma-associated herpesvirus reactivation. 2014 J. Virol. pmid:24227836
Unland R et al. Epigenetic repression of the dopamine receptor D4 in pediatric tumors of the central nervous system. 2014 J. Neurooncol. pmid:24264533
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Krause M et al. Probing the compressibility of tumor cell nuclei by combined atomic force-confocal microscopy. 2013 Phys Biol pmid:24304807
Serrat N et al. The response of secondary genes to lipopolysaccharides in macrophages depends on histone deacetylase and phosphorylation of C/EBPβ. 2014 J. Immunol. pmid:24307736
Han B et al. Trichostatin A stabilizes the expression of pluripotent genes in human mesenchymal stem cells during ex vivo expansion. 2013 PLoS ONE pmid:24312356
Hou SY et al. Expressions of MAGE-A9 and MAGE-A11 in breast cancer and their expression mechanism. 2014 Arch. Med. Res. pmid:24316396
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Tian Y et al. Ubiquitin B in cervical cancer: critical for the maintenance of cancer stem-like cell characters. 2013 PLoS ONE pmid:24367661
Alcarraz-Vizán G et al. Validation of NCM460 cell model as control in antitumor strategies targeting colon adenocarcinoma metabolic reprogramming: trichostatin A as a case study. 2014 Biochim. Biophys. Acta pmid:24368265
Mahmud N et al. Differential effects of epigenetic modifiers on the expansion and maintenance of human cord blood stem/progenitor cells. 2014 Biol. Blood Marrow Transplant. pmid:24374212
Koriyama Y et al. Neuritogenic activity of trichostatin A in adult rat retinal ganglion cells through acetylation of histone H3 lysine 9 and RARβ induction. 2014 J. Pharmacol. Sci. pmid:24389816
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Xie M et al. Histone deacetylase inhibition blunts ischemia/reperfusion injury by inducing cardiomyocyte autophagy. 2014 Circulation pmid:24396039
Sathe A et al. MicroRNA let-7f: a novel regulator of innate immune response in human endocervical cells. 2014 Am. J. Reprod. Immunol. pmid:24405266
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Poljak M et al. Class I to III histone deacetylases differentially regulate inflammation-induced matrix metalloproteinase 9 expression in primary amnion cells. 2014 Reprod Sci pmid:24429678
Oride A et al. Trichostatin A specifically stimulates gonadotropin FSHβ gene expression in gonadotroph LβT2 cells. 2014 Endocr. J. pmid:24430728
Kumar P et al. Histone deacetylase inhibitors modulate the transcriptional regulation of guanylyl cyclase/natriuretic peptide receptor-a gene: interactive roles of modified histones, histone acetyltransferase, p300, AND Sp1. 2014 J. Biol. Chem. pmid:24451378
Xiao W et al. Trichostatin A, a histone deacetylase inhibitor, suppresses proliferation and epithelial-mesenchymal transition in retinal pigment epithelium cells. 2014 J. Cell. Mol. Med. pmid:24456602
Li H et al. The histone deacetylase inhibitor trichostatin a promotes totipotency in the male gametophyte. 2014 Plant Cell pmid:24464291
Sassi Fde A et al. Inhibitory activities of trichostatin a in U87 glioblastoma cells and tumorsphere-derived cells. 2014 J. Mol. Neurosci. pmid:24464841
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Chen HY et al. Histone deacetylase inhibitors trichostatin A and suberoylanilide hydroxamic acid attenuate ventilator-induced lung injury. 2014 Pharmazie pmid:24601225
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