| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hypertension | D006973 | 115 associated lipids |
| Hypertension, Pulmonary | D006976 | 32 associated lipids |
| Hypesthesia | D006987 | 1 associated lipids |
| Immunologic Deficiency Syndromes | D007153 | 8 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Chromosome Inversion | D007446 | 1 associated lipids |
| Keloid | D007627 | 12 associated lipids |
| Leishmaniasis | D007896 | 19 associated lipids |
| Leukemia | D007938 | 74 associated lipids |
| Leukemia, Myeloid | D007951 | 52 associated lipids |
trichostatin A
Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with trichostatin A?
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with trichostatin A
PubChem Associated disorders and diseases
What pathways are associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with trichostatin A?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with trichostatin A?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with trichostatin A?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with trichostatin A?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with trichostatin A?
Mouse Model
Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with trichostatin A
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Qiang M et al. | Epigenetic mechanisms are involved in the regulation of ethanol consumption in mice. | 2014 | Int. J. Neuropsychopharmacol. | pmid:25522411 |
| Wong CH et al. | CTSL2 is a pro-apoptotic target of E2F1 and a modulator of histone deacetylase inhibitor and DNA damage-induced apoptosis. | 2014 | Oncogene | pmid:23542171 |
| Xie M et al. | Effects of 5-aza-2'-deoxycytidine and trichostatin A on high glucose- and interleukin-1β-induced secretory mediators from human retinal endothelial cells and retinal pigment epithelial cells. | 2014 | Mol. Vis. | pmid:25352747 |
| Xiong J et al. | USP22 transcriptional activity is negatively regulated by the histone deacetylase inhibitor trichostatin A. | 2014 | Mol Med Rep | pmid:25323692 |
| Li G et al. | Short-chain fatty acids enhance adipocyte differentiation in the stromal vascular fraction of porcine adipose tissue. | 2014 | J. Nutr. | pmid:25320182 |
| Shi QQ et al. | Effect of trichostatin A on anti HepG2 liver carcinoma cells: inhibition of HDAC activity and activation of Wnt/β-Catenin signaling. | 2014 | Asian Pac. J. Cancer Prev. | pmid:25292076 |
| Wei N et al. | Oxidative stress diverts tRNA synthetase to nucleus for protection against DNA damage. | 2014 | Mol. Cell | pmid:25284223 |
| An JH et al. | The expression of p21 is upregulated by forkhead box A1/2 in p53-null H1299 cells. | 2014 | FEBS Lett. | pmid:25281925 |
| Han RF et al. | Trichostatin A induces mesenchymal-like morphological change and gene expression but inhibits migration and colony formation in human cancer cells. | 2014 | Mol Med Rep | pmid:25269990 |
| Boucher J et al. | Insulin and insulin-like growth factor 1 receptors are required for normal expression of imprinted genes. | 2014 | Proc. Natl. Acad. Sci. U.S.A. | pmid:25246545 |
| Ishihara K | Eosinophil cell lines. | 2014 | Methods Mol. Biol. | pmid:24986606 |
| Liu H et al. | The Smn-independent beneficial effects of trichostatin A on an intermediate mouse model of spinal muscular atrophy. | 2014 | PLoS ONE | pmid:24984019 |
| Maldonado L et al. | An epigenetic marker panel for recurrence risk prediction of low grade papillary urothelial cell carcinoma (LGPUCC) and its potential use for surveillance after transurethral resection using urine. | 2014 | Oncotarget | pmid:24980822 |
| Wilson-Edell KA et al. | RPL24: a potential therapeutic target whose depletion or acetylation inhibits polysome assembly and cancer cell growth. | 2014 | Oncotarget | pmid:24970821 |
| Yang XL et al. | Effect of trichostatin A on CNE2 nasopharyngeal carcinoma cells--genome-wide DNA methylation alteration. | 2014 | Asian Pac. J. Cancer Prev. | pmid:24969901 |
| Hu Z and Wang J | Histone deacetylase inhibitor induces the expression of select epithelial genes in mouse utricle sensory epithelia-derived progenitor cells. | 2014 | Cell Reprogram | pmid:24945595 |
| Ma H et al. | HSPC117 is regulated by epigenetic modification and is involved in the migration of JEG-3 cells. | 2014 | Int J Mol Sci | pmid:24941254 |
| Thangavel J et al. | Combinatorial therapy with acetylation and methylation modifiers attenuates lung vascular hyperpermeability in endotoxemia-induced mouse inflammatory lung injury. | 2014 | Am. J. Pathol. | pmid:24929240 |
| Srirattana K et al. | Effects of trichostatin A on In vitro development and DNA methylation level of the satellite I region of swamp buffalo (Bubalus bubalis) cloned embryos. | 2014 | J. Reprod. Dev. | pmid:24909601 |
| Wang Y et al. | Effects of histone deacetylase inhibition on the survival, proliferation and migration of Schwann cells, as well as on the expression of neurotrophic factors and genes associated with myelination. | 2014 | Int. J. Mol. Med. | pmid:24888454 |
| Lee J et al. | Therapeutic targeting of epigenetic components in amyotrophic lateral sclerosis (ALS). | 2014 | Curr. Med. Chem. | pmid:25005187 |
| He G et al. | Inhibition of autophagy induced by TSA sensitizes colon cancer cell to radiation. | 2014 | Tumour Biol. | pmid:24122231 |
| Mathiyalagan P et al. | The primary microRNA-208b interacts with Polycomb-group protein, Ezh2, to regulate gene expression in the heart. | 2014 | Nucleic Acids Res. | pmid:24137001 |
| Tu CY et al. | Trichostatin A suppresses EGFR expression through induction of microRNA-7 in an HDAC-independent manner in lapatinib-treated cells. | 2014 | Biomed Res Int | pmid:24707474 |
| Zhang YW et al. | Integrated analysis of DNA methylation and mRNA expression profiling reveals candidate genes associated with cisplatin resistance in non-small cell lung cancer. | 2014 | Epigenetics | pmid:24699858 |
| Boyer JG et al. | Myogenic program dysregulation is contributory to disease pathogenesis in spinal muscular atrophy. | 2014 | Hum. Mol. Genet. | pmid:24691550 |
| Peiffer L et al. | Trichostatin A effectively induces apoptosis in chronic lymphocytic leukemia cells via inhibition of Wnt signaling and histone deacetylation. | 2014 | J. Cancer Res. Clin. Oncol. | pmid:24793644 |
| Deneberg S et al. | microRNA-34b/c on chromosome 11q23 is aberrantly methylated in chronic lymphocytic leukemia. | 2014 | Epigenetics | pmid:24686393 |
| Zhang Y et al. | Autophagy in pulmonary macrophages mediates lung inflammatory injury via NLRP3 inflammasome activation during mechanical ventilation. | 2014 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:24838752 |
| Zuo X et al. | Breast cancer cells are arrested at different phases of the cell cycle following the re-expression of ARHI. | 2014 | Oncol. Rep. | pmid:24676336 |
| Aune SE et al. | Selective inhibition of class I but not class IIb histone deacetylases exerts cardiac protection from ischemia reperfusion. | 2014 | J. Mol. Cell. Cardiol. | pmid:24632412 |
| Yuan TF et al. | The epigenetics changes in Parkinson's disease: a novel therapeutic target. | 2014 | CNS Neurosci Ther | pmid:24629108 |
| Sun S et al. | Trichostatin A targets the mitochondrial respiratory chain, increasing mitochondrial reactive oxygen species production to trigger apoptosis in human breast cancer cells. | 2014 | PLoS ONE | pmid:24626188 |
| Saayman S et al. | An HIV-encoded antisense long noncoding RNA epigenetically regulates viral transcription. | 2014 | Mol. Ther. | pmid:24576854 |
| McEachern LA and Murphy PR | Chromatin-remodeling factors mediate the balance of sense-antisense transcription at the FGF2 locus. | 2014 | Mol. Endocrinol. | pmid:24552587 |
| Felisbino MB et al. | Changes in chromatin structure in NIH 3T3 cells induced by valproic acid and trichostatin A. | 2014 | J. Cell. Biochem. | pmid:24913611 |
| Maleszewska M et al. | The effects of selected inhibitors of histone modifying enzyme on C6 glioma cells. | 2014 | Pharmacol Rep | pmid:24905315 |
| Zou JY and Crews FT | Release of neuronal HMGB1 by ethanol through decreased HDAC activity activates brain neuroimmune signaling. | 2014 | PLoS ONE | pmid:24551070 |
| Guilluy C et al. | Isolated nuclei adapt to force and reveal a mechanotransduction pathway in the nucleus. | 2014 | Nat. Cell Biol. | pmid:24609268 |
| Fetahu IS et al. | Calcium-sensing receptor silencing in colorectal cancer is associated with promoter hypermethylation and loss of acetylation on histone 3. | 2014 | Int. J. Cancer | pmid:24691920 |
| Saccone V et al. | HDAC-regulated myomiRs control BAF60 variant exchange and direct the functional phenotype of fibro-adipogenic progenitors in dystrophic muscles. | 2014 | Genes Dev. | pmid:24682306 |
| Alcarraz-Vizán G et al. | Validation of NCM460 cell model as control in antitumor strategies targeting colon adenocarcinoma metabolic reprogramming: trichostatin A as a case study. | 2014 | Biochim. Biophys. Acta | pmid:24368265 |
| Serrat N et al. | The response of secondary genes to lipopolysaccharides in macrophages depends on histone deacetylase and phosphorylation of C/EBPβ. | 2014 | J. Immunol. | pmid:24307736 |
| Hou SY et al. | Expressions of MAGE-A9 and MAGE-A11 in breast cancer and their expression mechanism. | 2014 | Arch. Med. Res. | pmid:24316396 |
| Johnson JL et al. | The desmosomal protein desmoglein 1 aids recovery of epidermal differentiation after acute UV light exposure. | 2014 | J. Invest. Dermatol. | pmid:24594668 |
| Chu Y et al. | Chromatin composition alterations and the critical role of MeCP2 for epigenetic silencing of progesterone receptor-B gene in endometrial cancers. | 2014 | Cell. Mol. Life Sci. | pmid:24531693 |
| Herr MJ et al. | Tetraspanin CD9 modulates human lymphoma cellular proliferation via histone deacetylase activity. | 2014 | Biochem. Biophys. Res. Commun. | pmid:24747564 |
| Cheng X et al. | Generation and characterization of gsuα:EGFP transgenic zebrafish for evaluating endocrine-disrupting effects. | 2014 | Toxicol. Appl. Pharmacol. | pmid:24747804 |
| Guo J et al. | Effect of 5-aza-2'-deoxycytidine combined with trichostatin A on RPMI-8226 cell proliferation, apoptosis and DLC-1 gene expression. | 2014 | Zhongguo Shi Yan Xue Ye Xue Za Zhi | pmid:24763005 |
| Blank M et al. | Basolateral amygdala activity is required for enhancement of memory consolidation produced by histone deacetylase inhibition in the hippocampus. | 2014 | Neurobiol Learn Mem | pmid:24583371 |