Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Reddy P | Editorial: HDAC inhibition begets more MDSCs. | 2012 | J. Leukoc. Biol. | pmid:22547132 |
Icardi L et al. | Opposed regulation of type I IFN-induced STAT3 and ISGF3 transcriptional activities by histone deacetylases (HDACS) 1 and 2. | 2012 | FASEB J. | pmid:21957129 |
Fan H et al. | Sulforaphane causes a major epigenetic repression of myostatin in porcine satellite cells. | 2012 | Epigenetics | pmid:23092945 |
Francisco R et al. | Histone deacetylase inhibition induces apoptosis and autophagy in human neuroblastoma cells. | 2012 | Cancer Lett. | pmid:22186300 |
Majumdar G et al. | Pan-histone deacetylase inhibitors regulate signaling pathways involved in proliferative and pro-inflammatory mechanisms in H9c2 cells. | 2012 | BMC Genomics | pmid:23249388 |
Xiong H et al. | Trichostatin A, a histone deacetylase inhibitor, suppresses JAK2/STAT3 signaling via inducing the promoter-associated histone acetylation of SOCS1 and SOCS3 in human colorectal cancer cells. | 2012 | Mol. Carcinog. | pmid:21520296 |
Rehni AK et al. | Modulation of histone deacetylase attenuates naloxone-precipitated opioid withdrawal syndrome. | 2012 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:22362134 |
Mostovich LA et al. | Integrin alpha9 (ITGA9) expression and epigenetic silencing in human breast tumors. | 2011 Sep-Oct | Cell Adh Migr | pmid:21975548 |
Stepanek I et al. | Effects of 5-azacytidine and trichostatin A on dendritic cell maturation. | 2011 Oct-Dec | J. Biol. Regul. Homeost. Agents | pmid:22217985 |
Kee HJ et al. | Trichostatin A prevents neointimal hyperplasia via activation of Krüppel like factor 4. | 2011 Nov-Dec | Vascul. Pharmacol. | pmid:21763782 |
Meng CF et al. | DNA demethylation is superior to histone acetylation for reactivating cancer-associated genes in ovarian cancer cells. | 2011 Nov-Dec | Mol Med Rep | pmid:21850374 |
Cowell IG et al. | Histone deacetylase inhibition redistributes topoisomerase IIβ from heterochromatin to euchromatin. | 2011 Jan-Feb | Nucleus | pmid:21647300 |
Tsai KW et al. | Epigenetic regulation of miR-34b and miR-129 expression in gastric cancer. | 2011 | Int. J. Cancer | pmid:21960261 |
Ohtani K et al. | Epigenetic regulation of endothelial lineage committed genes in pro-angiogenic hematopoietic and endothelial progenitor cells. | 2011 | Circ. Res. | pmid:21980126 |
Hagiwara H et al. | Histone deacetylase inhibitor trichostatin A enhances myogenesis by coordinating muscle regulatory factors and myogenic repressors. | 2011 | Biochem. Biophys. Res. Commun. | pmid:22019851 |
Kaichi S et al. | Cyclin-dependent kinase 9 forms a complex with GATA4 and is involved in the differentiation of mouse ES cells into cardiomyocytes. | 2011 | J. Cell. Physiol. | pmid:20665673 |
Gao A et al. | Epigenetic modification involved in benzene-induced apoptosis through regulating apoptosis-related genes expression. | 2011 | Cell Biol. Int. | pmid:21143203 |
Wang YS et al. | Production of cloned calves by combination treatment of both donor cells and early cloned embryos with 5-aza-2/-deoxycytidine and trichostatin A. | 2011 | Theriogenology | pmid:21144561 |
Shiratsuki S et al. | Trichostatin A-treated eight-cell bovine embryos had increased histone acetylation and gene expression, with increased cell numbers at the blastocyst stage. | 2011 | Theriogenology | pmid:21144563 |
Xia B et al. | Chromium(VI) causes down regulation of biotinidase in human bronchial epithelial cells by modifications of histone acetylation. | 2011 | Toxicol. Lett. | pmid:21641978 |
Seo SK et al. | Histone deacetylase inhibitors sensitize human non-small cell lung cancer cells to ionizing radiation through acetyl p53-mediated c-myc down-regulation. | 2011 | J Thorac Oncol | pmid:21642861 |
Jergil M et al. | Short-time gene expression response to valproic acid and valproic acid analogs in mouse embryonic stem cells. | 2011 | Toxicol. Sci. | pmid:21427059 |
Diao JS et al. | Trichostatin A inhibits collagen synthesis and induces apoptosis in keloid fibroblasts. | 2011 | Arch. Dermatol. Res. | pmid:21400246 |
Zhang J et al. | Inhibition of glyceroneogenesis by histone deacetylase 3 contributes to lipodystrophy in mice with adipose tissue inflammation. | 2011 | Endocrinology | pmid:21406501 |
Kawasaki H et al. | Mouse embryonic stem cells inhibit murine cytomegalovirus infection through a multi-step process. | 2011 | PLoS ONE | pmid:21407806 |
Li Z et al. | Epigenetic inactivation of PCDH10 in human prostate cancer cell lines. | 2011 | Cell Biol. Int. | pmid:21314642 |
Saiyed ZM et al. | HIV-1 Tat upregulates expression of histone deacetylase-2 (HDAC2) in human neurons: implication for HIV-associated neurocognitive disorder (HAND). | 2011 | Neurochem. Int. | pmid:21315782 |
Fang Y et al. | Synergistic efficacy in human ovarian cancer cells by histone deacetylase inhibitor TSA and proteasome inhibitor PS-341. | 2011 | Cancer Invest. | pmid:21345073 |
Wang Y et al. | The effects of 5-aza-2'- deoxycytidine and trichostatin A on gene expression and DNA methylation status in cloned bovine blastocysts. | 2011 | Cell Reprogram | pmid:21486115 |
Hattori N et al. | Methylation silencing of angiopoietin-like 4 in rat and human mammary carcinomas. | 2011 | Cancer Sci. | pmid:21489049 |
Miller L et al. | Histone deacetylase 1 (HDAC1) participates in the down-regulation of corticotropin releasing hormone gene (crh) expression. | 2011 | Physiol. Behav. | pmid:21463644 |
Tost J et al. | Methylation of specific CpG sites in the P2 promoter of parathyroid hormone-related protein determines the invasive potential of breast cancer cell lines. | 2011 | Epigenetics | pmid:21775817 |
Law AY et al. | Sp1 is a transcription repressor to stanniocalcin-1 expression in TSA-treated human colon cancer cells, HT29. | 2011 | J. Cell. Biochem. | pmid:21465530 |
Blanquart C et al. | Pharmacological characterization of histone deacetylase inhibitor and tumor cell-growth inhibition properties of new benzofuranone compounds. | 2011 | Curr Cancer Drug Targets | pmid:21762083 |
Pang M et al. | Histone deacetylase 1/2 mediates proliferation of renal interstitial fibroblasts and expression of cell cycle proteins. | 2011 | J. Cell. Biochem. | pmid:21465537 |
Wan Y et al. | Transcriptome profiling reveals a novel role for trichostatin A in antagonizing histone chaperone Chz1 mediated telomere anti-silencing. | 2011 | FEBS Lett. | pmid:21763693 |
Kimura T et al. | Chromium (VI) inhibits mouse metallothionein-I gene transcription by modifying the transcription potential of the co-activator p300. | 2011 | J Toxicol Sci | pmid:21467744 |
Hu Y et al. | Trichostatin A selectively suppresses the cold-induced transcription of the ZmDREB1 gene in maize. | 2011 | PLoS ONE | pmid:21811564 |
Lee SC et al. | HDAC activity is required for efficient core promoter function at the mouse mammary tumor virus promoter. | 2011 | J. Biomed. Biotechnol. | pmid:21253530 |
Yoon CY et al. | The histone deacetylase inhibitor trichostatin A synergistically resensitizes a cisplatin resistant human bladder cancer cell line. | 2011 | J. Urol. | pmid:21255805 |
Choi E et al. | Structure and property based design, synthesis and biological evaluation of γ-lactam based HDAC inhibitors. | 2011 | Bioorg. Med. Chem. Lett. | pmid:21256006 |
Mizuno S et al. | Inhibition of histone deacetylase causes emphysema. | 2011 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:21224215 |
Hai T et al. | Pluripotency maintenance in mouse somatic cell nuclear transfer embryos and its improvement by treatment with the histone deacetylase inhibitor TSA. | 2011 | Cell Reprogram | pmid:21241188 |
Nakamura J et al. | Expression of hypoxic marker CA IX is regulated by site-specific DNA methylation and is associated with the histology of gastric cancer. | 2011 | Am. J. Pathol. | pmid:21281785 |
Vojdani Z et al. | Cardiomyocyte marker expression in a human lymphocyte cell line using mouse cardiomyocyte extract. | 2011 | Hum. Cell | pmid:21547694 |
Neelarapu R et al. | Design, synthesis, docking, and biological evaluation of novel diazide-containing isoxazole- and pyrazole-based histone deacetylase probes. | 2011 | J. Med. Chem. | pmid:21548582 |
Vassiliev I et al. | Isolation and in vitro characterization of putative porcine embryonic stem cells from cloned embryos treated with trichostatin A. | 2011 | Cell Reprogram | pmid:21548828 |
Ververis K et al. | Histone deacetylase inhibitors augment doxorubicin-induced DNA damage in cardiomyocytes. | 2011 | Cell. Mol. Life Sci. | pmid:21584806 |
Misaki K et al. | Histone deacetylase inhibition alters dendritic cells to assume a tolerogenic phenotype and ameliorates arthritis in SKG mice. | 2011 | Arthritis Res. Ther. | pmid:21592365 |
Selinger CI et al. | Loss of special AT-rich binding protein 1 expression is a marker of poor survival in lung cancer. | 2011 | J Thorac Oncol | pmid:21597389 |