trichostatin A
Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with trichostatin A?
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with trichostatin A
PubChem Associated disorders and diseases
What pathways are associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with trichostatin A?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with trichostatin A?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with trichostatin A?
Related references are published most in these journals:
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What genes are associated with trichostatin A?
Related references are published most in these journals:
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What common seen animal models are associated with trichostatin A?
Mouse Model
Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with trichostatin A
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Tokési N et al. | TPPP/p25 promotes tubulin acetylation by inhibiting histone deacetylase 6. | 2010 | J. Biol. Chem. | pmid:20308065 |
| Zhou Q et al. | TGFbeta mediated transition of corneal fibroblasts from a proinflammatory state to a profibrotic state through modulation of histone acetylation. | 2010 | J. Cell. Physiol. | pmid:20232294 |
| Chen WP et al. | Alleviation of osteoarthritis by Trichostatin A, a histone deacetylase inhibitor, in experimental osteoarthritis. | 2010 | Mol. Biol. Rep. | pmid:20237852 |
| Urbinati G et al. | Liposomes loaded with histone deacetylase inhibitors for breast cancer therapy. | 2010 | Int J Pharm | pmid:20603204 |
| Sharma P et al. | Transcriptional regulation of human osteopontin promoter by histone deacetylase inhibitor, trichostatin A in cervical cancer cells. | 2010 | Mol. Cancer | pmid:20609221 |
| Kaichi S et al. | Cell line-dependent differentiation of induced pluripotent stem cells into cardiomyocytes in mice. | 2010 | Cardiovasc. Res. | pmid:20547733 |
| Her S et al. | Trichostatin A stimulates steroid 5alpha-reductase gene expression in rat C6 glioma cells via a mechanism involving Sp1 and Sp3 transcription factors. | 2010 | J. Mol. Neurosci. | pmid:19728174 |
| Yoshikawa M et al. | Trichostatin a prevents TGF-beta1-induced apoptosis by inhibiting ERK activation in human renal tubular epithelial cells. | 2010 | Eur. J. Pharmacol. | pmid:20553909 |
| Mousa SA et al. | Stress resistant human embryonic stem cells as a potential source for the identification of novel cancer stem cell markers. | 2010 | Cancer Lett. | pmid:19733430 |
| Russell SB et al. | Epigenetically altered wound healing in keloid fibroblasts. | 2010 | J. Invest. Dermatol. | pmid:20555348 |
| Repouskou A et al. | The circadian expression of c-MYC is modulated by the histone deacetylase inhibitor trichostatin A in synchronized murine neuroblastoma cells. | 2010 | Chronobiol. Int. | pmid:20560708 |
| Tessema M et al. | Re-expression of CXCL14, a common target for epigenetic silencing in lung cancer, induces tumor necrosis. | 2010 | Oncogene | pmid:20562917 |
| Kashiwagi Y et al. | Trichostatin A-induced TGF-beta type II receptor expression in retinoblastoma cell lines. | 2010 | Invest. Ophthalmol. Vis. Sci. | pmid:19737884 |
| Kaimori A et al. | Histone deacetylase inhibition suppresses the transforming growth factor beta1-induced epithelial-to-mesenchymal transition in hepatocytes. | 2010 | Hepatology | pmid:20564330 |
| Wessels I et al. | Changes in chromatin structure and methylation of the human interleukin-1beta gene during monopoiesis. | 2010 | Immunology | pmid:20141541 |
| Zhang C et al. | Epigenetic inactivation of the tumor suppressor gene RIZ1 in hepatocellular carcinoma involves both DNA methylation and histone modifications. | 2010 | J. Hepatol. | pmid:20675009 |
| Swingler TE et al. | MMP28 gene expression is regulated by Sp1 transcription factor acetylation. | 2010 | Biochem. J. | pmid:20144149 |
| Liu Z et al. | Deacetylase inhibitor trichostatin A down-regulates Foxp3 expression and reduces CD4+CD25+ regulatory T cells. | 2010 | Biochem. Biophys. Res. Commun. | pmid:20801101 |
| Liu TY et al. | EBV-positive Hodgkin lymphoma is associated with suppression of p21cip1/waf1 and a worse prognosis. | 2010 | Mol. Cancer | pmid:20144199 |
| Nam HJ et al. | Clostridium difficile toxin A decreases acetylation of tubulin, leading to microtubule depolymerization through activation of histone deacetylase 6, and this mediates acute inflammation. | 2010 | J. Biol. Chem. | pmid:20696758 |
| Awe S and Renkawitz-Pohl R | Histone H4 acetylation is essential to proceed from a histone- to a protamine-based chromatin structure in spermatid nuclei of Drosophila melanogaster. | 2010 | Syst Biol Reprod Med | pmid:20170286 |
| Jichan Nie SW et al. | Promoter hypermethylation of progesterone receptor isoform B (PR-B) in adenomyosis and its rectification by a histone deacetylase inhibitor and a demethylation agent. | 2010 | Reprod Sci | pmid:20697142 |
| Akiba Y et al. | Histone deacetylase inhibitors de-repress tyrosine hydroxylase expression in the olfactory bulb and rostral migratory stream. | 2010 | Biochem. Biophys. Res. Commun. | pmid:20170631 |
| Costa-Borges N et al. | Comparison between the effects of valproic acid and trichostatin A on the in vitro development, blastocyst quality, and full-term development of mouse somatic cell nuclear transfer embryos. | 2010 | Cell Reprogram | pmid:20698782 |
| Angst E et al. | Epigenetic regulation affects N-myc downstream-regulated gene 1 expression indirectly in pancreatic cancer cells. | 2010 | Pancreas | pmid:20173668 |
| Lee HS et al. | Enhanced histone acetylation in somatic cells induced by a histone deacetylase inhibitor improved inter-generic cloned leopard cat blastocysts. | 2010 | Theriogenology | pmid:20708232 |
| Zhang L et al. | Histone deacetylase inhibitors attenuate acute lung injury during cecal ligation and puncture-induced polymicrobial sepsis. | 2010 | World J Surg | pmid:20177680 |
| Tokoro M et al. | Deposition of acetylated histones by RNAP II promoter clearance may occur at onset of zygotic gene activation in preimplantation mouse embryos. | 2010 | J. Reprod. Dev. | pmid:20710121 |
| Torres J et al. | Biological effects of induced MYCN hyper-expression in MYCN-amplified neuroblastomas. | 2010 | Int. J. Oncol. | pmid:20811720 |
| Hutt DM et al. | Reduced histone deacetylase 7 activity restores function to misfolded CFTR in cystic fibrosis. | 2010 | Nat. Chem. Biol. | pmid:19966789 |
| Islam NM et al. | Bicyclic peptides as potent inhibitors of histone deacetylases: optimization of alkyl loop length. | 2010 | Bioorg. Med. Chem. Lett. | pmid:20045316 |
| Benny Klimek ME et al. | Acute inhibition of myostatin-family proteins preserves skeletal muscle in mouse models of cancer cachexia. | 2010 | Biochem. Biophys. Res. Commun. | pmid:20036643 |
| Peng CY et al. | Growth-inhibiting effects of arsenic trioxide plus epigenetic therapeutic agents on leukemia cell lines. | 2010 | Leuk. Lymphoma | pmid:20038232 |
| Li RJ et al. | Down-regulation of mitochondrial ATPase by hypermethylation mechanism in chronic myeloid leukemia is associated with multidrug resistance. | 2010 | Ann. Oncol. | pmid:20038517 |
| Nordén R et al. | Inhibition of protein deacetylation augments herpes simplex virus type 1-activated transcription of host fucosyltransferase genes associated with virus-induced sLex expression. | 2010 | Arch. Virol. | pmid:20039087 |
| Wang X et al. | Sequential treatment of CD34+ cells from patients with primary myelofibrosis with chromatin-modifying agents eliminate JAK2V617F-positive NOD/SCID marrow repopulating cells. | 2010 | Blood | pmid:20858855 |
| Gushchina SV et al. | [Cellular aspects of regulation of nuclear factor kappaB (NF-kappabeta) transcriptional activity in sensory neurons in vitro]. | 2010 | Morfologiia | pmid:20960709 |
| MacTavish H et al. | Enhancement of vaccinia virus based oncolysis with histone deacetylase inhibitors. | 2010 | PLoS ONE | pmid:21283510 |
| Yang H et al. | Histone modification-mediated CYP2E1 gene expression and apoptosis of HepG2 cells. | 2010 | Exp. Biol. Med. (Maywood) | pmid:20404016 |
| Lei L et al. | Epigenetic repression of SATB1 by polycomb group protein EZH2 in epithelial cells. | 2010 | Chin. Med. Sci. J. | pmid:21232178 |
| Wang G et al. | The effects of DNA methyltransferase inhibitors and histone deacetylase inhibitors on digit regeneration in mice. | 2010 | Regen Med | pmid:20210581 |
| Obier N et al. | Inhibition of histone deacetylases by Trichostatin A leads to a HoxB4-independent increase of hematopoietic progenitor/stem cell frequencies as a result of selective survival. | 2010 | Cytotherapy | pmid:20210674 |
| Krishnan M et al. | HDAC inhibitors regulate claudin-1 expression in colon cancer cells through modulation of mRNA stability. | 2010 | Oncogene | pmid:19881542 |
| Ninios YP et al. | Histone H1 subtype preferences of DFF40 and possible nuclear localization of DFF40/45 in normal and trichostatin A-treated NB4 leukemic cells. | 2010 | Apoptosis | pmid:19882353 |
| Zhao H et al. | New biomarkers probing depth of cell senescence assessed by laser scanning cytometry. | 2010 | Cytometry A | pmid:20939035 |
| Fernandez G and Zeichner SL | Cell line-dependent variability in HIV activation employing DNMT inhibitors. | 2010 | Virol. J. | pmid:20942961 |
| Lee CS et al. | Casein kinase 2 inhibition differentially modulates apoptotic effect of trichostatin A against epithelial ovarian carcinoma cell lines. | 2010 | Mol. Cell. Biochem. | pmid:20020183 |
| Ibanez de Caceres I et al. | IGFBP-3 hypermethylation-derived deficiency mediates cisplatin resistance in non-small-cell lung cancer. | 2010 | Oncogene | pmid:20023704 |
| Kuribayashi T et al. | Scriptaid, a novel histone deacetylase inhibitor, enhances the response of human tumor cells to radiation. | 2010 | Int. J. Mol. Med. | pmid:19956898 |
| Hui KF and Chiang AK | Suberoylanilide hydroxamic acid induces viral lytic cycle in Epstein-Barr virus-positive epithelial malignancies and mediates enhanced cell death. | 2010 | Int. J. Cancer | pmid:19816947 |