trichostatin A
Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with trichostatin A?
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with trichostatin A
PubChem Associated disorders and diseases
What pathways are associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with trichostatin A?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with trichostatin A?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with trichostatin A?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with trichostatin A?
Related references are published most in these journals:
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What common seen animal models are associated with trichostatin A?
Mouse Model
Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Related references are published most in these journals:
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NCBI Entrez Crosslinks
All references with trichostatin A
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
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| Gays F et al. | The mouse tumor cell lines EL4 and RMA display mosaic expression of NK-related and certain other surface molecules and appear to have a common origin. | 2000 | J. Immunol. | pmid:10799866 |
| McInerney JM et al. | Long-term silencing of retroviral vectors is resistant to reversal by trichostatin A and 5-azacytidine. | 2000 | Gene Ther. | pmid:10800088 |
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| Diamond SE and Gutierrez-Hartmann A | The Pit-1beta domain dictates active repression and alteration of histone acetylation of the proximal prolactin promoter. | 2000 | J. Biol. Chem. | pmid:10921928 |
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| Siavoshian S et al. | Butyrate and trichostatin A effects on the proliferation/differentiation of human intestinal epithelial cells: induction of cyclin D3 and p21 expression. | 2000 | Gut | pmid:10716680 |
| Lin F et al. | Unique anti-activator protein-1 activity of retinoic acid receptor beta. | 2000 | Cancer Res. | pmid:10866321 |
| Hemavathy K et al. | Human Slug is a repressor that localizes to sites of active transcription. | 2000 | Mol. Cell. Biol. | pmid:10866665 |
| Jin S et al. | Ecteinascidin 743, a transcription-targeted chemotherapeutic that inhibits MDR1 activation. | 2000 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10841572 |
| Claassen GF and Hann SR | A role for transcriptional repression of p21CIP1 by c-Myc in overcoming transforming growth factor beta -induced cell-cycle arrest. | 2000 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10920185 |
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| Amann JM et al. | ETO, a target of t(8;21) in acute leukemia, makes distinct contacts with multiple histone deacetylases and binds mSin3A through its oligomerization domain. | 2001 | Mol. Cell. Biol. | pmid:11533236 |
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| Deltour S et al. | Characterization of HRG22, a human homologue of the putative tumor suppressor gene HIC1. | 2001 | Biochem. Biophys. Res. Commun. | pmid:11554746 |
| Kiela PR et al. | Regulation of the rat NHE3 gene promoter by sodium butyrate. | 2001 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:11557515 |
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| Franco PJ et al. | The orphan nuclear receptor TR2 interacts directly with both class I and class II histone deacetylases. | 2001 | Mol. Endocrinol. | pmid:11463856 |
| Sutherland JE et al. | The histone deacetylase inhibitor trichostatin A reduces nickel-induced gene silencing in yeast and mammalian cells. | 2001 | Mutat. Res. | pmid:11470494 |
| Takakura M et al. | Telomerase activation by histone deacetylase inhibitor in normal cells. | 2001 | Nucleic Acids Res. | pmid:11452025 |
| Ferraro M et al. | Involvement of histone H4 acetylation in the epigenetic inheritance of different activity states of maternally and paternally derived genomes in the mealybug Planococcus citri. | 2001 | Chromosoma | pmid:11453559 |
| Marianna P et al. | Valproic acid, trichostatin and their combination with hemin preferentially enhance gamma-globin gene expression in human erythroid liquid cultures. | 2001 | Haematologica | pmid:11454524 |
| Cho JH et al. | DNA methylation regulates placental lactogen I gene expression. | 2001 | Endocrinology | pmid:11459782 |
| Walker GE et al. | Butyrate, a histone deacetylase inhibitor, activates the human IGF binding protein-3 promoter in breast cancer cells: molecular mechanism involves an Sp1/Sp3 multiprotein complex. | 2001 | Endocrinology | pmid:11517158 |
| Sourlingas TG et al. | Histone deacetylase inhibitors induce apoptosis in peripheral blood lymphocytes along with histone H4 acetylation and the expression of the linker histone variant, H1 degrees. | 2001 | Eur. J. Cell Biol. | pmid:11824792 |
| Sawa H et al. | Histone deacetylase inhibitors such as sodium butyrate and trichostatin A induce apoptosis through an increase of the bcl-2-related protein Bad. | 2001 | Brain Tumor Pathol | pmid:11908866 |
| Pujuguet P et al. | Trichostatin A inhibits beta-casein expression in mammary epithelial cells. | 2001 | J. Cell. Biochem. | pmid:11746508 |
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| Williams RJ | Trichostatin A, an inhibitor of histone deacetylase, inhibits hypoxia-induced angiogenesis. | 2001 | Expert Opin Investig Drugs | pmid:11785457 |
| Nair AR et al. | Paradoxical effects of trichostatin A: inhibition of NF-Y-associated histone acetyltransferase activity, phosphorylation of hGCN5 and downregulation of cyclin A and B1 mRNA. | 2001 | Cancer Lett. | pmid:11295287 |
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| Viollet B et al. | Embryonic but not postnatal reexpression of hepatocyte nuclear factor 1alpha (HNF1alpha) can reactivate the silent phenylalanine hydroxylase gene in HNF1alpha-deficient hepatocytes. | 2001 | Mol. Cell. Biol. | pmid:11340160 |
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| Meier JL | Reactivation of the human cytomegalovirus major immediate-early regulatory region and viral replication in embryonal NTera2 cells: role of trichostatin A, retinoic acid, and deletion of the 21-base-pair repeats and modulator. | 2001 | J. Virol. | pmid:11160656 |
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| Lavoie R et al. | Design and synthesis of a novel class of histone deacetylase inhibitors. | 2001 | Bioorg. Med. Chem. Lett. | pmid:11597413 |
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