trichostatin A
Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with trichostatin A?
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with trichostatin A
PubChem Associated disorders and diseases
What pathways are associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with trichostatin A?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with trichostatin A?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with trichostatin A?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with trichostatin A?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with trichostatin A?
Mouse Model
Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with trichostatin A
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Zhang Z et al. | Role of histone acetylation in activation of nuclear factor erythroid 2-related factor 2/heme oxygenase 1 pathway by manganese chloride. | 2017 | Toxicol. Appl. Pharmacol. | pmid:29054681 |
| Nagaraja SS et al. | Effect of Trichostatin A on radiation induced epithelial-mesenchymal transition in A549Â cells. | 2017 | Biochem. Biophys. Res. Commun. | pmid:28993195 |
| Zheng C et al. | Histone Deacetylase Inhibitors Relax Mouse Aorta Partly through Their Inhibitory Action on L-Type Ca Channels. | 2017 | J. Pharmacol. Exp. Ther. | pmid:28860353 |
| Jorstad NL et al. | Stimulation of functional neuronal regeneration from Müller glia in adult mice. | 2017 | Nature | pmid:28746305 |
| Jih G et al. | Unique roles for histone H3K9me states in RNAi and heritable silencing of transcription. | 2017 | Nature | pmid:28682306 |
| Jiang F et al. | Trichostatin A increases embryo and green plant regeneration in wheat. | 2017 | Plant Cell Rep. | pmid:28752355 |
| Bouzelfen A et al. | Heterogeneous epigenetic regulation of HACE1 in Burkitt- Lymphoma-derived cells. | 2017 | Leuk. Res. | pmid:28651105 |
| Jayaraman A et al. | The epigenetic drug Trichostatin A ameliorates experimental autoimmune encephalomyelitis via T cell tolerance induction and impaired influx of T cells into the spinal cord. | 2017 | Neurobiol. Dis. | pmid:28736194 |
| Ikeda K et al. | In vitro drug testing based on contractile activity of C2C12 cells in an epigenetic drug model. | 2017 | Sci Rep | pmid:28300163 |
| Duan HY et al. | Effect of Histone Deacetylase Inhibition on the Expression of Multidrug Resistance-associated Protein 2 in a Human Placental Trophoblast Cell Line. | 2017 | Chin. Med. J. | pmid:28524836 |
| Wei W et al. | Class I histone deacetylases are major histone decrotonylases: evidence for critical and broad function of histone crotonylation in transcription. | 2017 | Cell Res. | pmid:28497810 |
| Acun T et al. | HLJ1 (DNAJB4) Gene Is a Novel Biomarker Candidate in Breast Cancer. | 2017 | OMICS | pmid:28481734 |
| Golfier S et al. | High-throughput cell mechanical phenotyping for label-free titration assays of cytoskeletal modifications. | 2017 | Cytoskeleton (Hoboken) | pmid:28445605 |
| Kotantaki P and Mosialos G | The expression of tumor suppressor gene Cyld is upregulated by histone deacetylace inhibitors in human hepatocellular carcinoma cell lines. | 2016 | Cell Biochem. Funct. | pmid:27570065 |
| Shao A et al. | Enhancement of Autophagy by Histone Deacetylase Inhibitor Trichostatin A Ameliorates Neuronal Apoptosis After Subarachnoid Hemorrhage in Rats. | 2016 | Mol. Neurobiol. | pmid:25399954 |
| DÃaz-Núñez M et al. | Histone deacetylase inhibitors induce invasion of human melanoma cells in vitro via differential regulation of N-cadherin expression and RhoA activity. | 2016 | BMC Cancer | pmid:27549189 |
| Duffy S et al. | Overexpression screens identify conserved dosage chromosome instability genes in yeast and human cancer. | 2016 | Proc. Natl. Acad. Sci. U.S.A. | pmid:27551064 |
| Tiper IV and Webb TJ | Histone deacetylase inhibitors enhance CD1d-dependent NKT cell responses to lymphoma. | 2016 | Cancer Immunol. Immunother. | pmid:27614429 |
| Morinobu A et al. | Expression and Functions of Immediate Early Response Gene X-1 (IEX-1) in Rheumatoid Arthritis Synovial Fibroblasts. | 2016 | PLoS ONE | pmid:27736946 |
| Hrgovic I et al. | The histone deacetylase inhibitor trichostatin a decreases lymphangiogenesis by inducing apoptosis and cell cycle arrest via p21-dependent pathways. | 2016 | BMC Cancer | pmid:27716272 |
| Sobue S et al. | Mechanism of paclitaxel resistance in a human prostate cancer cell line, PC3-PR, and its sensitization by cabazitaxel. | 2016 | Biochem. Biophys. Res. Commun. | pmid:27687545 |
| Zhang Q et al. | Trichostatin A protects against intestinal injury in rats with acute liver failure. | 2016 | J. Surg. Res. | pmid:27620992 |
| Desjardins D et al. | Histone Deacetylase Inhibition Restores Retinal Pigment Epithelium Function in Hyperglycemia. | 2016 | PLoS ONE | pmid:27617745 |
| Park IH et al. | Trichostatin A Inhibits Epithelial Mesenchymal Transition Induced by TGF-β1 in Airway Epithelium. | 2016 | PLoS ONE | pmid:27571418 |
| Yagi K et al. | Histone Deacetylase Inhibition Protects Mice Against Lethal Postinfluenza Pneumococcal Infection. | 2016 | Crit. Care Med. | pmid:27352127 |
| Wei L et al. | Microinjection of histone deacetylase inhibitor into the ventrolateral orbital cortex potentiates morphine induced behavioral sensitization. | 2016 | Brain Res. | pmid:27312092 |
| Hakami NY et al. | Trichostatin A, a histone deacetylase inhibitor suppresses NADPH Oxidase 4-Derived Redox Signalling and Angiogenesis. | 2016 | J. Cell. Mol. Med. | pmid:27297729 |
| Raju I et al. | Epigenetic regulation of KLK7 gene expression in pancreatic and cervical cancer cells. | 2016 | Biol. Chem. | pmid:27279059 |
| Somanna NK et al. | Histone deacetyltransferase inhibitors Trichostatin A and Mocetinostat differentially regulate MMP9, IL-18 and RECK expression, and attenuate Angiotensin II-induced cardiac fibroblast migration and proliferation. | 2016 | Hypertens. Res. | pmid:27278287 |
| Kang HR et al. | Butyrate-mediated acquisition of chemoresistance by human colon cancer cells. | 2016 | Oncol. Rep. | pmid:27277338 |
| Agudelo M et al. | Profile of Class I Histone Deacetylases (HDAC) by Human Dendritic Cells after Alcohol Consumption and In Vitro Alcohol Treatment and Their Implication in Oxidative Stress: Role of HDAC Inhibitors Trichostatin A and Mocetinostat. | 2016 | PLoS ONE | pmid:27249803 |
| Allgayer J et al. | Widespread transcriptional gene inactivation initiated by a repair intermediate of 8-oxoguanine. | 2016 | Nucleic Acids Res. | pmid:27220469 |
| Du R et al. | Trichostatin A potentiates genistein-induced apoptosis and reverses EMT in HEp2 cells. | 2016 | Mol Med Rep | pmid:27121018 |
| Wang H et al. | [Effect of trichostatin A on the osteogenic differentiation potential of periodontal ligament stem cells in inflammatory microenvironment induced by tumor necrosis factor-α stimulation]. | 2016 | Zhonghua Kou Qiang Yi Xue Za Zhi | pmid:27117217 |
| Gehring KB et al. | Involvement of phosphorylated Apis mellifera CREB in gating a honeybee's behavioral response to an external stimulus. | 2016 | Learn. Mem. | pmid:27084927 |
| Li QQ et al. | Histone deacetylase inhibitor-induced cell death in bladder cancer is associated with chromatin modification and modifying protein expression: A proteomic approach. | 2016 | Int. J. Oncol. | pmid:27082124 |
| Ho TT et al. | Transient resistance to DNA damaging agents is associated with expression of microRNAs-135b and -196b in human leukemia cell lines. | 2016 | Int J Biochem Mol Biol | pmid:27570640 |
| Noh H et al. | Trichostatin A enhances estrogen receptor-alpha repression in MCF-7 breast cancer cells under hypoxia. | 2016 | Biochem. Biophys. Res. Commun. | pmid:26768368 |
| Hosseini SM et al. | Epigenetic modification with trichostatin A does not correct specific errors of somatic cell nuclear transfer at the transcriptomic level; highlighting the non-random nature of oocyte-mediated reprogramming errors. | 2016 | BMC Genomics | pmid:26725231 |
| Lee K et al. | Histone deacetylation-mediated cellular dedifferentiation in Arabidopsis. | 2016 | J. Plant Physiol. | pmid:26724747 |
| Calvert S et al. | A network pharmacology approach reveals new candidate caloric restriction mimetics in C. elegans. | 2016 | Aging Cell | pmid:26676933 |
| Zhang Q et al. | Trichostatin A inhibits inflammation in phorbol myristate acetate‑induced macrophages by regulating the acetylation of histone and/or non‑histone proteins. | 2016 | Mol Med Rep | pmid:26647731 |
| Kikuchi M et al. | Epigenetic regulation of ZEB1-RAB25/ESRP1 axis plays a critical role in phenylbutyrate treatment-resistant breast cancer. | 2016 | Oncotarget | pmid:26646320 |
| Sheng Y et al. | Methylation of tumor suppressor gene CDH13 and SHP1 promoters and their epigenetic regulation by the UHRF1/PRMT5 complex in endometrial carcinoma. | 2016 | Gynecol. Oncol. | pmid:26597461 |
| Yeh BW et al. | Histone deacetylase inhibitor trichostatin A resensitizes gemcitabine resistant urothelial carcinoma cells via suppression of TG-interacting factor. | 2016 | Toxicol. Appl. Pharmacol. | pmid:26589485 |
| Vargas-López V et al. | Histone deacetylase inhibition abolishes stress-induced spatial memory impairment. | 2016 | Neurobiol Learn Mem | pmid:27544851 |
| Piao J et al. | Superior efficacy of co-treatment with the dual PI3K/mTOR inhibitor BEZ235 and histone deacetylase inhibitor Trichostatin A against NSCLC. | 2016 | Oncotarget | pmid:27507059 |
| Meng Z et al. | PTEN activation through K163 acetylation by inhibiting HDAC6 contributes to tumour inhibition. | 2016 | Oncogene | pmid:26279303 |
| Pang X et al. | Knockdown of Rad9A enhanced DNA damage induced by trichostatin A in esophageal cancer cells. | 2016 | Tumour Biol. | pmid:26264615 |
| Kim SH et al. | The heat shock protein 90 inhibitor SNX5422 has a synergistic activity with histone deacetylase inhibitors in induction of death of anaplastic thyroid carcinoma cells. | 2016 | Endocrine | pmid:26219406 |