trichostatin A
Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with trichostatin A?
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with trichostatin A
PubChem Associated disorders and diseases
What pathways are associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with trichostatin A?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with trichostatin A?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with trichostatin A?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with trichostatin A?
Related references are published most in these journals:
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What common seen animal models are associated with trichostatin A?
Mouse Model
Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with trichostatin A
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Dai Q et al. | Histone deacetylase inhibitors attenuate P-aIgA1-induced cell proliferation and extracellular matrix synthesis in human renal mesangial cells in vitro. | 2016 | Acta Pharmacol. Sin. | pmid:26775659 |
| Rong X et al. | Effects of histone acetylation on superoxide dismutase 1 gene expression in the pathogenesis of senile cataract. | 2016 | Sci Rep | pmid:27703255 |
| Contreras-Leal E et al. | Histone deacetylase inhibitors promote the expression of ATP2A3 gene in breast cancer cell lines. | 2016 | Mol. Carcinog. | pmid:26331238 |
| Bricambert J et al. | Impaired histone deacetylases 5 and 6 expression mimics the effects of obesity and hypoxia on adipocyte function. | 2016 | Mol Metab | pmid:27900262 |
| Bauer I et al. | A Class 1 Histone Deacetylase with Potential as an Antifungal Target. | 2016 | MBio | pmid:27803184 |
| Xu Q et al. | Changes in cardiac Nav1.5 expression, function, and acetylation by pan-histone deacetylase inhibitors. | 2016 | Am. J. Physiol. Heart Circ. Physiol. | pmid:27638876 |
| Nadanaka S et al. | Histone deacetylase-mediated regulation of chondroitin 4-O-sulfotransferase-1 (Chst11) gene expression by Wnt/β-catenin signaling. | 2016 | Biochem. Biophys. Res. Commun. | pmid:27751852 |
| Tiper IV and Webb TJ | Histone deacetylase inhibitors enhance CD1d-dependent NKT cell responses to lymphoma. | 2016 | Cancer Immunol. Immunother. | pmid:27614429 |
| Drzewiecka H et al. | Decreased expression of connective tissue growth factor in non-small cell lung cancer is associated with clinicopathological variables and can be restored by epigenetic modifiers. | 2016 | J. Cancer Res. Clin. Oncol. | pmid:27393180 |
| Zhang NH et al. | Rejection of adenovirus infection is independent of coxsackie and adenovirus receptor expression in cisplatin-resistant human lung cancer cells. | 2016 | Oncol. Rep. | pmid:27373420 |
| Chang I and Wang CY | Inhibition of HDAC6 Protein Enhances Bortezomib-induced Apoptosis in Head and Neck Squamous Cell Carcinoma (HNSCC) by Reducing Autophagy. | 2016 | J. Biol. Chem. | pmid:27369083 |
| Yagi K et al. | Histone Deacetylase Inhibition Protects Mice Against Lethal Postinfluenza Pneumococcal Infection. | 2016 | Crit. Care Med. | pmid:27352127 |
| Wei L et al. | Microinjection of histone deacetylase inhibitor into the ventrolateral orbital cortex potentiates morphine induced behavioral sensitization. | 2016 | Brain Res. | pmid:27312092 |
| Kuan CS et al. | Sp1 and Sp3 Are the Transcription Activators of Human ek1 Promoter in TSA-Treated Human Colon Carcinoma Cells. | 2016 | PLoS ONE | pmid:26807725 |
| Noh H et al. | Trichostatin A enhances estrogen receptor-alpha repression in MCF-7 breast cancer cells under hypoxia. | 2016 | Biochem. Biophys. Res. Commun. | pmid:26768368 |
| Hosseini SM et al. | Epigenetic modification with trichostatin A does not correct specific errors of somatic cell nuclear transfer at the transcriptomic level; highlighting the non-random nature of oocyte-mediated reprogramming errors. | 2016 | BMC Genomics | pmid:26725231 |
| Trifunović D et al. | HDAC inhibition in the cpfl1 mouse protects degenerating cone photoreceptors in vivo. | 2016 | Hum. Mol. Genet. | pmid:28172811 |
| Nayak S et al. | Superior Versus Inferior Vestibular Neuritis: Are There Intrinsic Differences in Infection, Reactivation, or Production of Infectious Particles Between the Vestibular Ganglia? | 2015 | Otol. Neurotol. | pmid:25978655 |
| Chen MH et al. | A new trichostatin analog from Streptomyces sp. CPCC 203909. | 2015 | J Asian Nat Prod Res | pmid:25977996 |
| Inoue K et al. | Trichostatin A specifically improves the aberrant expression of transcription factor genes in embryos produced by somatic cell nuclear transfer. | 2015 | Sci Rep | pmid:25974394 |
| El-Awady RA et al. | Epigenetics and miRNA as predictive markers and targets for lung cancer chemotherapy. | 2015 | Cancer Biol. Ther. | pmid:25962089 |
| Chan N et al. | Attenuation of choroidal neovascularization by histone deacetylase inhibitor. | 2015 | PLoS ONE | pmid:25807249 |
| Asaoka N et al. | Inhibition of histone deacetylases enhances the function of serotoninergic neurons in organotypic raphe slice cultures. | 2015 | Neurosci. Lett. | pmid:25796177 |
| Butler PL et al. | Acetylation stimulates the epithelial sodium channel by reducing its ubiquitination and degradation. | 2015 | J. Biol. Chem. | pmid:25787079 |
| Zelko IN and Folz RJ | Regulation of Oxidative Stress in Pulmonary Artery Endothelium. Modulation of Extracellular Superoxide Dismutase and NOX4 Expression Using Histone Deacetylase Class I Inhibitors. | 2015 | Am. J. Respir. Cell Mol. Biol. | pmid:25749103 |
| Du J et al. | HDAC4 degradation mediates HDAC inhibition-induced protective effects against hypoxia/reoxygenation injury. | 2015 | J. Cell. Physiol. | pmid:25475100 |
| Xu T and Hu X | Copper-catalyzed 1,2-addition of α-carbonyl iodides to alkynes. | 2015 | Angew. Chem. Int. Ed. Engl. | pmid:25470461 |
| Rabineau M et al. | Cell guidance into quiescent state through chromatin remodeling induced by elastic modulus of substrate. | 2015 | Biomaterials | pmid:25453945 |
| Wang J et al. | Fungal metabolite myriocin promotes human herpes simplex virus-2 infection. | 2015 | Life Sci. | pmid:25447452 |
| Wang X et al. | Trichostatin A, a histone deacetylase inhibitor, reverses epithelial-mesenchymal transition in colorectal cancer SW480 and prostate cancer PC3 cells. | 2015 | Biochem. Biophys. Res. Commun. | pmid:25434997 |
| Ma X et al. | Effect of LIV1 on the sensitivity of ovarian cancer cells to trichostatin A. | 2015 | Oncol. Rep. | pmid:25420545 |
| Cui Y et al. | Interference of the Histone Deacetylase Inhibits Pollen Germination and Pollen Tube Growth in Picea wilsonii Mast. | 2015 | PLoS ONE | pmid:26710276 |
| Tao Y et al. | HDAC1 regulates the proliferation of radial glial cells in the developing Xenopus tectum. | 2015 | PLoS ONE | pmid:25789466 |
| Wang Y et al. | Inhibition of histone deacetylase in the basolateral amygdala facilitates morphine context-associated memory formation in rats. | 2015 | J. Mol. Neurosci. | pmid:24829091 |
| Yamanegi K et al. | Sodium valproate, a histone deacetylase inhibitor, modulates the vascular endothelial growth inhibitor-mediated cell death in human osteosarcoma and vascular endothelial cells. | 2015 | Int. J. Oncol. | pmid:25778932 |
| Cao QF et al. | TRPM2 mediates histone deacetylase inhibition-induced apoptosis in bladder cancer cells. | 2015 | Cancer Biother. Radiopharm. | pmid:25760728 |
| Mackmull MT et al. | Histone Deacetylase Inhibitors (HDACi) Cause the Selective Depletion of Bromodomain Containing Proteins (BCPs). | 2015 | Mol. Cell Proteomics | pmid:25755299 |
| Passeri E et al. | Enhanced conversion of induced neuronal cells (iN cells) from human fibroblasts: Utility in uncovering cellular deficits in mental illness-associated chromosomal abnormalities. | 2015 | Neurosci. Res. | pmid:26260244 |
| Cavalieri V and Spinelli G | Ectopic hbox12 Expression Evoked by Histone Deacetylase Inhibition Disrupts Axial Specification of the Sea Urchin Embryo. | 2015 | PLoS ONE | pmid:26618749 |
| Zhang Y et al. | The Induction Effect of Am80 and TSA on ESC Differentiation via Regulation of Stra8 in Chicken. | 2015 | PLoS ONE | pmid:26606052 |
| Kotze AC et al. | Histone deacetylase enzymes as drug targets for the control of the sheep blowfly, Lucilia cuprina. | 2015 | Int J Parasitol Drugs Drug Resist | pmid:27120067 |
| Hsing CH et al. | Histone Deacetylase Inhibitor Trichostatin A Ameliorated Endotoxin-Induced Neuroinflammation and Cognitive Dysfunction. | 2015 | Mediators Inflamm. | pmid:26273133 |
| Zhou L et al. | Inhibition of Histone Deacetylase Activity Aggravates Coxsackievirus B3-Induced Myocarditis by Promoting Viral Replication and Myocardial Apoptosis. | 2015 | J. Virol. | pmid:26269170 |
| Zheng J et al. | Gain-of-function STAT1 mutations impair STAT3 activity in patients with chronic mucocutaneous candidiasis (CMC). | 2015 | Eur. J. Immunol. | pmid:26255980 |
| Mehta A et al. | HDAC inhibitor prevents LPS mediated inhibition of CYP19A1 expression and 17β-estradiol production in granulosa cells. | 2015 | Mol. Cell. Endocrinol. | pmid:26213324 |
| Liu Y and Li S | A Cell Culture Model of Latent and Lytic Herpes Simplex Virus Type 1 Infection in Spiral Ganglion. | 2015 | ORL J. Otorhinolaryngol. Relat. Spec. | pmid:26022499 |
| Jost JO et al. | A miniaturized readout strategy for endogenous histone deacetylase activity. | 2015 | Mol Biosyst | pmid:26009008 |
| Koppaka V et al. | Effect of HDAC Inhibitors on Corneal Keratocyte Mechanical Phenotypes in 3-D Collagen Matrices. | 2015 | Mol. Vis. | pmid:25999677 |
| Ukaegbu UE et al. | A Unique Virulence Gene Occupies a Principal Position in Immune Evasion by the Malaria Parasite Plasmodium falciparum. | 2015 | PLoS Genet. | pmid:25993442 |
| Chen Z et al. | Promotion of Metastasis-associated Gene Expression in Survived PANC-1 Cells Following Trichostatin A Treatment. | 2015 | Anticancer Agents Med Chem | pmid:25991546 |