Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Das ZC et al. | Lyophilized somatic cells direct embryonic development after whole cell intracytoplasmic injection into pig oocytes. | 2010 | Cryobiology | pmid:20691649 |
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Gray SG et al. | IGF-II and IL-2 act synergistically to alter HDAC1 expression following treatments with trichostatin a. | 2000 | Cytokine | pmid:10880258 |
Wang S et al. | Sex steroid-induced DNA methylation changes and inflammation response in prostate cancer. | 2016 | Cytokine | pmid:27500645 |
Zhao XY et al. | Granulocyte-macrophage colony-stimulating factor induces de novo methylation of the p15 CpG island in hematopoietic cells. | 2005 | Cytokine | pmid:15996479 |
El-Khoury V et al. | Effects of the histone deacetylase inhibitor trichostatin A on nuclear texture and c-jun gene expression in drug-sensitive and drug-resistant human H69 lung carcinoma cells. | 2004 | Cytometry A | pmid:15517561 |
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Young JC et al. | Inhibitors of histone deacetylases promote hematopoietic stem cell self-renewal. | 2004 | Cytotherapy | pmid:16146885 |
Drela K et al. | Low oxygen atmosphere facilitates proliferation and maintains undifferentiated state of umbilical cord mesenchymal stem cells in an hypoxia inducible factor-dependent manner. | 2014 | Cytotherapy | pmid:24726658 |
Obier N et al. | Inhibition of histone deacetylases by Trichostatin A leads to a HoxB4-independent increase of hematopoietic progenitor/stem cell frequencies as a result of selective survival. | 2010 | Cytotherapy | pmid:20210674 |
Kishigami S et al. | Epigenetic abnormalities of the mouse paternal zygotic genome associated with microinsemination of round spermatids. | 2006 | Dev. Biol. | pmid:16325170 |
Almouzni G et al. | Histone acetylation influences both gene expression and development of Xenopus laevis. | 1994 | Dev. Biol. | pmid:7958429 |
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Shen YC et al. | The cytokine macrophage migration inhibitory factor (MIF) acts as a neurotrophin in the developing inner ear of the zebrafish, Danio rerio. | 2012 | Dev. Biol. | pmid:22210003 |
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Maatouk DM and Resnick JL | Continuing primordial germ cell differentiation in the mouse embryo is a cell-intrinsic program sensitive to DNA methylation. | 2003 | Dev. Biol. | pmid:12781693 |
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Iezzi S et al. | Deacetylase inhibitors increase muscle cell size by promoting myoblast recruitment and fusion through induction of follistatin. | 2004 | Dev. Cell | pmid:15130492 |
Fujita Y et al. | Priming of centromere for CENP-A recruitment by human hMis18alpha, hMis18beta, and M18BP1. | 2007 | Dev. Cell | pmid:17199038 |
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Shi LH et al. | Trichostatin A (TSA) improves the development of rabbit-rabbit intraspecies cloned embryos, but not rabbit-human interspecies cloned embryos. | 2008 | Dev. Dyn. | pmid:18265023 |
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Worrad DM et al. | Temporally restricted spatial localization of acetylated isoforms of histone H4 and RNA polymerase II in the 2-cell mouse embryo. | 1995 | Development | pmid:7555721 |
Svensson K et al. | The paternal allele of the H19 gene is progressively silenced during early mouse development: the acetylation status of histones may be involved in the generation of variegated expression patterns. | 1998 | Development | pmid:9389664 |
Yeh JR et al. | AML1-ETO reprograms hematopoietic cell fate by downregulating scl expression. | 2008 | Development | pmid:18156164 |