trichostatin A
Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with trichostatin A?
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with trichostatin A
PubChem Associated disorders and diseases
What pathways are associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with trichostatin A?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with trichostatin A?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with trichostatin A?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with trichostatin A?
Related references are published most in these journals:
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What common seen animal models are associated with trichostatin A?
Mouse Model
Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with trichostatin A
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Bo F et al. | Effect of trichostatin A on transfected donor cells and subsequent development of porcine cloned embryos. | 2011 | Zygote | pmid:20569515 |
| WEI Q et al. | [Trichostatin A inhibits the activation of CD(4)(+) T cells by suppressing CD(28) expression in mice]. | 2011 | Nan Fang Yi Ke Da Xue Xue Bao | pmid:21421475 |
| Watanabe Y and Tanaka M | p62/SQSTM1 in autophagic clearance of a non-ubiquitylated substrate. | 2011 | J. Cell. Sci. | pmid:21771882 |
| Cai HH et al. | Aberrant methylation frequency of TNFRSF10C promoter in pancreatic cancer cell lines. | 2011 | HBPD INT | pmid:21269942 |
| Shu G et al. | Zac1 is a histone acetylation-regulated NF-κB suppressor that mediates histone deacetylase inhibitor-induced apoptosis. | 2011 | Cell Death Differ. | pmid:21546906 |
| Salvi V et al. | Trichostatin A blocks type I interferon production by activated plasmacytoid dendritic cells. | 2010 Sep-Oct | Immunobiology | pmid:20573419 |
| Schuhmann NK et al. | Gene transfer into human cord blood-derived CD34(+) cells by adeno-associated viral vectors. | 2010 | Exp. Hematol. | pmid:20447441 |
| Zhang D et al. | [Effects of trichostatin A on human lung cancer cell strains A549]. | 2010 | Zhongguo Yi Xue Ke Xue Yuan Xue Bao | pmid:20450546 |
| Ju ZH et al. | [Effects of 5-Aza-2'-deoxycitydine and trichostatin A on expression and apoptosis of ALDH1a2 gene in human bladder cancer cell lines]. | 2010 | Zhonghua Wai Ke Za Zhi | pmid:20450613 |
| Lu L et al. | Role of SMAD and non-SMAD signals in the development of Th17 and regulatory T cells. | 2010 | J. Immunol. | pmid:20304828 |
| Tokési N et al. | TPPP/p25 promotes tubulin acetylation by inhibiting histone deacetylase 6. | 2010 | J. Biol. Chem. | pmid:20308065 |
| Kim J et al. | PS-341 and histone deacetylase inhibitor synergistically induce apoptosis in head and neck squamous cell carcinoma cells. | 2010 | Mol. Cancer Ther. | pmid:20571067 |
| Obier N and Müller AM | Chromatin flow cytometry identifies changes in epigenetic cell states. | 2010 | Cells Tissues Organs (Print) | pmid:19776550 |
| Fan J et al. | Expression and function of CD9 in melanoma cells. | 2010 | Mol. Carcinog. | pmid:19777564 |
| Xue K et al. | Synchronous behaviors of CBP and acetylations of lysine 18 and lysine 23 on histone H3 during porcine oocyte first meiotic division. | 2010 | Mol. Reprod. Dev. | pmid:20575085 |
| Alamdari N et al. | Sepsis and glucocorticoids upregulate p300 and downregulate HDAC6 expression and activity in skeletal muscle. | 2010 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:20538901 |
| Li J et al. | Proteomic analysis revealed association of aberrant ROS signaling with suberoylanilide hydroxamic acid-induced autophagy in Jurkat T-leukemia cells. | 2010 | Autophagy | pmid:20543569 |
| Vamadevan AS et al. | Regulation of Toll-like receptor 4-associated MD-2 in intestinal epithelial cells: a comprehensive analysis. | 2010 | Innate Immun | pmid:19710105 |
| Kaichi S et al. | Cell line-dependent differentiation of induced pluripotent stem cells into cardiomyocytes in mice. | 2010 | Cardiovasc. Res. | pmid:20547733 |
| Her S et al. | Trichostatin A stimulates steroid 5alpha-reductase gene expression in rat C6 glioma cells via a mechanism involving Sp1 and Sp3 transcription factors. | 2010 | J. Mol. Neurosci. | pmid:19728174 |
| Wood JP et al. | A comparison of differentiation protocols for RGC-5 cells. | 2010 | Invest. Ophthalmol. Vis. Sci. | pmid:20181845 |
| Das ZC et al. | Lyophilized somatic cells direct embryonic development after whole cell intracytoplasmic injection into pig oocytes. | 2010 | Cryobiology | pmid:20691649 |
| Mercer TR et al. | Long noncoding RNAs in neuronal-glial fate specification and oligodendrocyte lineage maturation. | 2010 | BMC Neurosci | pmid:20137068 |
| Heier CR et al. | Arrhythmia and cardiac defects are a feature of spinal muscular atrophy model mice. | 2010 | Hum. Mol. Genet. | pmid:20693262 |
| Hodges SJ et al. | The effect of epigenetic therapy on congenital neurogenic bladders--a pilot study. | 2010 | Urology | pmid:20138341 |
| Bradner JE et al. | Chemical phylogenetics of histone deacetylases. | 2010 | Nat. Chem. Biol. | pmid:20139990 |
| Gay S et al. | Nucleotide supply, not local histone acetylation, sets replication origin usage in transcribed regions. | 2010 | EMBO Rep. | pmid:20671737 |
| Okada T et al. | TWIST1 hypermethylation is observed frequently in colorectal tumors and its overexpression is associated with unfavorable outcomes in patients with colorectal cancer. | 2010 | Genes Chromosomes Cancer | pmid:20140954 |
| Shahabi S et al. | Epothilone B enhances surface EpCAM expression in ovarian cancer Hey cells. | 2010 | Gynecol. Oncol. | pmid:20674962 |
| Wessels I et al. | Changes in chromatin structure and methylation of the human interleukin-1beta gene during monopoiesis. | 2010 | Immunology | pmid:20141541 |
| Zhang C et al. | Epigenetic inactivation of the tumor suppressor gene RIZ1 in hepatocellular carcinoma involves both DNA methylation and histone modifications. | 2010 | J. Hepatol. | pmid:20675009 |
| Huber K et al. | Novel 3-arylideneindolin-2-ones as inhibitors of NAD+ -dependent histone deacetylases (sirtuins). | 2010 | J. Med. Chem. | pmid:20030343 |
| Kroening S et al. | Characterization of connective tissue growth factor expression in primary cultures of human tubular epithelial cells: modulation by hypoxia. | 2010 | Am. J. Physiol. Renal Physiol. | pmid:20032117 |
| Bracha AL et al. | Carbon metabolism-mediated myogenic differentiation. | 2010 | Nat. Chem. Biol. | pmid:20081855 |
| Pan L et al. | Vitamin D stimulates apoptosis in gastric cancer cells in synergy with trichostatin A /sodium butyrate-induced and 5-aza-2'-deoxycytidine-induced PTEN upregulation. | 2010 | FEBS J. | pmid:20089040 |
| Bayles R et al. | Histone modifications regulate the norepinephrine transporter gene. | 2010 | Cell Cycle | pmid:21088495 |
| Wang J et al. | Effect of EGF-induced HDAC6 activation on corneal epithelial wound healing. | 2010 | Invest. Ophthalmol. Vis. Sci. | pmid:20089874 |
| Hutt DM et al. | Reduced histone deacetylase 7 activity restores function to misfolded CFTR in cystic fibrosis. | 2010 | Nat. Chem. Biol. | pmid:19966789 |
| Meng CF et al. | Role of histone modifications and DNA methylation in the regulation of O6-methylguanine-DNA methyltransferase gene expression in human stomach cancer cells. | 2010 | Cancer Invest. | pmid:19857042 |
| Sayan BS et al. | Induction of TAp63 by histone deacetylase inhibitors. | 2010 | Biochem. Biophys. Res. Commun. | pmid:20043870 |
| Terracciano S et al. | Synthesis and biological activity of cyclotetrapeptide analogues of the natural HDAC inhibitor FR235222. | 2010 | Bioorg. Med. Chem. | pmid:20381359 |
| Zhang LX et al. | Targeted deletion of NF-kappaB p50 diminishes the cardioprotection of histone deacetylase inhibition. | 2010 | Am. J. Physiol. Heart Circ. Physiol. | pmid:20382965 |
| Pan L et al. | HDAC4 inhibits the transcriptional activation of mda-7/IL-24 induced by Sp1. | 2010 | Cell. Mol. Immunol. | pmid:20383178 |
| Kim HB et al. | Lipin 1 represses NFATc4 transcriptional activity in adipocytes to inhibit secretion of inflammatory factors. | 2010 | Mol. Cell. Biol. | pmid:20385772 |
| Varma A and Kwon-Chung KJ | Heteroresistance of Cryptococcus gattii to fluconazole. | 2010 | Antimicrob. Agents Chemother. | pmid:20385871 |
| Yang H et al. | Histone modification-mediated CYP2E1 gene expression and apoptosis of HepG2 cells. | 2010 | Exp. Biol. Med. (Maywood) | pmid:20404016 |
| Ellis JK et al. | Effect of the histone deacetylase inhibitor trichostatin a on the metabolome of cultured primary hepatocytes. | 2010 | J. Proteome Res. | pmid:19894772 |
| Wang N and Tilly JL | Epigenetic status determines germ cell meiotic commitment in embryonic and postnatal mammalian gonads. | 2010 | Cell Cycle | pmid:20009537 |
| Wang L et al. | Chronic cocaine-induced H3 acetylation and transcriptional activation of CaMKIIalpha in the nucleus accumbens is critical for motivation for drug reinforcement. | 2010 | Neuropsychopharmacology | pmid:20010550 |
| Jeon HW and Lee YM | Inhibition of histone deacetylase attenuates hypoxia-induced migration and invasion of cancer cells via the restoration of RECK expression. | 2010 | Mol. Cancer Ther. | pmid:20442303 |