Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Wolf G et al. | Epigenetic marking and repression of porcine endogenous retroviruses. | 2013 | J. Gen. Virol. | pmid:23324470 |
Laska MJ et al. | (Some) cellular mechanisms influencing the transcription of human endogenous retrovirus, HERV-Fc1. | 2013 | PLoS ONE | pmid:23382858 |
Bhargavan B et al. | Epigenetic repression of LEDGF during UVB exposure by recruitment of SUV39H1 and HDAC1 to the Sp1-responsive elements within LEDGF promoter CpG island. | 2013 | Epigenetics | pmid:23386123 |
Peng L et al. | Epigenetic inactivation of ADAMTS9 via promoter methylation in multiple myeloma. | 2013 | Mol Med Rep | pmid:23358566 |
Corvetta D et al. | Physical interaction between MYCN oncogene and polycomb repressive complex 2 (PRC2) in neuroblastoma: functional and therapeutic implications. | 2013 | J. Biol. Chem. | pmid:23362253 |
Ziesché E et al. | The coactivator role of histone deacetylase 3 in IL-1-signaling involves deacetylation of p65 NF-κB. | 2013 | Nucleic Acids Res. | pmid:23087373 |
Eriksson I et al. | The histone deacetylase inhibitor trichostatin A reduces lysosomal pH and enhances cisplatin-induced apoptosis. | 2013 | Exp. Cell Res. | pmid:23063877 |
Höring E et al. | The histone deacetylase inhibitor trichostatin a promotes apoptosis and antitumor immunity in glioblastoma cells. | 2013 | Anticancer Res. | pmid:23564772 |
Chen CH et al. | Synergistic effect of trichostatin A and scriptaid on the development of cloned rabbit embryos. | 2013 | Theriogenology | pmid:23566670 |
Sato A et al. | Suppressive effect of the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA) on hepatitis C virus replication. | 2013 | J. Cell. Biochem. | pmid:23519646 |
Wang Y et al. | Nuclear factor κB mediates suppression of canonical transient receptor potential 6 expression by reactive oxygen species and protein kinase C in kidney cells. | 2013 | J. Biol. Chem. | pmid:23525112 |
Sato T et al. | Enhancement of inflammatory protein expression and nuclear factor Κb (NF-Κb) activity by trichostatin A (TSA) in OP9 preadipocytes. | 2013 | PLoS ONE | pmid:23555753 |
Mateen S et al. | Silibinin synergizes with histone deacetylase and DNA methyltransferase inhibitors in upregulating E-cadherin expression together with inhibition of migration and invasion of human non-small cell lung cancer cells. | 2013 | J. Pharmacol. Exp. Ther. | pmid:23461975 |
Lauffer BE et al. | Histone deacetylase (HDAC) inhibitor kinetic rate constants correlate with cellular histone acetylation but not transcription and cell viability. | 2013 | J. Biol. Chem. | pmid:23897821 |
Lu JC et al. | Trichostatin A modulates thiazolidinedione-mediated suppression of tumor necrosis factor α-induced lipolysis in 3T3-L1 adipocytes. | 2013 | PLoS ONE | pmid:23951179 |
Seo J et al. | Trichostatin A epigenetically increases calpastatin expression and inhibits calpain activity and calcium-induced SH-SY5Y neuronal cell toxicity. | 2013 | FEBS J. | pmid:24200051 |
Itoh M et al. | Trichostatin A enhances glutamate transporter GLT-1 mRNA levels in C6 glioma cells via neurosteroid-mediated cell differentiation. | 2013 | J. Mol. Neurosci. | pmid:22711563 |
Ning SF et al. | Methylation characteristics and developmental potential of Guangxi Bama minipig (Sus scrofa domestica) cloned embryos from donor cells treated with trichostatin A and 5-aza-2'-deoxycytidine. | 2013 | Zygote | pmid:22355002 |
Cho JS et al. | Effects of histone deacetylase inhibitor on extracellular matrix production in human nasal polyp organ cultures. | 2013 | Am J Rhinol Allergy | pmid:23406592 |
Miyatake Y et al. | Protective roles of epithelial cells in the survival of adult T-cell leukemia/lymphoma cells. | 2013 | Am. J. Pathol. | pmid:23474084 |
Hansberg-Pastor V et al. | The role of DNA methylation and histone acetylation in the regulation of progesterone receptor isoforms expression in human astrocytoma cell lines. | 2013 | Steroids | pmid:23474171 |
Arora DS et al. | Hyposensitivity to gamma-aminobutyric acid in the ventral tegmental area during alcohol withdrawal: reversal by histone deacetylase inhibitors. | 2013 | Neuropsychopharmacology | pmid:23474591 |
Lee AR et al. | Nicotinamide: a class III HDACi delays in vitro aging of mouse oocytes. | 2013 | J. Reprod. Dev. | pmid:23474603 |
Matteucci E et al. | Epigenetic control of endothelin-1 axis affects invasiveness of breast carcinoma cells with bone tropism. | 2013 | Exp. Cell Res. | pmid:23660387 |
Ignatius MS et al. | Distinct functional and temporal requirements for zebrafish Hdac1 during neural crest-derived craniofacial and peripheral neuron development. | 2013 | PLoS ONE | pmid:23667588 |
Webster SJ et al. | Regulation of GTP-binding protein (Gαs) expression in human myometrial cells: a role for tumor necrosis factor in modulating Gαs promoter acetylation by transcriptional complexes. | 2013 | J. Biol. Chem. | pmid:23297421 |
Lee MS et al. | Stabilization of p21 (Cip1/WAF1) following Tip60-dependent acetylation is required for p21-mediated DNA damage response. | 2013 | Cell Death Differ. | pmid:23238566 |
Kamiya H et al. | Enhanced transgene expression from chromatinized plasmid DNA in mouse liver. | 2013 | Int J Pharm | pmid:23247018 |
Ji Z et al. | Integrating genomics and proteomics data to predict drug effects using binary linear programming. | 2014 | PLoS ONE | pmid:25036040 |
Lv W et al. | Histone deacetylase 1 and 3 regulate the mesodermal lineage commitment of mouse embryonic stem cells. | 2014 | PLoS ONE | pmid:25412078 |
Lu HK et al. | Ex vivo response to histone deacetylase (HDAC) inhibitors of the HIV long terminal repeat (LTR) derived from HIV-infected patients on antiretroviral therapy. | 2014 | PLoS ONE | pmid:25409334 |
Yang W et al. | Effect of trichostatin A on gelsolin levels, proteolysis of amyloid precursor protein, and amyloid beta-protein load in the brain of transgenic mouse model of Alzheimer's disease. | 2014 | Curr Alzheimer Res | pmid:25387339 |
Ying H et al. | Pressure overload-induced cardiac hypertrophy response requires janus kinase 2-histone deacetylase 2 signaling. | 2014 | Int J Mol Sci | pmid:25380525 |
Nishida N et al. | Identification of epigenetically inactivated genes in human hepatocellular carcinoma by integrative analyses of methylation profiling and pharmacological unmasking. | 2014 | Dig Dis | pmid:25376292 |
Xie M et al. | Effects of 5-aza-2'-deoxycytidine and trichostatin A on high glucose- and interleukin-1β-induced secretory mediators from human retinal endothelial cells and retinal pigment epithelial cells. | 2014 | Mol. Vis. | pmid:25352747 |
Xiong J et al. | USP22 transcriptional activity is negatively regulated by the histone deacetylase inhibitor trichostatin A. | 2014 | Mol Med Rep | pmid:25323692 |
Li G et al. | Short-chain fatty acids enhance adipocyte differentiation in the stromal vascular fraction of porcine adipose tissue. | 2014 | J. Nutr. | pmid:25320182 |
Shi QQ et al. | Effect of trichostatin A on anti HepG2 liver carcinoma cells: inhibition of HDAC activity and activation of Wnt/β-Catenin signaling. | 2014 | Asian Pac. J. Cancer Prev. | pmid:25292076 |
Quan H et al. | Hepatitis C virus core protein epigenetically silences SFRP1 and enhances HCC aggressiveness by inducing epithelial-mesenchymal transition. | 2014 | Oncogene | pmid:23770846 |
Dubois-Pot-Schneider H et al. | Inflammatory cytokines promote the retrodifferentiation of tumor-derived hepatocyte-like cells to progenitor cells. | 2014 | Hepatology | pmid:25098666 |
Wu TH et al. | Melatonin prevents neonatal dexamethasone induced programmed hypertension: histone deacetylase inhibition. | 2014 | J. Steroid Biochem. Mol. Biol. | pmid:25090636 |
Shi Q et al. | [Inhibitory effect of trichostatin A on HepG2 cell proliferation and the mechanisms]. | 2014 | Nan Fang Yi Ke Da Xue Xue Bao | pmid:25057056 |
Tsuji M et al. | Epigenetic regulation of resistance to emotional stress: possible involvement of 5-HT1A receptor-mediated histone acetylation. | 2014 | J. Pharmacol. Sci. | pmid:25048113 |
Huan YJ et al. | Epigenetic modification agents improve genomic methylation reprogramming in porcine cloned embryos. | 2014 | J. Reprod. Dev. | pmid:25047549 |
Sun G et al. | Insights into the lysine acetylproteome of human sperm. | 2014 | J Proteomics | pmid:25038526 |
Ishihara K | Eosinophil cell lines. | 2014 | Methods Mol. Biol. | pmid:24986606 |
Liu H et al. | The Smn-independent beneficial effects of trichostatin A on an intermediate mouse model of spinal muscular atrophy. | 2014 | PLoS ONE | pmid:24984019 |
Maldonado L et al. | An epigenetic marker panel for recurrence risk prediction of low grade papillary urothelial cell carcinoma (LGPUCC) and its potential use for surveillance after transurethral resection using urine. | 2014 | Oncotarget | pmid:24980822 |
Wilson-Edell KA et al. | RPL24: a potential therapeutic target whose depletion or acetylation inhibits polysome assembly and cancer cell growth. | 2014 | Oncotarget | pmid:24970821 |
Yang XL et al. | Effect of trichostatin A on CNE2 nasopharyngeal carcinoma cells--genome-wide DNA methylation alteration. | 2014 | Asian Pac. J. Cancer Prev. | pmid:24969901 |
Hu Z and Wang J | Histone deacetylase inhibitor induces the expression of select epithelial genes in mouse utricle sensory epithelia-derived progenitor cells. | 2014 | Cell Reprogram | pmid:24945595 |
Ma H et al. | HSPC117 is regulated by epigenetic modification and is involved in the migration of JEG-3 cells. | 2014 | Int J Mol Sci | pmid:24941254 |
Bartling TR et al. | Redox-sensitive gene-regulatory events controlling aberrant matrix metalloproteinase-1 expression. | 2014 | Free Radic. Biol. Med. | pmid:24973648 |
Thangavel J et al. | Combinatorial therapy with acetylation and methylation modifiers attenuates lung vascular hyperpermeability in endotoxemia-induced mouse inflammatory lung injury. | 2014 | Am. J. Pathol. | pmid:24929240 |
Poljak M et al. | Class I to III histone deacetylases differentially regulate inflammation-induced matrix metalloproteinase 9 expression in primary amnion cells. | 2014 | Reprod Sci | pmid:24429678 |
Unland R et al. | Epigenetic repression of the dopamine receptor D4 in pediatric tumors of the central nervous system. | 2014 | J. Neurooncol. | pmid:24264533 |
Sun DF et al. | Inhibition of mTOR signalling potentiates the effects of trichostatin A in human gastric cancer cell lines by promoting histone acetylation. | 2014 | Cell Biol. Int. | pmid:24030871 |
Lee J et al. | Therapeutic targeting of epigenetic components in amyotrophic lateral sclerosis (ALS). | 2014 | Curr. Med. Chem. | pmid:25005187 |
Smirnova L et al. | MicroRNA profiling as tool for in vitro developmental neurotoxicity testing: the case of sodium valproate. | 2014 | PLoS ONE | pmid:24896083 |
He G et al. | Inhibition of autophagy induced by TSA sensitizes colon cancer cell to radiation. | 2014 | Tumour Biol. | pmid:24122231 |
Palii CG et al. | Trichostatin A enhances vascular repair by injected human endothelial progenitors through increasing the expression of TAL1-dependent genes. | 2014 | Cell Stem Cell | pmid:24792117 |
Soler E and Grosveld F | Targeting epigenetics to speed up repair. | 2014 | Cell Stem Cell | pmid:24792110 |
Poplutz MK et al. | Regulation of the Interleukin-6 gene expression during monocytic differentiation of HL-60 cells by chromatin remodeling and methylation. | 2014 | Immunobiology | pmid:24746556 |
Rafehi H et al. | Vascular histone deacetylation by pharmacological HDAC inhibition. | 2014 | Genome Res. | pmid:24732587 |
Mathiyalagan P et al. | The primary microRNA-208b interacts with Polycomb-group protein, Ezh2, to regulate gene expression in the heart. | 2014 | Nucleic Acids Res. | pmid:24137001 |
Hassan MK et al. | Histone deacetylase inhibitors sensitize lung cancer cells to hyperthermia: involvement of Ku70/SirT-1 in thermo-protection. | 2014 | PLoS ONE | pmid:24728004 |
Drela K et al. | Low oxygen atmosphere facilitates proliferation and maintains undifferentiated state of umbilical cord mesenchymal stem cells in an hypoxia inducible factor-dependent manner. | 2014 | Cytotherapy | pmid:24726658 |
Zhu XJ et al. | Novel tumor-suppressor gene epidermal growth factor-containing fibulin-like extracellular matrix protein 1 is epigenetically silenced and associated with invasion and metastasis in human gastric cancer. | 2014 | Mol Med Rep | pmid:24718752 |
Tu CY et al. | Trichostatin A suppresses EGFR expression through induction of microRNA-7 in an HDAC-independent manner in lapatinib-treated cells. | 2014 | Biomed Res Int | pmid:24707474 |
Zhang YW et al. | Integrated analysis of DNA methylation and mRNA expression profiling reveals candidate genes associated with cisplatin resistance in non-small cell lung cancer. | 2014 | Epigenetics | pmid:24699858 |
Boyer JG et al. | Myogenic program dysregulation is contributory to disease pathogenesis in spinal muscular atrophy. | 2014 | Hum. Mol. Genet. | pmid:24691550 |
Deneberg S et al. | microRNA-34b/c on chromosome 11q23 is aberrantly methylated in chronic lymphocytic leukemia. | 2014 | Epigenetics | pmid:24686393 |
Zuo X et al. | Breast cancer cells are arrested at different phases of the cell cycle following the re-expression of ARHI. | 2014 | Oncol. Rep. | pmid:24676336 |
Song BS et al. | Valproic acid enhances early development of bovine somatic cell nuclear transfer embryos by alleviating endoplasmic reticulum stress. | 2014 | Reprod. Fertil. Dev. | pmid:23506644 |
Aune SE et al. | Selective inhibition of class I but not class IIb histone deacetylases exerts cardiac protection from ischemia reperfusion. | 2014 | J. Mol. Cell. Cardiol. | pmid:24632412 |
Bitman M et al. | Valproate activates ERK signaling pathway in primary human hepatocytes. | 2014 | Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub | pmid:23073524 |
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Xu S et al. | Cytostatic and apoptotic effects of DNMT and HDAC inhibitors in endometrial cancer cells. | 2014 | Curr. Pharm. Des. | pmid:23888960 |
Zou JY and Crews FT | Release of neuronal HMGB1 by ethanol through decreased HDAC activity activates brain neuroimmune signaling. | 2014 | PLoS ONE | pmid:24551070 |
Jin YX et al. | Histone deacetylase inhibitor trichostatin A affects porcine oocyte maturation in vitro. | 2014 | Reprod. Fertil. Dev. | pmid:23759302 |
Guilluy C et al. | Isolated nuclei adapt to force and reveal a mechanotransduction pathway in the nucleus. | 2014 | Nat. Cell Biol. | pmid:24609268 |
Fetahu IS et al. | Calcium-sensing receptor silencing in colorectal cancer is associated with promoter hypermethylation and loss of acetylation on histone 3. | 2014 | Int. J. Cancer | pmid:24691920 |
Kumar P et al. | Histone deacetylase inhibitors modulate the transcriptional regulation of guanylyl cyclase/natriuretic peptide receptor-a gene: interactive roles of modified histones, histone acetyltransferase, p300, AND Sp1. | 2014 | J. Biol. Chem. | pmid:24451378 |
Sathe A et al. | MicroRNA let-7f: a novel regulator of innate immune response in human endocervical cells. | 2014 | Am. J. Reprod. Immunol. | pmid:24405266 |
Varol N et al. | The epigenetically regulated effects of Wnt antagonists on the expression of genes in the apoptosis pathway in human bladder cancer cell line (T24). | 2014 | DNA Cell Biol. | pmid:24665856 |
Wisnieski F et al. | Differential expression of histone deacetylase and acetyltransferase genes in gastric cancer and their modulation by trichostatin A. | 2014 | Tumour Biol. | pmid:24668547 |
Yan YE et al. | Prenatal nicotinic exposure suppresses fetal adrenal steroidogenesis via steroidogenic factor 1 (SF-1) deacetylation. | 2014 | Toxicol. Appl. Pharmacol. | pmid:24709674 |
Cherry KE et al. | Identification of Tf1 integration events in S. pombe under nonselective conditions. | 2014 | Gene | pmid:24680781 |
Yang J et al. | PTEN methylation involved in benzene-induced hematotoxicity. | 2014 | Exp. Mol. Pathol. | pmid:24680972 |
Karki P et al. | Yin Yang 1 is a repressor of glutamate transporter EAAT2, and it mediates manganese-induced decrease of EAAT2 expression in astrocytes. | 2014 | Mol. Cell. Biol. | pmid:24469401 |
Serrat N et al. | The response of secondary genes to lipopolysaccharides in macrophages depends on histone deacetylase and phosphorylation of C/EBPβ. | 2014 | J. Immunol. | pmid:24307736 |
Hou SY et al. | Expressions of MAGE-A9 and MAGE-A11 in breast cancer and their expression mechanism. | 2014 | Arch. Med. Res. | pmid:24316396 |
Johnson JL et al. | The desmosomal protein desmoglein 1 aids recovery of epidermal differentiation after acute UV light exposure. | 2014 | J. Invest. Dermatol. | pmid:24594668 |
Chu Y et al. | Chromatin composition alterations and the critical role of MeCP2 for epigenetic silencing of progesterone receptor-B gene in endometrial cancers. | 2014 | Cell. Mol. Life Sci. | pmid:24531693 |
Herr MJ et al. | Tetraspanin CD9 modulates human lymphoma cellular proliferation via histone deacetylase activity. | 2014 | Biochem. Biophys. Res. Commun. | pmid:24747564 |
Reeves ME et al. | Evidence that RASSF1C stimulation of lung cancer cell proliferation depends on IGFBP-5 and PIWIL1 expression levels. | 2014 | PLoS ONE | pmid:25007054 |
Cheng X et al. | Generation and characterization of gsuα:EGFP transgenic zebrafish for evaluating endocrine-disrupting effects. | 2014 | Toxicol. Appl. Pharmacol. | pmid:24747804 |
Guo J et al. | Effect of 5-aza-2'-deoxycytidine combined with trichostatin A on RPMI-8226 cell proliferation, apoptosis and DLC-1 gene expression. | 2014 | Zhongguo Shi Yan Xue Ye Xue Za Zhi | pmid:24763005 |
Holownia A et al. | Histone acetylation and arachidonic acid cytotoxicity in HepG2 cells overexpressing CYP2E1. | 2014 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:24287576 |
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