Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Lam YM et al. | Histone deacetylase inhibitors induce leukemia gene expression in cord blood hematopoietic stem cells expanded ex vivo. | 2017 | Int. J. Hematol. | pmid:27531147 |
Scholpa NE et al. | Nephrotoxicity of epigenetic inhibitors used for the treatment of cancer. | 2016 | Chem. Biol. Interact. | pmid:27543423 |
Vargas-López V et al. | Histone deacetylase inhibition abolishes stress-induced spatial memory impairment. | 2016 | Neurobiol Learn Mem | pmid:27544851 |
Zhang XF et al. | Trichostatin A Enhances the Apoptotic Potential of Palladium Nanoparticles in Human Cervical Cancer Cells. | 2016 | Int J Mol Sci | pmid:27548148 |
Sugiyama KI et al. | Epigenetic mutagen as histone modulator can be detected by yeast flocculation. | 2016 | Mutagenesis | pmid:27549112 |
DÃaz-Núñez M et al. | Histone deacetylase inhibitors induce invasion of human melanoma cells in vitro via differential regulation of N-cadherin expression and RhoA activity. | 2016 | BMC Cancer | pmid:27549189 |
Duffy S et al. | Overexpression screens identify conserved dosage chromosome instability genes in yeast and human cancer. | 2016 | Proc. Natl. Acad. Sci. U.S.A. | pmid:27551064 |
Kotantaki P and Mosialos G | The expression of tumor suppressor gene Cyld is upregulated by histone deacetylace inhibitors in human hepatocellular carcinoma cell lines. | 2016 | Cell Biochem. Funct. | pmid:27570065 |
Ho TT et al. | Transient resistance to DNA damaging agents is associated with expression of microRNAs-135b and -196b in human leukemia cell lines. | 2016 | Int J Biochem Mol Biol | pmid:27570640 |
Park IH et al. | Trichostatin A Inhibits Epithelial Mesenchymal Transition Induced by TGF-β1 in Airway Epithelium. | 2016 | PLoS ONE | pmid:27571418 |
Tiper IV and Webb TJ | Histone deacetylase inhibitors enhance CD1d-dependent NKT cell responses to lymphoma. | 2016 | Cancer Immunol. Immunother. | pmid:27614429 |
Desjardins D et al. | Histone Deacetylase Inhibition Restores Retinal Pigment Epithelium Function in Hyperglycemia. | 2016 | PLoS ONE | pmid:27617745 |
Zhang Q et al. | Trichostatin A protects against intestinal injury in rats with acute liver failure. | 2016 | J. Surg. Res. | pmid:27620992 |
Chen W et al. | MicroRNA-455-3p modulates cartilage development and degeneration through modification of histone H3 acetylation. | 2016 | Biochim. Biophys. Acta | pmid:27638301 |
Xu Q et al. | Changes in cardiac Nav1.5 expression, function, and acetylation by pan-histone deacetylase inhibitors. | 2016 | Am. J. Physiol. Heart Circ. Physiol. | pmid:27638876 |
Tao W et al. | Histone deacetylase inhibitor-induced emergence of synaptic δ-opioid receptors and behavioral antinociception in persistent neuropathic pain. | 2016 | Neuroscience | pmid:27646288 |
Sobue S et al. | Mechanism of paclitaxel resistance in a human prostate cancer cell line, PC3-PR, and its sensitization by cabazitaxel. | 2016 | Biochem. Biophys. Res. Commun. | pmid:27687545 |
Rong X et al. | Effects of histone acetylation on superoxide dismutase 1 gene expression in the pathogenesis of senile cataract. | 2016 | Sci Rep | pmid:27703255 |
Ladrech S et al. | High mobility group box 1 (HMGB1): dual functions in the cochlear auditory neurons in response to stress? | 2017 | Histochem. Cell Biol. | pmid:27704212 |
Hrgovic I et al. | The histone deacetylase inhibitor trichostatin a decreases lymphangiogenesis by inducing apoptosis and cell cycle arrest via p21-dependent pathways. | 2016 | BMC Cancer | pmid:27716272 |
Morinobu A et al. | Expression and Functions of Immediate Early Response Gene X-1 (IEX-1) in Rheumatoid Arthritis Synovial Fibroblasts. | 2016 | PLoS ONE | pmid:27736946 |
Wisnieski F et al. | BMP8B Is a Tumor Suppressor Gene Regulated by Histone Acetylation in Gastric Cancer. | 2017 | J. Cell. Biochem. | pmid:27748538 |
Nadanaka S et al. | Histone deacetylase-mediated regulation of chondroitin 4-O-sulfotransferase-1 (Chst11) gene expression by Wnt/β-catenin signaling. | 2016 | Biochem. Biophys. Res. Commun. | pmid:27751852 |
Unruhe-Knauf B and Knauer SK | Analysis of HDACi-Induced Changes in Chromosomal Passenger Complex Localization. | 2017 | Methods Mol. Biol. | pmid:27761812 |
Buchou T et al. | Purification and Analysis of Male Germ Cells from Adult Mouse Testis. | 2017 | Methods Mol. Biol. | pmid:27761820 |
Pinz S and Rascle A | Assessing HDAC Function in the Regulation of Signal Transducer and Activator of Transcription 5 (STAT5) Activity Using Chromatin Immunoprecipitation (ChIP). | 2017 | Methods Mol. Biol. | pmid:27761827 |
Staberg M et al. | Inhibition of histone deacetylases sensitizes glioblastoma cells to lomustine. | 2017 | Cell Oncol (Dordr) | pmid:27766591 |
Bauer I et al. | A Class 1 Histone Deacetylase with Potential as an Antifungal Target. | 2016 | MBio | pmid:27803184 |
Zapletal O et al. | Butyrate alters expression of cytochrome P450 1A1 and metabolism of benzo[a]pyrene via its histone deacetylase activity in colon epithelial cell models. | 2017 | Arch. Toxicol. | pmid:27830268 |
Tombolan L et al. | Global DNA methylation profiling uncovers distinct methylation patterns of protocadherin alpha4 in metastatic and non-metastatic rhabdomyosarcoma. | 2016 | BMC Cancer | pmid:27842508 |
Choi SA et al. | A novel histone deacetylase inhibitor, CKD5, has potent anti-cancer effects in glioblastoma. | 2017 | Oncotarget | pmid:27852054 |
Kim HR et al. | Aberrant Expression of TIMP-2 and PBEF Genes in the Placentae of Cloned Mice Due to Epigenetic Reprogramming Error. | 2016 | PLoS ONE | pmid:27855185 |
Huynh NC et al. | Histone deacetylase inhibition enhances in-vivo bone regeneration induced by human periodontal ligament cells. | 2017 | Bone | pmid:27871909 |
Deng Z et al. | Histone Deacetylase Inhibitor Trichostatin a Promotes the Apoptosis of Osteosarcoma Cells through p53 Signaling Pathway Activation. | 2016 | Int. J. Biol. Sci. | pmid:27877082 |
Jia L et al. | Trichostatin A increases radiosensitization of tongue squamous cell carcinoma via miR‑375. | 2017 | Oncol. Rep. | pmid:27878285 |
Bricambert J et al. | Impaired histone deacetylases 5 and 6 expression mimics the effects of obesity and hypoxia on adipocyte function. | 2016 | Mol Metab | pmid:27900262 |
Cipriano M et al. | The role of epigenetic modifiers in extended cultures of functional hepatocyte-like cells derived from human neonatal mesenchymal stem cells. | 2017 | Arch. Toxicol. | pmid:27909741 |
Takamatsu G et al. | Tescalcin is a potential target of class I histone deacetylase inhibitors in neurons. | 2017 | Biochem. Biophys. Res. Commun. | pmid:27939885 |
Mengel A et al. | Nitric Oxide Modulates Histone Acetylation at Stress Genes by Inhibition of Histone Deacetylases. | 2017 | Plant Physiol. | pmid:27980017 |
Aquea F et al. | Chemical inhibition of the histone acetyltransferase activity in Arabidopsis thaliana. | 2017 | Biochem. Biophys. Res. Commun. | pmid:27993678 |
Choiniere J et al. | Pyruvate Dehydrogenase Kinase 4 Deficiency Results in Expedited Cellular Proliferation through E2F1-Mediated Increase of Cyclins. | 2017 | Mol. Pharmacol. | pmid:28003426 |
Duan H et al. | The effect of histone deacetylase inhibition on the expression of P-glycoprotein in human placental trophoblast cell lines. | 2017 | Placenta | pmid:28012453 |
Mazzio EA and Soliman KF | HTP Nutraceutical Screening for Histone Deacetylase Inhibitors and Effects of HDACis on Tumor-suppressing miRNAs by Trichostatin A and Grapeseed (Vitis vinifera) in HeLa cells. | 2017 | Cancer Genomics Proteomics | pmid:28031235 |
Alqinyah M et al. | Regulator of G Protein Signaling 10 (Rgs10) Expression Is Transcriptionally Silenced in Activated Microglia by Histone Deacetylase Activity. | 2017 | Mol. Pharmacol. | pmid:28031332 |
Campo VA | Comparative effects of histone deacetylases inhibitors and resveratrol on Trypanosoma cruzi replication, differentiation, infectivity and gene expression. | 2017 | Int J Parasitol Drugs Drug Resist | pmid:28038431 |
Pachano T et al. | Epigenetics regulates transcription and pathogenesis in the parasite Trichomonas vaginalis. | 2017 | Cell. Microbiol. | pmid:28054438 |
Hichino A et al. | Down-regulation of Claudin-2 Expression and Proliferation by Epigenetic Inhibitors in Human Lung Adenocarcinoma A549 Cells. | 2017 | J. Biol. Chem. | pmid:28057758 |
Chen L et al. | PI3K/mTOR dual inhibitor BEZ235 and histone deacetylase inhibitor Trichostatin A synergistically exert anti-tumor activity in breast cancer. | 2017 | Oncotarget | pmid:28060760 |
Cao Z et al. | TSA and BIX-01294 Induced Normal DNA and Histone Methylation and Increased Protein Expression in Porcine Somatic Cell Nuclear Transfer Embryos. | 2017 | PLoS ONE | pmid:28114389 |
Wang XJ et al. | Opposing Roles of Acetylation and Phosphorylation in LIFR-Dependent Self-Renewal Growth Signaling in Mouse Embryonic Stem Cells. | 2017 | Cell Rep | pmid:28122243 |
Vanneste M et al. | Hyaluronate synthase-2 overexpression alters estrogen dependence and induces histone deacetylase inhibitor-like effects on ER-driven genes in MCF7 breast tumor cells. | 2017 | Mol. Cell. Endocrinol. | pmid:28137613 |
Gilardini Montani MS et al. | Histone deacetylase inhibitors VPA and TSA induce apoptosis and autophagy in pancreatic cancer cells. | 2017 | Cell Oncol (Dordr) | pmid:28160167 |
Trifunović D et al. | HDAC inhibition in the cpfl1 mouse protects degenerating cone photoreceptors in vivo. | 2016 | Hum. Mol. Genet. | pmid:28172811 |
Wu Y et al. | Suppression of Excessive Histone Deacetylases Activity in Diabetic Hearts Attenuates Myocardial Ischemia/Reperfusion Injury via Mitochondria Apoptosis Pathway. | 2017 | J Diabetes Res | pmid:28191472 |
Li LF et al. | Trichostatin A attenuates ventilation-augmented epithelial-mesenchymal transition in mice with bleomycin-induced acute lung injury by suppressing the Akt pathway. | 2017 | PLoS ONE | pmid:28234968 |
Lin S et al. | Silencing of ATP4B of ATPase H/K Transporting Beta Subunit by Intragenic Epigenetic Alteration in Human Gastric Cancer Cells. | 2017 | Oncol. Res. | pmid:28281974 |
Ikeda K et al. | In vitro drug testing based on contractile activity of C2C12 cells in an epigenetic drug model. | 2017 | Sci Rep | pmid:28300163 |
Chang YW and Singh KP | Long-term exposure to estrogen enhances chemotherapeutic efficacy potentially through epigenetic mechanism in human breast cancer cells. | 2017 | PLoS ONE | pmid:28323900 |
Kim YH and Lee JK | Histone deacetylase inhibitors suppress immature dendritic cell's migration by regulating CC chemokine receptor 1 expression. | 2017 | Cell. Immunol. | pmid:28341057 |
Xie C et al. | In vitro analysis of factors influencing expression as potential determinants of interindividual variation. | 2017 | Pharmacol Res Perspect | pmid:28357125 |
Shao G et al. | Inactivation of EGFR/AKT signaling enhances TSA-induced ovarian cancer cell differentiation. | 2017 | Oncol. Rep. | pmid:28393191 |
Anderson L et al. | Histone deacetylase inhibition modulates histone acetylation at gene promoter regions and affects genome-wide gene transcription in Schistosoma mansoni. | 2017 | PLoS Negl Trop Dis | pmid:28406899 |
Lin W et al. | Klotho restoration via acetylation of Peroxisome Proliferation-Activated Receptor γ reduces the progression of chronic kidney disease. | 2017 | Kidney Int. | pmid:28416226 |
Golfier S et al. | High-throughput cell mechanical phenotyping for label-free titration assays of cytoskeletal modifications. | 2017 | Cytoskeleton (Hoboken) | pmid:28445605 |
Acun T et al. | HLJ1 (DNAJB4) Gene Is a Novel Biomarker Candidate in Breast Cancer. | 2017 | OMICS | pmid:28481734 |
Wei W et al. | Class I histone deacetylases are major histone decrotonylases: evidence for critical and broad function of histone crotonylation in transcription. | 2017 | Cell Res. | pmid:28497810 |
Kudo K et al. | Biosynthetic Origin of the Hydroxamic Acid Moiety of Trichostatin A: Identification of Unprecedented Enzymatic Machinery Involved in Hydroxylamine Transfer. | 2017 | J. Am. Chem. Soc. | pmid:28497964 |
Anantharaju PG et al. | Naturally occurring benzoic acid derivatives retard cancer cell growth by inhibiting histone deacetylases (HDAC). | 2017 | Cancer Biol. Ther. | pmid:28506198 |
Duan HY et al. | Effect of Histone Deacetylase Inhibition on the Expression of Multidrug Resistance-associated Protein 2 in a Human Placental Trophoblast Cell Line. | 2017 | Chin. Med. J. | pmid:28524836 |
Pandey P et al. | Dynamics of post-translationally modified histones during barley pollen embryogenesis in the presence or absence of the epi-drug trichostatin A. | 2017 | Plant Reprod | pmid:28526911 |
Ilicic M et al. | Modulation of Progesterone Receptor Isoform Expression in Pregnant Human Myometrium. | 2017 | Biomed Res Int | pmid:28540297 |
Yeakley JM et al. | A trichostatin A expression signature identified by TempO-Seq targeted whole transcriptome profiling. | 2017 | PLoS ONE | pmid:28542535 |
Gurgul A et al. | The effect of histone deacetylase inhibitor trichostatin A on porcine mesenchymal stem cell transcriptome. | 2017 | Biochimie | pmid:28552396 |
Hou X et al. | HDAC inhibitor TSA ameliorates mechanical hypersensitivity and potentiates analgesic effect of morphine in a rat model of bone cancer pain by restoring μ-opioid receptor in spinal cord. | 2017 | Brain Res. | pmid:28559159 |
Opiela J et al. | In vitro development and cytological quality of inter-species (porcine→bovine) cloned embryos are affected by trichostatin A-dependent epigenomic modulation of adult mesenchymal stem cells. | 2017 | Theriogenology | pmid:28583605 |
Bouzelfen A et al. | Heterogeneous epigenetic regulation of HACE1 in Burkitt- Lymphoma-derived cells. | 2017 | Leuk. Res. | pmid:28651105 |
Jih G et al. | Unique roles for histone H3K9me states in RNAi and heritable silencing of transcription. | 2017 | Nature | pmid:28682306 |
Pérez-Garrastachu M et al. | Nucleoporins redistribute inside the nucleus after cell cycle arrest induced by histone deacetylases inhibition. | 2017 | Nucleus | pmid:28696859 |
Wang SC et al. | Trichostatin A induces bladder cancer cell death via intrinsic apoptosis at the early phase and Sp1‑survivin downregulation at the late phase of treatment. | 2017 | Oncol. Rep. | pmid:28713892 |
Jayaraman A et al. | The epigenetic drug Trichostatin A ameliorates experimental autoimmune encephalomyelitis via T cell tolerance induction and impaired influx of T cells into the spinal cord. | 2017 | Neurobiol. Dis. | pmid:28736194 |
Green AL et al. | Valproate increases dopamine transporter expression through histone acetylation and enhanced promoter binding of Nurr1. | 2017 | Neuropharmacology | pmid:28743636 |
Jorstad NL et al. | Stimulation of functional neuronal regeneration from Müller glia in adult mice. | 2017 | Nature | pmid:28746305 |
Jiang F et al. | Trichostatin A increases embryo and green plant regeneration in wheat. | 2017 | Plant Cell Rep. | pmid:28752355 |
Ngwa CJ et al. | Transcriptional Profiling Defines Histone Acetylation as a Regulator of Gene Expression during Human-to-Mosquito Transmission of the Malaria Parasite . | 2017 | Front Cell Infect Microbiol | pmid:28791254 |
Simões-Pires CA et al. | Simultaneous Measurement of HDAC1 and HDAC6 Activity in HeLa Cells Using UHPLC-MS. | 2017 | J Vis Exp | pmid:28829415 |
Tao LL et al. | TSA increases C/EBP‑α expression by increasing its lysine acetylation in hepatic stellate cells. | 2017 | Mol Med Rep | pmid:28849174 |
Guo Y et al. | Trichostatin A attenuates oxidative stress-mediated myocardial injury through the FoxO3a signaling pathway. | 2017 | Int. J. Mol. Med. | pmid:28849190 |
Fujikawa J et al. | Kruppel-like factor 4 regulates matrix metalloproteinase and aggrecanase gene expression in chondrocytes. | 2017 | Cell Tissue Res. | pmid:28856432 |
Zheng C et al. | Histone Deacetylase Inhibitors Relax Mouse Aorta Partly through Their Inhibitory Action on L-Type Ca Channels. | 2017 | J. Pharmacol. Exp. Ther. | pmid:28860353 |
Shin S et al. | Trichostatin A Sensitizes Hepatocellular Carcinoma Cells to Enhanced NK Cell-mediated Killing by Regulating Immune-related Genes. | Cancer Genomics Proteomics | pmid:28871002 | |
Buishand FO et al. | Trichostatin A preferentially reverses the upregulation of gene-expression levels induced by gain of chromosome 7 in colorectal cancer cell lines. | 2018 | Genes Chromosomes Cancer | pmid:28940826 |
Zhang C et al. | An epigenetic bioactive composite scaffold with well-aligned nanofibers for functional tendon tissue engineering. | 2018 | Acta Biomater | pmid:28963019 |
Wei ZQ et al. | Curcumin inhibits hepatitis B virus infection by down-regulating cccDNA-bound histone acetylation. | 2017 | World J. Gastroenterol. | pmid:28974891 |
Nagaraja SS et al. | Effect of Trichostatin A on radiation induced epithelial-mesenchymal transition in A549Â cells. | 2017 | Biochem. Biophys. Res. Commun. | pmid:28993195 |
Song Y et al. | Trichostatin A and 5-Aza-2'-Deoxycytidine influence the expression of cold-induced genes in Arabidopsis. | 2017 | Plant Signal Behav | pmid:29027833 |
Androutsopoulos VP and Spandidos DA | Antiproliferative effects of TSA, PXD‑101 and MS‑275 in A2780 and MCF7 cells: Acetylated histone H4 and acetylated tubulin as markers for HDACi potency and selectivity. | 2017 | Oncol. Rep. | pmid:29039546 |
Zhang Z et al. | Role of histone acetylation in activation of nuclear factor erythroid 2-related factor 2/heme oxygenase 1 pathway by manganese chloride. | 2017 | Toxicol. Appl. Pharmacol. | pmid:29054681 |
Hartl M et al. | Lysine acetylome profiling uncovers novel histone deacetylase substrate proteins in . | 2017 | Mol. Syst. Biol. | pmid:29061669 |
Xing M et al. | Histone deacetylase inhibitor stimulates E2 and P4 secretion in sika deer ovarian granulosa cells at a moderate dose. | 2018 | Cell Biol. Int. | pmid:29064603 |
Ma T et al. | Suppression of BMP-7 by histone deacetylase 2 promoted apoptosis of renal tubular epithelial cells in acute kidney injury. | 2017 | Cell Death Dis | pmid:29072686 |