Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Sanyal S et al. | Differential regulation of the orphan nuclear receptor small heterodimer partner (SHP) gene promoter by orphan nuclear receptor ERR isoforms. | 2002 | J. Biol. Chem. | pmid:11705994 |
Inoue H et al. | Histone deacetylase inhibitors sensitize human colonic adenocarcinoma cell lines to TNF-related apoptosis inducing ligand-mediated apoptosis. | 2002 | Int. J. Mol. Med. | pmid:11956660 |
Galasinski SC et al. | Global regulation of post-translational modifications on core histones. | 2002 | J. Biol. Chem. | pmid:11709551 |
Sawa H et al. | Histone deacetylase inhibitors such as sodium butyrate and trichostatin A inhibit vascular endothelial growth factor (VEGF) secretion from human glioblastoma cells. | 2002 | Brain Tumor Pathol | pmid:12622137 |
Suzuki-Mizushima Y et al. | Enhancement of NGF- and cholera toxin-induced neurite outgrowth by butyrate in PC12 cells. | 2002 | Brain Res. | pmid:12270499 |
Boutillier AL et al. | Constitutive repression of E2F1 transcriptional activity through HDAC proteins is essential for neuronal survival. | 2002 | Ann. N. Y. Acad. Sci. | pmid:12485907 |
Zarnegar R et al. | Increasing the effectiveness of radioactive iodine therapy in the treatment of thyroid cancer using Trichostatin A, a histone deacetylase inhibitor. | 2002 | Surgery | pmid:12490845 |
Chen T et al. | Histone acetylation is involved in hsp70 gene transcription regulation in Drosophila melanogaster. | 2002 | Arch. Biochem. Biophys. | pmid:12464268 |
Rombouts K et al. | Actin filament formation, reorganization and migration are impaired in hepatic stellate cells under influence of trichostatin A, a histone deacetylase inhibitor. | 2002 | J. Hepatol. | pmid:12445420 |
Drewell RA et al. | Methylation-dependent silencing at the H19 imprinting control region by MeCP2. | 2002 | Nucleic Acids Res. | pmid:11861904 |
Murphy JC et al. | Control of cytomegalovirus lytic gene expression by histone acetylation. | 2002 | EMBO J. | pmid:11867539 |
Gregory RI et al. | Inhibition of histone deacetylases alters allelic chromatin conformation at the imprinted U2af1-rs1 locus in mouse embryonic stem cells. | 2002 | J. Biol. Chem. | pmid:11821379 |
Lim Y et al. | Trichostatin A-induced detransformation correlates with decreased focal adhesion kinase phosphorylation at tyrosine 861 in ras-transformed fibroblasts. | 2002 | J. Biol. Chem. | pmid:11821402 |
Yamashita K et al. | Pharmacologic unmasking of epigenetically silenced tumor suppressor genes in esophageal squamous cell carcinoma. | 2002 | Cancer Cell | pmid:12498717 |
Fahrner JA et al. | Dependence of histone modifications and gene expression on DNA hypermethylation in cancer. | 2002 | Cancer Res. | pmid:12499261 |
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Cabral AL et al. | Regulation of the cellular prion protein gene expression depends on chromatin conformation. | 2002 | J. Biol. Chem. | pmid:11739375 |
Park SH et al. | Transcriptional regulation of the transforming growth factor beta type II receptor gene by histone acetyltransferase and deacetylase is mediated by NF-Y in human breast cancer cells. | 2002 | J. Biol. Chem. | pmid:11744689 |
Suenaga M et al. | Histone deacetylase inhibitors suppress telomerase reverse transcriptase mRNA expression in prostate cancer cells. | 2002 | Int. J. Cancer | pmid:11807787 |
Gurova KV et al. | Expression of prostate specific antigen (PSA) is negatively regulated by p53. | 2002 | Oncogene | pmid:11791186 |
Maeda Y et al. | Repression of hepatocyte nuclear factor 4alpha tumor suppressor p53: involvement of the ligand-binding domain and histone deacetylase activity. | 2002 | Mol. Endocrinol. | pmid:11818510 |
Singal R et al. | Methylation of promoter proximal-transcribed sequences of an embryonic globin gene inhibits transcription in primary erythroid cells and promotes formation of a cell type-specific methyl cytosine binding complex. | 2002 | J. Biol. Chem. | pmid:11684679 |
Bordonaro M et al. | Cell type- and promoter-dependent modulation of the Wnt signaling pathway by sodium butyrate. | 2002 | Int. J. Cancer | pmid:11774242 |
Kikuchi T et al. | Aberrant methylation and histone deacetylation of cyclooxygenase 2 in gastric cancer. | 2002 | Int. J. Cancer | pmid:11774276 |
Ventura A et al. | The p66Shc longevity gene is silenced through epigenetic modifications of an alternative promoter. | 2002 | J. Biol. Chem. | pmid:11948181 |
Gradoville L et al. | Protein kinase C-independent activation of the Epstein-Barr virus lytic cycle. | 2002 | J. Virol. | pmid:11991990 |
Uesato S et al. | Novel histone deacetylase inhibitors: N-hydroxycarboxamides possessing a terminal bicyclic aryl group. | 2002 | Bioorg. Med. Chem. Lett. | pmid:11992774 |
Nambiar MP et al. | Effect of trichostatin A on human T cells resembles signaling abnormalities in T cells of patients with systemic lupus erythematosus: a new mechanism for TCR zeta chain deficiency and abnormal signaling. | 2002 | J. Cell. Biochem. | pmid:11967985 |
Fu M et al. | Androgen receptor acetylation governs trans activation and MEKK1-induced apoptosis without affecting in vitro sumoylation and trans-repression function. | 2002 | Mol. Cell. Biol. | pmid:11971970 |
Sirchia SM et al. | Endogenous reactivation of the RARbeta2 tumor suppressor gene epigenetically silenced in breast cancer. | 2002 | Cancer Res. | pmid:11980632 |
Milutinovic S et al. | Proliferating cell nuclear antigen associates with histone deacetylase activity, integrating DNA replication and chromatin modification. | 2002 | J. Biol. Chem. | pmid:11929879 |
Williams RS et al. | A common mechanism of action for three mood-stabilizing drugs. | 2002 | Nature | pmid:12015604 |
Veilleux S and Boissonneault G | Dynamics of reporter gene stimulation by HMG box proteins. | 2002 | DNA Cell Biol. | pmid:12015897 |
Huang HC et al. | Geldanamycin inhibits trichostatin A-induced cell death and histone H4 hyperacetylation in COS-7 cells. | 2002 | Life Sci. | pmid:12002521 |
Chiocca S et al. | Histone deacetylase 1 inactivation by an adenovirus early gene product. | 2002 | Curr. Biol. | pmid:11937030 |
Curradi M et al. | Molecular mechanisms of gene silencing mediated by DNA methylation. | 2002 | Mol. Cell. Biol. | pmid:11940673 |
Koyama N et al. | Differential effects of histone deacetylase inhibitors on interleukin-18 gene expression in myeloid cells. | 2002 | Biochem. Biophys. Res. Commun. | pmid:11944905 |
Zhang Y and Dufau ML | Silencing of transcription of the human luteinizing hormone receptor gene by histone deacetylase-mSin3A complex. | 2002 | J. Biol. Chem. | pmid:12091390 |
Danbara M et al. | DNA methylation dominates transcriptional silencing of Pax5 in terminally differentiated B cell lines. | 2002 | Mol. Immunol. | pmid:12044782 |
Lin HM et al. | Cyclin D1 Is a Ligand-independent Co-repressor for Thyroid Hormone Receptors. | 2002 | J. Biol. Chem. | pmid:12048199 |
Scott GK et al. | Transcriptional repression of ErbB2 by histone deacetylase inhibitors detected by a genomically integrated ErbB2 promoter-reporting cell screen. | 2002 | Mol. Cancer Ther. | pmid:12477051 |
Quivy V et al. | Synergistic activation of human immunodeficiency virus type 1 promoter activity by NF-kappaB and inhibitors of deacetylases: potential perspectives for the development of therapeutic strategies. | 2002 | J. Virol. | pmid:12368351 |
Smith WL and Edlind TD | Histone deacetylase inhibitors enhance Candida albicans sensitivity to azoles and related antifungals: correlation with reduction in CDR and ERG upregulation. | 2002 | Antimicrob. Agents Chemother. | pmid:12384361 |
Harada K et al. | Deregulation of caspase 8 and 10 expression in pediatric tumors and cell lines. | 2002 | Cancer Res. | pmid:12384554 |
Im H et al. | Histone deacetylase-dependent establishment and maintenance of broad low-level histone acetylation within a tissue-specific chromatin domain. | 2002 | Biochemistry | pmid:12484752 |
Zhang J et al. | Establishment of transcriptional competence in early and late S phase. | 2002 | Nature | pmid:12432398 |
Gong XQ and Li L | Dermo-1, a multifunctional basic helix-loop-helix protein, represses MyoD transactivation via the HLH domain, MEF2 interaction, and chromatin deacetylation. | 2002 | J. Biol. Chem. | pmid:11809751 |
Kostyniuk CL et al. | The ubiquitous and tissue specific promoters of the human SRC gene are repressed by inhibitors of histone deacetylases. | 2002 | Oncogene | pmid:12214274 |
Rössig L et al. | Inhibitors of histone deacetylation downregulate the expression of endothelial nitric oxide synthase and compromise endothelial cell function in vasorelaxation and angiogenesis. | 2002 | Circ. Res. | pmid:12411399 |
Hall IM et al. | Establishment and maintenance of a heterochromatin domain. | 2002 | Science | pmid:12215653 |
Lynch CA et al. | Reactivation of a silenced H19 gene in human rhabdomyosarcoma by demethylation of DNA but not by histone hyperacetylation. | 2002 | Mol. Cancer | pmid:12234381 |
Bereshchenko OR et al. | Acetylation inactivates the transcriptional repressor BCL6. | 2002 | Nat. Genet. | pmid:12402037 |
Chen Z et al. | Induction and superinduction of growth arrest and DNA damage gene 45 (GADD45) alpha and beta messenger RNAs by histone deacetylase inhibitors trichostatin A (TSA) and butyrate in SW620 human colon carcinoma cells. | 2002 | Cancer Lett. | pmid:12406558 |
Gálfi P et al. | Apoptosis sensitivity is not correlated with sensitivity to proliferation inhibition by the histone deacetylase inhibitors butyrate and TSA. | 2002 | Cancer Lett. | pmid:12406559 |
Hoshimoto A et al. | Caprylic acid and medium-chain triglycerides inhibit IL-8 gene transcription in Caco-2 cells: comparison with the potent histone deacetylase inhibitor trichostatin A. | 2002 | Br. J. Pharmacol. | pmid:12010777 |
Sourlingas TG et al. | The effect of the histone deacetylase inhibitor, trichostatin A, on total histone synthesis, H1(0) synthesis and histone H4 acetylation in peripheral blood lymphocytes increases as a function of increasing age: a model study. | 2002 Jan-Mar | Exp. Gerontol. | pmid:11772521 |
Iwata K et al. | Trichostatin A, a histone deacetylase inhibitor, down-regulates interleukin-12 transcription in SV-40-transformed lung epithelial cells. | 2002 Jul-Aug | Cell. Immunol. | pmid:12470611 |
Noss KR et al. | Methylation state of the prostate specific membrane antigen (PSMA) CpG island in prostate cancer cell lines. | 2002 May-Jun | Anticancer Res. | pmid:12168830 |
Rahman I et al. | Oxidative stress and TNF-alpha induce histone acetylation and NF-kappaB/AP-1 activation in alveolar epithelial cells: potential mechanism in gene transcription in lung inflammation. | 2002 May-Jun | Mol. Cell. Biochem. | pmid:12162440 |
Henderson C et al. | Role of caspases, Bid, and p53 in the apoptotic response triggered by histone deacetylase inhibitors trichostatin-A (TSA) and suberoylanilide hydroxamic acid (SAHA). | 2003 | J. Biol. Chem. | pmid:12556448 |
Rahman MM et al. | Two histone deacetylase inhibitors, trichostatin A and sodium butyrate, suppress differentiation into osteoclasts but not into macrophages. | 2003 | Blood | pmid:12511413 |
Musikacharoen T et al. | Histone acetylation and activation of cAMP-response element-binding protein regulate transcriptional activation of MKP-M in lipopolysaccharide-stimulated macrophages. | 2003 | J. Biol. Chem. | pmid:12511574 |
Gusterson RJ et al. | The transcriptional co-activators CREB-binding protein (CBP) and p300 play a critical role in cardiac hypertrophy that is dependent on their histone acetyltransferase activity. | 2003 | J. Biol. Chem. | pmid:12477714 |
James SY et al. | Regulation of retinoic acid receptor beta expression by peroxisome proliferator-activated receptor gamma ligands in cancer cells. | 2003 | Cancer Res. | pmid:12839938 |
Nambu Y et al. | Transcription-coupled events associating with immunoglobulin switch region chromatin. | 2003 | Science | pmid:14684824 |
Haggarty SJ et al. | Small molecule modulation of the human chromatid decatenation checkpoint. | 2003 | Chem. Biol. | pmid:14700634 |
Kim DK et al. | Synthesis and biological evaluation of 3-(4-substituted-phenyl)-N-hydroxy-2-propenamides, a new class of histone deacetylase inhibitors. | 2003 | J. Med. Chem. | pmid:14667227 |
Huang H et al. | Expression of P53, P21 in human lung adenocarcinoma A549 cell strains under hypoxia conditions and the effect of TSA on their expression. | 2003 | J. Huazhong Univ. Sci. Technol. Med. Sci. | pmid:15015635 |
Cho B et al. | Promoter hypomethylation of a novel cancer/testis antigen gene CAGE is correlated with its aberrant expression and is seen in premalignant stage of gastric carcinoma. | 2003 | Biochem. Biophys. Res. Commun. | pmid:12849980 |
Massillon D et al. | Regulation of glucose-6-phosphatase gene expression in cultured hepatocytes and H4IIE cells by short-chain fatty acids: role of hepatic nuclear factor-4alpha. | 2003 | J. Biol. Chem. | pmid:12915406 |
Hong CY et al. | Expression of MIS in the testis is downregulated by tumor necrosis factor alpha through the negative regulation of SF-1 transactivation by NF-kappa B. | 2003 | Mol. Cell. Biol. | pmid:12917325 |
Le Masson I et al. | Yaf9, a novel NuA4 histone acetyltransferase subunit, is required for the cellular response to spindle stress in yeast. | 2003 | Mol. Cell. Biol. | pmid:12917332 |
Zhong S et al. | Phosphorylation at serine 28 and acetylation at lysine 9 of histone H3 induced by trichostatin A. | 2003 | Oncogene | pmid:12917630 |
Xu Y et al. | SHP-1 sensitizes MCF-7 cells to trichostatin A-induced apoptosis by modulating PI3K-dependent events. | 2003 | Cell Death Differ. | pmid:14502244 |
Donadelli M et al. | Trichostatin A, an inhibitor of histone deacetylases, strongly suppresses growth of pancreatic adenocarcinoma cells. | 2003 | Mol. Carcinog. | pmid:14502645 |
Tominaga K et al. | MRGX is a novel transcriptional regulator that exhibits activation or repression of the B-myb promoter in a cell type-dependent manner. | 2003 | J. Biol. Chem. | pmid:14506250 |
Kawai H et al. | Overexpression of histone deacetylase HDAC1 modulates breast cancer progression by negative regulation of estrogen receptor alpha. | 2003 | Int. J. Cancer | pmid:14506733 |
Méndez-Pertuz M et al. | The thyroid hormone receptor antagonizes CREB-mediated transcription. | 2003 | EMBO J. | pmid:12805224 |
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Bhakat KK and Mitra S | CpG methylation-dependent repression of the human O6-methylguanine-DNA methyltransferase gene linked to chromatin structure alteration. | 2003 | Carcinogenesis | pmid:12807730 |
Lopatina NG et al. | Control mechanisms in the regulation of telomerase reverse transcriptase expression in differentiating human teratocarcinoma cells. | 2003 | Biochem. Biophys. Res. Commun. | pmid:12810068 |
Liu LT et al. | Histone deacetylase inhibitor up-regulates RECK to inhibit MMP-2 activation and cancer cell invasion. | 2003 | Cancer Res. | pmid:12810630 |
Shin HJ et al. | Inhibition of histone deacetylase activity increases chromosomal instability by the aberrant regulation of mitotic checkpoint activation. | 2003 | Oncogene | pmid:12813458 |
Mai A et al. | Discovery of (aryloxopropenyl)pyrrolyl hydroxyamides as selective inhibitors of class IIa histone deacetylase homologue HD1-A. | 2003 | J. Med. Chem. | pmid:14584932 |
Pace BS et al. | p38 MAP kinase activation mediates gamma-globin gene induction in erythroid progenitors. | 2003 | Exp. Hematol. | pmid:14585374 |
Shteper PJ et al. | Role of promoter methylation in regulation of the mammalian heparanase gene. | 2003 | Oncogene | pmid:14586400 |
Hirose T et al. | p53-independent induction of Gadd45 by histone deacetylase inhibitor: coordinate regulation by transcription factors Oct-1 and NF-Y. | 2003 | Oncogene | pmid:14586402 |
Hinoi T et al. | Silencing of CDX2 expression in colon cancer via a dominant repression pathway. | 2003 | J. Biol. Chem. | pmid:12947088 |
Nakano M et al. | Epigenetic assembly of centromeric chromatin at ectopic alpha-satellite sites on human chromosomes. | 2003 | J. Cell. Sci. | pmid:12953060 |
Kim EJ et al. | Identification of Daxx interacting with p73, one of the p53 family, and its regulation of p53 activity by competitive interaction with PML. | 2003 | Nucleic Acids Res. | pmid:12954772 |
Brugarolas JB et al. | TSC2 regulates VEGF through mTOR-dependent and -independent pathways. | 2003 | Cancer Cell | pmid:12957289 |
Cimini D et al. | Histone hyperacetylation in mitosis prevents sister chromatid separation and produces chromosome segregation defects. | 2003 | Mol. Biol. Cell | pmid:12972566 |
Schuettengruber B et al. | Autoregulation of mouse histone deacetylase 1 expression. | 2003 | Mol. Cell. Biol. | pmid:12972616 |
Yang Y et al. | The histone code regulating expression of the imprinted mouse Igf2r gene. | 2003 | Endocrinology | pmid:12975326 |
Kagoshima M et al. | Glucocorticoid suppression of nuclear factor-kappa B: a role for histone modifications. | 2003 | Biochem. Soc. Trans. | pmid:12546654 |
Bhat RA et al. | Alteration of GCN5 levels in maize reveals dynamic responses to manipulating histone acetylation. | 2003 | Plant J. | pmid:12581304 |
Jang IC et al. | Structure and expression of the rice class-I type histone deacetylase genes OsHDAC1-3: OsHDAC1 overexpression in transgenic plants leads to increased growth rate and altered architecture. | 2003 | Plant J. | pmid:12581311 |
Bouchain G et al. | Development of potential antitumor agents. Synthesis and biological evaluation of a new set of sulfonamide derivatives as histone deacetylase inhibitors. | 2003 | J. Med. Chem. | pmid:12593661 |
Castro-Galache MD et al. | Susceptibility of multidrug resistance tumor cells to apoptosis induction by histone deacetylase inhibitors. | 2003 | Int. J. Cancer | pmid:12594812 |
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