trichostatin A

Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.

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Introduction

To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with trichostatin A?

trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with trichostatin A

MeSH term MeSH ID Detail
Melanoma D008545 69 associated lipids
Medulloblastoma D008527 22 associated lipids
Mammary Neoplasms, Experimental D008325 67 associated lipids
Lymphoma, Follicular D008224 3 associated lipids
Lymphatic Metastasis D008207 10 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Lupus Vulgaris D008177 1 associated lipids
Lung Neoplasms D008175 171 associated lipids
Liver Cirrhosis D008103 67 associated lipids
Leukemia, Myeloid D007951 52 associated lipids
Leukemia D007938 74 associated lipids
Leishmaniasis D007896 19 associated lipids
Keloid D007627 12 associated lipids
Chromosome Inversion D007446 1 associated lipids
Inflammation D007249 119 associated lipids
Immunologic Deficiency Syndromes D007153 8 associated lipids
Hypesthesia D006987 1 associated lipids
Hypertension, Pulmonary D006976 32 associated lipids
Hypertension D006973 115 associated lipids
Hypersensitivity D006967 22 associated lipids
Per page 10 20 50 100 | Total 139

PubChem Associated disorders and diseases

What pathways are associated with trichostatin A

Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with trichostatin A?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with trichostatin A?


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Function Cross reference Weighted score Related literatures

What lipids are associated with trichostatin A?

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Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with trichostatin A?

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Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with trichostatin A?

Mouse Model

Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).

Xenograft Model

Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).

Cancer Model

Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with trichostatin A

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Per page 10 20 50 100 | Total 3126
Authors Title Published Journal PubMed Link
Rhodes LV et al. The histone deacetylase inhibitor trichostatin A alters microRNA expression profiles in apoptosis-resistant breast cancer cells. 2012 Oncol. Rep. pmid:21971930
He D et al. Protocadherin8 is a functional tumor suppressor frequently inactivated by promoter methylation in nasopharyngeal carcinoma. 2012 Eur. J. Cancer Prev. pmid:22273848
Hosoya T et al. Trichostatin analogues JBIR-109, JBIR-110, and JBIR-111 from the marine sponge-derived Streptomyces sp. RM72. 2012 J. Nat. Prod. pmid:22276693
Sadoul K et al. HDAC6 controls the kinetics of platelet activation. 2012 Blood pmid:22955928
de Souza CF et al. Mining gene expression signature for the detection of pre-malignant melanocytes and early melanomas with risk for metastasis. 2012 PLoS ONE pmid:22984562
Yao J et al. ERK inhibition enhances TSA-induced gastric cancer cell apoptosis via NF-κB-dependent and Notch-independent mechanism. 2012 Life Sci. pmid:22781708
Cheng DD et al. Antitumor activity of histone deacetylase inhibitor trichostatin A in osteosarcoma cells. 2012 Asian Pac. J. Cancer Prev. pmid:22799338
Jung N et al. Pharmacological unmasking microarray approach-based discovery of novel DNA methylation markers for hepatocellular carcinoma. 2012 J. Korean Med. Sci. pmid:22690089
Nunes MJ et al. Okadaic acid inhibits the trichostatin A-mediated increase of human CYP46A1 neuronal expression in a ERK1/2-Sp3-dependent pathway. 2012 J. Lipid Res. pmid:22693257
Karolczak-Bayatti M et al. Expression of the GTP-binding protein Gαs in human myometrial cells is regulated by ubiquitination and protein degradation: involvement of proteasomal inhibition by trichostatin A. 2012 Reprod Sci pmid:22875848
Dehnugara T et al. An in vitro, short-term culture method for mammalian haploid round spermatids amenable for molecular manipulation. 2012 Mol. Reprod. Dev. pmid:21953649
Xie BT et al. [Telomere lengthening by trichostatin A treatment in cloned pigs]. 2012 Yi Chuan pmid:23262106
Mehdi O et al. HDAC gene expression in pancreatic tumor cell lines following treatment with the HDAC inhibitors panobinostat (LBH589) and trichostatine (TSA). 2012 Mar-Apr Pancreatology pmid:22487525
Guo X et al. Histone deacetylase inhibitors promote mice corneal allograft survival through alteration of CD4+ effector T cells and induction of Foxp3+ regulatory T cells. 2012 May-Jun Cell. Immunol. pmid:22776176
Hou W et al. Hypoxia-induced deacetylation is required for tetraploid differentiation in response to testicular ischemia-reperfusion (IR) injury. 2012 Nov-Dec J. Androl. pmid:22556385
Darlyuk-Saadon I et al. The bZIP repressor proteins, c-Jun dimerization protein 2 and activating transcription factor 3, recruit multiple HDAC members to the ATF3 promoter. 2012 Nov-Dec Biochim. Biophys. Acta pmid:22989952
Tang X et al. Protocadherin 10 is frequently downregulated by promoter methylation and functions as a tumor suppressor gene in non-small cell lung cancer. 2012-2013 Cancer Biomark pmid:23321465
Wilson DW et al. Defining the timing of action of antimalarial drugs against Plasmodium falciparum. 2013 Antimicrob. Agents Chemother. pmid:23318799
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Laska MJ et al. (Some) cellular mechanisms influencing the transcription of human endogenous retrovirus, HERV-Fc1. 2013 PLoS ONE pmid:23382858
Pelascini LP et al. Histone deacetylase inhibition activates transgene expression from integration-defective lentiviral vectors in dividing and non-dividing cells. 2013 Hum. Gene Ther. pmid:23140481
You BR and Park WH Trichostatin A induces apoptotic cell death of HeLa cells in a Bcl-2 and oxidative stress-dependent manner. 2013 Int. J. Oncol. pmid:23165748
Ogura A et al. Recent advancements in cloning by somatic cell nuclear transfer. 2013 Philos. Trans. R. Soc. Lond., B, Biol. Sci. pmid:23166393
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Su SF et al. miR-30d, miR-181a and miR-199a-5p cooperatively suppress the endoplasmic reticulum chaperone and signaling regulator GRP78 in cancer. 2013 Oncogene pmid:23085757
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Eriksson I et al. The histone deacetylase inhibitor trichostatin A reduces lysosomal pH and enhances cisplatin-induced apoptosis. 2013 Exp. Cell Res. pmid:23063877
Khan DH and Davie JR HDAC inhibitors prevent the induction of the immediate-early gene FOSL1, but do not alter the nucleosome response. 2013 FEBS Lett. pmid:23542037
Chen J et al. Prevention of cytotoxicity of nickel by quercetin: the role of reactive oxygen species and histone acetylation. 2013 Toxicol Ind Health pmid:22294440
Wang F et al. HDAC inhibitor trichostatin A suppresses esophageal squamous cell carcinoma metastasis through HADC2 reduced MMP-2/9. 2013 Clin Invest Med pmid:23544610
Poplineau M et al. Epigenetically induced changes in nuclear textural patterns and gelatinase expression in human fibrosarcoma cells. 2013 Cell Prolif. pmid:23510467
Ding SZ et al. Epithelial-mesenchymal transition during oncogenic transformation induced by hexavalent chromium involves reactive oxygen species-dependent mechanism in lung epithelial cells. 2013 Toxicol. Appl. Pharmacol. pmid:23518002
Azechi T et al. Trichostatin A, an HDAC class I/II inhibitor, promotes Pi-induced vascular calcification via up-regulation of the expression of alkaline phosphatase. 2013 J. Atheroscler. Thromb. pmid:23518467
Duncan HF et al. Histone deacetylase inhibitors epigenetically promote reparative events in primary dental pulp cells. 2013 Exp. Cell Res. pmid:23562654
Wang Y et al. Role of histone deacetylase inhibitors in the aging of human umbilical cord mesenchymal stem cells. 2013 J. Cell. Biochem. pmid:23564418
Höring E et al. The histone deacetylase inhibitor trichostatin a promotes apoptosis and antitumor immunity in glioblastoma cells. 2013 Anticancer Res. pmid:23564772
Chen CH et al. Synergistic effect of trichostatin A and scriptaid on the development of cloned rabbit embryos. 2013 Theriogenology pmid:23566670
Doherty R et al. Epigenetic regulation of the innate immune response to LPS in bovine peripheral blood mononuclear cells (PBMC). 2013 Vet. Immunol. Immunopathol. pmid:23764468
Liu J et al. Direct differentiation of hepatic stem-like WB cells into insulin-producing cells using small molecules. 2013 Sci Rep pmid:23378917
Shah RR et al. Regulation of primitive hematopoiesis by class I histone deacetylases. 2013 Dev. Dyn. pmid:23184530
Gao SM et al. Histone deacetylases inhibitor sodium butyrate inhibits JAK2/STAT signaling through upregulation of SOCS1 and SOCS3 mediated by HDAC8 inhibition in myeloproliferative neoplasms. 2013 Exp. Hematol. pmid:23111066
Liu RF et al. Down-regulation of miR-517a and miR-517c promotes proliferation of hepatocellular carcinoma cells via targeting Pyk2. 2013 Cancer Lett. pmid:23142219
Jang SM et al. Transcription factor Sox4 is required for PUMA-mediated apoptosis induced by histone deacetylase inhibitor, TSA. 2013 Biochem. Biophys. Res. Commun. pmid:23916609
Luo C et al. Treatment of donor cells with trichostatin A improves in vitro development and reprogramming of buffalo (Bubalus bubalis) nucleus transfer embryos. 2013 Theriogenology pmid:24007823
Lauffer BE et al. Histone deacetylase (HDAC) inhibitor kinetic rate constants correlate with cellular histone acetylation but not transcription and cell viability. 2013 J. Biol. Chem. pmid:23897821
Lu JC et al. Trichostatin A modulates thiazolidinedione-mediated suppression of tumor necrosis factor α-induced lipolysis in 3T3-L1 adipocytes. 2013 PLoS ONE pmid:23951179
Peng L et al. [Tricostantin A inhibits self-renewal of breast cancer stem cells in vitro]. 2013 Nan Fang Yi Ke Da Xue Xue Bao pmid:24144739
Chen X et al. The epigenetic modifier trichostatin A, a histone deacetylase inhibitor, suppresses proliferation and epithelial-mesenchymal transition of lens epithelial cells. 2013 Cell Death Dis pmid:24157878
Liu YQ et al. Identification of a novel human testicular interstitial gene, RNF148, and its expression regulated by histone deacetylases. 2013 Genet. Mol. Res. pmid:24089095
Florea AM DNA methylation pyrosequencing assay is applicable for the assessment of epigenetic active environmental or clinical relevant chemicals. 2013 Biomed Res Int pmid:24093099
Liu S et al. Up-regulation of miR-182 expression after epigenetic modulation of human melanoma cells. 2013 Ann. Surg. Oncol. pmid:22752337
Ononye SN et al. Tropolones as lead-like natural products: the development of potent and selective histone deacetylase inhibitors. 2013 ACS Med Chem Lett pmid:24900743
Feng L et al. Histone deacetylase 3 inhibits expression of PUMA in gastric cancer cells. 2013 J. Mol. Med. pmid:22763818
Kadiyala V et al. Class I lysine deacetylases facilitate glucocorticoid-induced transcription. 2013 J. Biol. Chem. pmid:23946490
Itoh M et al. Trichostatin A enhances glutamate transporter GLT-1 mRNA levels in C6 glioma cells via neurosteroid-mediated cell differentiation. 2013 J. Mol. Neurosci. pmid:22711563
Jiao F et al. Effect of dynamic DNA methylation and histone acetylation on cPouV expression in differentiation of chick embryonic germ cells. 2013 Stem Cells Dev. pmid:23750509
Tian Y et al. Ubiquitin B in cervical cancer: critical for the maintenance of cancer stem-like cell characters. 2013 PLoS ONE pmid:24367661
Jung AR et al. Increased alternative lengthening of telomere phenotypes of telomerase-negative immortal cells upon trichostatin--a treatment. 2013 Anticancer Res. pmid:23482750
Piazza R et al. Epigenetic silencing of the proapoptotic gene BIM in anaplastic large cell lymphoma through an MeCP2/SIN3a deacetylating complex. 2013 Neoplasia pmid:23633923
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Kim YJ et al. HDAC inhibitors induce transcriptional repression of high copy number genes in breast cancer through elongation blockade. 2013 Oncogene pmid:23435418
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Yeo M et al. Bisphenol A delays the perinatal chloride shift in cortical neurons by epigenetic effects on the Kcc2 promoter. 2013 Proc. Natl. Acad. Sci. U.S.A. pmid:23440186
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Day JA and Cohen SM Investigating the selectivity of metalloenzyme inhibitors. 2013 J. Med. Chem. pmid:24074025
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Biernacka KM et al. Hyperglycaemia-induced chemoresistance of prostate cancer cells due to IGFBP2. 2013 Endocr. Relat. Cancer pmid:23959956
Majumder A et al. Inhibition of DNA methyltransferases and histone deacetylases induces astrocytic differentiation of neural progenitors. 2013 Stem Cell Res pmid:23644509
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Di Micco S et al. Structural basis for the design and synthesis of selective HDAC inhibitors. 2013 Bioorg. Med. Chem. pmid:23693069
Xia X et al. Effects of trichostatin A in a rat model of acute graft-versus-host disease after liver transplantation. 2013 Transplantation pmid:23694951
Fan J et al. Inhibition of HDAC2 protects the retina from ischemic injury. 2013 Invest. Ophthalmol. Vis. Sci. pmid:23696608
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Zhang Z et al. Stemness and inducing differentiation of small cell lung cancer NCI-H446 cells. 2013 Cell Death Dis pmid:23681228
Kannan V et al. Histone deacetylase inhibitors suppress immune activation in primary mouse microglia. 2013 J. Neurosci. Res. pmid:23686642
Oleksiewicz U et al. Cytoglobin has bimodal: tumour suppressor and oncogene functions in lung cancer cell lines. 2013 Hum. Mol. Genet. pmid:23591990
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Ignatius MS et al. Distinct functional and temporal requirements for zebrafish Hdac1 during neural crest-derived craniofacial and peripheral neuron development. 2013 PLoS ONE pmid:23667588
Iwashita J et al. Histone deacetylase induces accelerated maturation in Xenopus laevis oocytes. 2013 Dev. Growth Differ. pmid:23346879
Ji Q et al. Improvement of porcine cloning efficiency by trichostain A through early-stage induction of embryo apoptosis. 2013 Theriogenology pmid:23347745
Theisen JW et al. Biochemical analysis of histone deacetylase-independent transcriptional repression by MeCP2. 2013 J. Biol. Chem. pmid:23349465
Nunes MJ et al. Histone deacetylase inhibition decreases cholesterol levels in neuronal cells by modulating key genes in cholesterol synthesis, uptake and efflux. 2013 PLoS ONE pmid:23326422
Murko C et al. Histone deacetylase inhibitor Trichostatin A induces neural tube defects and promotes neural crest specification in the chicken neural tube. 2013 Differentiation pmid:23328540
Algamas-Dimantov A et al. Epigenetic control of HNF-4α in colon carcinoma cells affects MUC4 expression and malignancy. 2013 Cell Oncol (Dordr) pmid:23307400
Johnson D and Walmsley R Histone-deacetylase inhibitors produce positive results in the GADD45a-GFP GreenScreen HC assay. 2013 Mutat. Res. pmid:23340162
Zhou G et al. HSV carrying WT REST establishes latency but reactivates only if the synthesis of REST is suppressed. 2013 Proc. Natl. Acad. Sci. U.S.A. pmid:23341636
Chan ST et al. Quercetin enhances the antitumor activity of trichostatin A through upregulation of p53 protein expression in vitro and in vivo. 2013 PLoS ONE pmid:23342112