trichostatin A
Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with trichostatin A?
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with trichostatin A
PubChem Associated disorders and diseases
What pathways are associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with trichostatin A?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with trichostatin A?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with trichostatin A?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with trichostatin A?
Related references are published most in these journals:
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What common seen animal models are associated with trichostatin A?
Mouse Model
Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with trichostatin A
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Garcia BA et al. | Resetting the epigenetic histone code in the MRL-lpr/lpr mouse model of lupus by histone deacetylase inhibition. | 2005 Nov-Dec | J. Proteome Res. | pmid:16335948 |
| Kook SH et al. | Epstein-Barr virus-infected Akata cells are sensitive to histone deacetylase inhibitor TSA-provoked apoptosis. | 2005 | J. Biochem. Mol. Biol. | pmid:16336792 |
| Jung JW et al. | Effects of the histone deacetylases inhibitors sodium butyrate and trichostatin A on the inhibition of gap junctional intercellular communication by H2O2- and 12-O-tetradecanoylphorbol-13-acetate in rat liver epithelial cells. | 2006 | Cancer Lett. | pmid:16337085 |
| Gan Y et al. | Dual effects of histone deacetylase inhibition by trichostatin A on endothelial nitric oxide synthase expression in endothelial cells. | 2006 | Biochem. Biophys. Res. Commun. | pmid:16338217 |
| Nishiyama A et al. | Brd4 is required for recovery from antimicrotubule drug-induced mitotic arrest: preservation of acetylated chromatin. | 2006 | Mol. Biol. Cell | pmid:16339075 |
| Solomon JM et al. | Inhibition of SIRT1 catalytic activity increases p53 acetylation but does not alter cell survival following DNA damage. | 2006 | Mol. Cell. Biol. | pmid:16354677 |
| Kishigami S et al. | Significant improvement of mouse cloning technique by treatment with trichostatin A after somatic nuclear transfer. | 2006 | Biochem. Biophys. Res. Commun. | pmid:16356478 |
| Noh EJ et al. | Methyl CpG-binding domain protein 3 mediates cancer-selective cytotoxicity by histone deacetylase inhibitors via differential transcriptional reprogramming in lung cancer cells. | 2005 | Cancer Res. | pmid:16357148 |
| Pazmany T and Tomasi TB | The major histocompatibility complex class II transactivator is differentially regulated by interferon-gamma and transforming growth factor-beta in microglial cells. | 2006 | J. Neuroimmunol. | pmid:16360884 |
| Lee KY et al. | NF-kappaB and activator protein 1 response elements and the role of histone modifications in IL-1beta-induced TGF-beta1 gene transcription. | 2006 | J. Immunol. | pmid:16365456 |
| Wee G et al. | Inheritable histone H4 acetylation of somatic chromatins in cloned embryos. | 2006 | J. Biol. Chem. | pmid:16371357 |
| Hsu MC et al. | HER-2/neu represses the metastasis suppressor RECK via ERK and Sp transcription factors to promote cell invasion. | 2006 | J. Biol. Chem. | pmid:16377629 |
| Wetzel M et al. | Effect of trichostatin A, a histone deacetylase inhibitor, on glioma proliferation in vitro by inducing cell cycle arrest and apoptosis. | 2005 | J. Neurosurg. | pmid:16383255 |
| Baek SY et al. | Trichostatin A increases the thermosensitivity of human glioblastoma A172 cells. | 2006 | Neurosci. Lett. | pmid:16384639 |
| Takahashi K et al. | Homozygous deletion and reduced expression of the DOCK8 gene in human lung cancer. | 2006 | Int. J. Oncol. | pmid:16391785 |
| Bai T et al. | A novel mechanism for acquired cisplatin-resistance: suppressed translation of death-associated protein kinase mRNA is insensitive to 5-aza-2'-deoxycitidine and trichostatin in cisplatin-resistant cervical squamous cancer cells. | 2006 | Int. J. Oncol. | pmid:16391806 |
| Chen LJ et al. | [hCG-PLZF-RARalpha/hCG-RARalpha-PLZF transgenic mice developing into leukemia]. | 2005 | Zhongguo Shi Yan Xue Ye Xue Za Zhi | pmid:16403252 |
| Liu H et al. | [Antineoplastic effect of valproic acid and trichostatin on HL-60 and K562 cells]. | 2005 | Zhongguo Shi Yan Xue Ye Xue Za Zhi | pmid:16403260 |
| Hansen KR et al. | Evolutionary-conserved telomere-linked helicase genes of fission yeast are repressed by silencing factors, RNAi components and the telomere-binding protein Taz1. | 2006 | Nucleic Acids Res. | pmid:16407326 |
| Fischer S et al. | Histone acetylation dependent allelic expression imbalance of BAPX1 in patients with the oculo-auriculo-vertebral spectrum. | 2006 | Hum. Mol. Genet. | pmid:16407370 |
| Bieler A et al. | Novel three-pronged strategy to enhance cancer cell killing in glioblastoma cell lines: histone deacetylase inhibitor, chemotherapy, and oncolytic adenovirus dl520. | 2006 | Hum. Gene Ther. | pmid:16409125 |
| Lo PK et al. | Epigenetic suppression of secreted frizzled related protein 1 (SFRP1) expression in human breast cancer. | 2006 | Cancer Biol. Ther. | pmid:16410723 |
| Yamamoto G et al. | Correlation of invasion and metastasis of cancer cells, and expression of the RAD21 gene in oral squamous cell carcinoma. | 2006 | Virchows Arch. | pmid:16416296 |
| D'Andrea M et al. | Protein kinase C theta co-operates with calcineurin in the activation of slow muscle genes in cultured myogenic cells. | 2006 | J. Cell. Physiol. | pmid:16419034 |
| Deng G et al. | Regional hypermethylation and global hypomethylation are associated with altered chromatin conformation and histone acetylation in colorectal cancer. | 2006 | Int. J. Cancer | pmid:16425274 |
| Huang L et al. | Activation of ATP-sensitive K channels protects hippocampal CA1 neurons from hypoxia by suppressing p53 expression. | 2006 | Neurosci. Lett. | pmid:16426753 |
| Nambiar MP et al. | Transcriptional induction of cholinesterase expression and protection against chemical warfare nerve agents. | 2005 | Chem. Biol. Interact. | pmid:16429504 |
| Fandy TE and Srivastava RK | Trichostatin A sensitizes TRAIL-resistant myeloma cells by downregulation of the antiapoptotic Bcl-2 proteins. | 2006 | Cancer Chemother. Pharmacol. | pmid:16435155 |
| Gialitakis M et al. | Coordinated changes of histone modifications and HDAC mobilization regulate the induction of MHC class II genes by Trichostatin A. | 2006 | Nucleic Acids Res. | pmid:16452299 |
| Araki H et al. | Expansion of human umbilical cord blood SCID-repopulating cells using chromatin-modifying agents. | 2006 | Exp. Hematol. | pmid:16459182 |
| Sonnemann J et al. | Histone deacetylase inhibitors induce cell death and enhance the susceptibility to ionizing radiation, etoposide, and TRAIL in medulloblastoma cells. | 2006 | Int. J. Oncol. | pmid:16465382 |
| Kim IA et al. | Histone deacetylase inhibitor-mediated radiosensitization of human cancer cells: class differences and the potential influence of p53. | 2006 | Clin. Cancer Res. | pmid:16467109 |
| Osborn NK et al. | Aberrant methylation of the eyes absent 4 gene in ulcerative colitis-associated dysplasia. | 2006 | Clin. Gastroenterol. Hepatol. | pmid:16469682 |
| Baraz L et al. | Tumor suppressor p53 regulates heparanase gene expression. | 2006 | Oncogene | pmid:16474844 |
| Pedram M et al. | Telomere position effect and silencing of transgenes near telomeres in the mouse. | 2006 | Mol. Cell. Biol. | pmid:16479005 |
| Rybouchkin A et al. | Role of histone acetylation in reprogramming of somatic nuclei following nuclear transfer. | 2006 | Biol. Reprod. | pmid:16481594 |
| Banchio C et al. | Role of histone deacetylase in the expression of CTP:phosphocholine cytidylyltransferase alpha. | 2006 | J. Biol. Chem. | pmid:16484221 |
| Weaver IC et al. | Maternal care effects on the hippocampal transcriptome and anxiety-mediated behaviors in the offspring that are reversible in adulthood. | 2006 | Proc. Natl. Acad. Sci. U.S.A. | pmid:16484373 |
| Mukhopadhyay NK et al. | Effectiveness of trichostatin A as a potential candidate for anticancer therapy in non-small-cell lung cancer. | 2006 | Ann. Thorac. Surg. | pmid:16488717 |
| Swanson S | Invited commentary. | 2006 | Ann. Thorac. Surg. | pmid:16488718 |
| Song YF et al. | High-frequency promoter hypermethylation of the deleted in liver cancer-1 gene in multiple myeloma. | 2006 | J. Clin. Pathol. | pmid:16489177 |
| Kim MY et al. | Acetylation of estrogen receptor alpha by p300 at lysines 266 and 268 enhances the deoxyribonucleic acid binding and transactivation activities of the receptor. | 2006 | Mol. Endocrinol. | pmid:16497729 |
| Alao JP et al. | The cyclin D1 proto-oncogene is sequestered in the cytoplasm of mammalian cancer cell lines. | 2006 | Mol. Cancer | pmid:16503970 |
| Alao JP et al. | Histone deacetylase inhibitor, trichostatin A induces ubiquitin-dependent cyclin D1 degradation in MCF-7 breast cancer cells. | 2006 | Mol. Cancer | pmid:16504004 |
| Ostapkowicz A et al. | Lipid rafts remodeling in estrogen receptor-negative breast cancer is reversed by histone deacetylase inhibitor. | 2006 | Mol. Cancer Ther. | pmid:16505096 |
| Hellebrekers DM et al. | Angiostatic activity of DNA methyltransferase inhibitors. | 2006 | Mol. Cancer Ther. | pmid:16505122 |
| Kong X et al. | Histone deacetylase inhibitors induce VHL and ubiquitin-independent proteasomal degradation of hypoxia-inducible factor 1alpha. | 2006 | Mol. Cell. Biol. | pmid:16507982 |
| Rokhlin OW et al. | Mechanisms of cell death induced by histone deacetylase inhibitors in androgen receptor-positive prostate cancer cells. | 2006 | Mol. Cancer Res. | pmid:16513842 |
| Endo T et al. | Activities of maturation-promoting factor (MPF) and mitogen-activated protein kinase (MAPK) are not required for the global histone deacetylation observed after germinal vesicle breakdown (GVBD) in porcine oocytes. | 2006 | Reproduction | pmid:16514187 |
| Bates EA et al. | Differential contributions of Caenorhabditis elegans histone deacetylases to huntingtin polyglutamine toxicity. | 2006 | J. Neurosci. | pmid:16525063 |