Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Chen LJ et al. | [hCG-PLZF-RARalpha/hCG-RARalpha-PLZF transgenic mice developing into leukemia]. | 2005 | Zhongguo Shi Yan Xue Ye Xue Za Zhi | pmid:16403252 |
Liu H et al. | [Antineoplastic effect of valproic acid and trichostatin on HL-60 and K562 cells]. | 2005 | Zhongguo Shi Yan Xue Ye Xue Za Zhi | pmid:16403260 |
Chen J and Kang JH | Quercetin and trichostatin A cooperatively kill human leukemia cells. | 2005 | Pharmazie | pmid:16320950 |
Wei M et al. | BRCA1 promoter methylation in sporadic breast cancer is associated with reduced BRCA1 copy number and chromosome 17 aneusomy. | 2005 | Cancer Res. | pmid:16322213 |
Jori FP et al. | RB and RB2/p130 genes demonstrate both specific and overlapping functions during the early steps of in vitro neural differentiation of marrow stromal stem cells. | 2005 | Cell Death Differ. | pmid:15459751 |
Hammond SM et al. | Negative regulatory elements are present in the human LMO2 oncogene and may contribute to its expression in leukemia. | 2005 | Leuk. Res. | pmid:15541480 |
Menegola E et al. | Inhibition of histone deacetylase activity on specific embryonic tissues as a new mechanism for teratogenicity. | 2005 | Birth Defects Res. B Dev. Reprod. Toxicol. | pmid:16193500 |
Nome RV et al. | Cell cycle checkpoint signaling involved in histone deacetylase inhibition and radiation-induced cell death. | 2005 | Mol. Cancer Ther. | pmid:16093439 |
Liu AL et al. | [A new target of cancer therapy: advances in the study of histone deacetylase]. | 2005 | Yao Xue Xue Bao | pmid:16196262 |
Zhang Y et al. | Coordinated changes in DNA methylation and histone modifications regulate silencing/derepression of luteinizing hormone receptor gene transcription. | 2005 | Mol. Cell. Biol. | pmid:16135786 |
Ren C et al. | Peptide mass mapping of acetylated isoforms of histone H4 from mouse lymphosarcoma cells treated with histone deacetylase (HDACs) inhibitors. | 2005 | J. Am. Soc. Mass Spectrom. | pmid:16099169 |
Shinji C et al. | Design and synthesis of phthalimide-type histone deacetylase inhibitors. | 2005 | Bioorg. Med. Chem. Lett. | pmid:16137884 |
Danaher RJ et al. | Histone deacetylase inhibitors induce reactivation of herpes simplex virus type 1 in a latency-associated transcript-independent manner in neuronal cells. | 2005 | J. Neurovirol. | pmid:16036811 |
Laribee RN and Klemsz MJ | Histone H4 HDAC activity is necessary for expression of the PU.1 gene. | 2005 | Biochim. Biophys. Acta | pmid:16139904 |
Blagosklonny MV et al. | Depletion of mutant p53 and cytotoxicity of histone deacetylase inhibitors. | 2005 | Cancer Res. | pmid:16103091 |
Choi JH et al. | Trichostatin A exacerbates atherosclerosis in low density lipoprotein receptor-deficient mice. | 2005 | Arterioscler. Thromb. Vasc. Biol. | pmid:16141407 |
Krouwels IM et al. | A glue for heterochromatin maintenance: stable SUV39H1 binding to heterochromatin is reinforced by the SET domain. | 2005 | J. Cell Biol. | pmid:16103223 |
Ishihara K | [Role of eosinophils in allergic inflammation]. | 2005 | Yakugaku Zasshi | pmid:16141691 |
Lu Q et al. | Structure-based optimization of phenylbutyrate-derived histone deacetylase inhibitors. | 2005 | J. Med. Chem. | pmid:16107152 |
Yanada M et al. | Frequent hemizygous deletion at 1p36 and hypermethylation downregulate RUNX3 expression in human lung cancer cell lines. | 2005 | Oncol. Rep. | pmid:16142337 |
Uchida H et al. | Histone deacetylase inhibitors induce differentiation of human endometrial adenocarcinoma cells through up-regulation of glycodelin. | 2005 | Endocrinology | pmid:16123169 |
Su M et al. | Recruitment of nuclear factor Y to the inverted CCAAT element (ICE) by c-Jun and E1A stimulates basal transcription of the bone sialoprotein gene in osteosarcoma cells. | 2005 | J. Biol. Chem. | pmid:16087680 |
Wen J et al. | Tal1/SCL binding to pericentromeric DNA represses transcription. | 2005 | J. Biol. Chem. | pmid:15677454 |
Illi B et al. | Epigenetic histone modification and cardiovascular lineage programming in mouse embryonic stem cells exposed to laminar shear stress. | 2005 | Circ. Res. | pmid:15705964 |
Jalonen U et al. | Inhibition of tristetraprolin expression by dexamethasone in activated macrophages. | 2005 | Biochem. Pharmacol. | pmid:15710351 |
Schmittwolf C et al. | In vivo haematopoietic activity is induced in neurosphere cells by chromatin-modifying agents. | 2005 | EMBO J. | pmid:15660132 |
Kang J et al. | Antioxidants and trichostatin A synergistically protect against in vitro cytotoxicity of Ni2+ in human hepatoma cells. | 2005 | Toxicol In Vitro | pmid:15649630 |
Peltonen K et al. | Melanoma cell lines are susceptible to histone deacetylase inhibitor TSA provoked cell cycle arrest and apoptosis. | 2005 | Pigment Cell Res. | pmid:15892716 |
Schwahn DJ et al. | Dynamic regulation of the human dopachrome tautomerase promoter by MITF, ER-alpha and chromatin remodelers during proliferation and senescence of human melanocytes. | 2005 | Pigment Cell Res. | pmid:15892717 |
Camelo S et al. | Transcriptional therapy with the histone deacetylase inhibitor trichostatin A ameliorates experimental autoimmune encephalomyelitis. | 2005 | J. Neuroimmunol. | pmid:15885809 |
Young DA et al. | Differential effects of histone deacetylase inhibitors on phorbol ester- and TGF-beta1 induced murine tissue inhibitor of metalloproteinases-1 gene expression. | 2005 | FEBS J. | pmid:15819885 |
Canes D et al. | Histone deacetylase inhibitors upregulate plakoglobin expression in bladder carcinoma cells and display antineoplastic activity in vitro and in vivo. | 2005 | Int. J. Cancer | pmid:15499627 |
Yamaguchi K et al. | Histone deacetylase inhibitors suppress the induction of c-Jun and its target genes including COX-2. | 2005 | J. Biol. Chem. | pmid:15994313 |
Zhao XY et al. | Granulocyte-macrophage colony-stimulating factor induces de novo methylation of the p15 CpG island in hematopoietic cells. | 2005 | Cytokine | pmid:15996479 |
Sato N et al. | Epigenetic down-regulation of CDKN1C/p57KIP2 in pancreatic ductal neoplasms identified by gene expression profiling. | 2005 | Clin. Cancer Res. | pmid:16000561 |
Munshi A et al. | Histone deacetylase inhibitors radiosensitize human melanoma cells by suppressing DNA repair activity. | 2005 | Clin. Cancer Res. | pmid:16000590 |
Sng JC et al. | Inhibition of histone deacetylation by trichostatin A intensifies the transcriptions of neuronal c-fos and c-jun genes after kainate stimulation. | 2005 | Neurosci. Lett. | pmid:16002216 |
Shetty S et al. | Transcription factor NF-kappaB differentially regulates death receptor 5 expression involving histone deacetylase 1. | 2005 | Mol. Cell. Biol. | pmid:15964798 |
Place RF et al. | HDAC inhibition prevents NF-kappa B activation by suppressing proteasome activity: down-regulation of proteasome subunit expression stabilizes I kappa B alpha. | 2005 | Biochem. Pharmacol. | pmid:15950952 |
Endo T et al. | Changes in histone modifications during in vitro maturation of porcine oocytes. | 2005 | Mol. Reprod. Dev. | pmid:15736133 |
Fan S et al. | Valproic acid enhances gene expression from viral gene transfer vectors. | 2005 | J. Virol. Methods | pmid:15737413 |
Xu S et al. | Abrogation of DUSP6 by hypermethylation in human pancreatic cancer. | 2005 | J. Hum. Genet. | pmid:15824892 |
Strait KA et al. | Histone deacetylase inhibitors induce G2-checkpoint arrest and apoptosis in cisplatinum-resistant ovarian cancer cells associated with overexpression of the Bcl-2-related protein Bad. | 2005 | Mol. Cancer Ther. | pmid:15827334 |
McKenzie GJ et al. | Nuclear Ca2+ and CaM kinase IV specify hormonal- and Notch-responsiveness. | 2005 | J. Neurochem. | pmid:15773917 |
Blais M et al. | Synergy between deacetylase inhibitors and IL-1beta in activation of the serum amyloid A2 gene promoter. | 2005 | DNA Cell Biol. | pmid:15812237 |
Sato N et al. | Epigenetic inactivation of TFPI-2 as a common mechanism associated with growth and invasion of pancreatic ductal adenocarcinoma. | 2005 | Oncogene | pmid:15592528 |
Davidson SM et al. | The transcriptional coactivator p300 plays a critical role in the hypertrophic and protective pathways induced by phenylephrine in cardiac cells but is specific to the hypertrophic effect of urocortin. | 2005 | Chembiochem | pmid:15593114 |
Maxhimer JB et al. | Induction of apoptosis of lung and esophageal cancer cells treated with the combination of histone deacetylase inhibitor (trichostatin A) and protein kinase C inhibitor (calphostin C). | 2005 | J. Thorac. Cardiovasc. Surg. | pmid:15632825 |
Kondo T et al. | Loss of heterozygosity and histone hypoacetylation of the PINX1 gene are associated with reduced expression in gastric carcinoma. | 2005 | Oncogene | pmid:15637589 |
Nambiar MP et al. | Transcriptional induction of cholinesterase expression and protection against chemical warfare nerve agents. | 2005 | Chem. Biol. Interact. | pmid:16429504 |