trichostatin A
Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with trichostatin A?
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with trichostatin A
PubChem Associated disorders and diseases
What pathways are associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with trichostatin A?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with trichostatin A?
Related references are published most in these journals:
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What lipids are associated with trichostatin A?
Related references are published most in these journals:
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What genes are associated with trichostatin A?
Related references are published most in these journals:
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What common seen animal models are associated with trichostatin A?
Mouse Model
Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with trichostatin A
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Dong X et al. | Histone deacetylase inhibitors upregulate Rap1GAP and inhibit Rap activity in thyroid tumor cells. | 2011 | Endocr. Relat. Cancer | pmid:21367844 |
| Kogai T et al. | Enhancement of sodium/iodide symporter expression in thyroid and breast cancer. | 2006 | Endocr. Relat. Cancer | pmid:16954431 |
| López-Solache I et al. | Regulation of uncoupling protein-2 mRNA in L6 myotubules: II: Thyroid hormone amplifies stimulation of uncoupling protein-2 gene by thiazolidinediones and other peroxisome proliferator-activated receptor ligands in L6 myotubules: evidence for a priming effect. | 2002 | Endocrine | pmid:12588052 |
| Ruh MF et al. | The effects of histone acetylation on estrogen responsiveness in MCF-7 cells. | 1999 | Endocrine | pmid:10709763 |
| Kim SH et al. | The heat shock protein 90 inhibitor SNX5422 has a synergistic activity with histone deacetylase inhibitors in induction of death of anaplastic thyroid carcinoma cells. | 2016 | Endocrine | pmid:26219406 |
| Uchida H et al. | Histone deacetylase inhibitors stimulate cell migration in human endometrial adenocarcinoma cells through up-regulation of glycodelin. | 2007 | Endocrinology | pmid:17068141 |
| Cho JH et al. | DNA methylation regulates placental lactogen I gene expression. | 2001 | Endocrinology | pmid:11459782 |
| Walker GE et al. | Butyrate, a histone deacetylase inhibitor, activates the human IGF binding protein-3 promoter in breast cancer cells: molecular mechanism involves an Sp1/Sp3 multiprotein complex. | 2001 | Endocrinology | pmid:11517158 |
| Yacqub-Usman K et al. | Preincubation of pituitary tumor cells with the epidrugs zebularine and trichostatin A are permissive for retinoic acid-augmented expression of the BMP-4 and D2R genes. | 2013 | Endocrinology | pmid:23539512 |
| Ho AK et al. | Acetylation of histone H3 and adrenergic-regulated gene transcription in rat pinealocytes. | 2007 | Endocrinology | pmid:17628002 |
| Li Q et al. | Bisphenol A and Phthalates Modulate Peritoneal Macrophage Function in Female Mice Involving SYMD2-H3K36 Dimethylation. | 2018 | Endocrinology | pmid:29718165 |
| Uchida H et al. | Histone deacetylase inhibitors induce differentiation of human endometrial adenocarcinoma cells through up-regulation of glycodelin. | 2005 | Endocrinology | pmid:16123169 |
| Zhang J et al. | Inhibition of glyceroneogenesis by histone deacetylase 3 contributes to lipodystrophy in mice with adipose tissue inflammation. | 2011 | Endocrinology | pmid:21406501 |
| Mao C and Shapiro DJ | A histone deacetylase inhibitor potentiates estrogen receptor activation of a stably integrated vitellogenin promoter in HepG2 cells. | 2000 | Endocrinology | pmid:10875235 |
| Hu JF et al. | Allele-specific histone acetylation accompanies genomic imprinting of the insulin-like growth factor II receptor gene. | 2000 | Endocrinology | pmid:11108251 |
| Yang Y et al. | The histone code regulating expression of the imprinted mouse Igf2r gene. | 2003 | Endocrinology | pmid:12975326 |
| Bhargavan B et al. | Epigenetic repression of LEDGF during UVB exposure by recruitment of SUV39H1 and HDAC1 to the Sp1-responsive elements within LEDGF promoter CpG island. | 2013 | Epigenetics | pmid:23386123 |
| Ooi JY et al. | HDAC inhibition attenuates cardiac hypertrophy by acetylation and deacetylation of target genes. | 2015 | Epigenetics | pmid:25941940 |
| Devaney JM et al. | Genome-wide differentially methylated genes in prostate cancer tissues from African-American and Caucasian men. | 2015 | Epigenetics | pmid:25864488 |
| Huisman C et al. | Prolonged re-expression of the hypermethylated gene EPB41L3 using artificial transcription factors and epigenetic drugs. | 2015 | Epigenetics | pmid:25830725 |
| Fan H et al. | Sulforaphane causes a major epigenetic repression of myostatin in porcine satellite cells. | 2012 | Epigenetics | pmid:23092945 |
| Chen J et al. | Interplay of bromodomain and histone acetylation in the regulation of p300-dependent genes. | 2010 | Epigenetics | pmid:20505343 |
| Mateen S et al. | Epigenetic modifications and p21-cyclin B1 nexus in anticancer effect of histone deacetylase inhibitors in combination with silibinin on non-small cell lung cancer cells. | 2012 | Epigenetics | pmid:22965008 |
| Good KV et al. | Trichostatin A decreases the levels of MeCP2 expression and phosphorylation and increases its chromatin binding affinity. | 2017 | Epigenetics | pmid:29099289 |
| Mostovich LA et al. | The TCF4/β-catenin pathway and chromatin structure cooperate to regulate D-glucuronyl C5-epimerase expression in breast cancer. | 2012 | Epigenetics | pmid:22805760 |
| Zhang YW et al. | Integrated analysis of DNA methylation and mRNA expression profiling reveals candidate genes associated with cisplatin resistance in non-small cell lung cancer. | 2014 | Epigenetics | pmid:24699858 |
| Deneberg S et al. | microRNA-34b/c on chromosome 11q23 is aberrantly methylated in chronic lymphocytic leukemia. | 2014 | Epigenetics | pmid:24686393 |
| Soriano FX et al. | Role of histone acetylation in the activity-dependent regulation of sulfiredoxin and sestrin 2. | 2009 | Epigenetics | pmid:19430206 |
| da Costa Prando E et al. | Evidence of epigenetic regulation of the tumor suppressor gene cluster flanking RASSF1 in breast cancer cell lines. | 2011 | Epigenetics | pmid:22139571 |
| Tost J et al. | Methylation of specific CpG sites in the P2 promoter of parathyroid hormone-related protein determines the invasive potential of breast cancer cell lines. | 2011 | Epigenetics | pmid:21775817 |
| Costa VL et al. | TCF21 and PCDH17 methylation: An innovative panel of biomarkers for a simultaneous detection of urological cancers. | 2011 | Epigenetics | pmid:21847011 |
| Yang PM et al. | CD1d induction in solid tumor cells by histone deacetylase inhibitors through inhibition of HDAC1/2 and activation of Sp1. | 2012 | Epigenetics | pmid:22419072 |
| Mayor R et al. | Dynamics of bivalent chromatin domains upon drug induced reactivation and resilencing in cancer cells. | 2011 | Epigenetics | pmid:21852760 |
| Singh T et al. | Inhibition of class I histone deacetylases in non-small cell lung cancer by honokiol leads to suppression of cancer cell growth and induction of cell death in vitro and in vivo. | 2013 | Epigenetics | pmid:23221619 |
| Li Q and Chen H | Silencing of Wnt5a during colon cancer metastasis involves histone modifications. | 2012 | Epigenetics | pmid:22522911 |
| Meier BC and Wagner BK | Inhibition of HDAC3 as a strategy for developing novel diabetes therapeutics. | 2014 | Epigenomics | pmid:24811789 |
| Poplineau M et al. | Raman microspectroscopy detects epigenetic modifications in living Jurkat leukemic cells. | 2011 | Epigenomics | pmid:22126296 |
| Barr MP et al. | VEGF-mediated cell survival in non-small-cell lung cancer: implications for epigenetic targeting of VEGF receptors as a therapeutic approach. | 2015 | Epigenomics | pmid:26479311 |
| Hoffmann K et al. | Increase in antiepileptic efficacy during prolonged treatment with valproic acid: role of inhibition of histone deacetylases? | 2008 | Epilepsy Res. | pmid:18538545 |
| Duharcourt S and Yao MC | Role of histone deacetylation in developmentally programmed DNA rearrangements in Tetrahymena thermophila. | 2002 | Eukaryotic Cell | pmid:12455963 |
| Juranek SA et al. | snRNA and heterochromatin formation are involved in DNA excision during macronuclear development in stichotrichous ciliates. | 2005 | Eukaryotic Cell | pmid:16278460 |
| Tong K et al. | Schizosaccharomyces pombe Hat1 (Kat1) is associated with Mis16 and is required for telomeric silencing. | 2012 | Eukaryotic Cell | pmid:22771823 |
| GarcÃa I et al. | Chromatin rearrangements in the prnD-prnB bidirectional promoter: dependence on transcription factors. | 2004 | Eukaryotic Cell | pmid:14871945 |
| Smetana K et al. | To the nucleolar density and size in apoptotic human leukemic myeloblasts produced in vitro by Trichostatin A. | 2008 Jul-Sep | Eur J Histochem | pmid:18840553 |
| Chen Y et al. | 3D-QSAR studies of HDACs inhibitors using pharmacophore-based alignment. | 2009 | Eur J Med Chem | pmid:19136179 |
| Marrazzo A et al. | Antiproliferative activity of phenylbutyrate ester of haloperidol metabolite II [(±)-MRJF4] in prostate cancer cells. | 2011 | Eur J Med Chem | pmid:21055848 |
| Hou J et al. | Structure-based optimization of click-based histone deacetylase inhibitors. | 2011 | Eur J Med Chem | pmid:21621883 |
| Huang D et al. | A novel series of l-2-benzyloxycarbonylamino-8-(2-pyridyl)-disulfidyloctanoic acid derivatives as histone deacetylase inhibitors: design, synthesis and molecular modeling study. | 2012 | Eur J Med Chem | pmid:22465091 |
| Ragno R et al. | Class II-selective histone deacetylase inhibitors. Part 2: alignment-independent GRIND 3-D QSAR, homology and docking studies. | 2008 | Eur J Med Chem | pmid:17698257 |
| Bertrand P | Inside HDAC with HDAC inhibitors. | 2010 | Eur J Med Chem | pmid:20223566 |