trichostatin A
Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with trichostatin A?
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with trichostatin A
PubChem Associated disorders and diseases
What pathways are associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with trichostatin A?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with trichostatin A?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with trichostatin A?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with trichostatin A?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with trichostatin A?
Mouse Model
Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with trichostatin A
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Minetti GC et al. | Functional and morphological recovery of dystrophic muscles in mice treated with deacetylase inhibitors. | 2006 | Nat. Med. | pmid:16980968 |
| Ohnishi K | [Therapeutic strategies for patients with relapsed acute promyelocytic leukemia]. | 2006 | Rinsho Ketsueki | pmid:16986710 |
| Liu T et al. | Regulation of Cdx2 expression by promoter methylation, and effects of Cdx2 transfection on morphology and gene expression of human esophageal epithelial cells. | 2007 | Carcinogenesis | pmid:16990345 |
| Claus R et al. | Inhibitors of DNA methylation and histone deacetylation independently relieve AML1/ETO-mediated lysozyme repression. | 2006 | J. Leukoc. Biol. | pmid:17000900 |
| Mai A et al. | Synthesis and biological properties of novel, uracil-containing histone deacetylase inhibitors. | 2006 | J. Med. Chem. | pmid:17004718 |
| Yao J et al. | NF-kappaB signaling pathway is involved in growth inhibition, G2/M arrest and apoptosis induced by Trichostatin A in human tongue carcinoma cells. | 2006 | Pharmacol. Res. | pmid:17005413 |
| Inoue K et al. | Histone deacetylase inhibitor reduces monocyte adhesion to endothelium through the suppression of vascular cell adhesion molecule-1 expression. | 2006 | Arterioscler. Thromb. Vasc. Biol. | pmid:17008592 |
| Baqir S and Smith LC | Inhibitors of histone deacetylases and DNA methyltransferases alter imprinted gene regulation in embryonic stem cells. | 2006 | Cloning Stem Cells | pmid:17009896 |
| Sah NK et al. | Effect of downregulation of survivin expression on radiosensitivity of human epidermoid carcinoma cells. | 2006 | Int. J. Radiat. Oncol. Biol. Phys. | pmid:17011457 |
| Kumar KS et al. | Histone deacetylase inhibitors induce cell death in supratentorial primitive neuroectodermal tumor cells. | 2006 | Oncol. Rep. | pmid:17016591 |
| Alao JP et al. | Role of glycogen synthase kinase 3 beta (GSK3beta) in mediating the cytotoxic effects of the histone deacetylase inhibitor trichostatin A (TSA) in MCF-7 breast cancer cells. | 2006 | Mol. Cancer | pmid:17018141 |
| Zhao LY et al. | An EBF3-mediated transcriptional program that induces cell cycle arrest and apoptosis. | 2006 | Cancer Res. | pmid:17018599 |
| Cantor JP et al. | Epigenetic modulation of endogenous tumor suppressor expression in lung cancer xenografts suppresses tumorigenicity. | 2007 | Int. J. Cancer | pmid:17019711 |
| Ooi L et al. | BRG1 chromatin remodeling activity is required for efficient chromatin binding by repressor element 1-silencing transcription factor (REST) and facilitates REST-mediated repression. | 2006 | J. Biol. Chem. | pmid:17023429 |
| Zhou H et al. | Epigenetic allele silencing unveils recessive RYR1 mutations in core myopathies. | 2006 | Am. J. Hum. Genet. | pmid:17033962 |
| Zhong S et al. | Pharmacologic inhibition of epigenetic modifications, coupled with gene expression profiling, reveals novel targets of aberrant DNA methylation and histone deacetylation in lung cancer. | 2007 | Oncogene | pmid:17043644 |
| Berg T et al. | Reversal of p15/INK4b hypermethylation in AML1/ETO-positive and -negative myeloid leukemia cell lines. | 2007 | Leuk. Res. | pmid:17056112 |
| Uchida H et al. | Histone deacetylase inhibitors stimulate cell migration in human endometrial adenocarcinoma cells through up-regulation of glycodelin. | 2007 | Endocrinology | pmid:17068141 |
| Kishigami S et al. | Successful mouse cloning of an outbred strain by trichostatin A treatment after somatic nuclear transfer. | 2007 | J. Reprod. Dev. | pmid:17077581 |
| Balasubramaniyan V et al. | Effects of histone deacetylation inhibition on neuronal differentiation of embryonic mouse neural stem cells. | 2006 | Neuroscience | pmid:17084985 |
| Zou B et al. | Correlation between the single-site CpG methylation and expression silencing of the XAF1 gene in human gastric and colon cancers. | 2006 | Gastroenterology | pmid:17087954 |
| Anderson I | Deacetylase inhibitors aid recovery in muscular dystrophy. | 2006 | Lancet Neurol | pmid:17089447 |
| Kiefer J et al. | Mixtures of SCFA, composed according to physiologically available concentrations in the gut lumen, modulate histone acetylation in human HT29 colon cancer cells. | 2006 | Br. J. Nutr. | pmid:17092367 |
| Sato N et al. | RhoB is frequently downregulated in non-small-cell lung cancer and resides in the 2p24 homozygous deletion region of a lung cancer cell line. | 2007 | Int. J. Cancer | pmid:17096327 |
| Zhang R et al. | HP1 proteins are essential for a dynamic nuclear response that rescues the function of perturbed heterochromatin in primary human cells. | 2007 | Mol. Cell. Biol. | pmid:17101789 |
| Taghiyev AF et al. | TSA-induced cell death in prostate cancer cell lines is caspase-2 dependent and involves the PIDDosome. | 2006 | Cancer Biol. Ther. | pmid:17110788 |
| Sestáková B and Vachtenheim J | Distinct co-regulation of endogenous versus transfected MITF-dependent tyrosinase promoter. | 2006 | Folia Biol. (Praha) | pmid:17116288 |
| Roy S and Tenniswood M | Site-specific acetylation of p53 directs selective transcription complex assembly. | 2007 | J. Biol. Chem. | pmid:17121856 |
| Dowdy SC et al. | Histone deacetylase inhibitors and paclitaxel cause synergistic effects on apoptosis and microtubule stabilization in papillary serous endometrial cancer cells. | 2006 | Mol. Cancer Ther. | pmid:17121923 |
| Saunders LR and Verdin E | Ornithine decarboxylase activity in tumor cell lines correlates with sensitivity to cell death induced by histone deacetylase inhibitors. | 2006 | Mol. Cancer Ther. | pmid:17121924 |
| Henkens T et al. | Trichostatin A, a critical factor in maintaining the functional differentiation of primary cultured rat hepatocytes. | 2007 | Toxicol. Appl. Pharmacol. | pmid:17125810 |
| Yoshikawa M et al. | Inhibition of histone deacetylase activity suppresses epithelial-to-mesenchymal transition induced by TGF-beta1 in human renal epithelial cells. | 2007 | J. Am. Soc. Nephrol. | pmid:17135397 |
| Reddy RM et al. | Rapid and profound potentiation of Apo2L/TRAIL-mediated cytotoxicity and apoptosis in thoracic cancer cells by the histone deacetylase inhibitor Trichostatin A: the essential role of the mitochondria-mediated caspase activation cascade. | 2007 | Apoptosis | pmid:17136498 |
| Fang S et al. | Coordinated recruitment of histone methyltransferase G9a and other chromatin-modifying enzymes in SHP-mediated regulation of hepatic bile acid metabolism. | 2007 | Mol. Cell. Biol. | pmid:17145766 |
| ChuÄkin IA et al. | [Anti-proliferative effect of histone deacetylase inhibitors on murine embryonic stem cells]. | 2006 | Tsitologiia | pmid:17147260 |
| Trapp J et al. | Adenosine mimetics as inhibitors of NAD+-dependent histone deacetylases, from kinase to sirtuin inhibition. | 2006 | J. Med. Chem. | pmid:17149860 |
| Long JE and Cai X | Igf-2r expression regulated by epigenetic modification and the locus of gene imprinting disrupted in cloned cattle. | 2007 | Gene | pmid:17150312 |
| Baradari V et al. | Antiproliferative and proapoptotic effects of histone deacetylase inhibitors on gastrointestinal neuroendocrine tumor cells. | 2006 | Endocr. Relat. Cancer | pmid:17158768 |
| Liu TX et al. | Chromosome 5q deletion and epigenetic suppression of the gene encoding alpha-catenin (CTNNA1) in myeloid cell transformation. | 2007 | Nat. Med. | pmid:17159988 |
| Lee JH et al. | Histone deacetylase inhibitor enhances 5-fluorouracil cytotoxicity by down-regulating thymidylate synthase in human cancer cells. | 2006 | Mol. Cancer Ther. | pmid:17172411 |
| Shimazu T et al. | Multiple histone deacetylases and the CREB-binding protein regulate pre-mRNA 3'-end processing. | 2007 | J. Biol. Chem. | pmid:17172643 |
| Januchowski R and Jagodzinski PP | Trichostatin A down-regulates ZAP-70, LAT and SLP-76 content in Jurkat T cells. | 2007 | Int. Immunopharmacol. | pmid:17178387 |
| Araki H et al. | Chromatin-modifying agents permit human hematopoietic stem cells to undergo multiple cell divisions while retaining their repopulating potential. | 2007 | Blood | pmid:17185465 |
| Lee EL et al. | Impaired activity of volume-sensitive Cl- channel is involved in cisplatin resistance of cancer cells. | 2007 | J. Cell. Physiol. | pmid:17186499 |
| Koh E et al. | Trichostatin A and 5-aza-2'-deoxycytidine switch S1P from an inhibitor to a stimulator of motility through epigenetic regulation of S1P receptors. | 2007 | Cancer Lett. | pmid:17189669 |
| Kovács P and Csaba G | The effect of histone deacetylase inhibitor trichostatin A (TSA) on the incorporation of 32P (Pi) and 3H-palmitic acid into the phospholipids of Tetrahymena. | 2008 Jan-Feb | Cell Biochem. Funct. | pmid:17191269 |
| Bazhin AV et al. | Expression of GAGE family proteins in malignant melanoma. | 2007 | Cancer Lett. | pmid:17194529 |
| Markova NG et al. | Inhibition of histone deacetylation promotes abnormal epidermal differentiation and specifically suppresses the expression of the late differentiation marker profilaggrin. | 2007 | J. Invest. Dermatol. | pmid:17195011 |
| Fujita Y et al. | Priming of centromere for CENP-A recruitment by human hMis18alpha, hMis18beta, and M18BP1. | 2007 | Dev. Cell | pmid:17199038 |
| Katz RA et al. | High-frequency epigenetic repression and silencing of retroviruses can be antagonized by histone deacetylase inhibitors and transcriptional activators, but uniform reactivation in cell clones is restricted by additional mechanisms. | 2007 | J. Virol. | pmid:17202206 |