trichostatin A
Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with trichostatin A?
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with trichostatin A
PubChem Associated disorders and diseases
What pathways are associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with trichostatin A?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
What functions are associated with trichostatin A?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with trichostatin A?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
What genes are associated with trichostatin A?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with trichostatin A?
Mouse Model
Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
NCBI Entrez Crosslinks
All references with trichostatin A
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Coleman SL et al. | Unsaturated fatty acids repress the expression of adipocyte fatty acid binding protein via the modulation of histone deacetylation in RAW 264.7 macrophages. | 2011 | Eur J Nutr | pmid:21046125 |
| Shiau RJ et al. | Genistein and beta-carotene enhance the growth-inhibitory effect of trichostatin A in A549 cells. | 2010 | Eur J Nutr | pmid:19639378 |
| Lietz M et al. | RE-1 silencing transcription factor (REST) regulates human synaptophysin gene transcription through an intronic sequence-specific DNA-binding site. | 2003 | Eur. J. Biochem. | pmid:12492469 |
| Girardot V et al. | Relationship between core histone acetylation and histone H1(0) gene activity. | 1994 | Eur. J. Biochem. | pmid:7925412 |
| Astrand C et al. | Trichostatin A reduces hormone-induced transcription of the MMTV promoter and has pleiotropic effects on its chromatin structure. | 2004 | Eur. J. Biochem. | pmid:15009194 |
| Stöckel B et al. | Characterization of the 5'-flanking region of the human multidrug resistance protein 2 (MRP2) gene and its regulation in comparison withthe multidrug resistance protein 3 (MRP3) gene. | 2000 | Eur. J. Biochem. | pmid:10691972 |
| Ishiguro K and Sartorelli AC | Activation of transiently transfected reporter genes in 3T3 Swiss cells by the inducers of differentiation/apoptosis--dimethylsulfoxide, hexamethylene bisacetamide and trichostatin A. | 2004 | Eur. J. Biochem. | pmid:15182353 |
| Luo Y et al. | High mobility group box 1 released from necrotic cells enhances regrowth and metastasis of cancer cells that have survived chemotherapy. | 2013 | Eur. J. Cancer | pmid:23040637 |
| Gray SG et al. | Regulation of EP receptors in non-small cell lung cancer by epigenetic modifications. | 2009 | Eur. J. Cancer | pmid:19818596 |
| Chambers AE et al. | Histone acetylation-mediated regulation of genes in leukaemic cells. | 2003 | Eur. J. Cancer | pmid:12736119 |
| He D et al. | Protocadherin8 is a functional tumor suppressor frequently inactivated by promoter methylation in nasopharyngeal carcinoma. | 2012 | Eur. J. Cancer Prev. | pmid:22273848 |
| Sourlingas TG et al. | Histone deacetylase inhibitors induce apoptosis in peripheral blood lymphocytes along with histone H4 acetylation and the expression of the linker histone variant, H1 degrees. | 2001 | Eur. J. Cell Biol. | pmid:11824792 |
| Galiová G et al. | Chromatin changes induced by lamin A/C deficiency and the histone deacetylase inhibitor trichostatin A. | 2008 | Eur. J. Cell Biol. | pmid:18396346 |
| Ma XX et al. | Histone deacetylase inhibitor trichostatin A modulates cell cycles in A2780 human ovarian cancer cell lines. | 2009 | Eur. J. Gynaecol. Oncol. | pmid:19697617 |
| Chao KC et al. | Anti-tumor activity of histone deacetylase inhibitors and the effect on ATP-binding cassette in ovarian carcinoma cells. | 2010 | Eur. J. Gynaecol. Oncol. | pmid:20882882 |
| Yu J et al. | Regulation of radiosensitivity by HDAC inhibitor trichostatin A in the human cervical carcinoma cell line Hela. | 2012 | Eur. J. Gynaecol. Oncol. | pmid:22873101 |
| Serrat N et al. | Deacetylation of C/EBPβ is required for IL-4-induced arginase-1 expression in murine macrophages. | 2012 | Eur. J. Immunol. | pmid:22865229 |
| Zheng J et al. | Gain-of-function STAT1 mutations impair STAT3 activity in patients with chronic mucocutaneous candidiasis (CMC). | 2015 | Eur. J. Immunol. | pmid:26255980 |
| Hohl M and Thiel G | Cell type-specific regulation of RE-1 silencing transcription factor (REST) target genes. | 2005 | Eur. J. Neurosci. | pmid:16262660 |
| Wu Y and Guo SW | Suppression of IL-1beta-induced COX-2 expression by trichostatin A (TSA) in human endometrial stromal cells. | 2007 | Eur. J. Obstet. Gynecol. Reprod. Biol. | pmid:17296257 |
| Wu Y and Guo SW | Histone deacetylase inhibitors trichostatin A and valproic acid induce cell cycle arrest and p21 expression in immortalized human endometrial stromal cells. | 2008 | Eur. J. Obstet. Gynecol. Reprod. Biol. | pmid:17376583 |
| Yoshikawa M et al. | Trichostatin a prevents TGF-beta1-induced apoptosis by inhibiting ERK activation in human renal tubular epithelial cells. | 2010 | Eur. J. Pharmacol. | pmid:20553909 |
| Kim HN et al. | Trichostatin A inhibits osteoclastogenesis and bone resorption by suppressing the induction of c-Fos by RANKL. | 2009 | Eur. J. Pharmacol. | pmid:19766111 |
| Lee CS et al. | 18β-Glycyrrhetinic acid potentiates apoptotic effect of trichostatin A on human epithelial ovarian carcinoma cell lines. | 2010 | Eur. J. Pharmacol. | pmid:20868669 |
| Chen CJ et al. | Attenuation of c-Jun and Sp1 expression and p300 recruitment to gene promoter confers the trichostatin A-induced inhibition of 12(S)-lipoxygenase expression in EGF-treated A431 cells. | 2008 | Eur. J. Pharmacol. | pmid:18590721 |
| Kim B et al. | Clinically relevant concentrations of valproic acid modulate melatonin MT(1) receptor, HDAC and MeCP2 mRNA expression in C6 glioma cells. | 2008 | Eur. J. Pharmacol. | pmid:18550052 |
| Dombrowsky H and Uhlig S | Steroids and histone deacetylase in ventilation-induced gene transcription. | 2007 | Eur. Respir. J. | pmid:17626110 |
| Vadnal J et al. | Transcriptional signatures mediated by acetylation overlap with early-stage Alzheimer's disease. | 2012 | Exp Brain Res | pmid:22811216 |
| Min XJ et al. | Dysfunction of volume-sensitive chloride channels contributes to cisplatin resistance in human lung adenocarcinoma cells. | 2011 | Exp. Biol. Med. (Maywood) | pmid:21454376 |
| Zein S et al. | Identification of fetal hemoglobin-inducing agents using the human leukemia KU812 cell line. | 2010 | Exp. Biol. Med. (Maywood) | pmid:20975082 |
| Yang H et al. | Histone modification-mediated CYP2E1 gene expression and apoptosis of HepG2 cells. | 2010 | Exp. Biol. Med. (Maywood) | pmid:20404016 |
| Aoyama K et al. | Nuclear c-Abl-mediated tyrosine phosphorylation induces chromatin structural changes through histone modifications that include H4K16 hypoacetylation. | 2011 | Exp. Cell Res. | pmid:22001646 |
| Sundqvist A et al. | Functional knockout of the corepressor CtBP by the second exon of adenovirus E1a relieves repression of transcription. | 2001 | Exp. Cell Res. | pmid:11478854 |
| Eriksson I et al. | The histone deacetylase inhibitor trichostatin A reduces lysosomal pH and enhances cisplatin-induced apoptosis. | 2013 | Exp. Cell Res. | pmid:23063877 |
| Duncan HF et al. | Histone deacetylase inhibitors epigenetically promote reparative events in primary dental pulp cells. | 2013 | Exp. Cell Res. | pmid:23562654 |
| Vulcano F et al. | HDAC inhibition is associated to valproic acid induction of early megakaryocytic markers. | 2006 | Exp. Cell Res. | pmid:16739251 |
| Yoshida M and Beppu T | Reversible arrest of proliferation of rat 3Y1 fibroblasts in both the G1 and G2 phases by trichostatin A. | 1988 | Exp. Cell Res. | pmid:3134246 |
| Hoshikawa Y et al. | Trichostatin A induces morphological changes and gelsolin expression by inhibiting histone deacetylase in human carcinoma cell lines. | 1994 | Exp. Cell Res. | pmid:8082721 |
| Rombouts K et al. | Trichostatin A, a histone deacetylase inhibitor, suppresses collagen synthesis and prevents TGF-beta(1)-induced fibrogenesis in skin fibroblasts. | 2002 | Exp. Cell Res. | pmid:12169274 |
| Gray SG et al. | IGF-II enhances trichostatin A-induced TGFbeta1 and p21(Waf1,Cip1, sdi1) expression in Hep3B cells. | 1999 | Exp. Cell Res. | pmid:10585285 |
| Giustiniani J et al. | Basal endothelial nitric oxide synthase (eNOS) phosphorylation on Ser(1177) occurs in a stable microtubule- and tubulin acetylation-dependent manner. | 2009 | Exp. Cell Res. | pmid:19632222 |
| Rahmani M et al. | The histone deacetylase inhibitor sodium butyrate interacts synergistically with phorbol myristate acetate (PMA) to induce mitochondrial damage and apoptosis in human myeloid leukemia cells through a tumor necrosis factor-alpha-mediated process. | 2002 | Exp. Cell Res. | pmid:12061815 |
| Kim MS et al. | Sensitization to UV-induced apoptosis by the histone deacetylase inhibitor trichostatin A (TSA). | 2005 | Exp. Cell Res. | pmid:15878336 |
| Travers H et al. | Human CD34+ hematopoietic progenitor cells hyperacetylate core histones in response to sodium butyrate, but not trichostatin A. | 2002 | Exp. Cell Res. | pmid:12413881 |
| Nakajima H et al. | FR901228, a potent antitumor antibiotic, is a novel histone deacetylase inhibitor. | 1998 | Exp. Cell Res. | pmid:9633520 |
| Kato A et al. | Induction of truncated form of tenascin-X (XB-S) through dissociation of HDAC1 from SP-1/HDAC1 complex in response to hypoxic conditions. | 2008 | Exp. Cell Res. | pmid:18588874 |
| Law AY et al. | Histone deacetylase inhibitor-induced cellular apoptosis involves stanniocalcin-1 activation. | 2008 | Exp. Cell Res. | pmid:18652825 |
| Munro J et al. | Histone deacetylase inhibitors induce a senescence-like state in human cells by a p16-dependent mechanism that is independent of a mitotic clock. | 2004 | Exp. Cell Res. | pmid:15093749 |
| Matteucci E et al. | Epigenetic control of endothelin-1 axis affects invasiveness of breast carcinoma cells with bone tropism. | 2013 | Exp. Cell Res. | pmid:23660387 |
| Law AY and Wong CK | Stanniocalcin-2 is a HIF-1 target gene that promotes cell proliferation in hypoxia. | 2010 | Exp. Cell Res. | pmid:19786016 |