Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Sanyal S et al. | Differential regulation of the orphan nuclear receptor small heterodimer partner (SHP) gene promoter by orphan nuclear receptor ERR isoforms. | 2002 | J. Biol. Chem. | pmid:11705994 |
Inoue H et al. | Histone deacetylase inhibitors sensitize human colonic adenocarcinoma cell lines to TNF-related apoptosis inducing ligand-mediated apoptosis. | 2002 | Int. J. Mol. Med. | pmid:11956660 |
Galasinski SC et al. | Global regulation of post-translational modifications on core histones. | 2002 | J. Biol. Chem. | pmid:11709551 |
López-Solache I et al. | Regulation of uncoupling protein-2 mRNA in L6 myotubules: II: Thyroid hormone amplifies stimulation of uncoupling protein-2 gene by thiazolidinediones and other peroxisome proliferator-activated receptor ligands in L6 myotubules: evidence for a priming effect. | 2002 | Endocrine | pmid:12588052 |
Stimson KM and Vertino PM | Methylation-mediated silencing of TMS1/ASC is accompanied by histone hypoacetylation and CpG island-localized changes in chromatin architecture. | 2002 | J. Biol. Chem. | pmid:11733524 |
Sawa H et al. | Histone deacetylase inhibitors such as sodium butyrate and trichostatin A inhibit vascular endothelial growth factor (VEGF) secretion from human glioblastoma cells. | 2002 | Brain Tumor Pathol | pmid:12622137 |
Suzuki-Mizushima Y et al. | Enhancement of NGF- and cholera toxin-induced neurite outgrowth by butyrate in PC12 cells. | 2002 | Brain Res. | pmid:12270499 |
Rombouts K et al. | Actin filament formation, reorganization and migration are impaired in hepatic stellate cells under influence of trichostatin A, a histone deacetylase inhibitor. | 2002 | J. Hepatol. | pmid:12445420 |
Guo WH et al. | Inhibition of growth of mouse gastric cancer cells by Runx3, a novel tumor suppressor. | 2002 | Oncogene | pmid:12447699 |
Marin-Husstege M et al. | Histone deacetylase activity is necessary for oligodendrocyte lineage progression. | 2002 | J. Neurosci. | pmid:12451133 |
Wang ZM et al. | Trichostatin A inhibits proliferation and induces expression of p21WAF and p27 in human brain tumor cell lines. | 2002 | Ai Zheng | pmid:12508652 |
Duharcourt S and Yao MC | Role of histone deacetylation in developmentally programmed DNA rearrangements in Tetrahymena thermophila. | 2002 | Eukaryotic Cell | pmid:12455963 |
Strait KA et al. | Cell cycle blockade and differentiation of ovarian cancer cells by the histone deacetylase inhibitor trichostatin A are associated with changes in p21, Rb, and Id proteins. | 2002 | Mol. Cancer Ther. | pmid:12479699 |
Blagosklonny MV et al. | Histone deacetylase inhibitors all induce p21 but differentially cause tubulin acetylation, mitotic arrest, and cytotoxicity. | 2002 | Mol. Cancer Ther. | pmid:12481415 |
Drewell RA et al. | Methylation-dependent silencing at the H19 imprinting control region by MeCP2. | 2002 | Nucleic Acids Res. | pmid:11861904 |
Murphy JC et al. | Control of cytomegalovirus lytic gene expression by histone acetylation. | 2002 | EMBO J. | pmid:11867539 |
Kim JY et al. | Probing lysine acetylation with a modification-specific marker ion using high-performance liquid chromatography/electrospray-mass spectrometry with collision-induced dissociation. | 2002 | Anal. Chem. | pmid:12433071 |
Gregory RI et al. | Inhibition of histone deacetylases alters allelic chromatin conformation at the imprinted U2af1-rs1 locus in mouse embryonic stem cells. | 2002 | J. Biol. Chem. | pmid:11821379 |
Elaut G et al. | Major phase I biotransformation pathways of Trichostatin a in rat hepatocytes and in rat and human liver microsomes. | 2002 | Drug Metab. Dispos. | pmid:12433798 |
Lim Y et al. | Trichostatin A-induced detransformation correlates with decreased focal adhesion kinase phosphorylation at tyrosine 861 in ras-transformed fibroblasts. | 2002 | J. Biol. Chem. | pmid:11821402 |
Yáñez RJ and Porter AC | A chromosomal position effect on gene targeting in human cells. | 2002 | Nucleic Acids Res. | pmid:12433992 |
Wilson MA et al. | The histone deacetylase inhibitor trichostatin A blocks progesterone receptor-mediated transactivation of the mouse mammary tumor virus promoter in vivo. | 2002 | J. Biol. Chem. | pmid:11821430 |
Takechi S et al. | Chicken HDAC2 down-regulates IgM light chain gene promoter activity. | 2002 | Biochem. Biophys. Res. Commun. | pmid:12437980 |
Deroanne CF et al. | Histone deacetylases inhibitors as anti-angiogenic agents altering vascular endothelial growth factor signaling. | 2002 | Oncogene | pmid:11821955 |
Ego T et al. | The interaction of HTLV-1 Tax with HDAC1 negatively regulates the viral gene expression. | 2002 | Oncogene | pmid:12370815 |
Zhang W and Kone BC | NF-kappaB inhibits transcription of the H(+)-K(+)-ATPase alpha(2)-subunit gene: role of histone deacetylases. | 2002 | Am. J. Physiol. Renal Physiol. | pmid:12372765 |
Handumrongkul C et al. | Distinct sets of cellular genes control the expression of transfected, nuclear-localized genes. | 2002 | Mol. Ther. | pmid:11829526 |
Ailenberg M and Silverman M | Trichostatin A-histone deacetylase inhibitor with clinical therapeutic potential-is also a selective and potent inhibitor of gelatinase A expression. | 2002 | Biochem. Biophys. Res. Commun. | pmid:12379227 |
Herold C et al. | The histone-deacetylase inhibitor Trichostatin A blocks proliferation and triggers apoptotic programs in hepatoma cells. | 2002 | J. Hepatol. | pmid:11830335 |
Yamashita K et al. | Pharmacologic unmasking of epigenetically silenced tumor suppressor genes in esophageal squamous cell carcinoma. | 2002 | Cancer Cell | pmid:12498717 |
Zhou DC et al. | Frequent mutations in the ligand-binding domain of PML-RARalpha after multiple relapses of acute promyelocytic leukemia: analysis for functional relationship to response to all-trans retinoic acid and histone deacetylase inhibitors in vitro and in vivo. | 2002 | Blood | pmid:11830487 |
Fahrner JA et al. | Dependence of histone modifications and gene expression on DNA hypermethylation in cancer. | 2002 | Cancer Res. | pmid:12499261 |
Valapour M et al. | Histone deacetylation inhibits IL4 gene expression in T cells. | 2002 | J. Allergy Clin. Immunol. | pmid:11842291 |
Kishikawa S et al. | Roles of histone acetylation in the Dnmt1 gene expression. | 2002 | Nucleic Acids Res. Suppl. | pmid:12903179 |
Ginjala V et al. | Multiple cis elements within the Igf2/H19 insulator domain organize a distance-dependent silencer. A cautionary note. | 2002 | J. Biol. Chem. | pmid:11777900 |
Cabral AL et al. | Regulation of the cellular prion protein gene expression depends on chromatin conformation. | 2002 | J. Biol. Chem. | pmid:11739375 |
Park SH et al. | Transcriptional regulation of the transforming growth factor beta type II receptor gene by histone acetyltransferase and deacetylase is mediated by NF-Y in human breast cancer cells. | 2002 | J. Biol. Chem. | pmid:11744689 |
Suenaga M et al. | Histone deacetylase inhibitors suppress telomerase reverse transcriptase mRNA expression in prostate cancer cells. | 2002 | Int. J. Cancer | pmid:11807787 |
Gurova KV et al. | Expression of prostate specific antigen (PSA) is negatively regulated by p53. | 2002 | Oncogene | pmid:11791186 |
Maeda Y et al. | Repression of hepatocyte nuclear factor 4alpha tumor suppressor p53: involvement of the ligand-binding domain and histone deacetylase activity. | 2002 | Mol. Endocrinol. | pmid:11818510 |
Singal R et al. | Methylation of promoter proximal-transcribed sequences of an embryonic globin gene inhibits transcription in primary erythroid cells and promotes formation of a cell type-specific methyl cytosine binding complex. | 2002 | J. Biol. Chem. | pmid:11684679 |
Bordonaro M et al. | Cell type- and promoter-dependent modulation of the Wnt signaling pathway by sodium butyrate. | 2002 | Int. J. Cancer | pmid:11774242 |
Kikuchi T et al. | Aberrant methylation and histone deacetylation of cyclooxygenase 2 in gastric cancer. | 2002 | Int. J. Cancer | pmid:11774276 |
Rombouts K et al. | Trichostatin A, a histone deacetylase inhibitor, suppresses collagen synthesis and prevents TGF-beta(1)-induced fibrogenesis in skin fibroblasts. | 2002 | Exp. Cell Res. | pmid:12169274 |
Waterborg JH and Kapros T | Kinetic analysis of histone acetylation turnover and Trichostatin A induced hyper- and hypoacetylation in alfalfa. | 2002 | Biochem. Cell Biol. | pmid:12123281 |
Mikkelsen IM et al. | Activation of the gamma-glutamyltransferase promoter 2 in the rat colon carcinoma cell line CC531 by histone deacetylase inhibitors is mediated through the Sp1 binding motif. | 2002 | Biochem. Pharmacol. | pmid:12123752 |
Petti MC et al. | Complete remission through blast cell differentiation in PLZF/RARalpha-positive acute promyelocytic leukemia: in vitro and in vivo studies. | 2002 | Blood | pmid:12130525 |
Avram D et al. | COUP-TF (chicken ovalbumin upstream promoter transcription factor)-interacting protein 1 (CTIP1) is a sequence-specific DNA binding protein. | 2002 | Biochem. J. | pmid:12196208 |
Guo Y et al. | Regulation of DNA methylation in human breast cancer. Effect on the urokinase-type plasminogen activator gene production and tumor invasion. | 2002 | J. Biol. Chem. | pmid:12198113 |
Aapola U et al. | Imprinting regulator DNMT3L is a transcriptional repressor associated with histone deacetylase activity. | 2002 | Nucleic Acids Res. | pmid:12177302 |
Chang TH and Szabo E | Enhanced growth inhibition by combination differentiation therapy with ligands of peroxisome proliferator-activated receptor-gamma and inhibitors of histone deacetylase in adenocarcinoma of the lung. | 2002 | Clin. Cancer Res. | pmid:11948134 |
Ventura A et al. | The p66Shc longevity gene is silenced through epigenetic modifications of an alternative promoter. | 2002 | J. Biol. Chem. | pmid:11948181 |
Gradoville L et al. | Protein kinase C-independent activation of the Epstein-Barr virus lytic cycle. | 2002 | J. Virol. | pmid:11991990 |
Uesato S et al. | Novel histone deacetylase inhibitors: N-hydroxycarboxamides possessing a terminal bicyclic aryl group. | 2002 | Bioorg. Med. Chem. Lett. | pmid:11992774 |
Nambiar MP et al. | Effect of trichostatin A on human T cells resembles signaling abnormalities in T cells of patients with systemic lupus erythematosus: a new mechanism for TCR zeta chain deficiency and abnormal signaling. | 2002 | J. Cell. Biochem. | pmid:11967985 |
Fu M et al. | Androgen receptor acetylation governs trans activation and MEKK1-induced apoptosis without affecting in vitro sumoylation and trans-repression function. | 2002 | Mol. Cell. Biol. | pmid:11971970 |
Sirchia SM et al. | Endogenous reactivation of the RARbeta2 tumor suppressor gene epigenetically silenced in breast cancer. | 2002 | Cancer Res. | pmid:11980632 |
Milutinovic S et al. | Proliferating cell nuclear antigen associates with histone deacetylase activity, integrating DNA replication and chromatin modification. | 2002 | J. Biol. Chem. | pmid:11929879 |
Williams RS et al. | A common mechanism of action for three mood-stabilizing drugs. | 2002 | Nature | pmid:12015604 |
Veilleux S and Boissonneault G | Dynamics of reporter gene stimulation by HMG box proteins. | 2002 | DNA Cell Biol. | pmid:12015897 |
Huang HC et al. | Geldanamycin inhibits trichostatin A-induced cell death and histone H4 hyperacetylation in COS-7 cells. | 2002 | Life Sci. | pmid:12002521 |
Chiocca S et al. | Histone deacetylase 1 inactivation by an adenovirus early gene product. | 2002 | Curr. Biol. | pmid:11937030 |
Curradi M et al. | Molecular mechanisms of gene silencing mediated by DNA methylation. | 2002 | Mol. Cell. Biol. | pmid:11940673 |
Koyama N et al. | Differential effects of histone deacetylase inhibitors on interleukin-18 gene expression in myeloid cells. | 2002 | Biochem. Biophys. Res. Commun. | pmid:11944905 |
Nair RR et al. | Enhancement of transgene expression by combining glucocorticoids and anti-mitotic agents during transient transfection using DNA-cationic liposomes. | 2002 | Mol. Ther. | pmid:11945073 |
Qiu P and Li L | Histone acetylation and recruitment of serum responsive factor and CREB-binding protein onto SM22 promoter during SM22 gene expression. | 2002 | Circ. Res. | pmid:11988486 |
Mai A et al. | Binding mode analysis of 3-(4-benzoyl-1-methyl-1H-2-pyrrolyl)-N-hydroxy-2-propenamide: a new synthetic histone deacetylase inhibitor inducing histone hyperacetylation, growth inhibition, and terminal cell differentiation. | 2002 | J. Med. Chem. | pmid:11960489 |
Merezak C et al. | Inhibition of histone deacetylases induces bovine leukemia virus expression in vitro and in vivo. | 2002 | J. Virol. | pmid:11967319 |
Weston AD et al. | Requirement for RAR-mediated gene repression in skeletal progenitor differentiation. | 2002 | J. Cell Biol. | pmid:12105181 |
Toyooka S et al. | Progressive aberrant methylation of the RASSF1A gene in simian virus 40 infected human mesothelial cells. | 2002 | Oncogene | pmid:12082623 |
Maehara K et al. | Effects of histone acetylation on transcriptional regulation of manganese superoxide dismutase gene. | 2002 | Biochem. Biophys. Res. Commun. | pmid:12083788 |
Woo SH et al. | Structurally simple trichostatin A-like straight chain hydroxamates as potent histone deacetylase inhibitors. | 2002 | J. Med. Chem. | pmid:12061890 |
Chen Y et al. | On the epigenetic regulation of the human reelin promoter. | 2002 | Nucleic Acids Res. | pmid:12087179 |
Zhang Y and Dufau ML | Silencing of transcription of the human luteinizing hormone receptor gene by histone deacetylase-mSin3A complex. | 2002 | J. Biol. Chem. | pmid:12091390 |
Danbara M et al. | DNA methylation dominates transcriptional silencing of Pax5 in terminally differentiated B cell lines. | 2002 | Mol. Immunol. | pmid:12044782 |
Lin HM et al. | Cyclin D1 Is a Ligand-independent Co-repressor for Thyroid Hormone Receptors. | 2002 | J. Biol. Chem. | pmid:12048199 |
Scott GK et al. | Transcriptional repression of ErbB2 by histone deacetylase inhibitors detected by a genomically integrated ErbB2 promoter-reporting cell screen. | 2002 | Mol. Cancer Ther. | pmid:12477051 |
Quivy V et al. | Synergistic activation of human immunodeficiency virus type 1 promoter activity by NF-kappaB and inhibitors of deacetylases: potential perspectives for the development of therapeutic strategies. | 2002 | J. Virol. | pmid:12368351 |
Smith WL and Edlind TD | Histone deacetylase inhibitors enhance Candida albicans sensitivity to azoles and related antifungals: correlation with reduction in CDR and ERG upregulation. | 2002 | Antimicrob. Agents Chemother. | pmid:12384361 |
Harada K et al. | Deregulation of caspase 8 and 10 expression in pediatric tumors and cell lines. | 2002 | Cancer Res. | pmid:12384554 |
Zhang J et al. | Establishment of transcriptional competence in early and late S phase. | 2002 | Nature | pmid:12432398 |
Kostyniuk CL et al. | The ubiquitous and tissue specific promoters of the human SRC gene are repressed by inhibitors of histone deacetylases. | 2002 | Oncogene | pmid:12214274 |
Rössig L et al. | Inhibitors of histone deacetylation downregulate the expression of endothelial nitric oxide synthase and compromise endothelial cell function in vasorelaxation and angiogenesis. | 2002 | Circ. Res. | pmid:12411399 |
Hall IM et al. | Establishment and maintenance of a heterochromatin domain. | 2002 | Science | pmid:12215653 |
Lynch CA et al. | Reactivation of a silenced H19 gene in human rhabdomyosarcoma by demethylation of DNA but not by histone hyperacetylation. | 2002 | Mol. Cancer | pmid:12234381 |
Bereshchenko OR et al. | Acetylation inactivates the transcriptional repressor BCL6. | 2002 | Nat. Genet. | pmid:12402037 |
Chen Z et al. | Induction and superinduction of growth arrest and DNA damage gene 45 (GADD45) alpha and beta messenger RNAs by histone deacetylase inhibitors trichostatin A (TSA) and butyrate in SW620 human colon carcinoma cells. | 2002 | Cancer Lett. | pmid:12406558 |
Gálfi P et al. | Apoptosis sensitivity is not correlated with sensitivity to proliferation inhibition by the histone deacetylase inhibitors butyrate and TSA. | 2002 | Cancer Lett. | pmid:12406559 |
Travers H et al. | Human CD34+ hematopoietic progenitor cells hyperacetylate core histones in response to sodium butyrate, but not trichostatin A. | 2002 | Exp. Cell Res. | pmid:12413881 |
Wilson AJ et al. | Novel detection and differential utilization of a c-myc transcriptional block in colon cancer chemoprevention. | 2002 | Cancer Res. | pmid:12414619 |
Choy JS and Kron SJ | NuA4 subunit Yng2 function in intra-S-phase DNA damage response. | 2002 | Mol. Cell. Biol. | pmid:12417725 |
Ghoshal K et al. | Inhibitors of histone deacetylase and DNA methyltransferase synergistically activate the methylated metallothionein I promoter by activating the transcription factor MTF-1 and forming an open chromatin structure. | 2002 | Mol. Cell. Biol. | pmid:12417732 |
Hauser C et al. | Activation of the mouse histone deacetylase 1 gene by cooperative histone phosphorylation and acetylation. | 2002 | Mol. Cell. Biol. | pmid:12391151 |
Westendorf JJ et al. | Runx2 (Cbfa1, AML-3) interacts with histone deacetylase 6 and represses the p21(CIP1/WAF1) promoter. | 2002 | Mol. Cell. Biol. | pmid:12391164 |
Hoshimoto A et al. | Caprylic acid and medium-chain triglycerides inhibit IL-8 gene transcription in Caco-2 cells: comparison with the potent histone deacetylase inhibitor trichostatin A. | 2002 | Br. J. Pharmacol. | pmid:12010777 |
McGuinness MC et al. | Evaluation of pharmacological induction of fatty acid beta-oxidation in X-linked adrenoleukodystrophy. | 2001 Sep-Oct | Mol. Genet. Metab. | pmid:11592822 |
Rombouts K et al. | Trichostatin A, lead compound for development of antifibrogenic drugs. | 2001 Jul-Sep | Acta Gastroenterol. Belg. | pmid:11680040 |
Benjamin D and Jost JP | Reversal of methylation-mediated repression with short-chain fatty acids: evidence for an additional mechanism to histone deacetylation. | 2001 | Nucleic Acids Res. | pmid:11522830 |
Vigushin DM et al. | Trichostatin A is a histone deacetylase inhibitor with potent antitumor activity against breast cancer in vivo. | 2001 | Clin. Cancer Res. | pmid:11309348 |
Nervi C et al. | Inhibition of histone deacetylase activity by trichostatin A modulates gene expression during mouse embryogenesis without apparent toxicity. | 2001 | Cancer Res. | pmid:11245412 |