| MeSH term | MeSH ID | Detail |
|---|---|---|
| Liver Cirrhosis | D008103 | 67 associated lipids |
| Myeloproliferative Disorders | D009196 | 5 associated lipids |
| Osteoarthritis, Knee | D020370 | 13 associated lipids |
| Fibrosis | D005355 | 23 associated lipids |
| Carcinoma, Ductal, Breast | D018270 | 19 associated lipids |
| Carcinoma, Renal Cell | D002292 | 12 associated lipids |
| Immunologic Deficiency Syndromes | D007153 | 8 associated lipids |
| Leukemia, Promyelocytic, Acute | D015473 | 3 associated lipids |
| Stroke | D020521 | 32 associated lipids |
| Leukemia, Myeloid | D007951 | 52 associated lipids |
trichostatin A
Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with trichostatin A?
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with trichostatin A
PubChem Associated disorders and diseases
What pathways are associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with trichostatin A?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with trichostatin A?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with trichostatin A?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with trichostatin A?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with trichostatin A?
Mouse Model
Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with trichostatin A
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Mukhopadhyay NK et al. | Effectiveness of trichostatin A as a potential candidate for anticancer therapy in non-small-cell lung cancer. | 2006 | Ann. Thorac. Surg. | pmid:16488717 |
| Swanson S | Invited commentary. | 2006 | Ann. Thorac. Surg. | pmid:16488718 |
| Song YF et al. | High-frequency promoter hypermethylation of the deleted in liver cancer-1 gene in multiple myeloma. | 2006 | J. Clin. Pathol. | pmid:16489177 |
| Rokhlin OW et al. | Mechanisms of cell death induced by histone deacetylase inhibitors in androgen receptor-positive prostate cancer cells. | 2006 | Mol. Cancer Res. | pmid:16513842 |
| Endo T et al. | Activities of maturation-promoting factor (MPF) and mitogen-activated protein kinase (MAPK) are not required for the global histone deacetylation observed after germinal vesicle breakdown (GVBD) in porcine oocytes. | 2006 | Reproduction | pmid:16514187 |
| Sah NK et al. | Effect of downregulation of survivin expression on radiosensitivity of human epidermoid carcinoma cells. | 2006 | Int. J. Radiat. Oncol. Biol. Phys. | pmid:17011457 |
| Kumar KS et al. | Histone deacetylase inhibitors induce cell death in supratentorial primitive neuroectodermal tumor cells. | 2006 | Oncol. Rep. | pmid:17016591 |
| Wee G et al. | Inheritable histone H4 acetylation of somatic chromatins in cloned embryos. | 2006 | J. Biol. Chem. | pmid:16371357 |
| Alao JP et al. | Role of glycogen synthase kinase 3 beta (GSK3beta) in mediating the cytotoxic effects of the histone deacetylase inhibitor trichostatin A (TSA) in MCF-7 breast cancer cells. | 2006 | Mol. Cancer | pmid:17018141 |
| Hsu MC et al. | HER-2/neu represses the metastasis suppressor RECK via ERK and Sp transcription factors to promote cell invasion. | 2006 | J. Biol. Chem. | pmid:16377629 |
| Zhao LY et al. | An EBF3-mediated transcriptional program that induces cell cycle arrest and apoptosis. | 2006 | Cancer Res. | pmid:17018599 |
| Majumder S et al. | Epigenetic regulation of metallothionein-i gene expression: differential regulation of methylated and unmethylated promoters by DNA methyltransferases and methyl CpG binding proteins. | 2006 | J. Cell. Biochem. | pmid:16329111 |
| Zhou H et al. | Epigenetic allele silencing unveils recessive RYR1 mutations in core myopathies. | 2006 | Am. J. Hum. Genet. | pmid:17033962 |
| Ooi L et al. | BRG1 chromatin remodeling activity is required for efficient chromatin binding by repressor element 1-silencing transcription factor (REST) and facilitates REST-mediated repression. | 2006 | J. Biol. Chem. | pmid:17023429 |
| Gaymes TJ et al. | Histone deacetylase inhibitors (HDI) cause DNA damage in leukemia cells: a mechanism for leukemia-specific HDI-dependent apoptosis? | 2006 | Mol. Cancer Res. | pmid:16877702 |
| Malone CS et al. | B29 gene silencing in pituitary cells is regulated by its 3' enhancer. | 2006 | J. Mol. Biol. | pmid:16920149 |
| Lo PK et al. | Epigenetic suppression of secreted frizzled related protein 1 (SFRP1) expression in human breast cancer. | 2006 | Cancer Biol. Ther. | pmid:16410723 |
| Williams SA et al. | NF-kappaB p50 promotes HIV latency through HDAC recruitment and repression of transcriptional initiation. | 2006 | EMBO J. | pmid:16319923 |
| Zou B et al. | Correlation between the single-site CpG methylation and expression silencing of the XAF1 gene in human gastric and colon cancers. | 2006 | Gastroenterology | pmid:17087954 |
| Anderson I | Deacetylase inhibitors aid recovery in muscular dystrophy. | 2006 | Lancet Neurol | pmid:17089447 |
| Kiefer J et al. | Mixtures of SCFA, composed according to physiologically available concentrations in the gut lumen, modulate histone acetylation in human HT29 colon cancer cells. | 2006 | Br. J. Nutr. | pmid:17092367 |
| Kishigami S et al. | Epigenetic abnormalities of the mouse paternal zygotic genome associated with microinsemination of round spermatids. | 2006 | Dev. Biol. | pmid:16325170 |
| Mogal A and Abdulkadir SA | Effects of Histone Deacetylase Inhibitor (HDACi); Trichostatin-A (TSA) on the expression of housekeeping genes. | 2006 | Mol. Cell. Probes | pmid:16326072 |
| Gan Y et al. | Dual effects of histone deacetylase inhibition by trichostatin A on endothelial nitric oxide synthase expression in endothelial cells. | 2006 | Biochem. Biophys. Res. Commun. | pmid:16338217 |
| Nishiyama A et al. | Brd4 is required for recovery from antimicrotubule drug-induced mitotic arrest: preservation of acetylated chromatin. | 2006 | Mol. Biol. Cell | pmid:16339075 |
| Trapp J et al. | Adenosine mimetics as inhibitors of NAD+-dependent histone deacetylases, from kinase to sirtuin inhibition. | 2006 | J. Med. Chem. | pmid:17149860 |
| Solomon JM et al. | Inhibition of SIRT1 catalytic activity increases p53 acetylation but does not alter cell survival following DNA damage. | 2006 | Mol. Cell. Biol. | pmid:16354677 |
| Kishigami S et al. | Significant improvement of mouse cloning technique by treatment with trichostatin A after somatic nuclear transfer. | 2006 | Biochem. Biophys. Res. Commun. | pmid:16356478 |
| Baradari V et al. | Antiproliferative and proapoptotic effects of histone deacetylase inhibitors on gastrointestinal neuroendocrine tumor cells. | 2006 | Endocr. Relat. Cancer | pmid:17158768 |
| Taghiyev AF et al. | TSA-induced cell death in prostate cancer cell lines is caspase-2 dependent and involves the PIDDosome. | 2006 | Cancer Biol. Ther. | pmid:17110788 |
| Hishikawa K and Fujita T | [Basic research for renal regeneration]. | 2006 | Nippon Rinsho | pmid:16895225 |
| Baek SY et al. | Trichostatin A increases the thermosensitivity of human glioblastoma A172 cells. | 2006 | Neurosci. Lett. | pmid:16384639 |
| Meisel A et al. | Inhibition of histone deacetylation protects wild-type but not gelsolin-deficient neurons from oxygen/glucose deprivation. | 2006 | J. Neurochem. | pmid:16895577 |
| Bates EA et al. | Differential contributions of Caenorhabditis elegans histone deacetylases to huntingtin polyglutamine toxicity. | 2006 | J. Neurosci. | pmid:16525063 |
| Chuang HC et al. | Histone deacetylase 3 binds to and regulates the GCMa transcription factor. | 2006 | Nucleic Acids Res. | pmid:16528103 |
| Hsiao CH et al. | Fetal hemoglobin induction by histone deacetylase inhibitors involves generation of reactive oxygen species. | 2006 | Exp. Hematol. | pmid:16543060 |
| Yamamoto G et al. | Correlation of invasion and metastasis of cancer cells, and expression of the RAD21 gene in oral squamous cell carcinoma. | 2006 | Virchows Arch. | pmid:16416296 |
| Gagnon JF et al. | Irinotecan inactivation is modulated by epigenetic silencing of UGT1A1 in colon cancer. | 2006 | Clin. Cancer Res. | pmid:16551870 |
| Rebbaa A et al. | The role of histone acetylation versus DNA damage in drug-induced senescence and apoptosis. | 2006 | Cell Death Differ. | pmid:16557274 |
| Suuronen T et al. | Characterization of the pro-inflammatory signaling induced by protein acetylation in microglia. | 2006 | Neurochem. Int. | pmid:16797784 |
| Krishnan M et al. | Effects of epigenetic modulation on reporter gene expression: implications for stem cell imaging. | 2006 | FASEB J. | pmid:16246867 |
| Wallace DM et al. | Histone deacetylase activity regulates apaf-1 and caspase 3 expression in the developing mouse retina. | 2006 | Invest. Ophthalmol. Vis. Sci. | pmid:16799012 |
| Pampalakis G and Sotiropoulou G | Multiple mechanisms underlie the aberrant expression of the human kallikrein 6 gene in breast cancer. | 2006 | Biol. Chem. | pmid:16800739 |
| Wang Y et al. | Association between enhanced type I collagen expression and epigenetic repression of the FLI1 gene in scleroderma fibroblasts. | 2006 | Arthritis Rheum. | pmid:16802366 |
| Morinobu A et al. | Trichostatin A cooperates with Fas-mediated signal to induce apoptosis in rheumatoid arthritis synovial fibroblasts. | 2006 | J. Rheumatol. | pmid:16755652 |
| Son YO et al. | Involvement of caspase activation and mitochondrial stress in trichostatin A-induced apoptosis of Burkitt's lymphoma cell line, Akata. | 2006 | J. Cell. Biochem. | pmid:16817225 |
| Lau QC et al. | RUNX3 is frequently inactivated by dual mechanisms of protein mislocalization and promoter hypermethylation in breast cancer. | 2006 | Cancer Res. | pmid:16818622 |
| Peng C et al. | The transcriptional regulation role of BRD7 by binding to acetylated histone through bromodomain. | 2006 | J. Cell. Biochem. | pmid:16265664 |
| Foltz G et al. | Genome-wide analysis of epigenetic silencing identifies BEX1 and BEX2 as candidate tumor suppressor genes in malignant glioma. | 2006 | Cancer Res. | pmid:16818640 |
| Mori T et al. | Estrogen receptor-alpha methylation predicts melanoma progression. | 2006 | Cancer Res. | pmid:16818643 |
| Sato K et al. | Deficient expression of the DPD gene is caused by epigenetic modification in biliary tract cancer cells, and induces high sensitivity to 5-FU treatment. | 2006 | Int. J. Oncol. | pmid:16820886 |
| Tsuji H et al. | Dynamic and reversible changes in histone H3-Lys4 methylation and H3 acetylation occurring at submergence-inducible genes in rice. | 2006 | Plant Cell Physiol. | pmid:16774928 |
| Kwon O et al. | NF-kappaB inhibition increases chemosensitivity to trichostatin A-induced cell death of Ki-Ras-transformed human prostate epithelial cells. | 2006 | Carcinogenesis | pmid:16774937 |
| Zhao YM et al. | Effects of histone deacetylase inhibitors on transcriptional regulation of the hsp70 gene in Drosophila. | 2006 | Cell Res. | pmid:16775628 |
| Kong Y et al. | Suppression of class I and II histone deacetylases blunts pressure-overload cardiac hypertrophy. | 2006 | Circulation | pmid:16735673 |
| Dannenberg LO et al. | Differential regulation of the alcohol dehydrogenase 1B (ADH1B) and ADH1C genes by DNA methylation and histone deacetylation. | 2006 | Alcohol. Clin. Exp. Res. | pmid:16737450 |
| Cabrero JR et al. | Lymphocyte chemotaxis is regulated by histone deacetylase 6, independently of its deacetylase activity. | 2006 | Mol. Biol. Cell | pmid:16738306 |
| Vulcano F et al. | HDAC inhibition is associated to valproic acid induction of early megakaryocytic markers. | 2006 | Exp. Cell Res. | pmid:16739251 |
| Qi H and Ratnam M | Synergistic induction of folate receptor beta by all-trans retinoic acid and histone deacetylase inhibitors in acute myelogenous leukemia cells: mechanism and utility in enhancing selective growth inhibition by antifolates. | 2006 | Cancer Res. | pmid:16740727 |
| Nusinzon I and Horvath CM | Positive and negative regulation of the innate antiviral response and beta interferon gene expression by deacetylation. | 2006 | Mol. Cell. Biol. | pmid:16581785 |
| Ibanez de Caceres I et al. | Identification of novel target genes by an epigenetic reactivation screen of renal cancer. | 2006 | Cancer Res. | pmid:16707423 |
| Imre G et al. | Histone deacetylase inhibitors suppress the inducibility of nuclear factor-kappaB by tumor necrosis factor-alpha receptor-1 down-regulation. | 2006 | Cancer Res. | pmid:16707469 |
| Jaalouk DE et al. | Inhibition of histone deacetylation in 293GPG packaging cell line improves the production of self-inactivating MLV-derived retroviral vectors. | 2006 | Virol. J. | pmid:16603064 |
| Lu Z et al. | E2F-HDAC complexes negatively regulate the tumor suppressor gene ARHI in breast cancer. | 2006 | Oncogene | pmid:16158053 |
| Hwang DY and Ismail-Beigi F | Control of Glut1 promoter activity under basal conditions and in response to hyperosmolarity: role of Sp1. | 2006 | Am. J. Physiol., Cell Physiol. | pmid:16162661 |
| Kim MY et al. | Acetylation of estrogen receptor alpha by p300 at lysines 266 and 268 enhances the deoxyribonucleic acid binding and transactivation activities of the receptor. | 2006 | Mol. Endocrinol. | pmid:16497729 |
| Leng Y and Chuang DM | Endogenous alpha-synuclein is induced by valproic acid through histone deacetylase inhibition and participates in neuroprotection against glutamate-induced excitotoxicity. | 2006 | J. Neurosci. | pmid:16837598 |
| Hofmann A et al. | Epigenetic regulation of lentiviral transgene vectors in a large animal model. | 2006 | Mol. Ther. | pmid:16140581 |
| Aung HT et al. | LPS regulates proinflammatory gene expression in macrophages by altering histone deacetylase expression. | 2006 | FASEB J. | pmid:16816106 |
| Clem BF and Clark BJ | Association of the mSin3A-histone deacetylase 1/2 corepressor complex with the mouse steroidogenic acute regulatory protein gene. | 2006 | Mol. Endocrinol. | pmid:16109738 |
| Lee JH et al. | Histone deacetylase inhibitor enhances 5-fluorouracil cytotoxicity by down-regulating thymidylate synthase in human cancer cells. | 2006 | Mol. Cancer Ther. | pmid:17172411 |
| Mai A et al. | Synthesis and biological properties of novel, uracil-containing histone deacetylase inhibitors. | 2006 | J. Med. Chem. | pmid:17004718 |
| Yao J et al. | NF-kappaB signaling pathway is involved in growth inhibition, G2/M arrest and apoptosis induced by Trichostatin A in human tongue carcinoma cells. | 2006 | Pharmacol. Res. | pmid:17005413 |
| Inoue K et al. | Histone deacetylase inhibitor reduces monocyte adhesion to endothelium through the suppression of vascular cell adhesion molecule-1 expression. | 2006 | Arterioscler. Thromb. Vasc. Biol. | pmid:17008592 |
| Baqir S and Smith LC | Inhibitors of histone deacetylases and DNA methyltransferases alter imprinted gene regulation in embryonic stem cells. | 2006 | Cloning Stem Cells | pmid:17009896 |
| Hong ZY et al. | [Mechanism of apoptosis induced by trichostatin A in leukemia Molt-4 cells analyzed by microarray]. | 2006 | Ai Zheng | pmid:16965673 |
| Banwell CM et al. | Altered nuclear receptor corepressor expression attenuates vitamin D receptor signaling in breast cancer cells. | 2006 | Clin. Cancer Res. | pmid:16609009 |
| Ryu JK et al. | SK-7041, a new histone deacetylase inhibitor, induces G2-M cell cycle arrest and apoptosis in pancreatic cancer cell lines. | 2006 | Cancer Lett. | pmid:16009488 |
| Wang Q et al. | Histone phosphorylation and pericentromeric histone modifications in oocyte meiosis. | 2006 | Cell Cycle | pmid:16969090 |
| Kim MY et al. | A repressor complex, AP4 transcription factor and geminin, negatively regulates expression of target genes in nonneuronal cells. | 2006 | Proc. Natl. Acad. Sci. U.S.A. | pmid:16924111 |
| Mühlethaler-Mottet A et al. | Histone deacetylase inhibitors strongly sensitise neuroblastoma cells to TRAIL-induced apoptosis by a caspases-dependent increase of the pro- to anti-apoptotic proteins ratio. | 2006 | BMC Cancer | pmid:16930472 |
| Suzuki T et al. | Highly potent and selective histone deacetylase 6 inhibitors designed based on a small-molecular substrate. | 2006 | J. Med. Chem. | pmid:16884291 |
| Kim TY et al. | Epigenomic profiling reveals novel and frequent targets of aberrant DNA methylation-mediated silencing in malignant glioma. | 2006 | Cancer Res. | pmid:16885346 |
| Kimura N et al. | Alteration of developmental program in Paramecium by treatment with trichostatin a: a possible involvement of histone modification. | 2006 | Protist | pmid:16839811 |
| Monte M et al. | MAGE-A tumor antigens target p53 transactivation function through histone deacetylase recruitment and confer resistance to chemotherapeutic agents. | 2006 | Proc. Natl. Acad. Sci. U.S.A. | pmid:16847267 |
| Zaveri NT et al. | Regulation of the prepronociceptin gene and its effect on neuronal differentiation. | 2006 | Gene | pmid:16935438 |
| Dokras A et al. | Epigenetic regulation of maspin expression in the human placenta. | 2006 | Mol. Hum. Reprod. | pmid:16936308 |
| Yamamura K et al. | Pleiotropic role of histone deacetylases in the regulation of human adult erythropoiesis. | 2006 | Br. J. Haematol. | pmid:16939493 |
| Das PM et al. | Methylation mediated silencing of TMS1/ASC gene in prostate cancer. | 2006 | Mol. Cancer | pmid:16848908 |
| Puppin C et al. | HEX expression and localization in normal mammary gland and breast carcinoma. | 2006 | BMC Cancer | pmid:16854221 |
| Dannenberg LO and Edenberg HJ | Epigenetics of gene expression in human hepatoma cells: expression profiling the response to inhibition of DNA methylation and histone deacetylation. | 2006 | BMC Genomics | pmid:16854234 |
| Bell CW et al. | The extracellular release of HMGB1 during apoptotic cell death. | 2006 | Am. J. Physiol., Cell Physiol. | pmid:16855214 |
| Olaharski AJ et al. | The histone deacetylase inhibitor trichostatin a has genotoxic effects in human lymphoblasts in vitro. | 2006 | Toxicol. Sci. | pmid:16857700 |
| Lund P et al. | Oncogenic HRAS suppresses clusterin expression through promoter hypermethylation. | 2006 | Oncogene | pmid:16568090 |
| Piacentini P et al. | Trichostatin A enhances the response of chemotherapeutic agents in inhibiting pancreatic cancer cell proliferation. | 2006 | Virchows Arch. | pmid:16568310 |
| Alao JP et al. | The cyclin D1 proto-oncogene is sequestered in the cytoplasm of mammalian cancer cell lines. | 2006 | Mol. Cancer | pmid:16503970 |
| Kim IA et al. | Histone deacetylase inhibitor-mediated radiosensitization of human cancer cells: class differences and the potential influence of p53. | 2006 | Clin. Cancer Res. | pmid:16467109 |
| Osborn NK et al. | Aberrant methylation of the eyes absent 4 gene in ulcerative colitis-associated dysplasia. | 2006 | Clin. Gastroenterol. Hepatol. | pmid:16469682 |
| Baraz L et al. | Tumor suppressor p53 regulates heparanase gene expression. | 2006 | Oncogene | pmid:16474844 |
| Gialitakis M et al. | Coordinated changes of histone modifications and HDAC mobilization regulate the induction of MHC class II genes by Trichostatin A. | 2006 | Nucleic Acids Res. | pmid:16452299 |