| MeSH term | MeSH ID | Detail |
|---|---|---|
| Liver Cirrhosis | D008103 | 67 associated lipids |
| Myeloproliferative Disorders | D009196 | 5 associated lipids |
| Osteoarthritis, Knee | D020370 | 13 associated lipids |
| Fibrosis | D005355 | 23 associated lipids |
| Carcinoma, Ductal, Breast | D018270 | 19 associated lipids |
| Carcinoma, Renal Cell | D002292 | 12 associated lipids |
| Immunologic Deficiency Syndromes | D007153 | 8 associated lipids |
| Leukemia, Promyelocytic, Acute | D015473 | 3 associated lipids |
| Stroke | D020521 | 32 associated lipids |
| Leukemia, Myeloid | D007951 | 52 associated lipids |
trichostatin A
Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with trichostatin A?
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with trichostatin A
PubChem Associated disorders and diseases
What pathways are associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with trichostatin A?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with trichostatin A?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with trichostatin A?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with trichostatin A?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with trichostatin A?
Mouse Model
Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with trichostatin A
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Chang YW and Singh KP | Long-term exposure to estrogen enhances chemotherapeutic efficacy potentially through epigenetic mechanism in human breast cancer cells. | 2017 | PLoS ONE | pmid:28323900 |
| Lin S et al. | Silencing of ATP4B of ATPase H/K Transporting Beta Subunit by Intragenic Epigenetic Alteration in Human Gastric Cancer Cells. | 2017 | Oncol. Res. | pmid:28281974 |
| Li LF et al. | Trichostatin A attenuates ventilation-augmented epithelial-mesenchymal transition in mice with bleomycin-induced acute lung injury by suppressing the Akt pathway. | 2017 | PLoS ONE | pmid:28234968 |
| Wu Y et al. | Suppression of Excessive Histone Deacetylases Activity in Diabetic Hearts Attenuates Myocardial Ischemia/Reperfusion Injury via Mitochondria Apoptosis Pathway. | 2017 | J Diabetes Res | pmid:28191472 |
| Vanneste M et al. | Hyaluronate synthase-2 overexpression alters estrogen dependence and induces histone deacetylase inhibitor-like effects on ER-driven genes in MCF7 breast tumor cells. | 2017 | Mol. Cell. Endocrinol. | pmid:28137613 |
| Wang XJ et al. | Opposing Roles of Acetylation and Phosphorylation in LIFR-Dependent Self-Renewal Growth Signaling in Mouse Embryonic Stem Cells. | 2017 | Cell Rep | pmid:28122243 |
| Ladrech S et al. | High mobility group box 1 (HMGB1): dual functions in the cochlear auditory neurons in response to stress? | 2017 | Histochem. Cell Biol. | pmid:27704212 |
| Hrgovic I et al. | Histone deacetylase inhibitors interfere with angiogenesis by decreasing endothelial VEGFR-2 protein half-life in part via a VE-cadherin-dependent mechanism. | 2017 | Exp. Dermatol. | pmid:27487811 |
| Xie C et al. | In vitro analysis of factors influencing expression as potential determinants of interindividual variation. | 2017 | Pharmacol Res Perspect | pmid:28357125 |
| Mijiddorj T et al. | Retinoic acid and retinaldehyde dehydrogenase are not involved in the specific induction of the follicle-stimulating hormone β subunit by trichostatin A, a selective inhibitor of histone deacetylase. | 2017 | Gen. Comp. Endocrinol. | pmid:26654743 |
| Kim YH and Lee JK | Histone deacetylase inhibitors suppress immature dendritic cell's migration by regulating CC chemokine receptor 1 expression. | 2017 | Cell. Immunol. | pmid:28341057 |
| Unruhe-Knauf B and Knauer SK | Analysis of HDACi-Induced Changes in Chromosomal Passenger Complex Localization. | 2017 | Methods Mol. Biol. | pmid:27761812 |
| Gilardini Montani MS et al. | Histone deacetylase inhibitors VPA and TSA induce apoptosis and autophagy in pancreatic cancer cells. | 2017 | Cell Oncol (Dordr) | pmid:28160167 |
| Li L et al. | In Vivo Screening Using Transgenic Zebrafish Embryos Reveals New Effects of HDAC Inhibitors Trichostatin A and Valproic Acid on Organogenesis. | 2016 | PLoS ONE | pmid:26900852 |
| Hou X et al. | Histone deacetylase inhibitor regulates the balance of Th17/Treg in allergic asthma. | 2016 | Clin Respir J | pmid:25307458 |
| Pallocca G et al. | Identification of transcriptome signatures and biomarkers specific for potential developmental toxicants inhibiting human neural crest cell migration. | 2016 | Arch. Toxicol. | pmid:26705709 |
| Li X et al. | Role of histone deacetylases(HDACs) in progression and reversal of liver fibrosis. | 2016 | Toxicol. Appl. Pharmacol. | pmid:27396813 |
| Robert C et al. | Histone deacetylase inhibitors decrease NHEJ both by acetylation of repair factors and trapping of PARP1 at DNA double-strand breaks in chromatin. | 2016 | Leuk. Res. | pmid:27064363 |
| Mohammadi-Bardbori A et al. | Chromatin remodeling by curcumin alters endogenous aryl hydrocarbon receptor signaling. | 2016 | Chem. Biol. Interact. | pmid:27041069 |
| Li W et al. | Epigenetics Reactivation of Nrf2 in Prostate TRAMP C1 Cells by Curcumin Analogue FN1. | 2016 | Chem. Res. Toxicol. | pmid:26991801 |
| Wu TC et al. | The enhancing effect of genistein on apoptosis induced by trichostatin A in lung cancer cells with wild type p53 genes is associated with upregulation of histone acetyltransferase. | 2016 | Toxicol. Appl. Pharmacol. | pmid:26768552 |
| Adachi T et al. | Histone deacetylase inhibitors stimulate the susceptibility of A549Â cells to a plasma-activated medium treatment. | 2016 | Arch. Biochem. Biophys. | pmid:27470189 |
| Deng Z et al. | Histone Deacetylase Inhibitor Trichostatin a Promotes the Apoptosis of Osteosarcoma Cells through p53 Signaling Pathway Activation. | 2016 | Int. J. Biol. Sci. | pmid:27877082 |
| Sugiyama KI et al. | Epigenetic mutagen as histone modulator can be detected by yeast flocculation. | 2016 | Mutagenesis | pmid:27549112 |
| Zhang XF et al. | Trichostatin A Enhances the Apoptotic Potential of Palladium Nanoparticles in Human Cervical Cancer Cells. | 2016 | Int J Mol Sci | pmid:27548148 |
| Scholpa NE et al. | Nephrotoxicity of epigenetic inhibitors used for the treatment of cancer. | 2016 | Chem. Biol. Interact. | pmid:27543423 |
| Hou Y et al. | Expression Profiles of SIRT1 and APP Genes in Human Neuroblastoma SK-N-SH Cells Treated with Two Epigenetic Agents. | 2016 | Neurosci Bull | pmid:27522594 |
| Huang H et al. | Regulation of TWIK-related potassium channel-1 (Trek1) restitutes intestinal epithelial barrier function. | 2016 | Cell. Mol. Immunol. | pmid:25683610 |
| Wang S et al. | Sex steroid-induced DNA methylation changes and inflammation response in prostate cancer. | 2016 | Cytokine | pmid:27500645 |
| Por ED et al. | Trichostatin A Inhibits Retinal Pigmented Epithelium Activation in an In Vitro Model of Proliferative Vitreoretinopathy. | 2016 | J Ocul Pharmacol Ther | pmid:27494828 |
| Liu Y et al. | DNA methylation of claudin-6 promotes breast cancer cell migration and invasion by recruiting MeCP2 and deacetylating H3Ac and H4Ac. | 2016 | J. Exp. Clin. Cancer Res. | pmid:27461117 |
| Feng Q et al. | Histone deacetylase inhibitors suppress RSV infection and alleviate virus-induced airway inflammation. | 2016 | Int. J. Mol. Med. | pmid:27460781 |
| Miyake Y et al. | Structural insights into HDAC6 tubulin deacetylation and its selective inhibition. | 2016 | Nat. Chem. Biol. | pmid:27454931 |
| Duclot F et al. | Trichostatin A (TSA) facilitates formation of partner preference in male prairie voles (Microtus ochrogaster). | 2016 | Horm Behav | pmid:27074037 |
| Toki S et al. | The histone deacetylase inhibitor trichostatin A suppresses murine innate allergic inflammation by blocking group 2 innate lymphoid cell (ILC2) activation. | 2016 | Thorax | pmid:27071418 |
| Chen J et al. | Histone Deacetylase Inhibitors Trichostatin A and MCP30 Relieve Benzene-Induced Hematotoxicity via Restoring Topoisomerase IIα. | 2016 | PLoS ONE | pmid:27058040 |
| Zhang F et al. | Histone Acetylation Induced Transformation of B-DNA to Z-DNA in Cells Probed through FT-IR Spectroscopy. | 2016 | Anal. Chem. | pmid:27046421 |
| Huynh NC et al. | Inhibition of Histone Deacetylases Enhances the Osteogenic Differentiation of Human Periodontal Ligament Cells. | 2016 | J. Cell. Biochem. | pmid:27043246 |
| Gupta DK et al. | DNA damage regulation and its role in drug-related phenotypes in the malaria parasites. | 2016 | Sci Rep | pmid:27033103 |
| Clarke CJ et al. | ATRA transcriptionally induces nSMase2 through CBP/p300-mediated histone acetylation. | 2016 | J. Lipid Res. | pmid:27013100 |
| Zhang HP et al. | Association between histone hyperacetylation status in memory T lymphocytes and allergen-induced eosinophilic airway inflammation. | 2016 | Respirology | pmid:26991676 |
| Sharma K et al. | Constitutive hyperactivity of histone deacetylases enhances radioresistance in Lepidopteran Sf9 insect cells. | 2016 | Biochim. Biophys. Acta | pmid:26968462 |
| Majumdar G and Raghow R | Trichostatin A induces a unique set of microRNAs including miR-129-5p that blocks cyclin-dependent kinase 6 expression and proliferation in H9c2 cardiac myocytes. | 2016 | Mol. Cell. Biochem. | pmid:26946427 |
| Sakharkar AJ et al. | A role for histone acetylation mechanisms in adolescent alcohol exposure-induced deficits in hippocampal brain-derived neurotrophic factor expression and neurogenesis markers in adulthood. | 2016 | Brain Struct Funct | pmid:26941165 |
| Deguise MO et al. | Differential induction of muscle atrophy pathways in two mouse models of spinal muscular atrophy. | 2016 | Sci Rep | pmid:27349908 |
| Asgar MA et al. | Synergistic anticancer effects of cisplatin and histone deacetylase inhibitors (SAHA and TSA) on cholangiocarcinoma cell lines. | 2016 | Int. J. Oncol. | pmid:26575528 |
| Ranganathan P et al. | Histone deacetylase–mediated silencing of AMWAP expression contributes to cisplatin nephrotoxicity. | 2016 | Kidney Int. | pmid:26509586 |
| Selokar NL et al. | Buffalo (Bubalus bubalis) SCNT embryos produced from somatic cells isolated from frozen-thawed semen: effect of trichostatin A on the in vitro and in vivo developmental potential, quality and epigenetic status. | 2016 | Zygote | pmid:26503476 |
| Alizadeh E et al. | Upregulation of MiR-122 via Trichostatin A Treatments in Hepatocyte-like Cells Derived from Mesenchymal Stem Cells. | 2016 | Chem Biol Drug Des | pmid:26360933 |
| Tan CS et al. | Epigenetic Regulation of Cytosolic Phospholipase A2 in SH-SY5Y Human Neuroblastoma Cells. | 2016 | Mol. Neurobiol. | pmid:26162318 |