| MeSH term | MeSH ID | Detail |
|---|---|---|
| Liver Cirrhosis | D008103 | 67 associated lipids |
| Myeloproliferative Disorders | D009196 | 5 associated lipids |
| Osteoarthritis, Knee | D020370 | 13 associated lipids |
| Fibrosis | D005355 | 23 associated lipids |
| Carcinoma, Ductal, Breast | D018270 | 19 associated lipids |
| Carcinoma, Renal Cell | D002292 | 12 associated lipids |
| Immunologic Deficiency Syndromes | D007153 | 8 associated lipids |
| Leukemia, Promyelocytic, Acute | D015473 | 3 associated lipids |
| Stroke | D020521 | 32 associated lipids |
| Leukemia, Myeloid | D007951 | 52 associated lipids |
trichostatin A
Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with trichostatin A?
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with trichostatin A
PubChem Associated disorders and diseases
What pathways are associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with trichostatin A?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with trichostatin A?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with trichostatin A?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with trichostatin A?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with trichostatin A?
Mouse Model
Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with trichostatin A
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Sachs LM et al. | Involvement of histone deacetylase at two distinct steps in gene regulation during intestinal development in Xenopus laevis. | 2001 | Dev. Dyn. | pmid:11668605 |
| Amann JM et al. | ETO, a target of t(8;21) in acute leukemia, makes distinct contacts with multiple histone deacetylases and binds mSin3A through its oligomerization domain. | 2001 | Mol. Cell. Biol. | pmid:11533236 |
| Plant KE et al. | Intergenic transcription in the human beta-globin gene cluster. | 2001 | Mol. Cell. Biol. | pmid:11533239 |
| Chen Lf W et al. | Duration of nuclear NF-kappaB action regulated by reversible acetylation. | 2001 | Science | pmid:11533489 |
| Vinatzer U et al. | The leukaemia-associated transcription factors EVI-1 and MDS1/EVI1 repress transcription and interact with histone deacetylase. | 2001 | Br. J. Haematol. | pmid:11552981 |
| Sekimata M et al. | Involvement of a novel zinc finger protein, MIZF, in transcriptional repression by interacting with a methyl-CpG-binding protein, MBD2. | 2001 | J. Biol. Chem. | pmid:11553631 |
| Deltour S et al. | Characterization of HRG22, a human homologue of the putative tumor suppressor gene HIC1. | 2001 | Biochem. Biophys. Res. Commun. | pmid:11554746 |
| Kiela PR et al. | Regulation of the rat NHE3 gene promoter by sodium butyrate. | 2001 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:11557515 |
| Sawa H et al. | Histone deacetylase inhibitors such as sodium butyrate and trichostatin A induce apoptosis through an increase of the bcl-2-related protein Bad. | 2001 | Brain Tumor Pathol | pmid:11908866 |
| Benjamin D and Jost JP | Reversal of methylation-mediated repression with short-chain fatty acids: evidence for an additional mechanism to histone deacetylation. | 2001 | Nucleic Acids Res. | pmid:11522830 |
| Kim MS et al. | Histone deacetylases induce angiogenesis by negative regulation of tumor suppressor genes. | 2001 | Nat. Med. | pmid:11283670 |
| Vigushin DM et al. | Trichostatin A is a histone deacetylase inhibitor with potent antitumor activity against breast cancer in vivo. | 2001 | Clin. Cancer Res. | pmid:11309348 |
| Magdinier F and Wolffe AP | Selective association of the methyl-CpG binding protein MBD2 with the silent p14/p16 locus in human neoplasia. | 2001 | Proc. Natl. Acad. Sci. U.S.A. | pmid:11309512 |
| Grande A et al. | A functionally active RARalpha nuclear receptor is expressed in retinoic acid non responsive early myeloblastic cell lines. | 2001 | Cell Death Differ. | pmid:11313705 |
| Wu Y et al. | Negative regulation of bcl-2 expression by p53 in hematopoietic cells. | 2001 | Oncogene | pmid:11313951 |
| Greenberg VL et al. | Histone deacetylase inhibitors promote apoptosis and differential cell cycle arrest in anaplastic thyroid cancer cells. | 2001 | Thyroid | pmid:11349829 |
| Lea MA et al. | Induction of histone acetylation in mouse erythroleukemia cells by some organosulfur compounds including allyl isothiocyanate. | 2001 | Int. J. Cancer | pmid:11351296 |
| Jordan A et al. | The site of HIV-1 integration in the human genome determines basal transcriptional activity and response to Tat transactivation. | 2001 | EMBO J. | pmid:11285236 |
| Rashid SF et al. | Synergistic growth inhibition of prostate cancer cells by 1 alpha,25 Dihydroxyvitamin D(3) and its 19-nor-hexafluoride analogs in combination with either sodium butyrate or trichostatin A. | 2001 | Oncogene | pmid:11313934 |
| Bachl J et al. | Increased transcription levels induce higher mutation rates in a hypermutating cell line. | 2001 | J. Immunol. | pmid:11290786 |
| Osborne A et al. | Histone deacetylase activity represses gamma interferon-inducible HLA-DR gene expression following the establishment of a DNase I-hypersensitive chromatin conformation. | 2001 | Mol. Cell. Biol. | pmid:11533238 |
| Arthur JL et al. | Herpes simplex virus type 1 promoter activity during latency establishment, maintenance, and reactivation in primary dorsal root neurons in vitro. | 2001 | J. Virol. | pmid:11264377 |
| Lizcano F et al. | Cell type-specific roles of histone deacetylase in TR ligand-independent transcriptional repression. | 2001 | Mol. Cell. Endocrinol. | pmid:11165035 |
| Nervi C et al. | Inhibition of histone deacetylase activity by trichostatin A modulates gene expression during mouse embryogenesis without apparent toxicity. | 2001 | Cancer Res. | pmid:11245412 |
| Zhu WG et al. | DNA methyltransferase inhibition enhances apoptosis induced by histone deacetylase inhibitors. | 2001 | Cancer Res. | pmid:11245429 |
| Muth V et al. | Acetylation of TAF(I)68, a subunit of TIF-IB/SL1, activates RNA polymerase I transcription. | 2001 | EMBO J. | pmid:11250901 |
| Laribee RN and Klemsz MJ | Loss of PU.1 expression following inhibition of histone deacetylases. | 2001 | J. Immunol. | pmid:11673528 |
| Biade S et al. | Chemical agents that promote chromatin compaction radiosensitize tumour cells. | 2001 | Int. J. Radiat. Biol. | pmid:11682008 |
| Mishra SK et al. | Dynamic chromatin remodeling on the HER2 promoter in human breast cancer cells. | 2001 | FEBS Lett. | pmid:11682064 |
| Rombouts K et al. | Trichostatin A, lead compound for development of antifibrogenic drugs. | 2001 Jul-Sep | Acta Gastroenterol. Belg. | pmid:11680040 |
| McGuinness MC et al. | Evaluation of pharmacological induction of fatty acid beta-oxidation in X-linked adrenoleukodystrophy. | 2001 Sep-Oct | Mol. Genet. Metab. | pmid:11592822 |
| Guo WH et al. | Inhibition of growth of mouse gastric cancer cells by Runx3, a novel tumor suppressor. | 2002 | Oncogene | pmid:12447699 |
| Marin-Husstege M et al. | Histone deacetylase activity is necessary for oligodendrocyte lineage progression. | 2002 | J. Neurosci. | pmid:12451133 |
| Wang ZM et al. | Trichostatin A inhibits proliferation and induces expression of p21WAF and p27 in human brain tumor cell lines. | 2002 | Ai Zheng | pmid:12508652 |
| Duharcourt S and Yao MC | Role of histone deacetylation in developmentally programmed DNA rearrangements in Tetrahymena thermophila. | 2002 | Eukaryotic Cell | pmid:12455963 |
| Kishikawa S et al. | Roles of histone acetylation in the Dnmt1 gene expression. | 2002 | Nucleic Acids Res. Suppl. | pmid:12903179 |
| Ginjala V et al. | Multiple cis elements within the Igf2/H19 insulator domain organize a distance-dependent silencer. A cautionary note. | 2002 | J. Biol. Chem. | pmid:11777900 |
| Cabral AL et al. | Regulation of the cellular prion protein gene expression depends on chromatin conformation. | 2002 | J. Biol. Chem. | pmid:11739375 |
| Park SH et al. | Transcriptional regulation of the transforming growth factor beta type II receptor gene by histone acetyltransferase and deacetylase is mediated by NF-Y in human breast cancer cells. | 2002 | J. Biol. Chem. | pmid:11744689 |
| Aapola U et al. | Imprinting regulator DNMT3L is a transcriptional repressor associated with histone deacetylase activity. | 2002 | Nucleic Acids Res. | pmid:12177302 |
| Chang TH and Szabo E | Enhanced growth inhibition by combination differentiation therapy with ligands of peroxisome proliferator-activated receptor-gamma and inhibitors of histone deacetylase in adenocarcinoma of the lung. | 2002 | Clin. Cancer Res. | pmid:11948134 |
| Ventura A et al. | The p66Shc longevity gene is silenced through epigenetic modifications of an alternative promoter. | 2002 | J. Biol. Chem. | pmid:11948181 |
| Gradoville L et al. | Protein kinase C-independent activation of the Epstein-Barr virus lytic cycle. | 2002 | J. Virol. | pmid:11991990 |
| Uesato S et al. | Novel histone deacetylase inhibitors: N-hydroxycarboxamides possessing a terminal bicyclic aryl group. | 2002 | Bioorg. Med. Chem. Lett. | pmid:11992774 |
| Woo SH et al. | Structurally simple trichostatin A-like straight chain hydroxamates as potent histone deacetylase inhibitors. | 2002 | J. Med. Chem. | pmid:12061890 |
| Chen Y et al. | On the epigenetic regulation of the human reelin promoter. | 2002 | Nucleic Acids Res. | pmid:12087179 |
| Zhang Y and Dufau ML | Silencing of transcription of the human luteinizing hormone receptor gene by histone deacetylase-mSin3A complex. | 2002 | J. Biol. Chem. | pmid:12091390 |
| Danbara M et al. | DNA methylation dominates transcriptional silencing of Pax5 in terminally differentiated B cell lines. | 2002 | Mol. Immunol. | pmid:12044782 |
| Lin HM et al. | Cyclin D1 Is a Ligand-independent Co-repressor for Thyroid Hormone Receptors. | 2002 | J. Biol. Chem. | pmid:12048199 |
| Quivy V et al. | Synergistic activation of human immunodeficiency virus type 1 promoter activity by NF-kappaB and inhibitors of deacetylases: potential perspectives for the development of therapeutic strategies. | 2002 | J. Virol. | pmid:12368351 |