| MeSH term | MeSH ID | Detail |
|---|---|---|
| Primary Myelofibrosis | D055728 | 6 associated lipids |
| Leukemia, Myelomonocytic, Acute | D015479 | 6 associated lipids |
| Polycystic Kidney, Autosomal Dominant | D016891 | 6 associated lipids |
| Genomic Instability | D042822 | 7 associated lipids |
| Biliary Tract Neoplasms | D001661 | 7 associated lipids |
| Cytomegalovirus Infections | D003586 | 7 associated lipids |
| Enteritis | D004751 | 8 associated lipids |
| Carcinoma, Embryonal | D018236 | 8 associated lipids |
| Immunologic Deficiency Syndromes | D007153 | 8 associated lipids |
| Mast-Cell Sarcoma | D012515 | 9 associated lipids |
trichostatin A
Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with trichostatin A?
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with trichostatin A
PubChem Associated disorders and diseases
What pathways are associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with trichostatin A?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with trichostatin A?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with trichostatin A?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with trichostatin A?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with trichostatin A?
Mouse Model
Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with trichostatin A
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Ramakrishnan G et al. | Histone acetyltransferases and deacetylase in Entamoeba histolytica. | 2004 | Mol. Biochem. Parasitol. | pmid:15555732 |
| Fu M et al. | The androgen receptor acetylation site regulates cAMP and AKT but not ERK-induced activity. | 2004 | J. Biol. Chem. | pmid:15123687 |
| Phan D et al. | Identification of Sp2 as a transcriptional repressor of carcinoembryonic antigen-related cell adhesion molecule 1 in tumorigenesis. | 2004 | Cancer Res. | pmid:15126343 |
| Iezzi S et al. | Deacetylase inhibitors increase muscle cell size by promoting myoblast recruitment and fusion through induction of follistatin. | 2004 | Dev. Cell | pmid:15130492 |
| Bort R et al. | Role of hepatocyte nuclear factor 3 gamma in the expression of human CYP2C genes. | 2004 | Arch. Biochem. Biophys. | pmid:15130783 |
| Ishii S et al. | Aberrant dynamics of histone deacetylation at the thyrotropin-releasing hormone gene in resistance to thyroid hormone. | 2004 | Mol. Endocrinol. | pmid:15131262 |
| Winn RA and Heasley LE | Gamma-catenin expression is reduced or absent in a subset of human non-small cell lung cancers, and its re-expression inhibits cell growth. | 2004 | Chest | pmid:15136458 |
| Jin YH et al. | Transforming growth factor-beta stimulates p300-dependent RUNX3 acetylation, which inhibits ubiquitination-mediated degradation. | 2004 | J. Biol. Chem. | pmid:15138260 |
| Milutinovic S et al. | DNA methyltransferase 1 knock down induces gene expression by a mechanism independent of DNA methylation and histone deacetylation. | 2004 | J. Biol. Chem. | pmid:15087453 |
| Chang HC et al. | Involvement of histone deacetylation in ras-induced down-regulation of the metastasis suppressor RECK. | 2004 | Cell. Signal. | pmid:15093608 |
| Nishino N et al. | Synthesis and histone deacetylase inhibitory activity of cyclic tetrapeptides containing a retrohydroxamate as zinc ligand. | 2004 | Bioorg. Med. Chem. Lett. | pmid:15109626 |
| Koch A et al. | Mitogen-activated protein kinase modulation of nuclear factor-kappaB-induced granulocyte macrophage-colony-stimulating factor release from human alveolar macrophages. | 2004 | Am. J. Respir. Cell Mol. Biol. | pmid:12871851 |
| Wang DF et al. | QSAR studies of PC-3 cell line inhibition activity of TSA and SAHA-like hydroxamic acids. | 2004 | Bioorg. Med. Chem. Lett. | pmid:14741273 |
| Yan C et al. | A novel homologous recombination system to study 92 kDa type IV collagenase transcription demonstrates that the NF-kappaB motif drives the transition from a repressed to an activated state of gene expression. | 2004 | FASEB J. | pmid:14715692 |
| Zelko IN and Folz RJ | Sp1 and Sp3 transcription factors mediate trichostatin A-induced and basal expression of extracellular superoxide dismutase. | 2004 | Free Radic. Biol. Med. | pmid:15451065 |
| Chiba T et al. | Cell growth inhibition and gene expression induced by the histone deacetylase inhibitor, trichostatin A, on human hepatoma cells. | 2004 | Oncology | pmid:15452378 |
| Kypreou KP et al. | Age-dependent response of lymphocytes in the induction of the linker histone variant, H1 degrees and histone H4 acetylation after treatment with the histone deacetylase inhibitor, trichostatin A. | 2004 | Exp. Gerontol. | pmid:15050280 |
| Jose B et al. | Novel histone deacetylase inhibitors: cyclic tetrapeptide with trifluoromethyl and pentafluoroethyl ketones. | 2004 | Bioorg. Med. Chem. Lett. | pmid:15454224 |
| Uramoto H et al. | p73 competes with co-activators and recruits histone deacetylase to NF-Y in the repression of PDGF beta-receptor. | 2004 | J. Cell. Sci. | pmid:15454570 |
| De La Fuente R et al. | Major chromatin remodeling in the germinal vesicle (GV) of mammalian oocytes is dispensable for global transcriptional silencing but required for centromeric heterochromatin function. | 2004 | Dev. Biol. | pmid:15501230 |
| Lin AC et al. | The N termini of Friend of GATA (FOG) proteins define a novel transcriptional repression motif and a superfamily of transcriptional repressors. | 2004 | J. Biol. Chem. | pmid:15507435 |
| Wang S and Zhu J | The hTERT gene is embedded in a nuclease-resistant chromatin domain. | 2004 | J. Biol. Chem. | pmid:15516693 |
| El-Khoury V et al. | Effects of the histone deacetylase inhibitor trichostatin A on nuclear texture and c-jun gene expression in drug-sensitive and drug-resistant human H69 lung carcinoma cells. | 2004 | Cytometry A | pmid:15517561 |
| Vaquero A et al. | Human SirT1 interacts with histone H1 and promotes formation of facultative heterochromatin. | 2004 | Mol. Cell | pmid:15469825 |
| Ladd PD et al. | Identification of a genomic fragment that directs hematopoietic-specific expression of Rac2 and analysis of the DNA methylation profile of the gene locus. | 2004 | Gene | pmid:15474314 |
| Li H and Wu X | Histone deacetylase inhibitor, Trichostatin A, activates p21WAF1/CIP1 expression through downregulation of c-myc and release of the repression of c-myc from the promoter in human cervical cancer cells. | 2004 | Biochem. Biophys. Res. Commun. | pmid:15474507 |
| Astrand C et al. | Trichostatin A reduces hormone-induced transcription of the MMTV promoter and has pleiotropic effects on its chromatin structure. | 2004 | Eur. J. Biochem. | pmid:15009194 |
| Chen YX et al. | Histone acetylation regulates p21WAF1 expression in human colon cancer cell lines. | 2004 | World J. Gastroenterol. | pmid:15309711 |
| Heltweg B et al. | Subtype selective substrates for histone deacetylases. | 2004 | J. Med. Chem. | pmid:15456267 |
| Jang ER et al. | The histone deacetylase inhibitor trichostatin A sensitizes estrogen receptor alpha-negative breast cancer cells to tamoxifen. | 2004 | Oncogene | pmid:14676837 |
| Kramps C et al. | E2F and Sp1/Sp3 Synergize but are not sufficient to activate the MYCN gene in neuroblastomas. | 2004 | J. Biol. Chem. | pmid:14645238 |
| Iijima K et al. | Granulocytic differentiation of leukemic cells with t(9;11)(p22;q23) induced by all-trans-retinoic acid. | 2004 | Leuk. Lymphoma | pmid:15291362 |
| Tóth KF et al. | Trichostatin A-induced histone acetylation causes decondensation of interphase chromatin. | 2004 | J. Cell. Sci. | pmid:15292402 |
| Myzak MC et al. | A novel mechanism of chemoprotection by sulforaphane: inhibition of histone deacetylase. | 2004 | Cancer Res. | pmid:15313918 |
| Facchetti F et al. | Modulation of pro- and anti-apoptotic factors in human melanoma cells exposed to histone deacetylase inhibitors. | 2004 | Apoptosis | pmid:15314285 |
| Roh MS et al. | Mechanism of histone deacetylase inhibitor Trichostatin A induced apoptosis in human osteosarcoma cells. | 2004 | Apoptosis | pmid:15314286 |
| Yanaihara N et al. | Reduced expression of MYO18B, a candidate tumor-suppressor gene on chromosome arm 22q, in ovarian cancer. | 2004 | Int. J. Cancer | pmid:15305387 |
| Munro J et al. | Histone deacetylase inhibitors induce a senescence-like state in human cells by a p16-dependent mechanism that is independent of a mitotic clock. | 2004 | Exp. Cell Res. | pmid:15093749 |
| Gaudier E et al. | Butyrate specifically modulates MUC gene expression in intestinal epithelial goblet cells deprived of glucose. | 2004 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:15308471 |
| Schultz BE et al. | Kinetics and comparative reactivity of human class I and class IIb histone deacetylases. | 2004 | Biochemistry | pmid:15323567 |
| Kim JH et al. | Susceptibility and radiosensitization of human glioblastoma cells to trichostatin A, a histone deacetylase inhibitor. | 2004 | Int. J. Radiat. Oncol. Biol. Phys. | pmid:15234053 |
| Sakamoto S et al. | Histone deacetylase activity is required to recruit RNA polymerase II to the promoters of selected interferon-stimulated early response genes. | 2004 | J. Biol. Chem. | pmid:15194680 |
| Ng Y et al. | Expression of the human myotonic dystrophy kinase-related Cdc42-binding kinase gamma is regulated by promoter DNA methylation and Sp1 binding. | 2004 | J. Biol. Chem. | pmid:15194684 |
| Lu H et al. | Tax relieves transcriptional repression by promoting histone deacetylase 1 release from the human T-cell leukemia virus type 1 long terminal repeat. | 2004 | J. Virol. | pmid:15194748 |
| Moldenhauer A et al. | Histone deacetylase inhibition improves dendritic cell differentiation of leukemic blasts with AML1-containing fusion proteins. | 2004 | J. Leukoc. Biol. | pmid:15197237 |
| Min KN et al. | Estrogen receptor enhances the antiproliferative effects of trichostatin A and HC-toxin in human breast cancer cells. | 2004 | Arch. Pharm. Res. | pmid:15202563 |
| Jia S et al. | RNAi-independent heterochromatin nucleation by the stress-activated ATF/CREB family proteins. | 2004 | Science | pmid:15218150 |
| Sumer H et al. | Effects of scaffold/matrix alteration on centromeric function and gene expression. | 2004 | J. Biol. Chem. | pmid:15220334 |
| Lee YJ et al. | Mechanism of transcriptional repression by TEL/RUNX1 fusion protein. | 2004 | Mol. Cells | pmid:15179033 |
| Swank RA et al. | The histone deacetylase inhibitor, trichostatin A, reactivates the developmentally silenced gamma globin expression in somatic cell hybrids and induces gamma gene expression in adult BFUe cultures. | 2003 May-Jun | Blood Cells Mol. Dis. | pmid:12737942 |