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Trichostatin A, an Inhibitor of Histone Deacetylase, Inhibits the Viability and Invasiveness of Hypoxic Rheumatoid Arthritis Fibroblast-Like Synoviocytes via PI3K/Akt Signaling. |
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J. Biochem. Mol. Toxicol. |
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Histone deacetylase–mediated silencing of AMWAP expression contributes to cisplatin nephrotoxicity. |
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Kidney Int. |
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Buffalo (Bubalus bubalis) SCNT embryos produced from somatic cells isolated from frozen-thawed semen: effect of trichostatin A on the in vitro and in vivo developmental potential, quality and epigenetic status. |
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Zygote |
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Endocr. J. |
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Postmitotic Expression of SOD1(G93A) Gene Affects the Identity of Myogenic Cells and Inhibits Myoblasts Differentiation. |
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Mediators Inflamm. |
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Differential regulation of expression of RNA-editing enzymes, ADAR1 and ADAR2, by 5-aza-2'-deoxycytidine and trichostatin A in human neuronal SH-SY5Y cells. |
2015 |
Neuroreport |
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VEGF-mediated cell survival in non-small-cell lung cancer: implications for epigenetic targeting of VEGF receptors as a therapeutic approach. |
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Epigenomics |
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Increased Histone Deacetylase Activity Involved in the Suppressed Invasion of Cancer Cells Survived from ALA-Mediated Photodynamic Treatment. |
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Int J Mol Sci |
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Trichostatin A and Tamoxifen inhibit breast cancer cell growth by miR-204 and ERα reducing AKT/mTOR pathway. |
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Biochem. Biophys. Res. Commun. |
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Histone deacetylase inhibition activates Nrf2 and protects against osteoarthritis. |
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Cytoskeleton (Hoboken) |
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Upregulation of MiR-122 via Trichostatin A Treatments in Hepatocyte-like Cells Derived from Mesenchymal Stem Cells. |
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Chem Biol Drug Des |
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HDAC5-mTORC1 Interaction in Differential Regulation of Ghrelin and Nucleobindin 2 (NUCB2)/Nesfatin-1. |
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Mol. Endocrinol. |
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Combination of HDAC inhibitor TSA and silibinin induces cell cycle arrest and apoptosis by targeting survivin and cyclinB1/Cdk1 in pancreatic cancer cells. |
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Histone Deacetylase Inhibitors Activate Tristetraprolin Expression through Induction of Early Growth Response Protein 1 (EGR1) in Colorectal Cancer Cells. |
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Biomolecules |
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Enhancement of human mesenchymal stem cell differentiation by combination treatment with 5-azacytidine and trichostatin A. |
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Downregulation of growth differentiation factor-15 in trichostatin A-induced apoptosis could play a role in progression of gastric cancer. |
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Int J Clin Exp Pathol |
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Histone deacetylase inhibitors promote the expression of ATP2A3 gene in breast cancer cell lines. |
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Mol. Carcinog. |
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Histone deacetylase inhibitors relieve morphine resistance in neuropathic pain after peripheral nerve injury. |
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Histone Deacetylase Inhibitors Inhibit the Proliferation of Gallbladder Carcinoma Cells by Suppressing AKT/mTOR Signaling. |
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PLoS ONE |
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Differential involvement of RASSF2 hypermethylation in breast cancer subtypes and their prognosis. |
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Oncotarget |
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Histone acetylation regulates prostate ductal morphogenesis through a bone morphogenetic protein-dependent mechanism. |
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Dev. Dyn. |
pmid:26283270
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PTEN activation through K163 acetylation by inhibiting HDAC6 contributes to tumour inhibition. |
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Oncogene |
pmid:26279303
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Histone Deacetylase Inhibitor Trichostatin A Ameliorated Endotoxin-Induced Neuroinflammation and Cognitive Dysfunction. |
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Mediators Inflamm. |
pmid:26273133
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A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors. |
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Arch. Toxicol. |
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Inhibition of Histone Deacetylase Activity Aggravates Coxsackievirus B3-Induced Myocarditis by Promoting Viral Replication and Myocardial Apoptosis. |
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J. Virol. |
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Knockdown of Rad9A enhanced DNA damage induced by trichostatin A in esophageal cancer cells. |
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Tumour Biol. |
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Enhanced conversion of induced neuronal cells (iN cells) from human fibroblasts: Utility in uncovering cellular deficits in mental illness-associated chromosomal abnormalities. |
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Neurosci. Res. |
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Gain-of-function STAT1 mutations impair STAT3 activity in patients with chronic mucocutaneous candidiasis (CMC). |
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Eur. J. Immunol. |
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Grouping of histone deacetylase inhibitors and other toxicants disturbing neural crest migration by transcriptional profiling. |
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Neurotoxicology |
pmid:26238599
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The heat shock protein 90 inhibitor SNX5422 has a synergistic activity with histone deacetylase inhibitors in induction of death of anaplastic thyroid carcinoma cells. |
2016 |
Endocrine |
pmid:26219406
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HDAC inhibitor prevents LPS mediated inhibition of CYP19A1 expression and 17β-estradiol production in granulosa cells. |
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Mol. Cell. Endocrinol. |
pmid:26213324
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Global histone modifications in Fumonisin B1 exposure in rat kidney epithelial cells. |
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Toxicol In Vitro |
pmid:26208285
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Epigenetic Control of Macrophage Shape Transition towards an Atypical Elongated Phenotype by Histone Deacetylase Activity. |
2015 |
PLoS ONE |
pmid:26196676
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NRSF is an essential mediator for the neuroprotection of trichostatin A in the MPTP mouse model of Parkinson's disease. |
2015 |
Neuropharmacology |
pmid:26188143
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Human papillomavirus type 16 E7 oncoprotein upregulates the retinoic acid receptor-beta expression in cervical cancer cell lines and K14E7 transgenic mice. |
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Mol. Cell. Biochem. |
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Acetylation-dependent function of human single-stranded DNA binding protein 1. |
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Nucleic Acids Res. |
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Analysis of an independent tumor suppressor locus telomeric to Tp53 suggested Inpp5k and Myo1c as novel tumor suppressor gene candidates in this region. |
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BMC Genet. |
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[Association of irradiation-induced hippocampal neurogenesis impairment with histone H3 acetylation]. |
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Zhonghua Yi Xue Za Zhi |
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Epigenetic Regulation of Cytosolic Phospholipase A2 in SH-SY5Y Human Neuroblastoma Cells. |
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Mol. Neurobiol. |
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Dnmt3l-knockout donor cells improve somatic cell nuclear transfer reprogramming efficiency. |
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Reproduction |
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MYCNOS functions as an antisense RNA regulating MYCN. |
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RNA Biol |
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Histone deacetylase inhibitor restores surfactant protein-C expression in alveolar-epithelial type II cells and attenuates bleomycin-induced pulmonary fibrosis in vivo. |
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Exp. Lung Res. |
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Evaluation of Epigenetic Drug Targeting of Heterogenous Tumor Cell Fractions Using Potential Biomarkers of Response in Ovarian Cancer. |
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Clin. Cancer Res. |
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Extracellularly secreted APE1/Ref-1 triggers apoptosis in triple-negative breast cancer cells via RAGE binding, which is mediated through acetylation. |
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Oncotarget |
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Epigenetic modifiers reduce inflammation and modulate macrophage phenotype during endotoxemia-induced acute lung injury. |
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J. Cell. Sci. |
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Trichostatin A reduces GnRH mRNA expression with a concomitant increase in retinaldehyde dehydrogenase in GnRH-producing neurons. |
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Mol. Cell. Endocrinol. |
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Trichostatin A, a histone deacetylase inhibitor, modulates unloaded-induced skeletal muscle atrophy. |
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Histone deacetylases inhibitors effects on Cryptococcus neoformans major virulence phenotypes. |
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Virulence |
pmid:26103530
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Trichostatin A suppresses lung adenocarcinoma development in Grg1 overexpressing transgenic mice. |
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Biochem. Biophys. Res. Commun. |
pmid:26086099
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Trichostatin A reduces cisplatin-induced ototoxicity through the STAT6 signaling pathway. |
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Int. J. Mol. Med. |
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Epigenetic Modification Agents Improve Gene-Specific Methylation Reprogramming in Porcine Cloned Embryos. |
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PLoS ONE |
pmid:26068219
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Epigenetic Modification of Cloned Embryos Improves Nanog Reprogramming in Pigs. |
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Cell Reprogram |
pmid:26053519
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Role of epigenetic reprogramming in hematopoietic stem cell function. |
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Curr. Opin. Hematol. |
pmid:26049747
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Optimization of histone deacetylase inhibitor activity in non-secosteroidal vitamin D-receptor agonist hybrids. |
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Bioorg. Med. Chem. |
pmid:26048026
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Liu Y and Li S |
A Cell Culture Model of Latent and Lytic Herpes Simplex Virus Type 1 Infection in Spiral Ganglion. |
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ORL J. Otorhinolaryngol. Relat. Spec. |
pmid:26022499
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A miniaturized readout strategy for endogenous histone deacetylase activity. |
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Mol Biosyst |
pmid:26009008
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Arsenic exposure causes epigenetic dysregulation of IL-8 expression leading to proneoplastic changes in kidney cells. |
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Toxicol. Lett. |
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Koppaka V et al. |
Effect of HDAC Inhibitors on Corneal Keratocyte Mechanical Phenotypes in 3-D Collagen Matrices. |
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Mol. Vis. |
pmid:25999677
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Ukaegbu UE et al. |
A Unique Virulence Gene Occupies a Principal Position in Immune Evasion by the Malaria Parasite Plasmodium falciparum. |
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PLoS Genet. |
pmid:25993442
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Promotion of Metastasis-associated Gene Expression in Survived PANC-1 Cells Following Trichostatin A Treatment. |
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Anticancer Agents Med Chem |
pmid:25991546
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Superior Versus Inferior Vestibular Neuritis: Are There Intrinsic Differences in Infection, Reactivation, or Production of Infectious Particles Between the Vestibular Ganglia? |
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Otol. Neurotol. |
pmid:25978655
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A new trichostatin analog from Streptomyces sp. CPCC 203909. |
2015 |
J Asian Nat Prod Res |
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Trichostatin A specifically improves the aberrant expression of transcription factor genes in embryos produced by somatic cell nuclear transfer. |
2015 |
Sci Rep |
pmid:25974394
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Epigenetics and miRNA as predictive markers and targets for lung cancer chemotherapy. |
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Cancer Biol. Ther. |
pmid:25962089
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Trichostatin A rescues the disrupted imprinting induced by somatic cell nuclear transfer in pigs. |
2015 |
PLoS ONE |
pmid:25962071
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Koumbadinga GA et al. |
Increased stability of heterogeneous ribonucleoproteins by a deacetylase inhibitor. |
2015 |
Biochim. Biophys. Acta |
pmid:25959059
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Meschini R et al. |
Role of chromatin structure modulation by the histone deacetylase inhibitor trichostatin A on the radio-sensitivity of ataxia telangiectasia. |
2015 |
Mutat. Res. |
pmid:25942615
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HDAC inhibition attenuates cardiac hypertrophy by acetylation and deacetylation of target genes. |
2015 |
Epigenetics |
pmid:25941940
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Marquardt JU et al. |
Curcumin effectively inhibits oncogenic NF-κB signaling and restrains stemness features in liver cancer. |
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J. Hepatol. |
pmid:25937435
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Han Y et al. |
Murine hematopoietic stem cell dormancy controlled by induction of a novel short form of PSF1 by histone deacetylase inhibitors. |
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Exp. Cell Res. |
pmid:25933513
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Identification of Critical Elements for Regulation of Inorganic Pyrophosphatase (PPA1) in MCF7 Breast Cancer Cells. |
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PLoS ONE |
pmid:25923237
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Zhao W et al. |
A traditional Chinese medicine, Lujiao prescription, as a potential therapy for hypertrophic cardiomyocytes by acting on histone acetylation. |
2015 |
J Chin Med Assoc |
pmid:25913212
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IL-4 Modulates Macrophage Polarization in Ankylosing Spondylitis. |
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Cell. Physiol. Biochem. |
pmid:25896783
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Identification of novel pathways and molecules able to down-regulate PHOX2B gene expression by in vitro drug screening approaches in neuroblastoma cells. |
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Exp. Cell Res. |
pmid:25882494
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DNA methylation and histone modifications regulate SOX11 expression in lymphoid and solid cancer cells. |
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BMC Cancer |
pmid:25880212
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Samiec M et al. |
Trichostatin A-mediated epigenetic transformation of adult bone marrow-derived mesenchymal stem cells biases the in vitro developmental capability, quality, and pluripotency extent of porcine cloned embryos. |
2015 |
Biomed Res Int |
pmid:25866813
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Hou H et al. |
Influence of intra-articular administration of trichostatin a on autologous osteochondral transplantation in a rabbit model. |
2015 |
Biomed Res Int |
pmid:25866784
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Devaney JM et al. |
Genome-wide differentially methylated genes in prostate cancer tissues from African-American and Caucasian men. |
2015 |
Epigenetics |
pmid:25864488
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Ganatra DA et al. |
Association of histone acetylation at the ACTA2 promoter region with epithelial mesenchymal transition of lens epithelial cells. |
2015 |
Eye (Lond) |
pmid:25853442
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Tao W et al. |
Brainstem brain-derived neurotrophic factor signaling is required for histone deacetylase inhibitor-induced pain relief. |
2015 |
Mol. Pharmacol. |
pmid:25852071
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Bieluszewski T et al. |
AtEAF1 is a potential platform protein for Arabidopsis NuA4 acetyltransferase complex. |
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BMC Plant Biol. |
pmid:25849764
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Rumbaugh G et al. |
Pharmacological Selectivity Within Class I Histone Deacetylases Predicts Effects on Synaptic Function and Memory Rescue. |
2015 |
Neuropsychopharmacology |
pmid:25837283
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Acun T et al. |
PTPRD is homozygously deleted and epigenetically downregulated in human hepatocellular carcinomas. |
2015 |
OMICS |
pmid:25831062
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Huisman C et al. |
Prolonged re-expression of the hypermethylated gene EPB41L3 using artificial transcription factors and epigenetic drugs. |
2015 |
Epigenetics |
pmid:25830725
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Lactogenic hormone stimulation and epigenetic control of L-amino acid oxidase expression in lactating mammary glands. |
2015 |
J. Cell. Physiol. |
pmid:25820447
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Potential role of adolescent alcohol exposure-induced amygdaloid histone modifications in anxiety and alcohol intake during adulthood. |
2015 |
Neurobiol. Dis. |
pmid:25814047
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Ji M et al. |
HDAC inhibitors induce epithelial-mesenchymal transition in colon carcinoma cells. |
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Oncol. Rep. |
pmid:25813246
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Chan N et al. |
Attenuation of choroidal neovascularization by histone deacetylase inhibitor. |
2015 |
PLoS ONE |
pmid:25807249
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Inhibition of histone deacetylases enhances the function of serotoninergic neurons in organotypic raphe slice cultures. |
2015 |
Neurosci. Lett. |
pmid:25796177
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Tao Y et al. |
HDAC1 regulates the proliferation of radial glial cells in the developing Xenopus tectum. |
2015 |
PLoS ONE |
pmid:25789466
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Acetylation stimulates the epithelial sodium channel by reducing its ubiquitination and degradation. |
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J. Biol. Chem. |
pmid:25787079
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Yamanegi K et al. |
Sodium valproate, a histone deacetylase inhibitor, modulates the vascular endothelial growth inhibitor-mediated cell death in human osteosarcoma and vascular endothelial cells. |
2015 |
Int. J. Oncol. |
pmid:25778932
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Pinz S et al. |
Deacetylase inhibitors repress STAT5-mediated transcription by interfering with bromodomain and extra-terminal (BET) protein function. |
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Nucleic Acids Res. |
pmid:25769527
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Cao QF et al. |
TRPM2 mediates histone deacetylase inhibition-induced apoptosis in bladder cancer cells. |
2015 |
Cancer Biother. Radiopharm. |
pmid:25760728
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Fukui T et al. |
Histone deacetylase inhibitor attenuates neurotoxicity of clioquinol in PC12 cells. |
2015 |
Toxicology |
pmid:25758465
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Mackmull MT et al. |
Histone Deacetylase Inhibitors (HDACi) Cause the Selective Depletion of Bromodomain Containing Proteins (BCPs). |
2015 |
Mol. Cell Proteomics |
pmid:25755299
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Zelko IN and Folz RJ |
Regulation of Oxidative Stress in Pulmonary Artery Endothelium. Modulation of Extracellular Superoxide Dismutase and NOX4 Expression Using Histone Deacetylase Class I Inhibitors. |
2015 |
Am. J. Respir. Cell Mol. Biol. |
pmid:25749103
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Cao K et al. |
Histone deacetylase inhibitors prevent activation-induced cell death and promote anti-tumor immunity. |
2015 |
Oncogene |
pmid:25745993
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Mostafavi-Pour Z et al. |
Methylation of Integrin α4 and E-Cadherin Genes in Human Prostate Cancer. |
2015 |
Pathol. Oncol. Res. |
pmid:25743258
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