| MeSH term | MeSH ID | Detail |
|---|---|---|
| Nerve Degeneration | D009410 | 53 associated lipids |
| Cystic Fibrosis | D003550 | 65 associated lipids |
| Hypertension | D006973 | 115 associated lipids |
| Tongue Neoplasms | D014062 | 15 associated lipids |
| Cytomegalovirus Infections | D003586 | 7 associated lipids |
| Nasal Polyps | D009298 | 26 associated lipids |
| Leukemia, Myeloid, Acute | D015470 | 19 associated lipids |
| Mast-Cell Sarcoma | D012515 | 9 associated lipids |
| Leukemia, Lymphocytic, Chronic, B-Cell | D015451 | 25 associated lipids |
| Neoplasms, Hormone-Dependent | D009376 | 23 associated lipids |
trichostatin A
Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with trichostatin A?
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with trichostatin A
PubChem Associated disorders and diseases
What pathways are associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with trichostatin A?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with trichostatin A?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with trichostatin A?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with trichostatin A?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with trichostatin A?
Mouse Model
Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with trichostatin A
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Bayart E et al. | A major role for mitotic CDC2 kinase inactivation in the establishment of the mitotic DNA damage checkpoint. | 2004 | Cancer Res. | pmid:15604258 |
| Zhao LY et al. | An EBF3-mediated transcriptional program that induces cell cycle arrest and apoptosis. | 2006 | Cancer Res. | pmid:17018599 |
| Noh EJ et al. | Methyl CpG-binding domain protein 3 mediates cancer-selective cytotoxicity by histone deacetylase inhibitors via differential transcriptional reprogramming in lung cancer cells. | 2005 | Cancer Res. | pmid:16357148 |
| Shah S et al. | Targeting pioneering factor and hormone receptor cooperative pathways to suppress tumor progression. | 2012 | Cancer Res. | pmid:22258452 |
| Setiadi AF et al. | Epigenetic enhancement of antigen processing and presentation promotes immune recognition of tumors. | 2008 | Cancer Res. | pmid:19047136 |
| Sharma D et al. | Restoration of tamoxifen sensitivity in estrogen receptor-negative breast cancer cells: tamoxifen-bound reactivated ER recruits distinctive corepressor complexes. | 2006 | Cancer Res. | pmid:16778215 |
| Shi J et al. | Effects of chromatin-modifying agents on CD34+ cells from patients with idiopathic myelofibrosis. | 2007 | Cancer Res. | pmid:17616702 |
| Brest P et al. | Histone deacetylase inhibitors promote the tumoricidal effect of HAMLET. | 2007 | Cancer Res. | pmid:18056459 |
| Su GH et al. | A novel histone deacetylase inhibitor identified by high-throughput transcriptional screening of a compound library. | 2000 | Cancer Res. | pmid:10866300 |
| Lin F et al. | Unique anti-activator protein-1 activity of retinoic acid receptor beta. | 2000 | Cancer Res. | pmid:10866321 |
| Hsu PY et al. | Xenoestrogen-induced epigenetic repression of microRNA-9-3 in breast epithelial cells. | 2009 | Cancer Res. | pmid:19549897 |
| Heller G et al. | Genome-wide transcriptional response to 5-aza-2'-deoxycytidine and trichostatin a in multiple myeloma cells. | 2008 | Cancer Res. | pmid:18172295 |
| Allison SJ and Milner J | Loss of p53 has site-specific effects on histone H3 modification, including serine 10 phosphorylation important for maintenance of ploidy. | 2003 | Cancer Res. | pmid:14583461 |
| Lin YC et al. | Statins increase p21 through inhibition of histone deacetylase activity and release of promoter-associated HDAC1/2. | 2008 | Cancer Res. | pmid:18381445 |
| Ferrara FF et al. | Histone deacetylase-targeted treatment restores retinoic acid signaling and differentiation in acute myeloid leukemia. | 2001 | Cancer Res. | pmid:11196162 |
| Nishigaki M et al. | Discovery of aberrant expression of R-RAS by cancer-linked DNA hypomethylation in gastric cancer using microarrays. | 2005 | Cancer Res. | pmid:15781621 |
| Bai J et al. | Predominant Bcl-XL knockdown disables antiapoptotic mechanisms: tumor necrosis factor-related apoptosis-inducing ligand-based triple chemotherapy overcomes chemoresistance in pancreatic cancer cells in vitro. | 2005 | Cancer Res. | pmid:15781649 |
| Rahmani M et al. | Coadministration of histone deacetylase inhibitors and perifosine synergistically induces apoptosis in human leukemia cells through Akt and ERK1/2 inactivation and the generation of ceramide and reactive oxygen species. | 2005 | Cancer Res. | pmid:15781658 |
| Stiehl DP et al. | Histone deacetylase inhibitors synergize p300 autoacetylation that regulates its transactivation activity and complex formation. | 2007 | Cancer Res. | pmid:17332356 |
| Kim M et al. | LRRC3B, encoding a leucine-rich repeat-containing protein, is a putative tumor suppressor gene in gastric cancer. | 2008 | Cancer Res. | pmid:18757430 |
| Mori T et al. | Epigenetic up-regulation of C-C chemokine receptor 7 and C-X-C chemokine receptor 4 expression in melanoma cells. | 2005 | Cancer Res. | pmid:15753377 |
| Mizutani H et al. | Romidepsin (FK228), a potent histone deacetylase inhibitor, induces apoptosis through the generation of hydrogen peroxide. | 2010 | Cancer Sci. | pmid:20624163 |
| Sakuma M et al. | Promoter methylation status of the Cyclin D2 gene is associated with poor prognosis in human epithelial ovarian cancer. | 2007 | Cancer Sci. | pmid:17270028 |
| Tomosugi M et al. | Retinoblastoma gene-independent G1 phase arrest by flavone, phosphatidylinositol 3-kinase inhibitor, and histone deacetylase inhibitor. | 2012 | Cancer Sci. | pmid:22957647 |
| Chikamatsu K et al. | Alteration of cancer stem cell-like phenotype by histone deacetylase inhibitors in squamous cell carcinoma of the head and neck. | 2013 | Cancer Sci. | pmid:23992541 |
| Hattori N et al. | Methylation silencing of angiopoietin-like 4 in rat and human mammary carcinomas. | 2011 | Cancer Sci. | pmid:21489049 |
| Sasaki K et al. | Histone deacetylase inhibitors trichostatin A and valproic acid circumvent apoptosis in human leukemic cells expressing the RUNX1 chimera. | 2008 | Cancer Sci. | pmid:18271940 |
| Furumai R et al. | Histone deacetylase inhibitors block nuclear factor-κB-dependent transcription by interfering with RNA polymerase II recruitment. | 2011 | Cancer Sci. | pmid:21299717 |
| Yamada Y et al. | Aberrant methylation of the vascular endothelial growth factor receptor-1 gene in prostate cancer. | 2003 | Cancer Sci. | pmid:12824880 |
| Okada T et al. | Identification of genes specifically methylated in Epstein-Barr virus-associated gastric carcinomas. | 2013 | Cancer Sci. | pmid:23829175 |
| Akao Y et al. | Downregulation of microRNAs-143 and -145 in B-cell malignancies. | 2007 | Cancer Sci. | pmid:17892514 |
| Leng SL et al. | Insulin-like growth factor-II renders LIM 2405 human colon cancer cells resistant to butyrate-induced apoptosis: a potential mechanism for colon cancer cell survival in vivo. | 2001 | Carcinogenesis | pmid:11577001 |
| Ma J et al. | Promoter hypermethylation and histone hypoacetylation contribute to pancreatic-duodenal homeobox 1 silencing in gastric cancer. | 2010 | Carcinogenesis | pmid:20622005 |
| Kim YH et al. | Sodium butyrate sensitizes TRAIL-mediated apoptosis by induction of transcription from the DR5 gene promoter through Sp1 sites in colon cancer cells. | 2004 | Carcinogenesis | pmid:15142888 |
| Gastaldi T et al. | Plakoglobin is differentially expressed in alveolar and embryonal rhabdomyosarcoma and is regulated by DNA methylation and histone acetylation. | 2006 | Carcinogenesis | pmid:16537559 |
| Grassi G et al. | Inhibitors of DNA methylation and histone deacetylation activate cytomegalovirus promoter-controlled reporter gene expression in human glioblastoma cell line U87. | 2003 | Carcinogenesis | pmid:12869421 |
| Kwon O et al. | NF-kappaB inhibition increases chemosensitivity to trichostatin A-induced cell death of Ki-Ras-transformed human prostate epithelial cells. | 2006 | Carcinogenesis | pmid:16774937 |
| Chen CQ et al. | Pure curcumin increases the expression of SOCS1 and SOCS3 in myeloproliferative neoplasms through suppressing class I histone deacetylases. | 2013 | Carcinogenesis | pmid:23430957 |
| Thakur VS et al. | Green tea polyphenols causes cell cycle arrest and apoptosis in prostate cancer cells by suppressing class I histone deacetylases. | 2012 | Carcinogenesis | pmid:22114073 |
| Sharma A et al. | Trichostatin-A modulates claudin-1 mRNA stability through the modulation of Hu antigen R and tristetraprolin in colon cancer cells. | 2013 | Carcinogenesis | pmid:23880304 |
| Derks S et al. | Promoter CpG island hypermethylation- and H3K9me3 and H3K27me3-mediated epigenetic silencing targets the deleted in colon cancer (DCC) gene in colorectal carcinogenesis without affecting neighboring genes on chromosomal region 18q21. | 2009 | Carcinogenesis | pmid:19329758 |
| Jensen TJ et al. | Epigenetic remodeling during arsenical-induced malignant transformation. | 2008 | Carcinogenesis | pmid:18448484 |
| Bhakat KK and Mitra S | CpG methylation-dependent repression of the human O6-methylguanine-DNA methyltransferase gene linked to chromatin structure alteration. | 2003 | Carcinogenesis | pmid:12807730 |
| Xiang N et al. | Selenite reactivates silenced genes by modifying DNA methylation and histones in prostate cancer cells. | 2008 | Carcinogenesis | pmid:18676679 |
| Nandakumar V et al. | (-)-Epigallocatechin-3-gallate reactivates silenced tumor suppressor genes, Cip1/p21 and p16INK4a, by reducing DNA methylation and increasing histones acetylation in human skin cancer cells. | 2011 | Carcinogenesis | pmid:21209038 |
| Liu T et al. | Regulation of Cdx2 expression by promoter methylation, and effects of Cdx2 transfection on morphology and gene expression of human esophageal epithelial cells. | 2007 | Carcinogenesis | pmid:16990345 |
| Kamitani H et al. | Expression of 15-lipoxygenase-1 is regulated by histone acetylation in human colorectal carcinoma. | 2001 | Carcinogenesis | pmid:11159758 |
| Becker JR et al. | In vivo natriuretic peptide reporter assay identifies chemical modifiers of hypertrophic cardiomyopathy signalling. | 2012 | Cardiovasc. Res. | pmid:22198505 |
| Song S et al. | Trichostatin A enhances proliferation and migration of vascular smooth muscle cells by downregulating thioredoxin 1. | 2010 | Cardiovasc. Res. | pmid:19633316 |
| Zhao TC et al. | Inhibition of histone deacetylases triggers pharmacologic preconditioning effects against myocardial ischemic injury. | 2007 | Cardiovasc. Res. | pmid:17884027 |