| MeSH term | MeSH ID | Detail |
|---|---|---|
| Ventricular Remodeling | D020257 | 28 associated lipids |
| Endometriosis | D004715 | 29 associated lipids |
| Adrenoleukodystrophy | D000326 | 29 associated lipids |
| Endometrial Neoplasms | D016889 | 30 associated lipids |
| Cardiomegaly | D006332 | 31 associated lipids |
| Hypertension, Pulmonary | D006976 | 32 associated lipids |
| Neurodegenerative Diseases | D019636 | 32 associated lipids |
| Stroke | D020521 | 32 associated lipids |
| Thyroid Neoplasms | D013964 | 33 associated lipids |
| Neovascularization, Pathologic | D009389 | 39 associated lipids |
| Leukemia, Erythroblastic, Acute | D004915 | 41 associated lipids |
| Lupus Erythematosus, Systemic | D008180 | 43 associated lipids |
| Coronary Artery Disease | D003324 | 47 associated lipids |
| Osteosarcoma | D012516 | 50 associated lipids |
| Asthma | D001249 | 52 associated lipids |
| Leukemia, Myeloid | D007951 | 52 associated lipids |
| Nerve Degeneration | D009410 | 53 associated lipids |
| Cystic Fibrosis | D003550 | 65 associated lipids |
| Reperfusion Injury | D015427 | 65 associated lipids |
| Neuroblastoma | D009447 | 66 associated lipids |
trichostatin A
Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with trichostatin A?
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with trichostatin A
PubChem Associated disorders and diseases
What pathways are associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with trichostatin A?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with trichostatin A?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with trichostatin A?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with trichostatin A?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with trichostatin A?
Mouse Model
Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
NCBI Entrez Crosslinks
All references with trichostatin A
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Habeck M | Gelsolin: a new marker for breast cancer? | 1999 | Mol Med Today | pmid:10562712 |
| Condreay JP et al. | Transient and stable gene expression in mammalian cells transduced with a recombinant baculovirus vector. | 1999 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9874783 |
| Cameron EE et al. | Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer. | 1999 | Nat. Genet. | pmid:9916800 |
| Johnson BS et al. | Retinoid X receptor (RXR) agonist-induced activation of dominant-negative RXR-retinoic acid receptor alpha403 heterodimers is developmentally regulated during myeloid differentiation. | 1999 | Mol. Cell. Biol. | pmid:10207061 |
| Niki T et al. | A histone deacetylase inhibitor, trichostatin A, suppresses myofibroblastic differentiation of rat hepatic stellate cells in primary culture. | 1999 | Hepatology | pmid:10051490 |
| Hasegawa T et al. | Cloning of a GADD34-like gene that interacts with the zinc-finger transcription factor which binds to the p21(WAF) promoter. | 1999 | Biochem. Biophys. Res. Commun. | pmid:10066455 |
| Inokoshi J et al. | Neuronal differentiation of neuro 2a cells by inhibitors of cell cycle progression, trichostatin A and butyrolactone I. | 1999 | Biochem. Biophys. Res. Commun. | pmid:10079191 |
| Olsson TG et al. | Transient inhibition of histone deacetylase activity overcomes silencing in the mating-type region in fission yeast. | 1999 | Curr. Genet. | pmid:10079326 |
| Collas P et al. | Active transgenes in zebrafish are enriched in acetylated histone H4 and dynamically associate with RNA Pol II and splicing complexes. | 1999 | J. Cell. Sci. | pmid:10198286 |
| Saito A et al. | A synthetic inhibitor of histone deacetylase, MS-27-275, with marked in vivo antitumor activity against human tumors. | 1999 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10200307 |
| Tagami T et al. | Mechanisms that mediate negative regulation of the thyroid-stimulating hormone alpha gene by the thyroid hormone receptor. | 1999 | J. Biol. Chem. | pmid:10428804 |
| Radkov SA et al. | Epstein-Barr virus nuclear antigen 3C interacts with histone deacetylase to repress transcription. | 1999 | J. Virol. | pmid:10364319 |
| Croft JA et al. | Differences in the localization and morphology of chromosomes in the human nucleus. | 1999 | J. Cell Biol. | pmid:10366586 |
| Criqui-Filipe P et al. | Net, a negative Ras-switchable TCF, contains a second inhibition domain, the CID, that mediates repression through interactions with CtBP and de-acetylation. | 1999 | EMBO J. | pmid:10369679 |
| Zhao W et al. | Trichostatin A up-regulates human papillomavirus type 11 upstream regulatory region-E6 promoter activity in undifferentiated primary human keratinocytes. | 1999 | J. Virol. | pmid:10233965 |
| Fukuda K | Apoptosis-associated cleavage of beta-catenin in human colon cancer and rat hepatoma cells. | 1999 Mar-Apr | Int. J. Biochem. Cell Biol. | pmid:10224675 |
| Kitamura K et al. | Histone deacetylase inhibitor but not arsenic trioxide differentiates acute promyelocytic leukaemia cells with t(11;17) in combination with all-trans retinoic acid. | 2000 | Br. J. Haematol. | pmid:10792271 |
| Saleh M et al. | Cell signaling switches HOX-PBX complexes from repressors to activators of transcription mediated by histone deacetylases and histone acetyltransferases. | 2000 | Mol. Cell. Biol. | pmid:11046157 |
| Yu J et al. | Transcriptional repression by blimp-1 (PRDI-BF1) involves recruitment of histone deacetylase. | 2000 | Mol. Cell. Biol. | pmid:10713181 |
| Adachi N et al. | Cell-cycle regulation of the DNA topoisomerase IIalpha promoter is mediated by proximal CCAAT boxes: possible involvement of acetylation. | 2000 | Gene | pmid:10713444 |