trichostatin A
Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with trichostatin A?
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with trichostatin A
PubChem Associated disorders and diseases
What pathways are associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with trichostatin A?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with trichostatin A?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with trichostatin A?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with trichostatin A?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with trichostatin A?
Mouse Model
Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
NCBI Entrez Crosslinks
All references with trichostatin A
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Dowling DP et al. | Structural studies of human histone deacetylase 8 and its site-specific variants complexed with substrate and inhibitors. | 2008 | Biochemistry | pmid:19053282 |
| Ishii T et al. | [Epigenetic regulation in alcohol-related brain damage]. | 2008 | Nihon Arukoru Yakubutsu Igakkai Zasshi | pmid:19068777 |
| Zhu K et al. | Telomerase expression and cell proliferation in ovarian cancer cells induced by histone deacetylase inhibitors. | 2008 | Arch. Gynecol. Obstet. | pmid:17680259 |
| Usami M et al. | Butyrate and trichostatin A attenuate nuclear factor kappaB activation and tumor necrosis factor alpha secretion and increase prostaglandin E2 secretion in human peripheral blood mononuclear cells. | 2008 | Nutr Res | pmid:19083427 |
| Krämer OH et al. | Histone deacetylase inhibitors and hydroxyurea modulate the cell cycle and cooperatively induce apoptosis. | 2008 | Oncogene | pmid:17653085 |
| Nasu Y et al. | Trichostatin A, a histone deacetylase inhibitor, suppresses synovial inflammation and subsequent cartilage destruction in a collagen antibody-induced arthritis mouse model. | 2008 | Osteoarthr. Cartil. | pmid:18226559 |
| Lim HG et al. | Promoter-targeted siRNAs induce gene silencing of simian immunodeficiency virus (SIV) infection in vitro. | 2008 | Mol. Ther. | pmid:18227841 |
| Ruau D et al. | Pluripotency associated genes are reactivated by chromatin-modifying agents in neurosphere cells. | 2008 | Stem Cells | pmid:18203677 |
| Serrano E et al. | Epigenetic-based treatments emphasize the biologic differences of core-binding factor acute myeloid leukemias. | 2008 | Leuk. Res. | pmid:18206229 |
| Hamner JB et al. | The efficacy of combination therapy using adeno-associated virus--interferon beta and trichostatin A in vitro and in a murine model of neuroblastoma. | 2008 | J. Pediatr. Surg. | pmid:18206478 |
| Duhamel M et al. | Differential epigenetic regulation of Aiolos expression in human tumoral cell lines and primary cells. | 2008 | FEBS Lett. | pmid:18206652 |
| Campanero MR et al. | The histone deacetylase inhibitor trichostatin A induces GADD45 gamma expression via Oct and NF-Y binding sites. | 2008 | Oncogene | pmid:17724474 |
| Kikuno N et al. | Genistein mediated histone acetylation and demethylation activates tumor suppressor genes in prostate cancer cells. | 2008 | Int. J. Cancer | pmid:18431742 |
| Zhang HJ et al. | Oct4 is epigenetically regulated by methylation in normal placenta and gestational trophoblastic disease. | 2008 | Placenta | pmid:18440631 |
| Meja KK et al. | Curcumin restores corticosteroid function in monocytes exposed to oxidants by maintaining HDAC2. | 2008 | Am. J. Respir. Cell Mol. Biol. | pmid:18421014 |
| Sebastián C et al. | Deacetylase activity is required for STAT5-dependent GM-CSF functional activity in macrophages and differentiation to dendritic cells. | 2008 | J. Immunol. | pmid:18424709 |
| Biacsi R et al. | SIRT1 inhibition alleviates gene silencing in Fragile X mental retardation syndrome. | 2008 | PLoS Genet. | pmid:18369442 |
| Hishikawa K and Fujita T | [Kidney regeneration update]. | 2008 | Nippon Rinsho | pmid:18464514 |
| Lindström TM et al. | Histone deacetylase inhibitors exert time-dependent effects on nuclear factor-kappaB but consistently suppress the expression of proinflammatory genes in human myometrial cells. | 2008 | Mol. Pharmacol. | pmid:18375836 |
| Kato A et al. | Induction of truncated form of tenascin-X (XB-S) through dissociation of HDAC1 from SP-1/HDAC1 complex in response to hypoxic conditions. | 2008 | Exp. Cell Res. | pmid:18588874 |
| Chen CJ et al. | Attenuation of c-Jun and Sp1 expression and p300 recruitment to gene promoter confers the trichostatin A-induced inhibition of 12(S)-lipoxygenase expression in EGF-treated A431 cells. | 2008 | Eur. J. Pharmacol. | pmid:18590721 |
| Marengo E et al. | Evaluation of the variables characterized by significant discriminating power in the application of SIMCA classification method to proteomic studies. | 2008 | J. Proteome Res. | pmid:18543959 |
| Zhu X et al. | Deoxyribonucleic acid methyltransferase 3B promotes epigenetic silencing through histone 3 chromatin modifications in pituitary cells. | 2008 | J. Clin. Endocrinol. Metab. | pmid:18544619 |
| Gaviraghi M et al. | Identification of a candidate alternative promoter region of the human Bcl2L11 (Bim) gene. | 2008 | BMC Mol. Biol. | pmid:18549468 |
| Pluemsampant S et al. | Protein kinase CK2 is a key activator of histone deacetylase in hypoxia-associated tumors. | 2008 | Int. J. Cancer | pmid:17935135 |
| Nishino N et al. | Interaction of aliphatic cap group in inhibition of histone deacetylases by cyclic tetrapeptides. | 2008 | Bioorg. Med. Chem. | pmid:17900911 |
| Duan H et al. | Functional long-range interactions of the IgH 3' enhancers with the bcl-2 promoter region in t(14;18) lymphoma cells. | 2008 | Oncogene | pmid:18695675 |
| Ding X et al. | Increased pre-implantation development of cloned bovine embryos treated with 5-aza-2'-deoxycytidine and trichostatin A. | 2008 | Theriogenology | pmid:18556056 |
| Jia J and Chen J | Histone hyperacetylation is involved in the quercetin-induced human leukemia cell death. | 2008 | Pharmazie | pmid:18557424 |
| Narver HL et al. | Sustained improvement of spinal muscular atrophy mice treated with trichostatin A plus nutrition. | 2008 | Ann. Neurol. | pmid:18661558 |
| Han JQ et al. | [Effects of trichostatin A on the interaction between HBx and histone deacetylase protein 1]. | 2008 | Zhonghua Gan Zang Bing Za Zhi | pmid:18822204 |
| Pellicciotta I et al. | Presentation of telomerase reverse transcriptase, a self-tumor antigen, is down-regulated by histone deacetylase inhibition. | 2008 | Cancer Res. | pmid:18829567 |
| Cheli Y et al. | Transcriptional and epigenetic regulation of the integrin collagen receptor locus ITGA1-PELO-ITGA2. | 2007 Sep-Oct | Biochim. Biophys. Acta | pmid:17669516 |
| Yasuda K et al. | ERas oncogene expression and epigenetic regulation by histone acetylation in human cancer cells. | 2007 Nov-Dec | Anticancer Res. | pmid:18225573 |
| Kuwajima A et al. | The histone deacetylase inhibitor butyrate inhibits melanoma cell invasion of Matrigel. | 2007 Nov-Dec | Anticancer Res. | pmid:18225587 |
| Hosseinkhani M et al. | Trichostatin A induces myocardial differentiation of monkey ES cells. | 2007 | Biochem. Biophys. Res. Commun. | pmid:17368572 |
| Kim HJ et al. | Histone deacetylase inhibitors exhibit anti-inflammatory and neuroprotective effects in a rat permanent ischemic model of stroke: multiple mechanisms of action. | 2007 | J. Pharmacol. Exp. Ther. | pmid:17371805 |
| Kitamura H et al. | Down-regulation of HLA class I antigens in prostate cancer tissues and up-regulation by histone deacetylase inhibition. | 2007 | J. Urol. | pmid:17574613 |
| Vecsey CG et al. | Histone deacetylase inhibitors enhance memory and synaptic plasticity via CREB:CBP-dependent transcriptional activation. | 2007 | J. Neurosci. | pmid:17553985 |
| Pinnoji RC et al. | Repressor element-1 silencing transcription factor/neuronal restrictive silencer factor (REST/NRSF) can regulate HSV-1 immediate-early transcription via histone modification. | 2007 | Virol. J. | pmid:17555596 |
| Kishigami S et al. | Successful mouse cloning of an outbred strain by trichostatin A treatment after somatic nuclear transfer. | 2007 | J. Reprod. Dev. | pmid:17077581 |
| Khan Z et al. | HDAC inhibition amplifies gap junction communication in neural progenitors: potential for cell-mediated enzyme prodrug therapy. | 2007 | Exp. Cell Res. | pmid:17555745 |
| Donadelli M et al. | Synergistic inhibition of pancreatic adenocarcinoma cell growth by trichostatin A and gemcitabine. | 2007 | Biochim. Biophys. Acta | pmid:17555830 |
| Smetana K et al. | Effect of histone deacetylase inhibitors on the cell nucleus and nucleolus of leukemic myeloblasts in vitro - a cytochemical study. | 2007 | Acta Histochem. | pmid:17559910 |
| Cantor JP et al. | Epigenetic modulation of endogenous tumor suppressor expression in lung cancer xenografts suppresses tumorigenicity. | 2007 | Int. J. Cancer | pmid:17019711 |
| Cecconi D et al. | Proteomic analysis of pancreatic endocrine tumor cell lines treated with the histone deacetylase inhibitor trichostatin A. | 2007 | Proteomics | pmid:17443844 |
| Higashi T et al. | Histone H2A mobility is regulated by its tails and acetylation of core histone tails. | 2007 | Biochem. Biophys. Res. Commun. | pmid:17445770 |
| Hellebrekers DM et al. | Identification of epigenetically silenced genes in tumor endothelial cells. | 2007 | Cancer Res. | pmid:17483324 |
| Yi T et al. | Trichostatin A-mediated upregulation of p21(WAF1) contributes to osteoclast apoptosis. | 2007 | Exp. Mol. Med. | pmid:17464183 |
| Wong CM et al. | Tissue factor pathway inhibitor-2 as a frequently silenced tumor suppressor gene in hepatocellular carcinoma. | 2007 | Hepatology | pmid:17464989 |
| Chen Y et al. | Homeobox gene HOP has a potential tumor suppressive activity in human lung cancer. | 2007 | Int. J. Cancer | pmid:17417779 |
| Liu T et al. | Design and synthesis of a potent histone deacetylase inhibitor. | 2007 | J. Med. Chem. | pmid:17419603 |
| Hwang CK et al. | Evidence of endogenous mu opioid receptor regulation by epigenetic control of the promoters. | 2007 | Mol. Cell. Biol. | pmid:17452465 |
| Piotrowska H and Jagodzinski PP | Trichostatin A, sodium butyrate, and 5-aza-2'-deoxycytidine alter the expression of glucocorticoid receptor alpha and beta isoforms in Hut-78 T- and Raji B-lymphoma cell lines. | 2007 | Biomed. Pharmacother. | pmid:17498915 |
| Berg T et al. | Reversal of p15/INK4b hypermethylation in AML1/ETO-positive and -negative myeloid leukemia cell lines. | 2007 | Leuk. Res. | pmid:17056112 |
| Iliopoulos D et al. | Epigenetic regulation of leptin affects MMP-13 expression in osteoarthritic chondrocytes: possible molecular target for osteoarthritis therapeutic intervention. | 2007 | Ann. Rheum. Dis. | pmid:17502362 |
| Sato N et al. | RhoB is frequently downregulated in non-small-cell lung cancer and resides in the 2p24 homozygous deletion region of a lung cancer cell line. | 2007 | Int. J. Cancer | pmid:17096327 |
| Zhang R et al. | HP1 proteins are essential for a dynamic nuclear response that rescues the function of perturbed heterochromatin in primary human cells. | 2007 | Mol. Cell. Biol. | pmid:17101789 |
| Li YL et al. | [Impact of trichostatin A on gastric carcinoma cell line SGC-7901]. | 2007 | Zhonghua Wei Chang Wai Ke Za Zhi | pmid:17659468 |
| Wu Y et al. | The zinc finger repressor, ZBP-89, recruits histone deacetylase 1 to repress vimentin gene expression. | 2007 | Genes Cells | pmid:17663720 |
| Schneider G et al. | HDAC3 is linked to cell cycle machinery in MiaPaCa2 cells by regulating transcription of skp2. | 2007 | Cell Prolif. | pmid:17635519 |
| Bode KA et al. | Histone deacetylase inhibitors decrease Toll-like receptor-mediated activation of proinflammatory gene expression by impairing transcription factor recruitment. | 2007 | Immunology | pmid:17635610 |
| Imai N et al. | Inhibition of histone deacetylase activates side population cells in kidney and partially reverses chronic renal injury. | 2007 | Stem Cells | pmid:17641247 |
| Dai B and Rasmussen TP | Global epiproteomic signatures distinguish embryonic stem cells from differentiated cells. | 2007 | Stem Cells | pmid:17641388 |
| Kaida D et al. | Spliceostatin A targets SF3b and inhibits both splicing and nuclear retention of pre-mRNA. | 2007 | Nat. Chem. Biol. | pmid:17643111 |
| Kotake Y et al. | Splicing factor SF3b as a target of the antitumor natural product pladienolide. | 2007 | Nat. Chem. Biol. | pmid:17643112 |
| Kang JH et al. | Inhibition of trichostatin A-induced antiangiogenesis by small-interfering RNA for thrombospondin-1. | 2007 | Exp. Mol. Med. | pmid:17603295 |
| Subramanian C et al. | CREB-binding protein is a mediator of neuroblastoma cell death induced by the histone deacetylase inhibitor trichostatin A. | 2007 | Neoplasia | pmid:17603632 |
| Oyama T et al. | Cardiac side population cells have a potential to migrate and differentiate into cardiomyocytes in vitro and in vivo. | 2007 | J. Cell Biol. | pmid:17261849 |
| Zhang L et al. | Small molecule regulators of autophagy identified by an image-based high-throughput screen. | 2007 | Proc. Natl. Acad. Sci. U.S.A. | pmid:18024584 |
| Park JJ et al. | Functional interaction of the human cytomegalovirus IE2 protein with histone deacetylase 2 in infected human fibroblasts. | 2007 | J. Gen. Virol. | pmid:18024889 |
| Moiseeva EP et al. | Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells. | 2007 | Mol. Cancer Ther. | pmid:18025290 |
| Brest P et al. | Histone deacetylase inhibitors promote the tumoricidal effect of HAMLET. | 2007 | Cancer Res. | pmid:18056459 |
| Sourlingas TG et al. | Effect of the histone deacetylase inhibitor trichostatin a in human peripheral blood lymphocytes as a function of donor age. | 2007 | Ann. N. Y. Acad. Sci. | pmid:18056955 |
| Sekhavat A et al. | Competitive inhibition of histone deacetylase activity by trichostatin A and butyrate. | 2007 | Biochem. Cell Biol. | pmid:18059533 |
| Mazzarelli P et al. | Carnitine palmitoyltransferase I in human carcinomas: a novel role in histone deacetylation? | 2007 | Cancer Biol. Ther. | pmid:18253084 |
| Lee EL et al. | Impaired activity of volume-sensitive Cl- channel is involved in cisplatin resistance of cancer cells. | 2007 | J. Cell. Physiol. | pmid:17186499 |
| Koh E et al. | Trichostatin A and 5-aza-2'-deoxycytidine switch S1P from an inhibitor to a stimulator of motility through epigenetic regulation of S1P receptors. | 2007 | Cancer Lett. | pmid:17189669 |
| Feng W et al. | Multiple histone deacetylases repress tumor suppressor gene ARHI in breast cancer. | 2007 | Int. J. Cancer | pmid:17230502 |
| Wu ZQ et al. | Histone deacetylase inhibitor trichostatin A induced caspase-independent apoptosis in human gastric cancer cell. | 2007 | Chin. Med. J. | pmid:18167185 |
| Karam JA et al. | The use of histone deacetylase inhibitor FK228 and DNA hypomethylation agent 5-azacytidine in human bladder cancer therapy. | 2007 | Int. J. Cancer | pmid:17230511 |
| Ghosh AK et al. | Trichostatin A blocks TGF-beta-induced collagen gene expression in skin fibroblasts: involvement of Sp1. | 2007 | Biochem. Biophys. Res. Commun. | pmid:17234156 |
| Shimazu T et al. | Multiple histone deacetylases and the CREB-binding protein regulate pre-mRNA 3'-end processing. | 2007 | J. Biol. Chem. | pmid:17172643 |
| Januchowski R and Jagodzinski PP | Trichostatin A down-regulates ZAP-70, LAT and SLP-76 content in Jurkat T cells. | 2007 | Int. Immunopharmacol. | pmid:17178387 |
| Cras A et al. | Epigenetic patterns of the retinoic acid receptor beta2 promoter in retinoic acid-resistant thyroid cancer cells. | 2007 | Oncogene | pmid:17213810 |
| Zhou X et al. | The interferon-alpha responsive gene TMEM7 suppresses cell proliferation and is downregulated in human hepatocellular carcinoma. | 2007 | Cancer Genet. Cytogenet. | pmid:17693185 |
| Wang F et al. | Dynamic reprogramming of histone acetylation and methylation in the first cell cycle of cloned mouse embryos. | 2007 | Biol. Reprod. | pmid:17823087 |
| De los Santos M et al. | Combined effects of retinoic acid and histone deacetylase inhibitors on human neuroblastoma SH-SY5Y cells. | 2007 | Mol. Cancer Ther. | pmid:17431121 |
| Qi J et al. | [Hypermethylation and regulation of expression of secreted frizzled-related protein genes in colorectal tumor]. | 2007 | Zhonghua Zhong Liu Za Zhi | pmid:18396643 |
| Yang H et al. | Dexamethasone-induced protein degradation in cultured myotubes is p300/HAT dependent. | 2007 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:16973938 |
| Li T and Chiang JY | A novel role of transforming growth factor beta1 in transcriptional repression of human cholesterol 7alpha-hydroxylase gene. | 2007 | Gastroenterology | pmid:17920062 |
| Tao R et al. | Deacetylase inhibition promotes the generation and function of regulatory T cells. | 2007 | Nat. Med. | pmid:17922010 |
| Qi J et al. | [The role of secreted Wnt-antagonist genes hypermethylation in early detection of colorectal tumor]. | 2007 | Zhonghua Yi Xue Za Zhi | pmid:17923031 |
| Pulukuri SM et al. | Inhibition of histone deacetylase activity promotes invasion of human cancer cells through activation of urokinase plasminogen activator. | 2007 | J. Biol. Chem. | pmid:17923479 |
| Stapnes C et al. | Functional characteristics and gene expression profiles of primary acute myeloid leukaemia cells identify patient subgroups that differ in susceptibility to histone deacetylase inhibitors. | 2007 | Int. J. Oncol. | pmid:17982680 |
| Honda H et al. | Regulation of the CLDN3 gene in ovarian cancer cells. | 2007 | Cancer Biol. Ther. | pmid:17986852 |
| Renthal W et al. | Histone deacetylase 5 epigenetically controls behavioral adaptations to chronic emotional stimuli. | 2007 | Neuron | pmid:17988634 |
| Carén H et al. | Genetic and epigenetic changes in the common 1p36 deletion in neuroblastoma tumours. | 2007 | Br. J. Cancer | pmid:17940511 |
| Dompierre JP et al. | Histone deacetylase 6 inhibition compensates for the transport deficit in Huntington's disease by increasing tubulin acetylation. | 2007 | J. Neurosci. | pmid:17392473 |
| Hashii M et al. | Up-regulation of ras-GAP genes is reversed by a MEK inhibitor and doxorubicin in v-Ki-ras-transformed NIH/3T3 fibroblasts. | 2007 | Biochem. Biophys. Res. Commun. | pmid:17367762 |