Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Fenic I et al. | In vivo effects of histone-deacetylase inhibitor trichostatin-A on murine spermatogenesis. | 2004 Sep-Oct | J. Androl. | pmid:15292114 |
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Chen J and Kang JH | Quercetin and trichostatin A cooperatively kill human leukemia cells. | 2005 | Pharmazie | pmid:16320950 |
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Cismasiu VB et al. | BCL11B functionally associates with the NuRD complex in T lymphocytes to repress targeted promoter. | 2005 | Oncogene | pmid:16091750 |
Fang MZ et al. | Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy. | 2005 | Clin. Cancer Res. | pmid:16203797 |
GarcÃa-Morales P et al. | Histone deacetylase inhibitors induced caspase-independent apoptosis in human pancreatic adenocarcinoma cell lines. | 2005 | Mol. Cancer Ther. | pmid:16093438 |
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Zhang Y et al. | Coordinated changes in DNA methylation and histone modifications regulate silencing/derepression of luteinizing hormone receptor gene transcription. | 2005 | Mol. Cell. Biol. | pmid:16135786 |
Ren C et al. | Peptide mass mapping of acetylated isoforms of histone H4 from mouse lymphosarcoma cells treated with histone deacetylase (HDACs) inhibitors. | 2005 | J. Am. Soc. Mass Spectrom. | pmid:16099169 |
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Danaher RJ et al. | Histone deacetylase inhibitors induce reactivation of herpes simplex virus type 1 in a latency-associated transcript-independent manner in neuronal cells. | 2005 | J. Neurovirol. | pmid:16036811 |
Laribee RN and Klemsz MJ | Histone H4 HDAC activity is necessary for expression of the PU.1 gene. | 2005 | Biochim. Biophys. Acta | pmid:16139904 |
Blagosklonny MV et al. | Depletion of mutant p53 and cytotoxicity of histone deacetylase inhibitors. | 2005 | Cancer Res. | pmid:16103091 |
Choi JH et al. | Trichostatin A exacerbates atherosclerosis in low density lipoprotein receptor-deficient mice. | 2005 | Arterioscler. Thromb. Vasc. Biol. | pmid:16141407 |
Krouwels IM et al. | A glue for heterochromatin maintenance: stable SUV39H1 binding to heterochromatin is reinforced by the SET domain. | 2005 | J. Cell Biol. | pmid:16103223 |
Ishihara K | [Role of eosinophils in allergic inflammation]. | 2005 | Yakugaku Zasshi | pmid:16141691 |
Lu Q et al. | Structure-based optimization of phenylbutyrate-derived histone deacetylase inhibitors. | 2005 | J. Med. Chem. | pmid:16107152 |
Yanada M et al. | Frequent hemizygous deletion at 1p36 and hypermethylation downregulate RUNX3 expression in human lung cancer cell lines. | 2005 | Oncol. Rep. | pmid:16142337 |
Uchida H et al. | Histone deacetylase inhibitors induce differentiation of human endometrial adenocarcinoma cells through up-regulation of glycodelin. | 2005 | Endocrinology | pmid:16123169 |
Su M et al. | Recruitment of nuclear factor Y to the inverted CCAAT element (ICE) by c-Jun and E1A stimulates basal transcription of the bone sialoprotein gene in osteosarcoma cells. | 2005 | J. Biol. Chem. | pmid:16087680 |
Somech R et al. | The nuclear-envelope protein and transcriptional repressor LAP2beta interacts with HDAC3 at the nuclear periphery, and induces histone H4 deacetylation. | 2005 | J. Cell. Sci. | pmid:16129885 |
Cho HH et al. | Induction of osteogenic differentiation of human mesenchymal stem cells by histone deacetylase inhibitors. | 2005 | J. Cell. Biochem. | pmid:16088945 |
Lin KT et al. | Epigenetic activation of alpha4, beta2 and beta6 integrins involved in cell migration in trichostatin A-treated Hep3B cells. | 2005 | J. Biomed. Sci. | pmid:16132114 |
Smardová J et al. | CBP sensitizes v-myb-transformed monoblasts to differentiation inducers. | 2005 | Differentiation | pmid:16026544 |
Gurvich N et al. | Association of valproate-induced teratogenesis with histone deacetylase inhibition in vivo. | 2005 | FASEB J. | pmid:15901671 |
Sengupta S et al. | Tumor suppressor p53 represses transcription of RECQ4 helicase. | 2005 | Oncogene | pmid:15674334 |
Busson M et al. | Coactivation of nuclear receptors and myogenic factors induces the major BTG1 influence on muscle differentiation. | 2005 | Oncogene | pmid:15674337 |
Wen J et al. | Tal1/SCL binding to pericentromeric DNA represses transcription. | 2005 | J. Biol. Chem. | pmid:15677454 |
Illi B et al. | Epigenetic histone modification and cardiovascular lineage programming in mouse embryonic stem cells exposed to laminar shear stress. | 2005 | Circ. Res. | pmid:15705964 |
Jalonen U et al. | Inhibition of tristetraprolin expression by dexamethasone in activated macrophages. | 2005 | Biochem. Pharmacol. | pmid:15710351 |
Schmittwolf C et al. | In vivo haematopoietic activity is induced in neurosphere cells by chromatin-modifying agents. | 2005 | EMBO J. | pmid:15660132 |
Kang J et al. | Antioxidants and trichostatin A synergistically protect against in vitro cytotoxicity of Ni2+ in human hepatoma cells. | 2005 | Toxicol In Vitro | pmid:15649630 |
Peltonen K et al. | Melanoma cell lines are susceptible to histone deacetylase inhibitor TSA provoked cell cycle arrest and apoptosis. | 2005 | Pigment Cell Res. | pmid:15892716 |
Schwahn DJ et al. | Dynamic regulation of the human dopachrome tautomerase promoter by MITF, ER-alpha and chromatin remodelers during proliferation and senescence of human melanocytes. | 2005 | Pigment Cell Res. | pmid:15892717 |
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Rincón-Arano H et al. | YY1 and GATA-1 interaction modulate the chicken 3'-side alpha-globin enhancer activity. | 2005 | J. Mol. Biol. | pmid:15913647 |
Galfi P et al. | Divergent effects of resveratrol, a polyphenolic phytostilbene, on free radical levels and type of cell death induced by the histone deacetylase inhibitors butyrate and trichostatin A. | 2005 | J. Steroid Biochem. Mol. Biol. | pmid:15862948 |
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Xu ZM et al. | [Analysis of the methylation in the promoter of LRP15 gene and its expression]. | 2005 | Zhongguo Shi Yan Xue Ye Xue Za Zhi | pmid:15854274 |
Mai A et al. | Class II (IIa)-selective histone deacetylase inhibitors. 1. Synthesis and biological evaluation of novel (aryloxopropenyl)pyrrolyl hydroxyamides. | 2005 | J. Med. Chem. | pmid:15857140 |
Ho WC et al. | Nuclear factor-kappaB induced by doxorubicin is deficient in phosphorylation and acetylation and represses nuclear factor-kappaB-dependent transcription in cancer cells. | 2005 | Cancer Res. | pmid:15899819 |
Tran T et al. | Enhancement of folate receptor alpha expression in tumor cells through the glucocorticoid receptor: a promising means to improved tumor detection and targeting. | 2005 | Cancer Res. | pmid:15899836 |
Camelo S et al. | Transcriptional therapy with the histone deacetylase inhibitor trichostatin A ameliorates experimental autoimmune encephalomyelitis. | 2005 | J. Neuroimmunol. | pmid:15885809 |
Young DA et al. | Differential effects of histone deacetylase inhibitors on phorbol ester- and TGF-beta1 induced murine tissue inhibitor of metalloproteinases-1 gene expression. | 2005 | FEBS J. | pmid:15819885 |
Canes D et al. | Histone deacetylase inhibitors upregulate plakoglobin expression in bladder carcinoma cells and display antineoplastic activity in vitro and in vivo. | 2005 | Int. J. Cancer | pmid:15499627 |
Yamaguchi K et al. | Histone deacetylase inhibitors suppress the induction of c-Jun and its target genes including COX-2. | 2005 | J. Biol. Chem. | pmid:15994313 |
Zhao XY et al. | Granulocyte-macrophage colony-stimulating factor induces de novo methylation of the p15 CpG island in hematopoietic cells. | 2005 | Cytokine | pmid:15996479 |
Sato N et al. | Epigenetic down-regulation of CDKN1C/p57KIP2 in pancreatic ductal neoplasms identified by gene expression profiling. | 2005 | Clin. Cancer Res. | pmid:16000561 |
Munshi A et al. | Histone deacetylase inhibitors radiosensitize human melanoma cells by suppressing DNA repair activity. | 2005 | Clin. Cancer Res. | pmid:16000590 |
Sng JC et al. | Inhibition of histone deacetylation by trichostatin A intensifies the transcriptions of neuronal c-fos and c-jun genes after kainate stimulation. | 2005 | Neurosci. Lett. | pmid:16002216 |
Sonnemann J et al. | Histone deacetylase inhibitors interact synergistically with tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) to induce apoptosis in carcinoma cell lines. | 2005 | Invest New Drugs | pmid:15744585 |
Shetty S et al. | Transcription factor NF-kappaB differentially regulates death receptor 5 expression involving histone deacetylase 1. | 2005 | Mol. Cell. Biol. | pmid:15964798 |
Place RF et al. | HDAC inhibition prevents NF-kappa B activation by suppressing proteasome activity: down-regulation of proteasome subunit expression stabilizes I kappa B alpha. | 2005 | Biochem. Pharmacol. | pmid:15950952 |
Wooten LG and Ogretmen B | Sp1/Sp3-dependent regulation of human telomerase reverse transcriptase promoter activity by the bioactive sphingolipid ceramide. | 2005 | J. Biol. Chem. | pmid:15951564 |
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Komata T et al. | Histone deacetylase inhibitors, N-butyric acid and trichostatin A, induce caspase-8- but not caspase-9-dependent apoptosis in human malignant glioma cells. | 2005 | Int. J. Oncol. | pmid:15809727 |
Schroeder TM and Westendorf JJ | Histone deacetylase inhibitors promote osteoblast maturation. | 2005 | J. Bone Miner. Res. | pmid:16294278 |
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Fan S et al. | Valproic acid enhances gene expression from viral gene transfer vectors. | 2005 | J. Virol. Methods | pmid:15737413 |
Bártová E et al. | Nuclear levels and patterns of histone H3 modification and HP1 proteins after inhibition of histone deacetylases. | 2005 | J. Cell. Sci. | pmid:16254244 |
Xu S et al. | Abrogation of DUSP6 by hypermethylation in human pancreatic cancer. | 2005 | J. Hum. Genet. | pmid:15824892 |
Strait KA et al. | Histone deacetylase inhibitors induce G2-checkpoint arrest and apoptosis in cisplatinum-resistant ovarian cancer cells associated with overexpression of the Bcl-2-related protein Bad. | 2005 | Mol. Cancer Ther. | pmid:15827334 |
Magner WJ and Tomasi TB | Apoptotic and necrotic cells induced by different agents vary in their expression of MHC and costimulatory genes. | 2005 | Mol. Immunol. | pmid:15829293 |
Hu J and Colburn NH | Histone deacetylase inhibition down-regulates cyclin D1 transcription by inhibiting nuclear factor-kappaB/p65 DNA binding. | 2005 | Mol. Cancer Res. | pmid:15755876 |
Wagner S and Roemer K | Retinoblastoma protein is required for efficient colorectal carcinoma cell apoptosis by histone deacetylase inhibitors in the absence of p21Waf. | 2005 | Biochem. Pharmacol. | pmid:15763542 |
Mori T et al. | Epigenetic up-regulation of C-C chemokine receptor 7 and C-X-C chemokine receptor 4 expression in melanoma cells. | 2005 | Cancer Res. | pmid:15753377 |
Dowling M et al. | Mitotic spindle checkpoint inactivation by trichostatin a defines a mechanism for increasing cancer cell killing by microtubule-disrupting agents. | 2005 | Cancer Biol. Ther. | pmid:15753652 |
Dote H et al. | Aberrant promoter methylation in human DAB2 interactive protein (hDAB2IP) gene in gastrointestinal tumour. | 2005 | Br. J. Cancer | pmid:15770214 |
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Blais M et al. | Synergy between deacetylase inhibitors and IL-1beta in activation of the serum amyloid A2 gene promoter. | 2005 | DNA Cell Biol. | pmid:15812237 |
Sato N et al. | Epigenetic inactivation of TFPI-2 as a common mechanism associated with growth and invasion of pancreatic ductal adenocarcinoma. | 2005 | Oncogene | pmid:15592528 |
Davidson SM et al. | The transcriptional coactivator p300 plays a critical role in the hypertrophic and protective pathways induced by phenylephrine in cardiac cells but is specific to the hypertrophic effect of urocortin. | 2005 | Chembiochem | pmid:15593114 |
Maxhimer JB et al. | Induction of apoptosis of lung and esophageal cancer cells treated with the combination of histone deacetylase inhibitor (trichostatin A) and protein kinase C inhibitor (calphostin C). | 2005 | J. Thorac. Cardiovasc. Surg. | pmid:15632825 |
Kondo T et al. | Loss of heterozygosity and histone hypoacetylation of the PINX1 gene are associated with reduced expression in gastric carcinoma. | 2005 | Oncogene | pmid:15637589 |
Senawong T et al. | BCL11A-dependent recruitment of SIRT1 to a promoter template in mammalian cells results in histone deacetylation and transcriptional repression. | 2005 | Arch. Biochem. Biophys. | pmid:15639232 |
Nambiar MP et al. | Transcriptional induction of cholinesterase expression and protection against chemical warfare nerve agents. | 2005 | Chem. Biol. Interact. | pmid:16429504 |
Zhao Y et al. | Histone acetylation regulates both transcription initiation and elongation of hsp22 gene in Drosophila. | 2005 | Biochem. Biophys. Res. Commun. | pmid:15607742 |
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