| MeSH term | MeSH ID | Detail |
|---|---|---|
| Lymphoma, Large-Cell, Anaplastic | D017728 | 3 associated lipids |
| Fibromatosis, Aggressive | D018222 | 2 associated lipids |
| Rhabdomyosarcoma, Alveolar | D018232 | 2 associated lipids |
| Rhabdomyosarcoma, Embryonal | D018233 | 1 associated lipids |
| Carcinoma, Embryonal | D018236 | 8 associated lipids |
| Adenocarcinoma, Follicular | D018263 | 3 associated lipids |
| Carcinoma, Papillary, Follicular | D018265 | 1 associated lipids |
| Carcinoma, Ductal, Breast | D018270 | 19 associated lipids |
| Cystadenocarcinoma, Mucinous | D018282 | 1 associated lipids |
| Cystadenocarcinoma, Serous | D018284 | 2 associated lipids |
| Cystadenoma, Serous | D018293 | 1 associated lipids |
| Rhabdoid Tumor | D018335 | 1 associated lipids |
| Neuroendocrine Tumors | D018358 | 4 associated lipids |
| Thyroid Hormone Resistance Syndrome | D018382 | 1 associated lipids |
| Bone Marrow Neoplasms | D019046 | 2 associated lipids |
| Porcine Reproductive and Respiratory Syndrome | D019318 | 4 associated lipids |
| Roseolovirus Infections | D019349 | 1 associated lipids |
| Retinal Neoplasms | D019572 | 3 associated lipids |
| Neurodegenerative Diseases | D019636 | 32 associated lipids |
| Ventricular Remodeling | D020257 | 28 associated lipids |
trichostatin A
Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with trichostatin A?
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with trichostatin A
PubChem Associated disorders and diseases
What pathways are associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with trichostatin A?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with trichostatin A?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with trichostatin A?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with trichostatin A?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with trichostatin A?
Mouse Model
Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with trichostatin A
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Dogra SC et al. | Evidence that the coactivator CBP/p300 is important for phenobarbital-induced but not basal expression of the CYP2H1 gene. | 2003 | Mol. Pharmacol. | pmid:12488538 |
| Lietz M et al. | RE-1 silencing transcription factor (REST) regulates human synaptophysin gene transcription through an intronic sequence-specific DNA-binding site. | 2003 | Eur. J. Biochem. | pmid:12492469 |
| Grisolano JL et al. | An activated receptor tyrosine kinase, TEL/PDGFbetaR, cooperates with AML1/ETO to induce acute myeloid leukemia in mice. | 2003 | Proc. Natl. Acad. Sci. U.S.A. | pmid:12881486 |
| Konduri SD et al. | Promoter methylation and silencing of the tissue factor pathway inhibitor-2 (TFPI-2), a gene encoding an inhibitor of matrix metalloproteinases in human glioma cells. | 2003 | Oncogene | pmid:12881707 |
| Nakajima M et al. | Effects of histone deacetylation and DNA methylation on the constitutive and TCDD-inducible expressions of the human CYP1 family in MCF-7 and HeLa cells. | 2003 | Toxicol. Lett. | pmid:12927368 |
| Papeleu P et al. | Trichostatin A induces differential cell cycle arrests but does not induce apoptosis in primary cultures of mitogen-stimulated rat hepatocytes. | 2003 | J. Hepatol. | pmid:12927923 |
| Senawong T et al. | Involvement of the histone deacetylase SIRT1 in chicken ovalbumin upstream promoter transcription factor (COUP-TF)-interacting protein 2-mediated transcriptional repression. | 2003 | J. Biol. Chem. | pmid:12930829 |
| Klisovic DD et al. | Depsipeptide (FR901228) inhibits proliferation and induces apoptosis in primary and metastatic human uveal melanoma cell lines. | 2003 | Invest. Ophthalmol. Vis. Sci. | pmid:12766035 |
| Génin P et al. | Impairment of interferon-induced IRF-7 gene expression due to inhibition of ISGF3 formation by trichostatin A. | 2003 | J. Virol. | pmid:12768031 |
| Bartoli A et al. | Effect of trichostatin a and 5'-azacytidine on transgene reactivation in U937 transduced cells. | 2003 | Pharmacol. Res. | pmid:12770523 |
| Koeller KM et al. | Chemical genetic modifier screens: small molecule trichostatin suppressors as probes of intracellular histone and tubulin acetylation. | 2003 | Chem. Biol. | pmid:12770822 |
| Wong JE et al. | Therapeutic strategies in gastric cancer. | 2003 | J. Clin. Oncol. | pmid:14645406 |
| Suzuki M et al. | Direct association between PU.1 and MeCP2 that recruits mSin3A-HDAC complex for PU.1-mediated transcriptional repression. | 2003 | Oncogene | pmid:14647463 |
| Kim HS et al. | Regulation of the tyrosine hydroxylase gene promoter by histone deacetylase inhibitors. | 2003 | Biochem. Biophys. Res. Commun. | pmid:14651963 |
| Coombes MM et al. | Resetting the histone code at CDKN2A in HNSCC by inhibition of DNA methylation. | 2003 | Oncogene | pmid:14654786 |
| Chua YL et al. | The transcriptional enhancer of the pea plastocyanin gene associates with the nuclear matrix and regulates gene expression through histone acetylation. | 2003 | Plant Cell | pmid:12782737 |
| Cecconi D et al. | Proteomic profiling of pancreatic ductal carcinoma cell lines treated with trichostatin-A. | 2003 | Electrophoresis | pmid:12783462 |
| Fukuoka M et al. | Negative regulation of forkhead transcription factor AFX (Foxo4) by CBP-induced acetylation. | 2003 | Int. J. Mol. Med. | pmid:12964026 |
| Vanommeslaeghe K et al. | Ab initio study of the binding of Trichostatin A (TSA) in the active site of histone deacetylase like protein (HDLP). | 2003 | Org. Biomol. Chem. | pmid:12968347 |
| Foubister V | Anticancer drug shows promise against lupus. | 2003 | Drug Discov. Today | pmid:12681930 |
| Park WH et al. | Trichostatin inhibits the growth of ACHN renal cell carcinoma cells via cell cycle arrest in association with p27, or apoptosis. | 2003 | Int. J. Oncol. | pmid:12684681 |
| Farhan H et al. | Genistein inhibits vitamin D hydroxylases CYP24 and CYP27B1 expression in prostate cells. | 2003 | J. Steroid Biochem. Mol. Biol. | pmid:12732287 |
| Chambers AE et al. | Histone acetylation-mediated regulation of genes in leukaemic cells. | 2003 | Eur. J. Cancer | pmid:12736119 |
| Hoever G et al. | The mechanism of 3'-azido-2',3'-dideoxythymidine resistance to human lymphoid cells. | 2003 | Int. J. Mol. Med. | pmid:12736716 |
| Kao HH et al. | Genomic structure, gene expression, and promoter analysis of human multidrug resistance-associated protein 7. | 2003 Jan-Feb | J. Biomed. Sci. | pmid:12566991 |
| Kagoshima M et al. | How signaling pathways interact with gene transcription. | 2003 Jan-Mar | Monaldi Arch Chest Dis | pmid:14533280 |
| Swank RA et al. | The histone deacetylase inhibitor, trichostatin A, reactivates the developmentally silenced gamma globin expression in somatic cell hybrids and induces gamma gene expression in adult BFUe cultures. | 2003 May-Jun | Blood Cells Mol. Dis. | pmid:12737942 |
| Zoumpoulidou G et al. | Convergence of interferon-gamma and progesterone signaling pathways in human endometrium: role of PIASy (protein inhibitor of activated signal transducer and activator of transcription-y). | 2004 | Mol. Endocrinol. | pmid:15155784 |
| Wang LG et al. | Androgen receptor level controlled by a suppressor complex lost in an androgen-independent prostate cancer cell line. | 2004 | Oncogene | pmid:15156193 |
| Romanski A et al. | Use of a novel histone deacetylase inhibitor to induce apoptosis in cell lines of acute lymphoblastic leukemia. | 2004 | Haematologica | pmid:15075075 |
| Ahmed S et al. | A novel protein with similarities to Rb binding protein 2 compensates for loss of Chk1 function and affects histone modification in fission yeast. | 2004 | Mol. Cell. Biol. | pmid:15082762 |
| Amor DJ et al. | Human centromere repositioning "in progress". | 2004 | Proc. Natl. Acad. Sci. U.S.A. | pmid:15084747 |
| Margueron R et al. | Histone deacetylase inhibition and estrogen receptor alpha levels modulate the transcriptional activity of partial antiestrogens. | 2004 | J. Mol. Endocrinol. | pmid:15072561 |
| Reifenberger J et al. | Frequent alterations of Ras signaling pathway genes in sporadic malignant melanomas. | 2004 | Int. J. Cancer | pmid:14961576 |
| Sugimoto S et al. | Expression and regulation of tumor suppressor gene maspin in human bladder cancer. | 2004 | Cancer Lett. | pmid:14732229 |
| Vaisburg A et al. | (2-amino-phenyl)-amides of omega-substituted alkanoic acids as new histone deacetylase inhibitors. | 2004 | Bioorg. Med. Chem. Lett. | pmid:14684344 |
| Nojima H et al. | Increase in DNA methylation downregulates conceptus interferon-tau gene expression. | 2004 | Mol. Reprod. Dev. | pmid:14991730 |
| Chua YL et al. | Microarray analysis of chromatin-immunoprecipitated DNA identifies specific regions of tobacco genes associated with acetylated histones. | 2004 | Plant J. | pmid:14996214 |
| Khan AN et al. | An epigenetically altered tumor cell vaccine. | 2004 | Cancer Immunol. Immunother. | pmid:14997346 |
| Ragno R et al. | 3-(4-Aroyl-1-methyl-1H-pyrrol-2-yl)-N-hydroxy-2-propenamides as a new class of synthetic histone deacetylase inhibitors. 3. Discovery of novel lead compounds through structure-based drug design and docking studies. | 2004 | J. Med. Chem. | pmid:14998325 |
| Hwang CK et al. | Transcriptional regulation of mouse mu opioid receptor gene by PU.1. | 2004 | J. Biol. Chem. | pmid:14998994 |
| Fan X et al. | Regulation of RANKL promoter activity is associated with histone remodeling in murine bone stromal cells. | 2004 | J. Cell. Biochem. | pmid:15389882 |
| Chaturvedi V et al. | Resistance to UV-induced apoptosis in human keratinocytes during accelerated senescence is associated with functional inactivation of p53. | 2004 | J. Cell. Physiol. | pmid:14584049 |
| Kang J et al. | Synergistic killing of human leukemia cells by antioxidants and trichostatin A. | 2004 | Cancer Chemother. Pharmacol. | pmid:15248029 |
| Jin B and Ryu DY | Regulation of CYP1A2 by histone deacetylase inhibitors in mouse hepatocytes. | 2004 | J. Biochem. Mol. Toxicol. | pmid:15252868 |
| Gilchrist S et al. | Nuclear organization of centromeric domains is not perturbed by inhibition of histone deacetylases. | 2004 | Chromosome Res. | pmid:15254368 |
| Aggarwal BD and Calvi BR | Chromatin regulates origin activity in Drosophila follicle cells. | 2004 | Nature | pmid:15254542 |
| Sanderson L et al. | Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice. | 2004 | Drug Metab. Dispos. | pmid:15269190 |
| Li X et al. | Regulation of histone acetylation and apoptosis by trichostatin in HL-60 cells. | 2004 | J. Huazhong Univ. Sci. Technol. Med. Sci. | pmid:15791844 |
| ChuÄkin IA et al. | [Transcription of c-fos gene and DNA binding activity of transcription factor AP-1 increase upon differentiation of mouse F9 teratocarcinoma cells]. | 2004 | Tsitologiia | pmid:15747838 |