Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Gavin DP et al. | Reduced baseline acetylated histone 3 levels, and a blunted response to HDAC inhibition in lymphocyte cultures from schizophrenia subjects. | 2008 | Schizophr. Res. | pmid:18539439 |
Vadie N et al. | MYCNOS functions as an antisense RNA regulating MYCN. | 2015 | RNA Biol | pmid:26156430 |
Katsuno M et al. | [Dysfunction of dynactin 1 in motor neuron degeneration]. | 2013 | Rinsho Shinkeigaku | pmid:24291886 |
Ohnishi K | [Therapeutic strategies for patients with relapsed acute promyelocytic leukemia]. | 2006 | Rinsho Ketsueki | pmid:16986710 |
Nakamura C et al. | Anti-arthritic effects of combined treatment with histone deacetylase inhibitor and low-intensity ultrasound in the presence of microbubbles in human rheumatoid synovial cells. | 2008 | Rheumatology (Oxford) | pmid:18281366 |
Chen WP et al. | Trichostatin A inhibits expression of cathepsins in experimental osteoarthritis. | 2011 | Rheumatol. Int. | pmid:20390279 |
Zhang HP et al. | Association between histone hyperacetylation status in memory T lymphocytes and allergen-induced eosinophilic airway inflammation. | 2016 | Respirology | pmid:26991676 |
Chen J et al. | E1A has no effect on LPS-induced IL-6 secretion in rat alveolar epithelial cells. | 2009 | Respiration | pmid:19299891 |
Bodas M et al. | Inhibition of histone-deacetylase activity rescues inflammatory cystic fibrosis lung disease by modulating innate and adaptive immune responses. | 2018 | Respir. Res. | pmid:29301535 |
Endo T et al. | Activities of maturation-promoting factor (MPF) and mitogen-activated protein kinase (MAPK) are not required for the global histone deacetylation observed after germinal vesicle breakdown (GVBD) in porcine oocytes. | 2006 | Reproduction | pmid:16514187 |
Oliveira CS et al. | HDAC inhibition decreases XIST expression on female IVP bovine blastocysts. | 2013 | Reproduction | pmid:23104973 |
Kerr JB et al. | The primordial follicle reserve is not renewed after chemical or γ-irradiation mediated depletion. | 2012 | Reproduction | pmid:22301887 |
Liao HF et al. | Dnmt3l-knockout donor cells improve somatic cell nuclear transfer reprogramming efficiency. | 2015 | Reproduction | pmid:26159833 |
Wee G et al. | Epigenetic alteration of the donor cells does not recapitulate the reprogramming of DNA methylation in cloned embryos. | 2007 | Reproduction | pmid:18042635 |
Bui HT et al. | Regulation of chromatin and chromosome morphology by histone H3 modifications in pig oocytes. | 2007 | Reproduction | pmid:17307905 |
Di Renzo F et al. | VPA-related axial skeletal defects and apoptosis: a proposed event cascade. | 2010 | Reprod. Toxicol. | pmid:19850124 |
Oliveira CS et al. | Effects of histone hyperacetylation on the preimplantation development of male and female bovine embryos. | 2010 | Reprod. Fertil. Dev. | pmid:20591338 |
Song BS et al. | Valproic acid enhances early development of bovine somatic cell nuclear transfer embryos by alleviating endoplasmic reticulum stress. | 2014 | Reprod. Fertil. Dev. | pmid:23506644 |
Jin YX et al. | Histone deacetylase inhibitor trichostatin A affects porcine oocyte maturation in vitro. | 2014 | Reprod. Fertil. Dev. | pmid:23759302 |
Saini M et al. | Treatment of buffalo (Bubalus bubalis) donor cells with trichostatin A and 5-aza-2'-deoxycytidine alters their growth characteristics, gene expression and epigenetic status and improves the in vitro developmental competence, quality and epigenetic status of cloned embryos. | 2016 | Reprod. Fertil. Dev. | pmid:25409339 |