Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.
To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with trichostatin A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).
Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).
Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Armstrong K et al. | NF-kappaB activation upregulates fibroblast growth factor 8 expression in prostate cancer cells. | 2006 | Prostate | pmid:16683270 |
Mavis CK et al. | Expression level and DNA methylation status of glutathione-S-transferase genes in normal murine prostate and TRAMP tumors. | 2009 | Prostate | pmid:19444856 |
Frønsdal K and Saatcioglu F | Histone deacetylase inhibitors differentially mediate apoptosis in prostate cancer cells. | 2005 | Prostate | pmid:15389787 |
Walton TJ et al. | DNA demethylation and histone deacetylation inhibition co-operate to re-express estrogen receptor beta and induce apoptosis in prostate cancer cell-lines. | 2008 | Prostate | pmid:18092350 |
Soleymani Fard S et al. | Prostaglandin E2 induces growth inhibition, apoptosis and differentiation in T and B cell-derived acute lymphoblastic leukemia cell lines (CCRF-CEM and Nalm-6). | 2012 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22749740 |
Viñuelas J et al. | Towards experimental manipulation of stochasticity in gene expression. | 2012 | Prog. Biophys. Mol. Biol. | pmid:22609563 |
Akiyama T et al. | Inadequate histone deacetylation during oocyte meiosis causes aneuploidy and embryo death in mice. | 2006 | Proc. Natl. Acad. Sci. U.S.A. | pmid:16651529 |
Grisolano JL et al. | An activated receptor tyrosine kinase, TEL/PDGFbetaR, cooperates with AML1/ETO to induce acute myeloid leukemia in mice. | 2003 | Proc. Natl. Acad. Sci. U.S.A. | pmid:12881486 |
Xu D et al. | Switch from Myc/Max to Mad1/Max binding and decrease in histone acetylation at the telomerase reverse transcriptase promoter during differentiation of HL60 cells. | 2001 | Proc. Natl. Acad. Sci. U.S.A. | pmid:11274400 |
Chen WY and Townes TM | Molecular mechanism for silencing virally transduced genes involves histone deacetylation and chromatin condensation. | 2000 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10618426 |
Xu CR et al. | Histone acetylation affects expression of cellular patterning genes in the Arabidopsis root epidermis. | 2005 | Proc. Natl. Acad. Sci. U.S.A. | pmid:16176989 |
Emiliani S et al. | Characterization of a human RPD3 ortholog, HDAC3. | 1998 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9501169 |
Kenneth NS et al. | TRRAP and GCN5 are used by c-Myc to activate RNA polymerase III transcription. | 2007 | Proc. Natl. Acad. Sci. U.S.A. | pmid:17848523 |
Condreay JP et al. | Transient and stable gene expression in mammalian cells transduced with a recombinant baculovirus vector. | 1999 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9874783 |
Crump NT et al. | Dynamic acetylation of all lysine-4 trimethylated histone H3 is evolutionarily conserved and mediated by p300/CBP. | 2011 | Proc. Natl. Acad. Sci. U.S.A. | pmid:21518915 |
Saito A et al. | A synthetic inhibitor of histone deacetylase, MS-27-275, with marked in vivo antitumor activity against human tumors. | 1999 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10200307 |
Jansen MS et al. | Short-chain fatty acids enhance nuclear receptor activity through mitogen-activated protein kinase activation and histone deacetylase inhibition. | 2004 | Proc. Natl. Acad. Sci. U.S.A. | pmid:15103026 |
Furumai R et al. | Potent histone deacetylase inhibitors built from trichostatin A and cyclic tetrapeptide antibiotics including trapoxin. | 2001 | Proc. Natl. Acad. Sci. U.S.A. | pmid:11134513 |
McCullough SD et al. | Reelin is a target of polyglutamine expanded ataxin-7 in human spinocerebellar ataxia type 7 (SCA7) astrocytes. | 2012 | Proc. Natl. Acad. Sci. U.S.A. | pmid:23236151 |
Weaver IC et al. | Maternal care effects on the hippocampal transcriptome and anxiety-mediated behaviors in the offspring that are reversible in adulthood. | 2006 | Proc. Natl. Acad. Sci. U.S.A. | pmid:16484373 |